JP2009518397A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009518397A5 JP2009518397A5 JP2008544353A JP2008544353A JP2009518397A5 JP 2009518397 A5 JP2009518397 A5 JP 2009518397A5 JP 2008544353 A JP2008544353 A JP 2008544353A JP 2008544353 A JP2008544353 A JP 2008544353A JP 2009518397 A5 JP2009518397 A5 JP 2009518397A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- compound
- compound according
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- 125000004404 heteroalkyl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 201000004792 malaria Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000003544 oxime group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003871 sulfonates Chemical class 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 0 C[C@](CC[C@]1[C@](C)[C@@](CC2(C[C@]([C@@](C)[C@@]3CC[C@]4C)O[C@@]5O[C@@](C)CC[C@]4[C@@]35O*)OC(*)(*)OC2)O[C@@]2O[C@@](C)CC3)[C@@]3[C@@]12O* Chemical compound C[C@](CC[C@]1[C@](C)[C@@](CC2(C[C@]([C@@](C)[C@@]3CC[C@]4C)O[C@@]5O[C@@](C)CC[C@]4[C@@]35O*)OC(*)(*)OC2)O[C@@]2O[C@@](C)CC3)[C@@]3[C@@]12O* 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74854805P | 2005-12-08 | 2005-12-08 | |
| US76512506P | 2006-02-03 | 2006-02-03 | |
| US79481106P | 2006-04-25 | 2006-04-25 | |
| PCT/US2006/044845 WO2007067333A2 (en) | 2005-12-08 | 2006-11-17 | Trioxane dimers having high anticancer and long-lasting antimalarial activities |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009518397A JP2009518397A (ja) | 2009-05-07 |
| JP2009518397A5 true JP2009518397A5 (https=) | 2010-01-14 |
Family
ID=38123365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008544353A Pending JP2009518397A (ja) | 2005-12-08 | 2006-11-17 | 高い抗癌活性及び持続性抗マラリア活性を有するトリオキサンダイマー |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090291923A1 (https=) |
| EP (1) | EP1962596A4 (https=) |
| JP (1) | JP2009518397A (https=) |
| KR (1) | KR20080081310A (https=) |
| AU (1) | AU2006323040A1 (https=) |
| BR (1) | BRPI0619759A2 (https=) |
| CA (1) | CA2632200A1 (https=) |
| IL (1) | IL191597A0 (https=) |
| MX (1) | MX2008007358A (https=) |
| WO (1) | WO2007067333A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2141499A1 (en) * | 2008-07-02 | 2010-01-06 | Apoptec AG | COPD diagnosis |
| US8592611B2 (en) | 2008-07-17 | 2013-11-26 | The Johns Hopkins University | Trioxane dimer sulfur compounds |
| WO2010032165A2 (en) * | 2008-09-19 | 2010-03-25 | North-West University | Prodrugs of artemisinin |
| US8884032B2 (en) | 2009-05-19 | 2014-11-11 | The Johns Hopkins University | Trioxane monomers and dimers |
| WO2011071947A2 (en) | 2009-12-07 | 2011-06-16 | Johns Hopkins University | Bis-acylated hydroxylamine derivatives |
| US20110144067A1 (en) * | 2009-12-07 | 2011-06-16 | Toscano John P | N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives |
| US9493480B2 (en) | 2011-04-15 | 2016-11-15 | The Johns Hopkins University | Monomeric trioxane amide sulfur compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL121749A0 (en) * | 1997-09-11 | 1998-02-22 | Yeda Res & Dev | 2,3-dioxabicycloÚ3.3.1¾nonane derivatives and antimalarial pharmaceutical compositions comprising them |
| US6160004A (en) * | 1997-12-30 | 2000-12-12 | Hauser, Inc. | C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities |
| AU2003233509A1 (en) * | 2002-05-07 | 2003-11-11 | University Of Mississipi | Artemisinin-based peroxide compounds as broad spectrum anti-infective agents |
| WO2004028476A2 (en) * | 2002-09-27 | 2004-04-08 | Johns Hopkins University | Artemisinin-derived trioxane dimers |
-
2006
- 2006-11-17 EP EP06848509A patent/EP1962596A4/en not_active Withdrawn
- 2006-11-17 JP JP2008544353A patent/JP2009518397A/ja active Pending
- 2006-11-17 KR KR1020087016634A patent/KR20080081310A/ko not_active Ceased
- 2006-11-17 MX MX2008007358A patent/MX2008007358A/es not_active Application Discontinuation
- 2006-11-17 AU AU2006323040A patent/AU2006323040A1/en not_active Abandoned
- 2006-11-17 US US12/096,015 patent/US20090291923A1/en not_active Abandoned
- 2006-11-17 BR BRPI0619759-0A patent/BRPI0619759A2/pt not_active Application Discontinuation
- 2006-11-17 CA CA002632200A patent/CA2632200A1/en not_active Abandoned
- 2006-11-17 WO PCT/US2006/044845 patent/WO2007067333A2/en not_active Ceased
-
2008
- 2008-05-21 IL IL191597A patent/IL191597A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020169171A5 (https=) | ||
| CN111989332A (zh) | 作为cdk抑制剂的大环化合物、其制备方法及其在医药上的应用 | |
| RU2477723C2 (ru) | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе | |
| JP2019524883A5 (https=) | ||
| JP2018504437A5 (https=) | ||
| JP2014193925A5 (https=) | ||
| RU2011101774A (ru) | Новые замещенные пиридин-2-оны и пиридазин-3-оны | |
| JP2010511721A5 (https=) | ||
| JP2015505296A5 (https=) | ||
| JP2014500870A5 (https=) | ||
| JP2016519062A5 (https=) | ||
| JP2010527913A5 (https=) | ||
| CN101142198A (zh) | 用于治疗疾病的异唑坎布雷它斯丁衍生物 | |
| JP2009543802A5 (https=) | ||
| JP2008510770A5 (https=) | ||
| JP2012515776A5 (https=) | ||
| JP2016040288A5 (https=) | ||
| JP2012510502A5 (https=) | ||
| JP2020532545A5 (https=) | ||
| JP2011513410A5 (https=) | ||
| JP2017536416A5 (https=) | ||
| JP2021046404A5 (https=) | ||
| JP2020063289A5 (https=) | ||
| JP2013536227A5 (https=) | ||
| JP2005527542A5 (https=) |