JP2009519716A5 - - Google Patents
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- JP2009519716A5 JP2009519716A5 JP2008545980A JP2008545980A JP2009519716A5 JP 2009519716 A5 JP2009519716 A5 JP 2009519716A5 JP 2008545980 A JP2008545980 A JP 2008545980A JP 2008545980 A JP2008545980 A JP 2008545980A JP 2009519716 A5 JP2009519716 A5 JP 2009519716A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- hvr
- sequence
- tyrosine
- serine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 5
- -1 tyrosine Amino acid Chemical class 0.000 claims description 5
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
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- 235000001014 amino acid Nutrition 0.000 claims 227
- 229940024606 amino acid Drugs 0.000 claims 224
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- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 51
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- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 14
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 14
- 235000003704 aspartic acid Nutrition 0.000 claims 14
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- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 14
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 14
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 13
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 13
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 13
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 13
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- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 12
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75108105P | 2005-12-15 | 2005-12-15 | |
| US60/751,081 | 2005-12-15 | ||
| US79398006P | 2006-04-21 | 2006-04-21 | |
| US60/793,980 | 2006-04-21 | ||
| PCT/US2006/062115 WO2007120334A2 (en) | 2005-12-15 | 2006-12-14 | Methods and compositions for targeting polyubiquitin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013097951A Division JP6143538B2 (ja) | 2005-12-15 | 2013-05-07 | ポリユビキチンを標的とする方法と組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009519716A JP2009519716A (ja) | 2009-05-21 |
| JP2009519716A5 true JP2009519716A5 (enExample) | 2011-02-17 |
| JP5358187B2 JP5358187B2 (ja) | 2013-12-04 |
Family
ID=38610006
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008545980A Active JP5358187B2 (ja) | 2005-12-15 | 2006-12-14 | ポリユビキチンを標的とする方法と組成物 |
| JP2013097951A Active JP6143538B2 (ja) | 2005-12-15 | 2013-05-07 | ポリユビキチンを標的とする方法と組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013097951A Active JP6143538B2 (ja) | 2005-12-15 | 2013-05-07 | ポリユビキチンを標的とする方法と組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US7763245B2 (enExample) |
| EP (3) | EP1973948B1 (enExample) |
| JP (2) | JP5358187B2 (enExample) |
| KR (1) | KR101538521B1 (enExample) |
| CN (1) | CN103396485B (enExample) |
| AR (1) | AR057237A1 (enExample) |
| BR (1) | BRPI0620697A2 (enExample) |
| CA (1) | CA2633887C (enExample) |
| CL (1) | CL2013002738A1 (enExample) |
| ES (1) | ES2535856T3 (enExample) |
| IL (2) | IL191617A (enExample) |
| NO (1) | NO20083127L (enExample) |
| RU (1) | RU2008128134A (enExample) |
| TW (1) | TWI395753B (enExample) |
| WO (1) | WO2007120334A2 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| RU2442793C2 (ru) | 2005-11-30 | 2012-02-20 | Эбботт Лэборетриз | АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ |
| PL1976877T5 (pl) | 2005-11-30 | 2017-09-29 | Abbvie Inc | Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania |
| EP1973948B1 (en) * | 2005-12-15 | 2015-02-11 | Genentech, Inc. | Methods and compositions for targeting polyubiquitin |
| US20070264155A1 (en) * | 2006-05-09 | 2007-11-15 | Brady Michael D | Aerosol jet deposition method and system for creating a reference region/sample region on a biosensor |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
| CA2710398A1 (en) * | 2008-01-18 | 2009-10-15 | Genentech, Inc. | Methods and compositions for targeting polyubiquitin |
| JP2009278908A (ja) * | 2008-05-22 | 2009-12-03 | Fujifilm Corp | 抗オステオカルシン抗体及びそれを用いた免疫測定方法 |
| EP2513148B1 (en) * | 2009-12-16 | 2016-08-31 | AbbVie Biotherapeutics Inc. | Anti-her2 antibodies and their uses |
| WO2011130377A2 (en) | 2010-04-15 | 2011-10-20 | Abbott Laboratories | Amyloid-beta binding proteins |
| RU2603093C2 (ru) | 2010-04-15 | 2016-11-20 | Дженентек, Инк. | Антитела против полиубиквитина и способы их применения |
| US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| US9383367B1 (en) | 2010-12-07 | 2016-07-05 | Chunli Liu | Methods of detecting conjugation site-specific and hidden epitope/antigen |
| MX2014001238A (es) | 2011-08-05 | 2014-09-22 | Genentech Inc | Anticuerpos contra poliubiquitina y métodos de uso. |
| WO2013041241A1 (en) * | 2011-09-23 | 2013-03-28 | Medical Research Council | Ubiquitin chain analysis |
| WO2013056352A1 (en) * | 2011-10-19 | 2013-04-25 | University Health Network | Antibodies and antibody fragments targeting sirp-alpha and their use in treating hematologic cancers |
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| EP3448987A4 (en) | 2016-04-29 | 2020-05-27 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
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