JP2010530376A5 - - Google Patents
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- Publication number
- JP2010530376A5 JP2010530376A5 JP2010512544A JP2010512544A JP2010530376A5 JP 2010530376 A5 JP2010530376 A5 JP 2010530376A5 JP 2010512544 A JP2010512544 A JP 2010512544A JP 2010512544 A JP2010512544 A JP 2010512544A JP 2010530376 A5 JP2010530376 A5 JP 2010530376A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitors
- receptor modulator
- compound
- medicament
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 2
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 2
- 230000001028 anti-proliverative effect Effects 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 239000002834 estrogen receptor modulator Substances 0.000 claims 2
- 239000004030 hiv protease inhibitor Substances 0.000 claims 2
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 claims 2
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 229940075993 receptor modulator Drugs 0.000 claims 2
- 102000027483 retinoid hormone receptors Human genes 0.000 claims 2
- 108091008679 retinoid hormone receptors Proteins 0.000 claims 2
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 2
- 239000000849 selective androgen receptor modulator Substances 0.000 claims 2
- 102000004357 Transferases Human genes 0.000 claims 1
- 108090000992 Transferases Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000003558 transferase inhibitor Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007028515.0 | 2007-06-21 | ||
| DE102007028515A DE102007028515A1 (de) | 2007-06-21 | 2007-06-21 | 6-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
| PCT/EP2008/004151 WO2008155000A1 (de) | 2007-06-21 | 2008-05-23 | 6-(pyrrolopyridinyl)- pyrimidin-2-yl-amin-derivate und ihre verwendung zur behandlung von krebs und aids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010530376A JP2010530376A (ja) | 2010-09-09 |
| JP2010530376A5 true JP2010530376A5 (https=) | 2011-07-07 |
| JP5411849B2 JP5411849B2 (ja) | 2014-02-12 |
Family
ID=39916277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010512544A Expired - Fee Related JP5411849B2 (ja) | 2007-06-21 | 2008-05-23 | ６−（ピロロピリジニル）−ピリミジン−２−イルアミン誘導体ならびに癌およびａｉｄｓの処置のためのその使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8546390B2 (https=) |
| EP (1) | EP2155745B1 (https=) |
| JP (1) | JP5411849B2 (https=) |
| KR (1) | KR20100040862A (https=) |
| CN (1) | CN101679425B (https=) |
| AR (1) | AR067081A1 (https=) |
| AU (1) | AU2008266584B2 (https=) |
| BR (1) | BRPI0812944A2 (https=) |
| CA (1) | CA2691223C (https=) |
| DE (1) | DE102007028515A1 (https=) |
| EA (1) | EA016160B1 (https=) |
| ES (1) | ES2533873T3 (https=) |
| IL (1) | IL202828A0 (https=) |
| MX (1) | MX2009013341A (https=) |
| WO (1) | WO2008155000A1 (https=) |
| ZA (1) | ZA201000432B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009010984A (es) * | 2007-04-10 | 2010-01-15 | Sgx Pharmaceuticals Inc | Moduladores de heterociclo cinasa de anillo fusionado. |
| DE102008031517A1 (de) * | 2008-07-03 | 2010-01-07 | Merck Patent Gmbh | Pyrrolopyridinyl-pyrimidin-2-yl-amin-derivate |
| DE102009019962A1 (de) * | 2009-05-05 | 2010-11-11 | Merck Patent Gmbh | 3-([1,2,3]Triazol-4-yl)-pyrrolo[2,3-b]pyridinderivate |
| DE102009060174A1 (de) * | 2009-12-23 | 2011-06-30 | Merck Patent GmbH, 64293 | Pyrrolopyridinyl-pyrimidin-2-yl-amin-derivate |
| DE102009060175A1 (de) | 2009-12-23 | 2011-06-30 | Merck Patent GmbH, 64293 | Pyrrolo[2,3-d] pyrazin-7-yl-pyrimidin-Verbindungen |
| DE102010050558A1 (de) | 2010-11-05 | 2012-05-10 | Merck Patent Gmbh | 1H-Pyrrolo[2,3-b]pyridinderivate |
| DE102010053347A1 (de) * | 2010-12-03 | 2012-06-06 | Merck Patent Gmbh | 3-Hetaryl-substituierte Pyrrolo[2,3-b] pyridin-derivative als PDK1-Inhibitoren |
| DE102011009961A1 (de) | 2011-02-01 | 2012-08-02 | Merck Patent Gmbh | 7-Azaindolderivate |
| EP2867236B1 (en) | 2012-06-29 | 2017-06-14 | Pfizer Inc | Novel 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors |
| JP6199991B2 (ja) * | 2013-01-18 | 2017-09-20 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ３置換ピラゾール及びｄｌｋ阻害剤としての使用 |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| DK2970265T3 (en) * | 2013-03-15 | 2018-10-01 | Plexxikon Inc | HETEROCYCLIC COMPOUNDS AND APPLICATIONS THEREOF |
| EP3083618B1 (en) | 2013-12-17 | 2018-02-21 | Pfizer Inc | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
| RU2722149C1 (ru) | 2015-09-14 | 2020-05-27 | Пфайзер Инк. | Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2 |
| WO2017161004A1 (en) | 2016-03-15 | 2017-09-21 | University Of South Florida | PKCδ INHIBITOR FORMULATIONS AND USES THEREOF CROSS-REFERENCE TO RELATED APPLICATIONS |
| KR20220071293A (ko) | 2016-04-01 | 2022-05-31 | 리커리엄 아이피 홀딩스, 엘엘씨 | 에스트로겐 수용체 조절제 |
| US10717735B2 (en) | 2017-10-13 | 2020-07-21 | Plexxikon Inc. | Solid forms of a compound for modulating kinases |
| SG11202110714VA (en) * | 2019-04-09 | 2021-10-28 | Plexxikon Inc | Condensed azines for ep300 or cbp modulation and indications therefor |
| KR20220044528A (ko) | 2019-08-06 | 2022-04-08 | 리커리엄 아이피 홀딩스, 엘엘씨 | 돌연변이체를 치료하기 위한 에스트로겐 수용체 조절제 |
| CN118772140B (zh) * | 2023-04-07 | 2026-04-17 | 四川大学 | 一类化合物及其在治疗hDHODH介导的疾病中的用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| US6265434B1 (en) | 1999-04-06 | 2001-07-24 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| ES2364340T3 (es) * | 2004-03-30 | 2011-08-31 | Vertex Pharmaceuticals Incorporated | Azaindoles útiles como inhibidores de jak y otras proteína quinasas. |
| JP2008502687A (ja) * | 2004-06-14 | 2008-01-31 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| WO2006015123A1 (en) * | 2004-07-27 | 2006-02-09 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| EP1828180A4 (en) * | 2004-12-08 | 2010-09-15 | Glaxosmithkline Llc | 1H-pyrrolo [2,3-BETA] PYRIDINE |
| RU2387653C2 (ru) * | 2005-05-16 | 2010-04-27 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеинкиназ |
| DE102006012617A1 (de) * | 2006-03-20 | 2007-09-27 | Merck Patent Gmbh | 4-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
-
2007
- 2007-06-21 DE DE102007028515A patent/DE102007028515A1/de not_active Withdrawn
-
2008
- 2008-05-23 MX MX2009013341A patent/MX2009013341A/es not_active Application Discontinuation
- 2008-05-23 BR BRPI0812944-4A2A patent/BRPI0812944A2/pt not_active IP Right Cessation
- 2008-05-23 AU AU2008266584A patent/AU2008266584B2/en not_active Ceased
- 2008-05-23 CA CA2691223A patent/CA2691223C/en not_active Expired - Fee Related
- 2008-05-23 WO PCT/EP2008/004151 patent/WO2008155000A1/de not_active Ceased
- 2008-05-23 EA EA201000004A patent/EA016160B1/ru not_active IP Right Cessation
- 2008-05-23 CN CN2008800197101A patent/CN101679425B/zh not_active Expired - Fee Related
- 2008-05-23 ES ES08758743.2T patent/ES2533873T3/es active Active
- 2008-05-23 EP EP08758743.2A patent/EP2155745B1/de not_active Not-in-force
- 2008-05-23 KR KR1020107001385A patent/KR20100040862A/ko not_active Withdrawn
- 2008-05-23 JP JP2010512544A patent/JP5411849B2/ja not_active Expired - Fee Related
- 2008-05-23 US US12/664,791 patent/US8546390B2/en not_active Expired - Fee Related
- 2008-06-20 AR ARP080102634A patent/AR067081A1/es unknown
-
2009
- 2009-12-17 IL IL202828A patent/IL202828A0/en unknown
-
2010
- 2010-01-20 ZA ZA201000432A patent/ZA201000432B/xx unknown
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