JP2009518422A - ミオスタチン・アンタゴニストの使用 - Google Patents

ミオスタチン・アンタゴニストの使用 Download PDF

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JP2009518422A
JP2009518422A JP2008544468A JP2008544468A JP2009518422A JP 2009518422 A JP2009518422 A JP 2009518422A JP 2008544468 A JP2008544468 A JP 2008544468A JP 2008544468 A JP2008544468 A JP 2008544468A JP 2009518422 A JP2009518422 A JP 2009518422A
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myostatin
binder
binding
independently
peptide
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Japanese (ja)
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JP2009518422A5 (https=
Inventor
ハン，エイチキュー
デパオリ，アレキサンダー
ル，ジョン・ジャオ−ニアン
ワン，ジン・リン
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アムジェン インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pain & Pain Management (AREA)
  • Pregnancy & Childbirth (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
JP2008544468A 2005-12-06 2006-12-06 ミオスタチン・アンタゴニストの使用 Pending JP2009518422A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74273105P 2005-12-06 2005-12-06
PCT/US2006/046546 WO2007067616A2 (en) 2005-12-06 2006-12-06 Uses of myostatin antagonists

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012200485A Division JP2013028620A (ja) 2005-12-06 2012-09-12 ミオスタチン・アンタゴニストの使用

Publications (2)

Publication Number Publication Date
JP2009518422A true JP2009518422A (ja) 2009-05-07
JP2009518422A5 JP2009518422A5 (https=) 2010-07-08

Family

ID=38123451

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2008544468A Pending JP2009518422A (ja) 2005-12-06 2006-12-06 ミオスタチン・アンタゴニストの使用
JP2012200485A Pending JP2013028620A (ja) 2005-12-06 2012-09-12 ミオスタチン・アンタゴニストの使用
JP2014111126A Pending JP2014224115A (ja) 2005-12-06 2014-05-29 ミオスタチン・アンタゴニストの使用
JP2015235158A Pending JP2016094427A (ja) 2005-12-06 2015-12-01 ミオスタチン・アンタゴニストの使用

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2012200485A Pending JP2013028620A (ja) 2005-12-06 2012-09-12 ミオスタチン・アンタゴニストの使用
JP2014111126A Pending JP2014224115A (ja) 2005-12-06 2014-05-29 ミオスタチン・アンタゴニストの使用
JP2015235158A Pending JP2016094427A (ja) 2005-12-06 2015-12-01 ミオスタチン・アンタゴニストの使用

Country Status (7)

Country Link
US (3) US20070149458A1 (https=)
EP (1) EP1968621A2 (https=)
JP (4) JP2009518422A (https=)
AU (3) AU2006321906C1 (https=)
CA (2) CA2632544C (https=)
MX (1) MX2008007324A (https=)
WO (1) WO2007067616A2 (https=)

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UA92504C2 (en) * 2005-10-12 2010-11-10 Эли Лилли Энд Компани Anti-myostatin monoclonal antibody
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
KR20190006086A (ko) 2005-11-23 2019-01-16 악셀레론 파마 인코포레이티드 액티빈-ａｃｔｒⅱａ 길항제 및 골 성장을 촉진하기 위한 이들의 용도
CA2661836A1 (en) * 2006-09-05 2008-03-13 Eli Lilly And Company Anti-myostatin antibodies
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US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
EP2111229B1 (en) 2007-02-01 2013-04-10 Acceleron Pharma, Inc. Pharmaceutical compositions comprising Activin-ActRIIA antagonists for use in preventing or treating breast cancer metastasis or breast cancer related bone loss
TWI782836B (zh) 2007-02-02 2022-11-01 美商艾瑟勒朗法瑪公司 衍生自ActRIIB的變體與其用途
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EP3243524A1 (en) 2007-09-18 2017-11-15 Acceleron Pharma Inc. Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion
AU2009262970A1 (en) 2008-06-26 2009-12-30 Acceleron Pharma Inc. Methods for dosing an activin-ActRIIa antagonist and monitoring of treated patients
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BRPI1010587A2 (pt) 2009-06-08 2019-04-09 Acceleron Pharma Inc. métodos para aumentar adipócitos termogênicos
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JPN6012013116; Ｍｕｄａｌｉ　Ｓ　ａｎｄ　Ｄｏｂｓ　ＡＳ．: 'Ｅｆｆｅｃｔｓ　ｏｆ　ｔｅｓｔｏｓｔｅｒｏｎｅ　ｏｎ　ｂｏｄｙ　ｃｏｍｐｏｓｉｔｉｏｎ　ｏｆ　ｔｈｅ　ａｇｉｎｇ　ｍａｌｅ．' Ｍｅｃｈ　Ａｇｅｉｎｇ　Ｄｅｖ． Ｖｏｌ．１２５　ｎｏ．４, 200404, ｐｐ．２９７-３０４ *
JPN6012013118; Ｇｏｒｄｏｎ　Ｓ　Ｌ: 'Ｕｐｄａｔｅ　ｏｎ　ｔｈｅｒａｐｉｅｓ　ｆｏｒ　ｓａｒｃｏｐｅｎｉａ：　ｎｏｖｅｌ　ａｐｐｒｏａｃｈｅｓ　ｆｏｒ　ａｇｅ-ｒｅｌａｔｅｄ　ｍｕｓｃｌｅ　ｗａｓｔｉｎｇ　ａｎｄ　ｗｅａｋｎｅｓｓ' Ｅｘｐｅｒｔ　Ｏｐｉｎｉｏｎ　ｏｎ　Ｔｈｅｒａｐｅｕｔｉｃ　Ｐａｔｅｎｔｓ Ｖｏｌ．１４　Ｎｏ．９, 200409, ｐｐ．１３２９-１３４４ *
JPN6012013121; Ｋｏｊｉｍａ　Ｉ　ｅｔ　ａｌ．: 'Ｒｏｌｅ　ｏｆ　ｔｈｅ　ａｃｔｉｖｉｎ-ｆｏｌｌｉｓｔａｔｉｎ　ｓｙｓｔｅｍ　ｉｎ　ｔｈｅ　ｍｏｒｐｈｏｇｅｎｅｓｉｓ　ａｎｄ　ｒｅｇｅｎｅｒａｔｉｏｎ　ｏｆ　ｔｈｅ　ｒｅｎａｌ　ｔｕｂｕｌｅｓ' Ｍｏｌｅｃｕｌａｒ　ａｎｄ　Ｃｅｌｌｕｌａｒ　Ｅｎｄｏｃｒｉｎｏｌｏｇｙ Ｖｏｌ．１８０　ｎｏ．１-２, 2001, ｐｐ．１７９-１８２ *
JPN6012013123; 前島明人ら: '腎の再生医学' 医学のあゆみ Ｖｏｌ．１９９　ｎｏ．１３, 20011229, ｐｐ．１１０７-１１１２ *
JPN6012013125; Ｄｏｈｉ　Ｔ　ｅｔ　ａｌ．: 'Ｔｈｅｒａｐｅｕｔｉｃ　ｐｏｔｅｎｔｉａｌ　ｏｆ　ｆｏｌｌｉｓｔａｔｉｎ　ｆｏｒ　ｃｏｌｏｎｉｃ　ｉｎｆｌａｍｍａｔｉｏｎ　ｉｎ　ｍｉｃｅ．' Ｇａｓｔｒｏｅｎｔｅｒｏｌｏｇｙ． Ｖｏｌ．１２８　ｎｏ．２, 200502, ｐｐ．４１１-４２３ *

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JP2013028620A (ja) 2013-02-07
AU2006321906A1 (en) 2007-06-14
CA2632544A1 (en) 2007-06-14
AU2006321906B2 (en) 2010-09-09
MX2008007324A (es) 2009-03-04
AU2006321906C1 (en) 2014-01-16
US20140294866A1 (en) 2014-10-02
CA2632544C (en) 2014-09-23
WO2007067616A3 (en) 2008-10-09
AU2010214673A1 (en) 2010-09-16
JP2014224115A (ja) 2014-12-04
US20070149458A1 (en) 2007-06-28
AU2010214691B2 (en) 2013-09-12
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AU2010214691A1 (en) 2010-09-16
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