JP2009530413A5 - - Google Patents
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- Publication number
- JP2009530413A5 JP2009530413A5 JP2009501667A JP2009501667A JP2009530413A5 JP 2009530413 A5 JP2009530413 A5 JP 2009530413A5 JP 2009501667 A JP2009501667 A JP 2009501667A JP 2009501667 A JP2009501667 A JP 2009501667A JP 2009530413 A5 JP2009530413 A5 JP 2009530413A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- composition
- methyl
- adenosine receptor
- trihydropurine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78357506P | 2006-03-17 | 2006-03-17 | |
| US60/783,575 | 2006-03-17 | ||
| PCT/US2007/064182 WO2007109547A2 (en) | 2006-03-17 | 2007-03-16 | Method of preventing and treating hepatic disease using a2b adenosine receptor antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012268193A Division JP2013049719A (ja) | 2006-03-17 | 2012-12-07 | Ａ２ｂアデノシン受容体拮抗物質を用いる肝疾患の予防および処置の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009530413A JP2009530413A (ja) | 2009-08-27 |
| JP2009530413A5 true JP2009530413A5 (https=) | 2011-03-03 |
| JP5250848B2 JP5250848B2 (ja) | 2013-07-31 |
Family
ID=38514256
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009501667A Active JP5250848B2 (ja) | 2006-03-17 | 2007-03-16 | Ａ２ｂアデノシン受容体拮抗物質を用いる肝疾患の予防および処置の方法 |
| JP2012268193A Pending JP2013049719A (ja) | 2006-03-17 | 2012-12-07 | Ａ２ｂアデノシン受容体拮抗物質を用いる肝疾患の予防および処置の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012268193A Pending JP2013049719A (ja) | 2006-03-17 | 2012-12-07 | Ａ２ｂアデノシン受容体拮抗物質を用いる肝疾患の予防および処置の方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US7795268B2 (https=) |
| EP (1) | EP1996201A2 (https=) |
| JP (2) | JP5250848B2 (https=) |
| KR (1) | KR101428113B1 (https=) |
| CN (1) | CN101405003B (https=) |
| AU (1) | AU2007227021B2 (https=) |
| CA (2) | CA2646333C (https=) |
| IL (1) | IL194158A0 (https=) |
| MX (1) | MX2008011828A (https=) |
| NO (1) | NO20083968L (https=) |
| NZ (1) | NZ571324A (https=) |
| RU (1) | RU2457842C2 (https=) |
| WO (1) | WO2007109547A2 (https=) |
| ZA (1) | ZA200807894B (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080194593A1 (en) * | 2001-11-09 | 2008-08-14 | Rao Kalla | A2b adenosine receptor antagonists |
| US7317017B2 (en) * | 2002-11-08 | 2008-01-08 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US20080318983A1 (en) * | 2001-11-09 | 2008-12-25 | Rao Kalla | A2b adenosine receptor antagonists |
| ES2557310T3 (es) * | 2003-08-25 | 2016-01-25 | Dogwood Pharmaceuticals, Inc. | 8-heteroaril xantinas substituidas |
| EP1799221A1 (en) | 2004-10-15 | 2007-06-27 | Cv Therapeutics, Inc. | Method of preventing and treating airway remodeling and pulmonary inflammation using a2b adenosine receptor antagonists |
| US7598379B2 (en) | 2005-02-25 | 2009-10-06 | Pgx Health, Llc | Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines |
| US7579348B2 (en) * | 2005-02-25 | 2009-08-25 | Pgxhealth, Llc | Derivatives of 8-substituted xanthines |
| WO2006091898A2 (en) * | 2005-02-25 | 2006-08-31 | Adenosine Therapeutics, Llc | Pyrazolyl substituted xanthines |
| EP1891070A1 (en) * | 2005-06-16 | 2008-02-27 | Cv Therapeutics, Inc. | Prodrugs of a2b adenosine receptor antagonists |
| AU2007227021B2 (en) | 2006-03-17 | 2012-12-20 | Gilead Sciences, Inc. | Method of preventing and treating hepatic disease using A2B adenosine receptor antagonists |
| US7884100B2 (en) * | 2006-06-16 | 2011-02-08 | Pgxhealth, Llc | Substituted 8-[6-amino-3-pyridyl]xanthines |
| WO2008000743A2 (en) * | 2006-06-27 | 2008-01-03 | Biovitrum Ab (Publ) | Novel 2',3'-methylidene acetyl adenosine prodrugs for use as prodrugs for adenosine receptor agonists |
| US7767685B2 (en) * | 2006-06-29 | 2010-08-03 | King Pharmaceuticals Research And Development, Inc. | Adenosine A2B receptor antagonists |
| US20090208550A1 (en) * | 2007-10-26 | 2009-08-20 | Cronstein Bruce N | Methods and compositions for treating hepatic diseases |
| US7875608B2 (en) * | 2007-12-17 | 2011-01-25 | Thompson Robert D | Substituted 8-[6-amino-3pyridyl]xanthines |
| EP2268641B1 (en) * | 2008-03-26 | 2014-09-03 | Advinus Therapeutics Pvt. Ltd. | Heterocyclic compounds as adenosine receptor antagonist |
| JP5765239B2 (ja) | 2009-03-13 | 2015-08-19 | アドヴィナス・セラピューティックス・リミテッド | 置換縮合ピリミジン化合物 |
| JP5843778B2 (ja) | 2009-11-09 | 2016-01-13 | アドヴィナス・セラピューティックス・リミテッド | 置換縮合ピリミジン化合物、その調製およびその使用 |
| CN103261200B (zh) | 2010-09-13 | 2016-03-30 | 阿迪维纳斯疗法有限公司 | 作为a2b腺苷受体拮抗剂的前药的嘌呤化合物、它们的制备方法及医药用途 |
| US20140142113A1 (en) * | 2012-11-09 | 2014-05-22 | Michael W. Burnet | Method of treating inflammatory diseases using adenosine 2b receptor antagonists |
| US10583102B2 (en) | 2014-10-06 | 2020-03-10 | The Johns Hopkins University | Targeting liver nuclear receptors as a treatment for wilson disease |
| WO2016129760A1 (ko) * | 2015-02-13 | 2016-08-18 | 한국과학기술원 | Tnp(n2-(m-trifluorobenzyl), n6-(p-nitrobenzyl)purine)를 유효성분으로 함유하는 아세트아미노펜 유래 간 독성 예방 및 치료용 조성물 |
| KR101666605B1 (ko) | 2015-02-13 | 2016-10-18 | 한국과학기술원 | TNP(N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine)를 유효성분으로 함유하는 아세트아미노펜 유래 간 독성 예방 및 치료용 조성물 |
| EP3368064B1 (en) | 2015-10-29 | 2021-05-19 | CLS Therapeutics Limited | Use of dnase to improve safety and efficacy of anti-cancer chemotherapy |
| WO2017139455A1 (en) | 2016-02-10 | 2017-08-17 | Wake Forest University Health Sciences | Model system of liver fibrosis and method of making and using the same |
| KR101709307B1 (ko) * | 2016-10-31 | 2017-02-23 | 퓨쳐메디신 주식회사 | 아데노신 유도체를 포함하는 비알콜성 지방간염, 간섬유증 및 간경변증 예방 및 치료용 약학적 조성물 |
| US11220492B2 (en) | 2017-05-17 | 2022-01-11 | Arcus Biosciences, Inc. | Quinazoline-pyrazole derivatives for the treatment of cancer-related disorders |
| CN111629728A (zh) * | 2017-08-31 | 2020-09-04 | 科尔沃斯制药股份有限公司 | 用于调节腺苷a2b受体和腺苷a2a受体的化合物和方法 |
| ES2975753T3 (es) | 2018-03-05 | 2024-07-12 | Teon Therapeutics Inc | Antagonistas del receptor de adenosina y usos de los mismos |
| GB201804922D0 (en) | 2018-03-27 | 2018-05-09 | Ucl Business Plc | Traatment |
| US12064433B2 (en) | 2018-07-27 | 2024-08-20 | Arcus Biosciences, Inc. | Pyridone A2R antagonists |
| CN111686239B (zh) * | 2019-03-11 | 2021-12-24 | 中国科学院微生物研究所 | 抗真菌化合物的应用 |
| US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0028383D0 (en) * | 2000-11-21 | 2001-01-03 | Novartis Ag | Organic compounds |
| DK1444233T3 (da) * | 2001-11-09 | 2011-10-17 | Gilead Palo Alto Inc | A2B-adenosinreceptorantagonister |
| US7125993B2 (en) * | 2001-11-09 | 2006-10-24 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| ES2208063B1 (es) | 2002-04-01 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de la 4-(pirrolopirimidin-6-il)bencenosulfonamida. |
| IL160133A0 (en) * | 2002-05-30 | 2004-06-20 | King Pharmaceuticals Res & Dev | Pharmaceutically active compounds having a tricyclic pyrazolotriazolopyrimidine ring structure and methods of use |
| WO2004086052A2 (en) * | 2003-03-28 | 2004-10-07 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor adenosine a2b (adora2b) |
| GB0401336D0 (en) * | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| EP1891070A1 (en) | 2005-06-16 | 2008-02-27 | Cv Therapeutics, Inc. | Prodrugs of a2b adenosine receptor antagonists |
| AU2007227021B2 (en) * | 2006-03-17 | 2012-12-20 | Gilead Sciences, Inc. | Method of preventing and treating hepatic disease using A2B adenosine receptor antagonists |
-
2007
- 2007-03-16 AU AU2007227021A patent/AU2007227021B2/en active Active
- 2007-03-16 JP JP2009501667A patent/JP5250848B2/ja active Active
- 2007-03-16 EP EP07758704A patent/EP1996201A2/en not_active Withdrawn
- 2007-03-16 WO PCT/US2007/064182 patent/WO2007109547A2/en not_active Ceased
- 2007-03-16 MX MX2008011828A patent/MX2008011828A/es active IP Right Grant
- 2007-03-16 NZ NZ571324A patent/NZ571324A/en unknown
- 2007-03-16 CN CN2007800095071A patent/CN101405003B/zh active Active
- 2007-03-16 US US11/687,236 patent/US7795268B2/en active Active
- 2007-03-16 CA CA2646333A patent/CA2646333C/en active Active
- 2007-03-16 KR KR1020087022707A patent/KR101428113B1/ko active Active
- 2007-03-16 RU RU2008137279/15A patent/RU2457842C2/ru active
- 2007-03-16 CA CA2849661A patent/CA2849661A1/en not_active Abandoned
-
2008
- 2008-09-15 ZA ZA200807894A patent/ZA200807894B/xx unknown
- 2008-09-17 NO NO20083968A patent/NO20083968L/no not_active Application Discontinuation
- 2008-09-17 IL IL194158A patent/IL194158A0/en unknown
-
2010
- 2010-08-10 US US12/853,510 patent/US8188099B2/en active Active
-
2012
- 2012-02-28 US US13/407,616 patent/US8609671B2/en active Active
- 2012-12-07 JP JP2012268193A patent/JP2013049719A/ja active Pending
-
2013
- 2013-10-04 US US14/046,847 patent/US20140243358A1/en not_active Abandoned
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