JP2009518422A5 - - Google Patents
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- Publication number
- JP2009518422A5 JP2009518422A5 JP2008544468A JP2008544468A JP2009518422A5 JP 2009518422 A5 JP2009518422 A5 JP 2009518422A5 JP 2008544468 A JP2008544468 A JP 2008544468A JP 2008544468 A JP2008544468 A JP 2008544468A JP 2009518422 A5 JP2009518422 A5 JP 2009518422A5
- Authority
- JP
- Japan
- Prior art keywords
- myostatin
- pharmaceutical composition
- binding
- composition according
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74273105P | 2005-12-06 | 2005-12-06 | |
| PCT/US2006/046546 WO2007067616A2 (en) | 2005-12-06 | 2006-12-06 | Uses of myostatin antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012200485A Division JP2013028620A (ja) | 2005-12-06 | 2012-09-12 | ミオスタチン・アンタゴニストの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009518422A JP2009518422A (ja) | 2009-05-07 |
| JP2009518422A5 true JP2009518422A5 (https=) | 2010-07-08 |
Family
ID=38123451
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008544468A Pending JP2009518422A (ja) | 2005-12-06 | 2006-12-06 | ミオスタチン・アンタゴニストの使用 |
| JP2012200485A Pending JP2013028620A (ja) | 2005-12-06 | 2012-09-12 | ミオスタチン・アンタゴニストの使用 |
| JP2014111126A Pending JP2014224115A (ja) | 2005-12-06 | 2014-05-29 | ミオスタチン・アンタゴニストの使用 |
| JP2015235158A Pending JP2016094427A (ja) | 2005-12-06 | 2015-12-01 | ミオスタチン・アンタゴニストの使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012200485A Pending JP2013028620A (ja) | 2005-12-06 | 2012-09-12 | ミオスタチン・アンタゴニストの使用 |
| JP2014111126A Pending JP2014224115A (ja) | 2005-12-06 | 2014-05-29 | ミオスタチン・アンタゴニストの使用 |
| JP2015235158A Pending JP2016094427A (ja) | 2005-12-06 | 2015-12-01 | ミオスタチン・アンタゴニストの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20070149458A1 (https=) |
| EP (1) | EP1968621A2 (https=) |
| JP (4) | JP2009518422A (https=) |
| AU (3) | AU2006321906C1 (https=) |
| CA (2) | CA2632544C (https=) |
| MX (1) | MX2008007324A (https=) |
| WO (1) | WO2007067616A2 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1771470B1 (en) | 2004-07-23 | 2013-06-26 | Acceleron Pharma Inc. | Actrii receptor polypeptides, methods and compositions |
| BRPI0616923A2 (pt) * | 2005-10-06 | 2011-07-05 | Lilly Co Eli | anticorpos monoclonais, seus usos e composição farmacêutica |
| UA92504C2 (en) * | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| KR20190006086A (ko) | 2005-11-23 | 2019-01-16 | 악셀레론 파마 인코포레이티드 | 액티빈-actrⅱa 길항제 및 골 성장을 촉진하기 위한 이들의 용도 |
| CA2661836A1 (en) * | 2006-09-05 | 2008-03-13 | Eli Lilly And Company | Anti-myostatin antibodies |
| DK2124999T3 (da) | 2006-12-18 | 2013-01-14 | Acceleron Pharma Inc | Activin-actrii antagonister og anvendelser til behandling af anæmi |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| EP2111229B1 (en) | 2007-02-01 | 2013-04-10 | Acceleron Pharma, Inc. | Pharmaceutical compositions comprising Activin-ActRIIA antagonists for use in preventing or treating breast cancer metastasis or breast cancer related bone loss |
| TWI782836B (zh) | 2007-02-02 | 2022-11-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| ES2756725T3 (es) | 2007-02-09 | 2020-04-27 | Acceleron Pharma Inc | Composiciones farmacéuticas que comprenden antagonistas de Activina-ActRIIA |
| EP3243524A1 (en) | 2007-09-18 | 2017-11-15 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
| AU2009262970A1 (en) | 2008-06-26 | 2009-12-30 | Acceleron Pharma Inc. | Methods for dosing an activin-ActRIIa antagonist and monitoring of treated patients |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| SMT202300222T1 (it) | 2008-08-14 | 2023-09-06 | Acceleron Pharma Inc | Trappole di gdf |
| US8138142B2 (en) | 2009-01-13 | 2012-03-20 | Acceleron Pharma Inc. | Methods for increasing adiponectin in a patient in need thereof |
| JP5766179B2 (ja) | 2009-04-27 | 2015-08-19 | ノバルティス アーゲー | 筋肉増殖を増加させるための組成物および方法 |
| BRPI1010587A2 (pt) | 2009-06-08 | 2019-04-09 | Acceleron Pharma Inc. | métodos para aumentar adipócitos termogênicos |
| EP2440577A4 (en) | 2009-06-12 | 2013-01-23 | Acceleron Pharma Inc | SHORTEN ACTRIIB FC FUSION PROTEINS |
| JP6267425B2 (ja) | 2009-11-17 | 2018-01-24 | アクセルロン ファーマ, インコーポレイテッド | 筋ジストロフィー治療のためのユートロフィン誘導に関するactriibタンパク質およびその改変体およびその使用 |
| JO3340B1 (ar) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
| UY33421A (es) | 2010-06-03 | 2011-12-30 | Glaxo Wellcome House | Proteinas de union al antígeno humanizados |
| US8999343B2 (en) | 2010-08-16 | 2015-04-07 | Amgen Inc. | Antibodies that bind myostatin, compositions and methods |
| CN103298832A (zh) | 2010-11-08 | 2013-09-11 | 阿塞勒隆制药公司 | Actriia结合剂及其用途 |
| WO2012151718A1 (zh) * | 2011-05-11 | 2012-11-15 | 湖北省农业科学院畜牧兽医研究所 | 猪肌抑素基因启动子及其应用 |
| AU2012339722B2 (en) | 2011-11-14 | 2017-09-14 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing GDF8 and/or Activin A |
| WO2013137832A1 (en) * | 2012-03-16 | 2013-09-19 | Nanyang Technological University | Myostatin inhibitors |
| TWI633117B (zh) | 2012-09-13 | 2018-08-21 | 必治妥美雅史谷比公司 | 結合至肌肉生長抑制素(myostatin)以纖維連接蛋白爲主之支架結構域蛋白質 |
| NZ707477A (en) | 2012-11-02 | 2019-09-27 | Celgene Corp | Activin-actrii antagonists and uses for treating bone and other disorders |
| US20160038588A1 (en) * | 2013-03-15 | 2016-02-11 | Amgen Inc. | Myostatin Antagonism in Human Subjects |
| WO2014189475A1 (en) * | 2013-05-24 | 2014-11-27 | Alkoçlar Erdal Can | A composition for treating the muscle weakness and the loss of muscle mass following chronic stroke and coma |
| TW201920262A (zh) | 2013-07-30 | 2019-06-01 | 美商再生元醫藥公司 | 抗活化素a之抗體及其用途 |
| WO2015134535A1 (en) * | 2014-03-03 | 2015-09-11 | Pinta Biotherapeutics, Inc. | Combination therapy |
| WO2015187733A2 (en) * | 2014-06-02 | 2015-12-10 | Pinta Biotherapeutics, Inc. | Myostatin inhibitors for treatment of diabetes |
| US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
| US10023621B2 (en) * | 2014-06-04 | 2018-07-17 | Acceleron Pharma Inc. | Follistatin-related fusion proteins |
| WO2015192111A1 (en) | 2014-06-13 | 2015-12-17 | Acceleron Pharma, Inc. | Methods and compositions for treating ulcers |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| JP2018501307A (ja) | 2014-12-03 | 2018-01-18 | セルジーン コーポレイション | アクチビン−ActRIIアンタゴニスト及び貧血を治療するための使用 |
| MX2017007519A (es) * | 2014-12-08 | 2017-08-22 | Novartis Ag | Antagonistas de miostatina o activina para el tratamiento de sarcopenia. |
| AU2016238254B2 (en) * | 2015-03-26 | 2022-05-05 | Acceleron Pharma Inc. | Follistatin-related fusion proteins and uses thereof |
| WO2016168613A1 (en) | 2015-04-15 | 2016-10-20 | Regeneron Pharmaceuticals, Inc. | Methods of increasing strength and functionality with gdf8 inhibitors |
| WO2017031324A1 (en) * | 2015-08-18 | 2017-02-23 | Massachusetts Institute Of Technology | Microfluidic platform for rapid biologics analysis |
| IL258574B2 (en) * | 2015-11-11 | 2025-01-01 | Novartis Ag | Uses of myostatin antagonists, combinations containing them and their uses |
| JP6987072B2 (ja) | 2016-03-10 | 2021-12-22 | アクセレロン ファーマ インコーポレーテッド | アクチビン2型受容体結合タンパク質及びその使用 |
| TWI897843B (zh) | 2017-05-03 | 2025-09-21 | 美商必治妥美雅史谷比公司 | 結合至肌肉生長抑制素以纖維連接蛋白為主之支架結構域蛋白質的穩定調配物 |
| WO2018218273A1 (en) * | 2017-05-29 | 2018-12-06 | Paranta Biosciences Limited | Method of treating hypertension and kidney disease |
| CN111787981B (zh) | 2018-03-01 | 2025-12-30 | 瑞泽恩制药公司 | 增加肌肉量和减少脂肪量的方法 |
| WO2025177263A1 (en) | 2024-02-25 | 2025-08-28 | Biohaven Therapeutics Ltd. | Myostatin-binding proteins |
| WO2025219859A1 (en) | 2024-04-14 | 2025-10-23 | Biohaven Therapeutics Ltd. | Combination therapy to treat overweight, obesity, and related health conditions |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5567584A (en) * | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
| US5750375A (en) * | 1988-01-22 | 1998-05-12 | Zymogenetics, Inc. | Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions |
| DK0690873T3 (da) * | 1993-03-19 | 2003-09-29 | Univ Johns Hopkins Med | Vækstdifferentieringsfaktor-8 |
| US5994618A (en) * | 1997-02-05 | 1999-11-30 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 transgenic mice |
| US7393682B1 (en) * | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| US6465239B1 (en) * | 1993-03-19 | 2002-10-15 | The John Hopkins University School Of Medicine | Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species |
| US6607884B1 (en) * | 1993-03-19 | 2003-08-19 | The Johns Hopkins University School Of Medicine | Methods of detecting growth differentiation factor-8 |
| US6656475B1 (en) * | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| US6891082B2 (en) * | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| US6369201B1 (en) * | 1998-02-19 | 2002-04-09 | Metamorphix International, Inc. | Myostatin multimers |
| ES2330062T3 (es) * | 1998-05-06 | 2009-12-03 | Metamorphix, Inc. | Procedimientos para tratar la diabetes por inhibicion de gdf-8. |
| US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US6284882B1 (en) * | 1999-06-10 | 2001-09-04 | Abbott Laboratories | Myostatin gene promoter and inhibition of activation thereof |
| US7368534B2 (en) * | 2000-01-18 | 2008-05-06 | Orico Limited | Myostatin and mimetics thereof |
| US7320789B2 (en) * | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| AR047392A1 (es) * | 2002-10-22 | 2006-01-18 | Wyeth Corp | Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines |
| CN101287484B (zh) * | 2002-12-20 | 2012-10-10 | 安姆根有限公司 | 抑制肌肉生长抑制素的结合剂 |
| BRPI0410927A (pt) * | 2003-06-02 | 2006-06-27 | Wyeth Corp | métodos terapêuticos e profiláticos para distúrbios neuromusculares |
| JP2007507429A (ja) * | 2003-10-06 | 2007-03-29 | モナシュ ユニバーシティー | 治療方法 |
| ATE555133T1 (de) * | 2003-11-13 | 2012-05-15 | Hanmi Holdings Co Ltd | Igg fc fragment für einen arzneimittelträger und verfahren zu dessen herstellung |
| US8110665B2 (en) * | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
| EP1729793B1 (en) * | 2004-03-02 | 2015-07-22 | Acceleron Pharma Inc. | Alk7 and myostatin inhibitors for muscle wasting disorders |
| ATE557042T1 (de) * | 2004-03-23 | 2012-05-15 | Lilly Co Eli | Anti-myostatin-antikörper |
| EA011879B1 (ru) * | 2004-09-24 | 2009-06-30 | Эмджин Инк. | МОЛЕКУЛЫ С МОДИФИЦИРОВАННЫМ Fc ФРАГМЕНТОМ |
| KR100754667B1 (ko) * | 2005-04-08 | 2007-09-03 | 한미약품 주식회사 | 비펩타이드성 중합체로 개질된 면역글로불린 Fc 단편 및이를 포함하는 약제학적 조성물 |
-
2006
- 2006-12-06 JP JP2008544468A patent/JP2009518422A/ja active Pending
- 2006-12-06 EP EP06848525A patent/EP1968621A2/en not_active Withdrawn
- 2006-12-06 WO PCT/US2006/046546 patent/WO2007067616A2/en not_active Ceased
- 2006-12-06 AU AU2006321906A patent/AU2006321906C1/en not_active Ceased
- 2006-12-06 MX MX2008007324A patent/MX2008007324A/es active IP Right Grant
- 2006-12-06 US US11/635,731 patent/US20070149458A1/en not_active Abandoned
- 2006-12-06 CA CA2632544A patent/CA2632544C/en not_active Expired - Fee Related
- 2006-12-06 CA CA2856436A patent/CA2856436A1/en not_active Abandoned
-
2010
- 2010-08-26 AU AU2010214691A patent/AU2010214691B2/en not_active Ceased
- 2010-08-26 AU AU2010214673A patent/AU2010214673B2/en not_active Ceased
- 2010-09-27 US US12/891,741 patent/US20110008375A1/en not_active Abandoned
-
2012
- 2012-09-12 JP JP2012200485A patent/JP2013028620A/ja active Pending
-
2014
- 2014-05-29 JP JP2014111126A patent/JP2014224115A/ja active Pending
- 2014-06-19 US US14/309,590 patent/US20140294866A1/en not_active Abandoned
-
2015
- 2015-12-01 JP JP2015235158A patent/JP2016094427A/ja active Pending
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