JP2009517395A5 - - Google Patents
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- Publication number
- JP2009517395A5 JP2009517395A5 JP2008542483A JP2008542483A JP2009517395A5 JP 2009517395 A5 JP2009517395 A5 JP 2009517395A5 JP 2008542483 A JP2008542483 A JP 2008542483A JP 2008542483 A JP2008542483 A JP 2008542483A JP 2009517395 A5 JP2009517395 A5 JP 2009517395A5
- Authority
- JP
- Japan
- Prior art keywords
- cysteamine
- pharmaceutical composition
- viral infection
- compound
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960003151 mercaptamine Drugs 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 claims 8
- -1 cysteamine compound Chemical class 0.000 claims 8
- 208000036142 Viral infection Diseases 0.000 claims 7
- 230000009385 viral infection Effects 0.000 claims 7
- OGMADIBCHLQMIP-UHFFFAOYSA-N 2-aminoethanethiol;hydron;chloride Chemical group Cl.NCCS OGMADIBCHLQMIP-UHFFFAOYSA-N 0.000 claims 2
- PVFLVRWZVJAUAJ-UHFFFAOYSA-N 2-aminoethanethiol;phosphoric acid Chemical compound NCCS.OP(O)(O)=O PVFLVRWZVJAUAJ-UHFFFAOYSA-N 0.000 claims 2
- 239000003443 antiviral agent Substances 0.000 claims 2
- 229940097265 cysteamine hydrochloride Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 241000712461 unidentified influenza virus Species 0.000 claims 2
- UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 claims 1
- 241000711573 Coronaviridae Species 0.000 claims 1
- 241000710831 Flavivirus Species 0.000 claims 1
- 241000701806 Human papillomavirus Species 0.000 claims 1
- 241000713112 Orthobunyavirus Species 0.000 claims 1
- 241000709664 Picornaviridae Species 0.000 claims 1
- 241000125945 Protoparvovirus Species 0.000 claims 1
- 241000702263 Reovirus sp. Species 0.000 claims 1
- 229960004150 aciclovir Drugs 0.000 claims 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 1
- 229960003805 amantadine Drugs 0.000 claims 1
- 229960002963 ganciclovir Drugs 0.000 claims 1
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 claims 1
- VSZGPKBBMSAYNT-RRFJBIMHSA-N oseltamivir Chemical compound CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 VSZGPKBBMSAYNT-RRFJBIMHSA-N 0.000 claims 1
- 229960003752 oseltamivir Drugs 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229960000888 rimantadine Drugs 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74058405P | 2005-11-28 | 2005-11-28 | |
| US60/740,584 | 2005-11-28 | ||
| US81077306P | 2006-06-02 | 2006-06-02 | |
| US60/810,773 | 2006-06-02 | ||
| US81888506P | 2006-07-06 | 2006-07-06 | |
| US60/818,885 | 2006-07-06 | ||
| US84702006P | 2006-09-25 | 2006-09-25 | |
| US60/847,020 | 2006-09-25 | ||
| PCT/US2006/045652 WO2007062272A1 (en) | 2005-11-28 | 2006-11-28 | Materials and methods for treating viral infections with a cysteamine compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009517395A JP2009517395A (ja) | 2009-04-30 |
| JP2009517395A5 true JP2009517395A5 (https=) | 2010-01-07 |
| JP5138603B2 JP5138603B2 (ja) | 2013-02-06 |
Family
ID=37769370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008542483A Expired - Fee Related JP5138603B2 (ja) | 2005-11-28 | 2006-11-28 | システアミン化合物を用いてウイルス感染を治療するための材料および方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8415398B2 (https=) |
| EP (1) | EP1954258B8 (https=) |
| JP (1) | JP5138603B2 (https=) |
| KR (1) | KR101440629B1 (https=) |
| CN (1) | CN102038667A (https=) |
| AP (1) | AP2877A (https=) |
| AR (1) | AR057623A1 (https=) |
| AU (1) | AU2006318355B2 (https=) |
| BR (1) | BRPI0619377A2 (https=) |
| CA (1) | CA2631241C (https=) |
| DK (1) | DK1954258T3 (https=) |
| ES (1) | ES2392976T3 (https=) |
| IL (1) | IL191705A (https=) |
| MX (1) | MX2008006851A (https=) |
| MY (1) | MY141003A (https=) |
| NZ (1) | NZ568464A (https=) |
| PL (1) | PL1954258T3 (https=) |
| PT (1) | PT1954258E (https=) |
| TW (1) | TWI401079B (https=) |
| WO (1) | WO2007062272A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1706104A2 (en) * | 2004-01-13 | 2006-10-04 | Omega Bio-Pharma (I.P.2) Limited | Methods for treating stress and affecting biological immune systems using a cysteamine compound |
| AR057623A1 (es) * | 2005-11-28 | 2007-12-05 | Omega Bio Pharma H K Ltd | Materiales y metodos para el tratamiento de las infecciones virales |
| PT1919458E (pt) | 2006-01-27 | 2012-08-23 | Univ California | Cisteamina revestida entericamente, cisteamina e seus derivados |
| WO2009023356A2 (en) * | 2007-05-25 | 2009-02-19 | Omega-Biopharma (H.K.) Limited | Materials and methods for treating influenza infections |
| EP2276479B1 (en) | 2008-04-15 | 2014-07-02 | SineVir Therapeutics LLC | Prodrugs of neuraminidase inhibitors |
| GB0905451D0 (en) * | 2009-03-31 | 2009-05-13 | Novabiotics Ltd | Biofilms |
| WO2010138419A2 (en) * | 2009-05-23 | 2010-12-02 | Obio Pharmaceutical (H.K.) Ltd. | Materials and methods for treating viral infections |
| WO2011094693A1 (en) * | 2010-02-01 | 2011-08-04 | Mount Sinai School Of Medicine | Interferon-inducing compounds and uses thereof |
| AU2011241478B2 (en) * | 2010-04-15 | 2016-12-01 | Biota Scientific Management Pty Ltd | Compound for treatment of respiratory condition or disease |
| GB201021186D0 (en) | 2010-12-14 | 2011-01-26 | Novabiotics Ltd | Composition |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| DE202012012955U1 (de) | 2011-10-21 | 2014-07-14 | Abbvie Inc. | Eine Kombination aus mindestens zwei direkt wirkenden antiviralen Wirkstoffen (DAAs) für die Verwendung zur Behandlung von HCV |
| EP2583677A3 (en) | 2011-10-21 | 2013-07-03 | Abbvie Inc. | Methods for treating HCV comprising at least two direct acting antiviral agent, ribavirin but not interferon. |
| TWI649100B (zh) | 2013-06-17 | 2019-02-01 | 地平線罕見醫學製藥有限責任公司 | 延遲釋放型半胱胺珠粒調配物，以及其製備及使用方法 |
| MX377396B (es) | 2013-09-12 | 2025-03-10 | Janssen Biopharma Inc | Compuestos de azapiridona y usos de los mismos. |
| US10208045B2 (en) | 2015-03-11 | 2019-02-19 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| US10143665B2 (en) | 2015-11-17 | 2018-12-04 | Horizon Orphan Llc | Methods for storing cysteamine formulations and related methods of treatment |
| CA3017797A1 (en) | 2016-03-17 | 2017-09-21 | Thiogenesis Therapeutics, Inc. | Compositions for controlled release of cysteamine and systemic treatment of cysteamine sensitive disorders |
| EA201892448A1 (ru) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
| GB201609940D0 (en) | 2016-06-07 | 2016-07-20 | Novabiotics Ltd | Microparticles |
| US10905660B2 (en) * | 2016-06-07 | 2021-02-02 | Novabiotics Limited | Microparticles |
| US11758928B2 (en) | 2016-12-15 | 2023-09-19 | Société des Produits Nestlé S.A. | Compositions and methods that modulate phosphorus or enzymes in a companion animal |
| CA3076392A1 (en) | 2017-09-20 | 2019-03-28 | Thiogenesis Therapeutics, Inc. | Methods for the treatment of cysteamine sensitive disorders |
| WO2020079186A1 (en) | 2018-10-17 | 2020-04-23 | Novabiotics Limited | Dosage regime |
| CN120346194A (zh) * | 2020-04-01 | 2025-07-22 | 硫创治疗公司 | 用于治疗乙型冠状病毒感染的半胱胺前体化合物 |
| EP4149451A4 (en) | 2020-05-13 | 2024-06-19 | The Regents Of The University Of Michigan | Cysteamine for the treatment of sars-cov-2 infection |
| IL298267A (en) * | 2020-05-25 | 2023-01-01 | Novabiotics Ltd | Anti-viral therapy |
| WO2022040045A1 (en) * | 2020-08-18 | 2022-02-24 | New Amsterdam Sciences, Inc. | Sod mimetic and methods of using same for the treatment of covid-19 |
| AU2022405530A1 (en) * | 2021-12-07 | 2024-07-11 | Cila Therapeutic Inc. | Anti-viral therapeutic agents and uses thereof |
| WO2024009307A1 (en) * | 2022-07-06 | 2024-01-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Viroporins blockers/inhibitors as anti-flaviviruses agents |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3152180A (en) | 1960-08-25 | 1964-10-06 | Studiengesellschaft Kohle Mbh | Process for the production of nu-tert-alkyl amides and, if desired, nu-tert. alkyl amines |
| US3352912A (en) | 1963-07-24 | 1967-11-14 | Du Pont | Adamantanes and tricyclo[4. 3. 1. 1 3.8] undecanes |
| US3538160A (en) | 1965-03-24 | 1970-11-03 | Smithkline Corp | Pentacyclooctaneamines |
| US3483254A (en) | 1967-01-03 | 1969-12-09 | Merck & Co Inc | 2-bornanemethylamines |
| US3496228A (en) | 1967-02-16 | 1970-02-17 | Smithkline Corp | Aminotricyclononanes and the salts thereof |
| US3534084A (en) | 1968-10-16 | 1970-10-13 | Squibb & Sons Inc | Adamantylamino-naphthyloxypropanols and related compounds |
| US3592934A (en) | 1969-06-20 | 1971-07-13 | Du Pont | Pharmaceutical compositions and methods of controlling influenza a virus infection utilizing substituted adamantanes and tricyclo(4.3.1.13.8) undecanes |
| IT1055560B (it) * | 1974-05-02 | 1982-01-11 | Istituto Chemioterapico | Derivati pirimidinici e relative composizioni per il trattamento di infezioni virali |
| US5576351A (en) * | 1989-12-29 | 1996-11-19 | Mcgaw, Inc. | Use of arginine as an immunostimulator |
| US5292773A (en) * | 1990-02-14 | 1994-03-08 | Hirsch Gerald P | Treating aids and HIV infection with methionine |
| ES2027527A6 (es) * | 1990-12-17 | 1992-06-01 | Andromaco Lab | Procedimiento para la obtencion de polimeros dotados de actividad antiviral. |
| DE4103177A1 (de) | 1991-02-02 | 1992-08-06 | Boehringer Mannheim Gmbh | Thiazolo-(2,3-a)isoindol-derivate und diese enthaltende arzneimittel |
| US5314917A (en) * | 1991-03-22 | 1994-05-24 | E. B. Michaels Research Associates, Inc. | Method for inactivating enveloped viruses and sperm |
| US5554655A (en) * | 1991-09-30 | 1996-09-10 | Jess G. Thoene | Method of treating HIV infection |
| PT100914A (pt) | 1991-09-30 | 1993-10-29 | Jess G Thoene | Uso de compostos capazes de sofrer uma permuta mista com dissulfureto, com uma ligacao dissulfureto, no tratamento de infeccao por hiv |
| US5686436A (en) * | 1993-05-13 | 1997-11-11 | Hiv Diagnostics, Inc. | Multi-faceted method to repress reproduction of latent viruses in humans and animals |
| WO1995010268A1 (en) * | 1993-10-15 | 1995-04-20 | Thoene Jess G | Prevention of hiv infection |
| US5725870A (en) * | 1993-10-15 | 1998-03-10 | Thoene; Jess G. | Methods, composites and articles for contraception |
| US5714519A (en) | 1995-06-07 | 1998-02-03 | Ergo Science Incorporated | Method for regulating glucose metabolism |
| US5684024A (en) | 1996-01-25 | 1997-11-04 | Viropharma Incorporated | Pyrazole dimers compositions and methods for treating influenza |
| US5821243A (en) | 1996-07-22 | 1998-10-13 | Viropharma Incorporated | Compounds compositions and methods for treating influenza |
| WO1999049860A1 (en) * | 1998-03-30 | 1999-10-07 | The Endowment For Research In Human Biology, Inc. | Agents and methods for modulation of zinc transfer by metallothionein |
| DE19817511A1 (de) * | 1998-04-20 | 1999-10-21 | Werner Slenczka | Antivirale Wirksamkeit der Pantothensäure, des Dexpanthenols und ihrer Derivate. Hemmwirkung auf die Virusreplikation umhüllter Viren durch Blockade des Fusionsvorgangs. |
| US6063383A (en) * | 1999-01-28 | 2000-05-16 | Hsu; Wu-Ching | Pharmaceutical suppository composites for fever and influenza and method of producing the composites |
| US6468522B1 (en) | 1999-07-22 | 2002-10-22 | University Of Medicine And Dentistry Of New Jersey | Controlled release of thioamide moiety-containing therapeutic agents |
| US6521266B1 (en) | 1999-09-23 | 2003-02-18 | Morris A. Mann | Composition for growth hormone production and release, appetite suppression, and methods related thereto |
| RU2175230C1 (ru) | 2001-01-23 | 2001-10-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" | Фармацевтическая композиция с противовирусной активностью и способ ее получения |
| ES2269671T3 (es) * | 2001-04-25 | 2007-04-01 | Cobalz Limited | Composiciones medicas para su uso en el tratamiento o la prevencion de una insuficiencia de vitamina b12 funcional. |
| GB2377874B (en) * | 2001-07-23 | 2005-06-22 | Walcom Bio Chemicals Ind Ltd | Poultry feed and the use thereof |
| WO2004006900A2 (en) * | 2002-07-11 | 2004-01-22 | Immune Network Ltd. | Sulphydryl compounds in combination with sulphone or sulphnamide conpounds for use in microbial inflammatory diseases |
| US8017651B2 (en) * | 2002-11-22 | 2011-09-13 | Bionexus, Ltd. | Compositions and methods for the treatment of HIV-associated fat maldistribution and hyperlipidemia |
| AU2003900064A0 (en) * | 2003-01-09 | 2003-01-23 | Penam Investments Pty. Ltd. | A method of treatment or prophylaxis of viral infection. |
| GB2398497A (en) * | 2003-02-19 | 2004-08-25 | Walcom Animal Science | Composition for improving immunity of animals |
| US20040191295A1 (en) * | 2003-03-28 | 2004-09-30 | Locniskar Mary Frances | Composition and method for viral inhibition |
| DE10340845A1 (de) * | 2003-09-04 | 2005-03-31 | Flavin-Koenig, Dana F., Dr. | Pharmazeutisches Kombinationspräparat, enthaltend Glycyrrhizinsäure, Zink und eine Verbindung, die eine Thiolgruppe oder eine zu dieser metabolisierbare Gruppe enthält |
| AR057623A1 (es) * | 2005-11-28 | 2007-12-05 | Omega Bio Pharma H K Ltd | Materiales y metodos para el tratamiento de las infecciones virales |
-
2006
- 2006-11-22 AR ARP060105117A patent/AR057623A1/es unknown
- 2006-11-24 TW TW095143633A patent/TWI401079B/zh not_active IP Right Cessation
- 2006-11-27 MY MYPI20064570A patent/MY141003A/en unknown
- 2006-11-28 AP AP2008004511A patent/AP2877A/xx active
- 2006-11-28 PT PT06838553T patent/PT1954258E/pt unknown
- 2006-11-28 MX MX2008006851A patent/MX2008006851A/es active IP Right Grant
- 2006-11-28 WO PCT/US2006/045652 patent/WO2007062272A1/en not_active Ceased
- 2006-11-28 KR KR1020087015869A patent/KR101440629B1/ko not_active Expired - Fee Related
- 2006-11-28 PL PL06838553T patent/PL1954258T3/pl unknown
- 2006-11-28 AU AU2006318355A patent/AU2006318355B2/en not_active Ceased
- 2006-11-28 CN CN2010105707294A patent/CN102038667A/zh active Pending
- 2006-11-28 JP JP2008542483A patent/JP5138603B2/ja not_active Expired - Fee Related
- 2006-11-28 NZ NZ568464A patent/NZ568464A/en not_active IP Right Cessation
- 2006-11-28 BR BRPI0619377-3A patent/BRPI0619377A2/pt not_active IP Right Cessation
- 2006-11-28 ES ES06838553T patent/ES2392976T3/es active Active
- 2006-11-28 DK DK06838553.3T patent/DK1954258T3/da active
- 2006-11-28 CA CA2631241A patent/CA2631241C/en not_active Expired - Fee Related
- 2006-11-28 US US11/605,551 patent/US8415398B2/en not_active Expired - Fee Related
- 2006-11-28 EP EP06838553A patent/EP1954258B8/en not_active Not-in-force
-
2008
- 2008-05-26 IL IL191705A patent/IL191705A/en not_active IP Right Cessation
-
2013
- 2013-04-04 US US13/856,911 patent/US9283198B2/en not_active Expired - Fee Related
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