JP2009519971A - スキンケア組成物及び治療法 - Google Patents
スキンケア組成物及び治療法 Download PDFInfo
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- JP2009519971A JP2009519971A JP2008545973A JP2008545973A JP2009519971A JP 2009519971 A JP2009519971 A JP 2009519971A JP 2008545973 A JP2008545973 A JP 2008545973A JP 2008545973 A JP2008545973 A JP 2008545973A JP 2009519971 A JP2009519971 A JP 2009519971A
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- 239000001717 vitis vinifera seed extract Substances 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/985—Skin or skin outgrowth, e.g. hair, nails
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/33—Fibroblasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75044705P | 2005-12-14 | 2005-12-14 | |
| PCT/US2006/062090 WO2007070850A2 (en) | 2005-12-14 | 2006-12-14 | Skin care compositions and treatments |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013140481A Division JP2013224323A (ja) | 2005-12-14 | 2013-07-04 | スキンケア組成物及び治療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009519971A true JP2009519971A (ja) | 2009-05-21 |
| JP2009519971A5 JP2009519971A5 (https=) | 2010-01-28 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008545973A Pending JP2009519971A (ja) | 2005-12-14 | 2006-12-14 | スキンケア組成物及び治療法 |
| JP2013140481A Pending JP2013224323A (ja) | 2005-12-14 | 2013-07-04 | スキンケア組成物及び治療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013140481A Pending JP2013224323A (ja) | 2005-12-14 | 2013-07-04 | スキンケア組成物及び治療法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20090202654A1 (https=) |
| EP (1) | EP1969120A4 (https=) |
| JP (2) | JP2009519971A (https=) |
| CN (1) | CN101379182A (https=) |
| AU (1) | AU2006325778A1 (https=) |
| BR (1) | BRPI0619967A2 (https=) |
| CA (1) | CA2633201A1 (https=) |
| IL (1) | IL192198A0 (https=) |
| RU (2) | RU2008128451A (https=) |
| WO (1) | WO2007070850A2 (https=) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2014508160A (ja) * | 2011-03-04 | 2014-04-03 | アル−カタニ，アーメッド・エイチ | スキンクリーム |
| JP2016008177A (ja) * | 2014-06-20 | 2016-01-18 | 共栄化学工業株式会社 | 皮膚外用剤 |
| WO2018179374A1 (ja) * | 2017-03-31 | 2018-10-04 | 株式会社セルバンク | 真皮線維芽細胞の培養上清液を含む化粧用組成物およびその製造方法 |
| JP2019510829A (ja) * | 2016-04-01 | 2019-04-18 | バイオコズ・グローバル・コリア・コーポレイションＢｉｏｃｏｚ Ｇｌｏｂａｌ Ｋｏｒｅａ Ｃｏｒｐ． | 細胞培養培地中に有効成分として、アルブミン、ヒアルロン酸またはコラーゲンを含む化粧品組成物 |
| JP2022120123A (ja) * | 2013-08-09 | 2022-08-17 | サイトレリス バイオシステムズ，インコーポレーテッド | 非熱組織切除を使用する皮膚治療のための方法及び機器 |
| JP2024529240A (ja) * | 2021-07-30 | 2024-08-06 | ロレアル | 細胞外小胞、分泌型生体分子、及び／又は馴化培地を含む組成物、並びにそれを製造及び使用する方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP4385076B2 (ja) * | 2006-01-13 | 2009-12-16 | 独立行政法人科学技術振興機構 | 動物細胞を無血清培養するための培地用添加剤、キット及びこれらの利用 |
| EP2082030A2 (en) * | 2006-10-20 | 2009-07-29 | Keracure, Inc. | Devices with cells cultured on flexible supports |
| US8439940B2 (en) * | 2010-12-22 | 2013-05-14 | Cabochon Aesthetics, Inc. | Dissection handpiece with aspiration means for reducing the appearance of cellulite |
| US20120156134A1 (en) | 2007-12-20 | 2012-06-21 | Shayne Squires | Compositions and methods for detecting or eliminating senescent cells to diagnose or treat disease |
| WO2010048441A2 (en) * | 2008-10-22 | 2010-04-29 | Regenemed, Inc. | Culture systems |
| IT1394690B1 (it) * | 2008-10-23 | 2012-07-13 | Carli De | Metodo di trattamento dermocosmetico della cute mediante applicazione di composizioni contenenti ngf. |
| KR101712501B1 (ko) * | 2008-11-11 | 2017-03-07 | 고쿠리츠다이가쿠호진 히로시마다이가쿠 | 분화 유도 배지용 첨가제 및 그의 용도 |
| US20110294731A1 (en) * | 2009-02-13 | 2011-12-01 | Invitrx, Inc. | Skin cream |
| FI20095355A0 (fi) * | 2009-04-01 | 2009-04-01 | Helsingin Yliopisto | Regeneroituva aktiivinen matriisi ja sen käytöt |
| FR2948286B1 (fr) * | 2009-07-27 | 2011-08-26 | Jean-Noel Thorel | Composition injectable associant un agent de comblement et un milieu de croissance des fibroblastes |
| US20120315259A1 (en) * | 2010-02-18 | 2012-12-13 | Hyman Friedlander | Method and composition for skin care comprising cord blood serum or plasma or components thereof |
| CA2792802C (en) | 2010-03-10 | 2017-10-31 | Two Cells Co., Ltd. | Cell preparation containing mesenchymal stem cells, and method for producing same |
| WO2013005235A1 (en) * | 2011-07-06 | 2013-01-10 | Orf Liftaekni Hf | Method of use of stabilised non-plant-derived growth factor in skin care |
| KR20140119023A (ko) | 2011-12-13 | 2014-10-08 | 버크 인스티튜트 포 리서치 온 에이징 | 의료 요법을 개선하는 방법 |
| KR101446706B1 (ko) | 2011-12-29 | 2014-10-07 | 연세대학교 산학협력단 | Ｆｇｆ를 포함하는 피부 재생용 조성물 |
| US11744856B1 (en) * | 2012-04-11 | 2023-09-05 | Medicell Technologies, Llc | Compositions and methods to improve skin quality and appearance, cure skin and tissue damage, and use in therapy |
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| KR20160068781A (ko) | 2013-09-09 | 2016-06-15 | 디디 카르마 엘엘씨 | 파지형 더마플래닝 장치 및 더마플래닝 처리 |
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| US9974813B1 (en) | 2014-01-15 | 2018-05-22 | Serucell Corporation | Therapeutic serum obtained from co-cultured cells |
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| US10137085B2 (en) * | 2014-03-19 | 2018-11-27 | Nano And Advanced Materials Institute Limited | Nanoemulsion for transdermal delivery and method of making the same |
| US10801009B2 (en) * | 2014-11-17 | 2020-10-13 | Biocoz Global Korea Corp. | Cosmetic composition for improving condition of skin, containing cell culture medium, epidermal growth factor and bovine serum albumin |
| US10076479B1 (en) | 2018-05-08 | 2018-09-18 | Avon Products, Inc. | Methods for treating skin |
| ES2758431T3 (es) | 2015-03-05 | 2020-05-05 | Avon Prod Inc | Métodos para tratar la piel |
| CN104689301A (zh) * | 2015-03-27 | 2015-06-10 | 吴开刚 | 一种祛除妊娠纹的药物及其制备方法 |
| CA2998483C (en) | 2015-09-16 | 2022-09-06 | Dfb Soria, Llc | Delivery of drug nanoparticles and methods of use thereof |
| WO2017100425A1 (en) * | 2015-12-10 | 2017-06-15 | Aesthetics Biomedical, Inc. | Topical formulation for skin care |
| US20170172909A1 (en) * | 2015-12-22 | 2017-06-22 | Elc Management Llc | Method Of Counteracting The Impact Of Chronic Stress On Skin |
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| WO2018150440A1 (en) * | 2017-02-16 | 2018-08-23 | OCT Therapies and Research Private Limited | Stem cell conditioned media for clinical and cosmetic applications |
| WO2018170196A1 (en) | 2017-03-15 | 2018-09-20 | Dfb Soria, Llc | Topical therapy for the treatment of skin malignancies using nanoparticles of taxanes |
| CN106929474B (zh) * | 2017-03-31 | 2021-09-14 | 北京恒峰铭成生物科技有限公司 | 一种m2巨噬细胞诱导剂 |
| EP3437650A1 (en) * | 2017-07-31 | 2019-02-06 | Accanis Biotech F&E GmbH & Co KG | Treatment of local skin hypotrophy conditions |
| GB201715930D0 (en) * | 2017-09-30 | 2017-11-15 | Upside Biotechnologies Ltd | Cell Culture Medium |
| US11497726B2 (en) | 2018-03-16 | 2022-11-15 | Dfb Soria, Ll. | Topical therapy for the treatment of cervical intraepithelial neoplasia (CIN) and cervical cancer using nanoparticles of taxanes |
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| JP2022524687A (ja) * | 2019-03-27 | 2022-05-10 | プルリステム リミテッド | 審美および化粧処置ならびに毛髪成長の刺激のための方法および組成物 |
| CN111939458A (zh) * | 2020-08-25 | 2020-11-17 | 四川大学 | 一种具有超薄柔性背衬层的微针贴片及其制备方法 |
| FR3126617B1 (fr) * | 2021-09-06 | 2023-12-29 | Oreal | compositions comprenant des vésicules extracellulaires, des biomolécules sécrétées et/ou des milieux conditionnés, et procédés pour les produire |
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| CN118319830B (zh) * | 2024-04-22 | 2025-01-28 | 广州博科化妆品有限公司 | 一种紧致皮肤抗皱精华液及其制备方法 |
| CN121320229A (zh) * | 2025-12-12 | 2026-01-13 | 中国医学科学院生物医学工程研究所 | 一种三维人表皮类器官的分化培养基、制备方法及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08508742A (ja) * | 1993-04-20 | 1996-09-17 | ユニリーバー・ナームローゼ・ベンノートシヤープ | セラミド前駆体を含む化粧品組成物 |
| JPH11513038A (ja) * | 1996-07-02 | 1999-11-09 | ザ、プロクター、エンド、ギャンブル、カンパニー | 皮膚美白組成物 |
| WO2001014527A1 (en) * | 1999-08-23 | 2001-03-01 | Organogenesis Inc. | Skin care compositions and treatments |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256294A (en) * | 1990-09-17 | 1993-10-26 | Genentech, Inc. | Tangential flow filtration process and apparatus |
| US5587396A (en) * | 1994-08-26 | 1996-12-24 | Mary Kay Inc. | Method of ameliorating cellulite by disrupting the barrier function of the stratum corneum |
| US6482839B1 (en) * | 1997-06-02 | 2002-11-19 | Cellegy Pharmaceuticals, Inc. | Pyridine-thiols for treatment of a follicular dermatosis |
| US6566118B1 (en) * | 1997-09-05 | 2003-05-20 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| US6093745A (en) * | 1997-11-25 | 2000-07-25 | Psorx, L.L.C. | Methods and composition for treating skin proliferative diseases |
| WO2000057889A1 (fr) * | 1999-03-31 | 2000-10-05 | Cci Corporation | Preparations pour la peau a usage externe |
| US6372494B1 (en) * | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
| US6833349B2 (en) * | 1999-06-08 | 2004-12-21 | Regeneron Pharmaceuticals, Inc. | Methods of treating inflammatory skin diseases |
| US6607669B2 (en) * | 2000-06-23 | 2003-08-19 | Scilog, Inc. | Method and apparatus for enhancing filtration yields in tangential flow filtration |
| US6346595B1 (en) * | 2000-07-07 | 2002-02-12 | Siltech Llc | Aromatic dimethicone copolyol polymers as sunscreen agents |
| EP1406573A4 (en) * | 2001-06-07 | 2005-03-30 | Skinmedica Inc | CONDITIONED CELL CULTURE MEDIA AND ITS USES |
| WO2003057152A2 (en) * | 2001-12-31 | 2003-07-17 | Isolagen Technologies, Inc | Hair follicle growth |
| FR2912917B1 (fr) * | 2007-02-26 | 2012-05-18 | Oreal | Milieu conditionne et ses utilisations |
-
2006
- 2006-12-14 JP JP2008545973A patent/JP2009519971A/ja active Pending
- 2006-12-14 BR BRPI0619967-4A patent/BRPI0619967A2/pt not_active IP Right Cessation
- 2006-12-14 US US12/097,132 patent/US20090202654A1/en not_active Abandoned
- 2006-12-14 WO PCT/US2006/062090 patent/WO2007070850A2/en not_active Ceased
- 2006-12-14 CA CA002633201A patent/CA2633201A1/en not_active Abandoned
- 2006-12-14 RU RU2008128451/15A patent/RU2008128451A/ru not_active Application Discontinuation
- 2006-12-14 CN CNA2006800527742A patent/CN101379182A/zh active Pending
- 2006-12-14 EP EP06840261A patent/EP1969120A4/en not_active Withdrawn
- 2006-12-14 AU AU2006325778A patent/AU2006325778A1/en not_active Abandoned
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2008
- 2008-06-15 IL IL192198A patent/IL192198A0/en unknown
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2011
- 2011-06-07 US US13/155,058 patent/US20120009233A1/en not_active Abandoned
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2013
- 2013-07-04 JP JP2013140481A patent/JP2013224323A/ja active Pending
- 2013-07-23 RU RU2013134412/15A patent/RU2013134412A/ru not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08508742A (ja) * | 1993-04-20 | 1996-09-17 | ユニリーバー・ナームローゼ・ベンノートシヤープ | セラミド前駆体を含む化粧品組成物 |
| JPH11513038A (ja) * | 1996-07-02 | 1999-11-09 | ザ、プロクター、エンド、ギャンブル、カンパニー | 皮膚美白組成物 |
| WO2001014527A1 (en) * | 1999-08-23 | 2001-03-01 | Organogenesis Inc. | Skin care compositions and treatments |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014508160A (ja) * | 2011-03-04 | 2014-04-03 | アル−カタニ，アーメッド・エイチ | スキンクリーム |
| JP2022120123A (ja) * | 2013-08-09 | 2022-08-17 | サイトレリス バイオシステムズ，インコーポレーテッド | 非熱組織切除を使用する皮膚治療のための方法及び機器 |
| JP2016008177A (ja) * | 2014-06-20 | 2016-01-18 | 共栄化学工業株式会社 | 皮膚外用剤 |
| JP2019510829A (ja) * | 2016-04-01 | 2019-04-18 | バイオコズ・グローバル・コリア・コーポレイションＢｉｏｃｏｚ Ｇｌｏｂａｌ Ｋｏｒｅａ Ｃｏｒｐ． | 細胞培養培地中に有効成分として、アルブミン、ヒアルロン酸またはコラーゲンを含む化粧品組成物 |
| WO2018179374A1 (ja) * | 2017-03-31 | 2018-10-04 | 株式会社セルバンク | 真皮線維芽細胞の培養上清液を含む化粧用組成物およびその製造方法 |
| JP2024529240A (ja) * | 2021-07-30 | 2024-08-06 | ロレアル | 細胞外小胞、分泌型生体分子、及び／又は馴化培地を含む組成物、並びにそれを製造及び使用する方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1969120A4 (en) | 2012-05-30 |
| EP1969120A2 (en) | 2008-09-17 |
| US20120009233A1 (en) | 2012-01-12 |
| WO2007070850A3 (en) | 2007-11-08 |
| JP2013224323A (ja) | 2013-10-31 |
| US20090202654A1 (en) | 2009-08-13 |
| CN101379182A (zh) | 2009-03-04 |
| CA2633201A1 (en) | 2007-06-21 |
| AU2006325778A1 (en) | 2007-06-21 |
| RU2013134412A (ru) | 2015-01-27 |
| RU2008128451A (ru) | 2010-01-20 |
| WO2007070850A2 (en) | 2007-06-21 |
| IL192198A0 (en) | 2008-12-29 |
| BRPI0619967A2 (pt) | 2011-10-25 |
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