BRPI0619759A2 - dìmeros de trioxano tendo atividades antimalária de longa duração e anticáncer elevadas - Google Patents
dìmeros de trioxano tendo atividades antimalária de longa duração e anticáncer elevadas Download PDFInfo
- Publication number
- BRPI0619759A2 BRPI0619759A2 BRPI0619759-0A BRPI0619759A BRPI0619759A2 BR PI0619759 A2 BRPI0619759 A2 BR PI0619759A2 BR PI0619759 A BRPI0619759 A BR PI0619759A BR PI0619759 A2 BRPI0619759 A2 BR PI0619759A2
- Authority
- BR
- Brazil
- Prior art keywords
- formula
- substituted
- unsubstituted
- compound according
- mmol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pest Control & Pesticides (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74854805P | 2005-12-08 | 2005-12-08 | |
| US60/748,548 | 2005-12-08 | ||
| US76512506P | 2006-02-03 | 2006-02-03 | |
| US60/765,125 | 2006-02-03 | ||
| US79481106P | 2006-04-25 | 2006-04-25 | |
| US60/794,811 | 2006-04-25 | ||
| PCT/US2006/044845 WO2007067333A2 (en) | 2005-12-08 | 2006-11-17 | Trioxane dimers having high anticancer and long-lasting antimalarial activities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0619759A2 true BRPI0619759A2 (pt) | 2011-10-18 |
Family
ID=38123365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0619759-0A BRPI0619759A2 (pt) | 2005-12-08 | 2006-11-17 | dìmeros de trioxano tendo atividades antimalária de longa duração e anticáncer elevadas |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090291923A1 (https=) |
| EP (1) | EP1962596A4 (https=) |
| JP (1) | JP2009518397A (https=) |
| KR (1) | KR20080081310A (https=) |
| AU (1) | AU2006323040A1 (https=) |
| BR (1) | BRPI0619759A2 (https=) |
| CA (1) | CA2632200A1 (https=) |
| IL (1) | IL191597A0 (https=) |
| MX (1) | MX2008007358A (https=) |
| WO (1) | WO2007067333A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2141499A1 (en) * | 2008-07-02 | 2010-01-06 | Apoptec AG | COPD diagnosis |
| US8592611B2 (en) | 2008-07-17 | 2013-11-26 | The Johns Hopkins University | Trioxane dimer sulfur compounds |
| WO2010032165A2 (en) * | 2008-09-19 | 2010-03-25 | North-West University | Prodrugs of artemisinin |
| US8884032B2 (en) | 2009-05-19 | 2014-11-11 | The Johns Hopkins University | Trioxane monomers and dimers |
| WO2011071947A2 (en) | 2009-12-07 | 2011-06-16 | Johns Hopkins University | Bis-acylated hydroxylamine derivatives |
| US20110144067A1 (en) * | 2009-12-07 | 2011-06-16 | Toscano John P | N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives |
| US9493480B2 (en) | 2011-04-15 | 2016-11-15 | The Johns Hopkins University | Monomeric trioxane amide sulfur compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL121749A0 (en) * | 1997-09-11 | 1998-02-22 | Yeda Res & Dev | 2,3-dioxabicycloÚ3.3.1¾nonane derivatives and antimalarial pharmaceutical compositions comprising them |
| US6160004A (en) * | 1997-12-30 | 2000-12-12 | Hauser, Inc. | C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities |
| AU2003233509A1 (en) * | 2002-05-07 | 2003-11-11 | University Of Mississipi | Artemisinin-based peroxide compounds as broad spectrum anti-infective agents |
| WO2004028476A2 (en) * | 2002-09-27 | 2004-04-08 | Johns Hopkins University | Artemisinin-derived trioxane dimers |
-
2006
- 2006-11-17 EP EP06848509A patent/EP1962596A4/en not_active Withdrawn
- 2006-11-17 JP JP2008544353A patent/JP2009518397A/ja active Pending
- 2006-11-17 KR KR1020087016634A patent/KR20080081310A/ko not_active Ceased
- 2006-11-17 MX MX2008007358A patent/MX2008007358A/es not_active Application Discontinuation
- 2006-11-17 AU AU2006323040A patent/AU2006323040A1/en not_active Abandoned
- 2006-11-17 US US12/096,015 patent/US20090291923A1/en not_active Abandoned
- 2006-11-17 BR BRPI0619759-0A patent/BRPI0619759A2/pt not_active Application Discontinuation
- 2006-11-17 CA CA002632200A patent/CA2632200A1/en not_active Abandoned
- 2006-11-17 WO PCT/US2006/044845 patent/WO2007067333A2/en not_active Ceased
-
2008
- 2008-05-21 IL IL191597A patent/IL191597A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL191597A0 (en) | 2009-02-11 |
| WO2007067333A2 (en) | 2007-06-14 |
| WO2007067333A3 (en) | 2008-01-31 |
| KR20080081310A (ko) | 2008-09-09 |
| AU2006323040A1 (en) | 2007-06-14 |
| EP1962596A2 (en) | 2008-09-03 |
| JP2009518397A (ja) | 2009-05-07 |
| US20090291923A1 (en) | 2009-11-26 |
| EP1962596A4 (en) | 2010-09-22 |
| MX2008007358A (es) | 2008-11-10 |
| CA2632200A1 (en) | 2007-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |