DE102007028515A1 - 6-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate - Google Patents
6-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate Download PDFInfo
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- DE102007028515A1 DE102007028515A1 DE102007028515A DE102007028515A DE102007028515A1 DE 102007028515 A1 DE102007028515 A1 DE 102007028515A1 DE 102007028515 A DE102007028515 A DE 102007028515A DE 102007028515 A DE102007028515 A DE 102007028515A DE 102007028515 A1 DE102007028515 A1 DE 102007028515A1
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- 229960001727 tretinoin Drugs 0.000 description 1
- 229960005526 triapine Drugs 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 229960001099 trimetrexate Drugs 0.000 description 1
- NOYPYLRCIDNJJB-UHFFFAOYSA-N trimetrexate Chemical compound COC1=C(OC)C(OC)=CC(NCC=2C(=C3C(N)=NC(N)=NC3=CC=2)C)=C1 NOYPYLRCIDNJJB-UHFFFAOYSA-N 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- UMKFEPPTGMDVMI-UHFFFAOYSA-N trofosfamide Chemical compound ClCCN(CCCl)P1(=O)OCCCN1CCCl UMKFEPPTGMDVMI-UHFFFAOYSA-N 0.000 description 1
- 229960000875 trofosfamide Drugs 0.000 description 1
- 229950010147 troxacitabine Drugs 0.000 description 1
- RXRGZNYSEHTMHC-BQBZGAKWSA-N troxacitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)OC1 RXRGZNYSEHTMHC-BQBZGAKWSA-N 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 239000002691 unilamellar liposome Substances 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 229960000653 valrubicin Drugs 0.000 description 1
- ZOCKGBMQLCSHFP-KQRAQHLDSA-N valrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC(OC)=C4C(=O)C=3C(O)=C21)(O)C(=O)COC(=O)CCCC)[C@H]1C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O1 ZOCKGBMQLCSHFP-KQRAQHLDSA-N 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- NMDYYWFGPIMTKO-HBVLKOHWSA-N vinflunine Chemical compound C([C@@](C1=C(C2=CC=CC=C2N1)C1)(C2=C(OC)C=C3N(C)[C@@H]4[C@@]5(C3=C2)CCN2CC=C[C@]([C@@H]52)([C@H]([C@]4(O)C(=O)OC)OC(C)=O)CC)C(=O)OC)[C@H]2C[C@@H](C(C)(F)F)CN1C2 NMDYYWFGPIMTKO-HBVLKOHWSA-N 0.000 description 1
- 229960000922 vinflunine Drugs 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- FBTUMDXHSRTGRV-ALTNURHMSA-N zorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(\C)=N\NC(=O)C=1C=CC=CC=1)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 FBTUMDXHSRTGRV-ALTNURHMSA-N 0.000 description 1
- 229960000641 zorubicin Drugs 0.000 description 1
- VLCYCQAOQCDTCN-ZCFIWIBFSA-N α-difluoromethylornithine Chemical compound NCCC[C@@](N)(C(F)F)C(O)=O VLCYCQAOQCDTCN-ZCFIWIBFSA-N 0.000 description 1
- 229930195724 β-lactose Natural products 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007028515A DE102007028515A1 (de) | 2007-06-21 | 2007-06-21 | 6-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
| EP08758743.2A EP2155745B1 (de) | 2007-06-21 | 2008-05-23 | 6-(Pyrrolopyridinyl)- Pyrimidin-2-yl-Amin-Derivate und ihre Verwendung zur Behandlung von Krebs und Aids |
| JP2010512544A JP5411849B2 (ja) | 2007-06-21 | 2008-05-23 | ６−（ピロロピリジニル）−ピリミジン−２−イルアミン誘導体ならびに癌およびａｉｄｓの処置のためのその使用 |
| CA2691223A CA2691223C (en) | 2007-06-21 | 2008-05-23 | 6-(pyrrolopyridinyl) pyrimidin-2-ylamine derivatives and the use thereof for the treatment of cancer and aids |
| US12/664,791 US8546390B2 (en) | 2007-06-21 | 2008-05-23 | 6-(pyrrolopyridinyl) pyrimidin-2-ylamine derivatives and the use thereof for the treatment of cancer and AIDS |
| EA201000004A EA016160B1 (ru) | 2007-06-21 | 2008-05-23 | Производные 6-(пирролопиридинил)пиримидин-2-иламина и их применение для лечения злокачественного новообразования |
| PCT/EP2008/004151 WO2008155000A1 (de) | 2007-06-21 | 2008-05-23 | 6-(pyrrolopyridinyl)- pyrimidin-2-yl-amin-derivate und ihre verwendung zur behandlung von krebs und aids |
| BRPI0812944-4A2A BRPI0812944A2 (pt) | 2007-06-21 | 2008-05-23 | Derivados de 6-(pirrolopiridinil)pirimidin-2-ilamina e o uso dos mesmos para o tratamento de câncer e aids |
| KR1020107001385A KR20100040862A (ko) | 2007-06-21 | 2008-05-23 | 6-(피롤로피리디닐)-피리미딘-2-일-아민 유도체 |
| AU2008266584A AU2008266584B2 (en) | 2007-06-21 | 2008-05-23 | 6-(pyrrolopyridinyl)-pyrimidine-2-yl-amine derivatives |
| CN2008800197101A CN101679425B (zh) | 2007-06-21 | 2008-05-23 | 6-(吡咯并吡啶基)嘧啶-2-基胺及其治疗癌症和艾滋病的用途 |
| MX2009013341A MX2009013341A (es) | 2007-06-21 | 2008-05-23 | Derivados de 6-(pirrolopiridinil)-pirimidinil-2-amina. |
| ES08758743.2T ES2533873T3 (es) | 2007-06-21 | 2008-05-23 | Derivados de 6-(pirrolopiridinil)-pirimidin-2-il-amina y su utilización para el tratamiento del cáncer y del SIDA |
| ARP080102634A AR067081A1 (es) | 2007-06-21 | 2008-06-20 | Derivados de pirrolo[2,3-b]piridin-pirimidina,proceso de preparacion, medicamentos que los contienen y usos de los mismos para el tratamiento de tumores cancerigenos y metastasis tumorales. |
| IL202828A IL202828A0 (en) | 2007-06-21 | 2009-12-17 | 6-(pyrrolopyridinyl)pyrimidin - 2 - ylamine derivatives and the use thereof for the treatment of cancer and aids |
| ZA201000432A ZA201000432B (en) | 2007-06-21 | 2010-01-20 | 6-(pyrrolopyridinyl)pyrimidin-2-ylamine derivatives and the use thereof for the treatment of cancer and aids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007028515A DE102007028515A1 (de) | 2007-06-21 | 2007-06-21 | 6-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102007028515A1 true DE102007028515A1 (de) | 2008-12-24 |
Family
ID=39916277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102007028515A Withdrawn DE102007028515A1 (de) | 2007-06-21 | 2007-06-21 | 6-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8546390B2 (https=) |
| EP (1) | EP2155745B1 (https=) |
| JP (1) | JP5411849B2 (https=) |
| KR (1) | KR20100040862A (https=) |
| CN (1) | CN101679425B (https=) |
| AR (1) | AR067081A1 (https=) |
| AU (1) | AU2008266584B2 (https=) |
| BR (1) | BRPI0812944A2 (https=) |
| CA (1) | CA2691223C (https=) |
| DE (1) | DE102007028515A1 (https=) |
| EA (1) | EA016160B1 (https=) |
| ES (1) | ES2533873T3 (https=) |
| IL (1) | IL202828A0 (https=) |
| MX (1) | MX2009013341A (https=) |
| WO (1) | WO2008155000A1 (https=) |
| ZA (1) | ZA201000432B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012104007A3 (de) * | 2011-02-01 | 2013-10-17 | Merck Patent Gmbh | 7-azaindolderivate |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009010984A (es) * | 2007-04-10 | 2010-01-15 | Sgx Pharmaceuticals Inc | Moduladores de heterociclo cinasa de anillo fusionado. |
| DE102008031517A1 (de) * | 2008-07-03 | 2010-01-07 | Merck Patent Gmbh | Pyrrolopyridinyl-pyrimidin-2-yl-amin-derivate |
| DE102009019962A1 (de) * | 2009-05-05 | 2010-11-11 | Merck Patent Gmbh | 3-([1,2,3]Triazol-4-yl)-pyrrolo[2,3-b]pyridinderivate |
| DE102009060174A1 (de) * | 2009-12-23 | 2011-06-30 | Merck Patent GmbH, 64293 | Pyrrolopyridinyl-pyrimidin-2-yl-amin-derivate |
| DE102009060175A1 (de) | 2009-12-23 | 2011-06-30 | Merck Patent GmbH, 64293 | Pyrrolo[2,3-d] pyrazin-7-yl-pyrimidin-Verbindungen |
| DE102010050558A1 (de) | 2010-11-05 | 2012-05-10 | Merck Patent Gmbh | 1H-Pyrrolo[2,3-b]pyridinderivate |
| DE102010053347A1 (de) * | 2010-12-03 | 2012-06-06 | Merck Patent Gmbh | 3-Hetaryl-substituierte Pyrrolo[2,3-b] pyridin-derivative als PDK1-Inhibitoren |
| EP2867236B1 (en) | 2012-06-29 | 2017-06-14 | Pfizer Inc | Novel 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors |
| JP6199991B2 (ja) * | 2013-01-18 | 2017-09-20 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ３置換ピラゾール及びｄｌｋ阻害剤としての使用 |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| DK2970265T3 (en) * | 2013-03-15 | 2018-10-01 | Plexxikon Inc | HETEROCYCLIC COMPOUNDS AND APPLICATIONS THEREOF |
| EP3083618B1 (en) | 2013-12-17 | 2018-02-21 | Pfizer Inc | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
| RU2722149C1 (ru) | 2015-09-14 | 2020-05-27 | Пфайзер Инк. | Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2 |
| WO2017161004A1 (en) | 2016-03-15 | 2017-09-21 | University Of South Florida | PKCδ INHIBITOR FORMULATIONS AND USES THEREOF CROSS-REFERENCE TO RELATED APPLICATIONS |
| KR20220071293A (ko) | 2016-04-01 | 2022-05-31 | 리커리엄 아이피 홀딩스, 엘엘씨 | 에스트로겐 수용체 조절제 |
| US10717735B2 (en) | 2017-10-13 | 2020-07-21 | Plexxikon Inc. | Solid forms of a compound for modulating kinases |
| SG11202110714VA (en) * | 2019-04-09 | 2021-10-28 | Plexxikon Inc | Condensed azines for ep300 or cbp modulation and indications therefor |
| KR20220044528A (ko) | 2019-08-06 | 2022-04-08 | 리커리엄 아이피 홀딩스, 엘엘씨 | 돌연변이체를 치료하기 위한 에스트로겐 수용체 조절제 |
| CN118772140B (zh) * | 2023-04-07 | 2026-04-17 | 四川大学 | 一类化合物及其在治疗hDHODH介导的疾病中的用途 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6069134A (en) | 1991-03-06 | 2000-05-30 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| WO2000050032A1 (en) | 1999-02-25 | 2000-08-31 | Pharmacia & Upjohn S.P.A. | Antitumour synergistic composition |
| WO2000059503A1 (en) | 1999-04-06 | 2000-10-12 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| WO2004089913A1 (en) | 2003-04-11 | 2004-10-21 | Novartis Ag | Aminopyrimidine derivatives and their medical use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2364340T3 (es) * | 2004-03-30 | 2011-08-31 | Vertex Pharmaceuticals Incorporated | Azaindoles útiles como inhibidores de jak y otras proteína quinasas. |
| JP2008502687A (ja) * | 2004-06-14 | 2008-01-31 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| WO2006015123A1 (en) * | 2004-07-27 | 2006-02-09 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| EP1828180A4 (en) * | 2004-12-08 | 2010-09-15 | Glaxosmithkline Llc | 1H-pyrrolo [2,3-BETA] PYRIDINE |
| RU2387653C2 (ru) * | 2005-05-16 | 2010-04-27 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеинкиназ |
| DE102006012617A1 (de) * | 2006-03-20 | 2007-09-27 | Merck Patent Gmbh | 4-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
-
2007
- 2007-06-21 DE DE102007028515A patent/DE102007028515A1/de not_active Withdrawn
-
2008
- 2008-05-23 MX MX2009013341A patent/MX2009013341A/es not_active Application Discontinuation
- 2008-05-23 BR BRPI0812944-4A2A patent/BRPI0812944A2/pt not_active IP Right Cessation
- 2008-05-23 AU AU2008266584A patent/AU2008266584B2/en not_active Ceased
- 2008-05-23 CA CA2691223A patent/CA2691223C/en not_active Expired - Fee Related
- 2008-05-23 WO PCT/EP2008/004151 patent/WO2008155000A1/de not_active Ceased
- 2008-05-23 EA EA201000004A patent/EA016160B1/ru not_active IP Right Cessation
- 2008-05-23 CN CN2008800197101A patent/CN101679425B/zh not_active Expired - Fee Related
- 2008-05-23 ES ES08758743.2T patent/ES2533873T3/es active Active
- 2008-05-23 EP EP08758743.2A patent/EP2155745B1/de not_active Not-in-force
- 2008-05-23 KR KR1020107001385A patent/KR20100040862A/ko not_active Withdrawn
- 2008-05-23 JP JP2010512544A patent/JP5411849B2/ja not_active Expired - Fee Related
- 2008-05-23 US US12/664,791 patent/US8546390B2/en not_active Expired - Fee Related
- 2008-06-20 AR ARP080102634A patent/AR067081A1/es unknown
-
2009
- 2009-12-17 IL IL202828A patent/IL202828A0/en unknown
-
2010
- 2010-01-20 ZA ZA201000432A patent/ZA201000432B/xx unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6069134A (en) | 1991-03-06 | 2000-05-30 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| WO2000050032A1 (en) | 1999-02-25 | 2000-08-31 | Pharmacia & Upjohn S.P.A. | Antitumour synergistic composition |
| WO2000059503A1 (en) | 1999-04-06 | 2000-10-12 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| WO2004089913A1 (en) | 2003-04-11 | 2004-10-21 | Novartis Ag | Aminopyrimidine derivatives and their medical use |
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| P. M. Fresneda et al. in Tetrahedron 57 (2001) 2355-2363 |
| Pharmaceutical Research, 3(6), 318 (1986) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012104007A3 (de) * | 2011-02-01 | 2013-10-17 | Merck Patent Gmbh | 7-azaindolderivate |
| EP2746281A3 (de) * | 2011-02-01 | 2014-10-08 | Merck Patent GmbH | 7-Azaindolderivate |
| US8981101B2 (en) | 2011-02-01 | 2015-03-17 | Merck Patent Gmbh | 7-azaindole derivatives |
| US9266887B2 (en) | 2011-02-01 | 2016-02-23 | Merck Patent Gmbh | 7-azaindole derivatives |
| EP3133074A3 (de) * | 2011-02-01 | 2017-05-17 | Merck Patent GmbH | 7-azaindolderivate |
| US9725446B2 (en) | 2011-02-01 | 2017-08-08 | Merck Patent Gmbh | 7-azaindole derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010530376A (ja) | 2010-09-09 |
| US8546390B2 (en) | 2013-10-01 |
| KR20100040862A (ko) | 2010-04-21 |
| CN101679425B (zh) | 2013-11-06 |
| CA2691223A1 (en) | 2008-12-24 |
| AR067081A1 (es) | 2009-09-30 |
| EA201000004A1 (ru) | 2010-06-30 |
| ZA201000432B (en) | 2010-10-27 |
| AU2008266584A1 (en) | 2008-12-24 |
| ES2533873T3 (es) | 2015-04-15 |
| EA016160B1 (ru) | 2012-02-28 |
| US20110082140A1 (en) | 2011-04-07 |
| MX2009013341A (es) | 2010-01-18 |
| CA2691223C (en) | 2015-12-01 |
| WO2008155000A1 (de) | 2008-12-24 |
| CN101679425A (zh) | 2010-03-24 |
| AU2008266584B2 (en) | 2013-04-04 |
| EP2155745B1 (de) | 2015-01-28 |
| IL202828A0 (en) | 2010-06-30 |
| EP2155745A1 (de) | 2010-02-24 |
| JP5411849B2 (ja) | 2014-02-12 |
| BRPI0812944A2 (pt) | 2014-12-16 |
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