IL191597A0 - Trioxane dimers having high anticancer and long-lasting antimalarial activities - Google Patents

Trioxane dimers having high anticancer and long-lasting antimalarial activities

Info

Publication number
IL191597A0
IL191597A0 IL191597A IL19159708A IL191597A0 IL 191597 A0 IL191597 A0 IL 191597A0 IL 191597 A IL191597 A IL 191597A IL 19159708 A IL19159708 A IL 19159708A IL 191597 A0 IL191597 A0 IL 191597A0
Authority
IL
Israel
Prior art keywords
long
high anticancer
trioxane dimers
antimalarial activities
lasting
Prior art date
Application number
IL191597A
Other languages
English (en)
Original Assignee
Univ Johns Hopkins
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins, Us Gov Health & Human Serv filed Critical Univ Johns Hopkins
Publication of IL191597A0 publication Critical patent/IL191597A0/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL191597A 2005-12-08 2008-05-21 Trioxane dimers having high anticancer and long-lasting antimalarial activities IL191597A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74854805P 2005-12-08 2005-12-08
US76512506P 2006-02-03 2006-02-03
US79481106P 2006-04-25 2006-04-25
PCT/US2006/044845 WO2007067333A2 (en) 2005-12-08 2006-11-17 Trioxane dimers having high anticancer and long-lasting antimalarial activities

Publications (1)

Publication Number Publication Date
IL191597A0 true IL191597A0 (en) 2009-02-11

Family

ID=38123365

Family Applications (1)

Application Number Title Priority Date Filing Date
IL191597A IL191597A0 (en) 2005-12-08 2008-05-21 Trioxane dimers having high anticancer and long-lasting antimalarial activities

Country Status (10)

Country Link
US (1) US20090291923A1 (https=)
EP (1) EP1962596A4 (https=)
JP (1) JP2009518397A (https=)
KR (1) KR20080081310A (https=)
AU (1) AU2006323040A1 (https=)
BR (1) BRPI0619759A2 (https=)
CA (1) CA2632200A1 (https=)
IL (1) IL191597A0 (https=)
MX (1) MX2008007358A (https=)
WO (1) WO2007067333A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2141499A1 (en) * 2008-07-02 2010-01-06 Apoptec AG COPD diagnosis
US8592611B2 (en) 2008-07-17 2013-11-26 The Johns Hopkins University Trioxane dimer sulfur compounds
WO2010032165A2 (en) * 2008-09-19 2010-03-25 North-West University Prodrugs of artemisinin
US8884032B2 (en) 2009-05-19 2014-11-11 The Johns Hopkins University Trioxane monomers and dimers
WO2011071947A2 (en) 2009-12-07 2011-06-16 Johns Hopkins University Bis-acylated hydroxylamine derivatives
US20110144067A1 (en) * 2009-12-07 2011-06-16 Toscano John P N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives
US9493480B2 (en) 2011-04-15 2016-11-15 The Johns Hopkins University Monomeric trioxane amide sulfur compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL121749A0 (en) * 1997-09-11 1998-02-22 Yeda Res & Dev 2,3-dioxabicycloÚ3.3.1¾nonane derivatives and antimalarial pharmaceutical compositions comprising them
US6160004A (en) * 1997-12-30 2000-12-12 Hauser, Inc. C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities
AU2003233509A1 (en) * 2002-05-07 2003-11-11 University Of Mississipi Artemisinin-based peroxide compounds as broad spectrum anti-infective agents
WO2004028476A2 (en) * 2002-09-27 2004-04-08 Johns Hopkins University Artemisinin-derived trioxane dimers

Also Published As

Publication number Publication date
WO2007067333A2 (en) 2007-06-14
WO2007067333A3 (en) 2008-01-31
KR20080081310A (ko) 2008-09-09
AU2006323040A1 (en) 2007-06-14
EP1962596A2 (en) 2008-09-03
JP2009518397A (ja) 2009-05-07
US20090291923A1 (en) 2009-11-26
EP1962596A4 (en) 2010-09-22
MX2008007358A (es) 2008-11-10
CA2632200A1 (en) 2007-06-14
BRPI0619759A2 (pt) 2011-10-18

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