KR20080081310A - 항암 효과가 높고 항말라리아 활성이 오래 지속되는트리옥산 이량체 - Google Patents

항암 효과가 높고 항말라리아 활성이 오래 지속되는트리옥산 이량체 Download PDF

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Publication number
KR20080081310A
KR20080081310A KR1020087016634A KR20087016634A KR20080081310A KR 20080081310 A KR20080081310 A KR 20080081310A KR 1020087016634 A KR1020087016634 A KR 1020087016634A KR 20087016634 A KR20087016634 A KR 20087016634A KR 20080081310 A KR20080081310 A KR 20080081310A
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KR
South Korea
Prior art keywords
substituted
unsubstituted
compound
mmol
mhz
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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KR1020087016634A
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English (en)
Korean (ko)
Inventor
개리 에이치. 포스너
익현 백
크리스티나 보르스트닉
원숙 장
산드라 시니쉬타쥐
윌리암 안소니 마이오
존 개타노 드'안젤로
로렌 엘라인 우다드
앨빈 솔로먼 캘린다
에이미 알. 우세라
린드세이 캐서린 헤스
앤드류 스콧 로젠탈
성호 오
아스트리드 씨. 배지
Original Assignee
더 존스 홉킨스 유니버시티
더 거번먼트 오브 더 유나이티드 스테이츠 오브 어메리카 애즈 레프리젠티드 바이 더 세크러터리 오브 더 디파트먼트 오브 헬쓰 앤드 휴먼 써비시즈
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Application filed by 더 존스 홉킨스 유니버시티, 더 거번먼트 오브 더 유나이티드 스테이츠 오브 어메리카 애즈 레프리젠티드 바이 더 세크러터리 오브 더 디파트먼트 오브 헬쓰 앤드 휴먼 써비시즈 filed Critical 더 존스 홉킨스 유니버시티
Publication of KR20080081310A publication Critical patent/KR20080081310A/ko
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020087016634A 2005-12-08 2006-11-17 항암 효과가 높고 항말라리아 활성이 오래 지속되는트리옥산 이량체 Ceased KR20080081310A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US74854805P 2005-12-08 2005-12-08
US60/748,548 2005-12-08
US76512506P 2006-02-03 2006-02-03
US60/765,125 2006-02-03
US79481106P 2006-04-25 2006-04-25
US60/794,811 2006-04-25

Publications (1)

Publication Number Publication Date
KR20080081310A true KR20080081310A (ko) 2008-09-09

Family

ID=38123365

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087016634A Ceased KR20080081310A (ko) 2005-12-08 2006-11-17 항암 효과가 높고 항말라리아 활성이 오래 지속되는트리옥산 이량체

Country Status (10)

Country Link
US (1) US20090291923A1 (https=)
EP (1) EP1962596A4 (https=)
JP (1) JP2009518397A (https=)
KR (1) KR20080081310A (https=)
AU (1) AU2006323040A1 (https=)
BR (1) BRPI0619759A2 (https=)
CA (1) CA2632200A1 (https=)
IL (1) IL191597A0 (https=)
MX (1) MX2008007358A (https=)
WO (1) WO2007067333A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010135427A3 (en) * 2009-05-19 2011-04-21 The Johns Hopkins University Trioxane monomers and dimers

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2141499A1 (en) * 2008-07-02 2010-01-06 Apoptec AG COPD diagnosis
US8592611B2 (en) 2008-07-17 2013-11-26 The Johns Hopkins University Trioxane dimer sulfur compounds
WO2010032165A2 (en) * 2008-09-19 2010-03-25 North-West University Prodrugs of artemisinin
WO2011071947A2 (en) 2009-12-07 2011-06-16 Johns Hopkins University Bis-acylated hydroxylamine derivatives
US20110144067A1 (en) * 2009-12-07 2011-06-16 Toscano John P N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives
US9493480B2 (en) 2011-04-15 2016-11-15 The Johns Hopkins University Monomeric trioxane amide sulfur compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL121749A0 (en) * 1997-09-11 1998-02-22 Yeda Res & Dev 2,3-dioxabicycloÚ3.3.1¾nonane derivatives and antimalarial pharmaceutical compositions comprising them
US6160004A (en) * 1997-12-30 2000-12-12 Hauser, Inc. C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities
AU2003233509A1 (en) * 2002-05-07 2003-11-11 University Of Mississipi Artemisinin-based peroxide compounds as broad spectrum anti-infective agents
WO2004028476A2 (en) * 2002-09-27 2004-04-08 Johns Hopkins University Artemisinin-derived trioxane dimers

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010135427A3 (en) * 2009-05-19 2011-04-21 The Johns Hopkins University Trioxane monomers and dimers

Also Published As

Publication number Publication date
IL191597A0 (en) 2009-02-11
WO2007067333A2 (en) 2007-06-14
WO2007067333A3 (en) 2008-01-31
AU2006323040A1 (en) 2007-06-14
EP1962596A2 (en) 2008-09-03
JP2009518397A (ja) 2009-05-07
US20090291923A1 (en) 2009-11-26
EP1962596A4 (en) 2010-09-22
MX2008007358A (es) 2008-11-10
CA2632200A1 (en) 2007-06-14
BRPI0619759A2 (pt) 2011-10-18

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