JP2009514861A5 - - Google Patents
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- Publication number
- JP2009514861A5 JP2009514861A5 JP2008538960A JP2008538960A JP2009514861A5 JP 2009514861 A5 JP2009514861 A5 JP 2009514861A5 JP 2008538960 A JP2008538960 A JP 2008538960A JP 2008538960 A JP2008538960 A JP 2008538960A JP 2009514861 A5 JP2009514861 A5 JP 2009514861A5
- Authority
- JP
- Japan
- Prior art keywords
- gallium
- compound
- effective amount
- concentration
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052733 gallium Inorganic materials 0.000 claims 42
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 claims 39
- 150000002259 gallium compounds Chemical class 0.000 claims 33
- 238000000034 method Methods 0.000 claims 20
- 229940034610 toothpaste Drugs 0.000 claims 7
- 239000000606 toothpaste Substances 0.000 claims 7
- CHPZKNULDCNCBW-UHFFFAOYSA-N gallium nitrate Chemical compound [Ga+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O CHPZKNULDCNCBW-UHFFFAOYSA-N 0.000 claims 6
- 235000013305 food Nutrition 0.000 claims 4
- 239000006041 probiotic Substances 0.000 claims 4
- 235000018291 probiotics Nutrition 0.000 claims 4
- ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical compound O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 claims 3
- YEEGWNXDUZONAA-UHFFFAOYSA-K 5-hydroxy-2,8,9-trioxa-1-gallabicyclo[3.3.2]decane-3,7,10-trione Chemical compound [Ga+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YEEGWNXDUZONAA-UHFFFAOYSA-K 0.000 claims 3
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 3
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 3
- 241000186660 Lactobacillus Species 0.000 claims 3
- 102000010445 Lactoferrin Human genes 0.000 claims 3
- 108010063045 Lactoferrin Proteins 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 3
- 102000004338 Transferrin Human genes 0.000 claims 3
- 108090000901 Transferrin Proteins 0.000 claims 3
- FYWVTSQYJIPZLW-UHFFFAOYSA-K diacetyloxygallanyl acetate Chemical compound [Ga+3].CC([O-])=O.CC([O-])=O.CC([O-])=O FYWVTSQYJIPZLW-UHFFFAOYSA-K 0.000 claims 3
- AJNVQOSZGJRYEI-UHFFFAOYSA-N digallium;oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Ga+3].[Ga+3] AJNVQOSZGJRYEI-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940044658 gallium nitrate Drugs 0.000 claims 3
- 229910001195 gallium oxide Inorganic materials 0.000 claims 3
- -1 gallium oxime Chemical class 0.000 claims 3
- 229910000154 gallium phosphate Inorganic materials 0.000 claims 3
- 229910000373 gallium sulfate Inorganic materials 0.000 claims 3
- UPWPDUACHOATKO-UHFFFAOYSA-K gallium trichloride Chemical compound Cl[Ga](Cl)Cl UPWPDUACHOATKO-UHFFFAOYSA-K 0.000 claims 3
- LWFNJDOYCSNXDO-UHFFFAOYSA-K gallium;phosphate Chemical compound [Ga+3].[O-]P([O-])([O-])=O LWFNJDOYCSNXDO-UHFFFAOYSA-K 0.000 claims 3
- SBDRYJMIQMDXRH-UHFFFAOYSA-N gallium;sulfuric acid Chemical compound [Ga].OS(O)(=O)=O SBDRYJMIQMDXRH-UHFFFAOYSA-N 0.000 claims 3
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims 3
- 229940039696 lactobacillus Drugs 0.000 claims 3
- 229940078795 lactoferrin Drugs 0.000 claims 3
- 235000021242 lactoferrin Nutrition 0.000 claims 3
- LVWZTYCIRDMTEY-UHFFFAOYSA-N metamizole Chemical compound O=C1C(N(CS(O)(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 LVWZTYCIRDMTEY-UHFFFAOYSA-N 0.000 claims 3
- 244000005700 microbiome Species 0.000 claims 3
- 239000002324 mouth wash Substances 0.000 claims 3
- 229940051866 mouthwash Drugs 0.000 claims 3
- 229940095064 tartrate Drugs 0.000 claims 3
- 239000012581 transferrin Substances 0.000 claims 3
- 244000000010 microbial pathogen Species 0.000 claims 2
- 210000000214 mouth Anatomy 0.000 claims 2
- 230000000529 probiotic effect Effects 0.000 claims 2
- 206010040872 skin infection Diseases 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 241000251468 Actinopterygii Species 0.000 claims 1
- 241000222122 Candida albicans Species 0.000 claims 1
- 240000001046 Lactobacillus acidophilus Species 0.000 claims 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims 1
- 241001134654 Lactobacillus leichmannii Species 0.000 claims 1
- 240000006024 Lactobacillus plantarum Species 0.000 claims 1
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims 1
- 206010046914 Vaginal infection Diseases 0.000 claims 1
- 229940095731 candida albicans Drugs 0.000 claims 1
- 235000013339 cereals Nutrition 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 235000013365 dairy product Nutrition 0.000 claims 1
- 208000002925 dental caries Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 claims 1
- 235000019688 fish Nutrition 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 150000003278 haem Chemical class 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims 1
- 229940072205 lactobacillus plantarum Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000013372 meat Nutrition 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
- 235000013311 vegetables Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73187505P | 2005-11-01 | 2005-11-01 | |
| US60/731,875 | 2005-11-01 | ||
| PCT/US2006/042381 WO2007053581A2 (en) | 2005-11-01 | 2006-10-31 | Growth control of oral and superficial microorganisms using gallium compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012204408A Division JP5877776B2 (ja) | 2005-11-01 | 2012-09-18 | ガリウム化合物を使用する医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009514861A JP2009514861A (ja) | 2009-04-09 |
| JP2009514861A5 true JP2009514861A5 (https=) | 2009-12-24 |
| JP5264494B2 JP5264494B2 (ja) | 2013-08-14 |
Family
ID=38006451
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538960A Expired - Fee Related JP5264494B2 (ja) | 2005-11-01 | 2006-10-31 | ガリウム化合物を使用する口および表在性の微生物の成長制御 |
| JP2012204408A Expired - Fee Related JP5877776B2 (ja) | 2005-11-01 | 2012-09-18 | ガリウム化合物を使用する医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012204408A Expired - Fee Related JP5877776B2 (ja) | 2005-11-01 | 2012-09-18 | ガリウム化合物を使用する医薬組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20110038809A1 (https=) |
| EP (2) | EP1962774B1 (https=) |
| JP (2) | JP5264494B2 (https=) |
| KR (2) | KR20080072697A (https=) |
| CN (2) | CN101484178A (https=) |
| CA (2) | CA2784168C (https=) |
| WO (1) | WO2007053581A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1962774B1 (en) | 2005-11-01 | 2014-01-01 | Mount Sinai School of Medicine | Growth control of oral and superficial microorganisms using gallium compounds |
| WO2009009171A2 (en) * | 2007-04-02 | 2009-01-15 | Sideromics, Llc | Methods for preventing or treating infectious diseases using gallium compounds |
| BE1018018A6 (nl) | 2008-02-28 | 2010-04-06 | Gielen Cornelis | Oplossing voor het biologisch reinigen van tandenborstels en bijhorende inrichting. |
| EP2765948B8 (en) | 2011-10-05 | 2019-09-25 | Multi Oral BV | Oral care composition, applicator for such a composition and method for oral care |
| SG11201402057VA (en) * | 2011-12-15 | 2014-06-27 | Colgate Palmolive Co | Oral care compositions |
| KR20140139058A (ko) * | 2012-03-30 | 2014-12-04 | 덴츠플라이 아이에이치 에이비 | 항균 금속을 포함하는 표면을 구비한 의료 기기 |
| EP2662051A1 (en) * | 2012-05-11 | 2013-11-13 | Dentsply IH AB | Medical device having a surface comprising nanoparticles |
| CN111973484A (zh) * | 2013-03-12 | 2020-11-24 | 普莱玛疗法公司 | 包含螯合剂和碱的牙用组合物 |
| US10537661B2 (en) | 2017-03-28 | 2020-01-21 | DePuy Synthes Products, Inc. | Orthopedic implant having a crystalline calcium phosphate coating and methods for making the same |
| US10537658B2 (en) | 2017-03-28 | 2020-01-21 | DePuy Synthes Products, Inc. | Orthopedic implant having a crystalline gallium-containing hydroxyapatite coating and methods for making the same |
| WO2019165425A1 (en) * | 2018-02-26 | 2019-08-29 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Antimicrobial gallium compounds and methods |
| CN109481208A (zh) * | 2018-12-21 | 2019-03-19 | 南京汉瑞生物科技有限公司 | 一种应用镓元素的医疗护理设备 |
| JP7271341B2 (ja) * | 2019-06-28 | 2023-05-11 | サンスター スイス エスエー | 歯周病進行リスク測定方法及びキット |
| CN111876879A (zh) * | 2020-07-31 | 2020-11-03 | 储旭 | 抗菌面料及其制备方法 |
| CN111719196A (zh) * | 2020-07-31 | 2020-09-29 | 储旭 | 复合抗菌纤维及其制备方法 |
| CN113600827B (zh) * | 2021-07-30 | 2022-07-19 | 山东大学 | 一种Au/Ga2O3/AuGa2多相复合材料及其制备方法与应用 |
| CN115024391A (zh) * | 2022-06-27 | 2022-09-09 | 广东粤港澳大湾区国家纳米科技创新研究院 | 一种抗菌饲料添加剂及其制备方法以及应用 |
| CN117257955B (zh) * | 2023-11-17 | 2024-03-15 | 深圳大学 | 铁氧还蛋白还原酶Fpr作为绿脓杆菌治疗药物靶点的应用 |
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| GB654472A (en) * | 1947-03-12 | 1951-06-20 | Procter & Gamble | Preparations for use in contact with the teeth |
| US4177475A (en) * | 1977-10-31 | 1979-12-04 | Burroughs Corporation | High temperature amorphous memory device for an electrically alterable read-only memory |
| US4203123A (en) * | 1977-12-12 | 1980-05-13 | Burroughs Corporation | Thin film memory device employing amorphous semiconductor materials |
| US4388321A (en) * | 1981-08-06 | 1983-06-14 | Monsanto Company | Method for inhibiting growth of food poisoning organisms |
| EP0109564B1 (en) | 1982-10-22 | 1988-04-27 | Sloan-Kettering Institute For Cancer Research | The use of gallium salts for the manufacture of pharmaceutical compositions for the treatment of disorders of calcium homeostasis |
| CA2071867A1 (en) * | 1989-11-06 | 1991-05-07 | Edith Mathiowitz | Method for producing protein microspheres |
| US6004951A (en) | 1989-11-22 | 1999-12-21 | Bernstein; Lawrence Richard | Administration of gallium complexes of 3-hydroxy-4-pyrones to provide physiologically active gallium levels in a mammalian individual |
| US5574027A (en) | 1989-11-22 | 1996-11-12 | Bernstein; Lawrence R. | Pharmaceutical compositions of gallium complexes of 3-hydroxy-4-pyrones |
| US5258376A (en) | 1989-11-22 | 1993-11-02 | Bernstein Lawrence R | Pharmaceutical compositions of gallium complexes of 3-hydroxy-4-pyrones |
| US5556645A (en) * | 1990-01-12 | 1996-09-17 | Bockman; Richard | Methods of enhancing wound healing and tissue repair |
| DE69033606T2 (de) | 1990-01-12 | 2001-04-26 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Verfahren zur verbesserung der wundheilung und gewebeerneuerung |
| US5686116A (en) * | 1990-01-12 | 1997-11-11 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Methods of enhancing repair, healing and augmentation of bone implants |
| GB9009437D0 (en) * | 1990-04-26 | 1990-06-20 | Glaxo Group Ltd | Chemical compounds |
| SU1739957A1 (ru) * | 1990-06-29 | 1992-06-15 | Н.И.Лебедев, В.В.Степанок и С.Н.Лебедева | Способ силосовани зеленых кормов |
| JPH06506694A (ja) * | 1991-04-10 | 1994-07-28 | カペリ，クリストフアー・シー | 医療用に有用な抗微生物組成物 |
| US5286480A (en) * | 1992-06-29 | 1994-02-15 | The Procter & Gamble Company | Use of N-acetylated amino acid complexes in oral care compositions |
| US5363329A (en) * | 1993-11-10 | 1994-11-08 | Eugeniy Troyan | Semiconductor memory device for use in an electrically alterable read-only memory |
| US5858350A (en) * | 1993-12-01 | 1999-01-12 | Marine Polymer Technologies | Methods and compositions for poly-β-1→4-N-acetylglucosamine cell therapy system |
| US5641519A (en) * | 1995-05-18 | 1997-06-24 | The Ohio State University | Method of treating endotoxic shock employing gallium compounds |
| AUPN881396A0 (en) * | 1996-03-20 | 1996-04-18 | Arnott's Biscuits Limited | Enhancement of microbial colonization of the gastrointestinal tract |
| US5843936A (en) * | 1996-06-28 | 1998-12-01 | Bernstein; Lawrence R. | Topical administration of azaspiranes to prevent or treat skin conditions associated with hyperproliferation of keratinocytes |
| US5747482A (en) | 1996-07-30 | 1998-05-05 | Bernstein; Lawrence R. | Methods and compositions to inhibit keratinocyte proliferation |
| US6203822B1 (en) * | 1996-09-03 | 2001-03-20 | University Of Iowa Research Foundation | Gallium-containing compounds for the treatment of infections caused by intracellular pathogens and pathogens causing chronic pulmonary infection |
| WO1998030102A1 (en) * | 1997-01-09 | 1998-07-16 | Emory University | Non-iron metalloporphyrins and methods of use |
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| MXPA02003463A (es) * | 1999-10-04 | 2004-09-10 | R Bernstein Lawrence | Complejos de galio de 3-hidroxi-4-pironas para tratar la infeccion por procariontes intracelulares, virus de adn y retrovirus. |
| JP2001314181A (ja) * | 2000-05-10 | 2001-11-13 | Mi Tec:Kk | キレート化合物含有酒類 |
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| SE521022C2 (sv) * | 2001-09-20 | 2003-09-23 | Ellen Ab | Mjölksyraproducerande bakterier för användning som probiotiska organismer i vaginan hos människa |
| US20050100563A1 (en) * | 2001-01-26 | 2005-05-12 | Hexamer Don L. | Antifungal compositions and methods of treatment therewith |
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| US20060073197A1 (en) * | 2004-05-20 | 2006-04-06 | Ramaekers Joseph C | Encapsulated transfer factor compositions and methods of use |
| US6507061B1 (en) * | 2001-08-31 | 2003-01-14 | Intel Corporation | Multiple layer phase-change memory |
| US6660262B2 (en) * | 2001-09-28 | 2003-12-09 | Bovine Health Products, Inc. | Broad spectrum antimicrobial compound and treatment |
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| EP1691614B1 (en) * | 2003-12-04 | 2013-02-13 | University Of Iowa Research Foundation | Gallium inhibits biofilm formation |
| WO2005058331A1 (en) * | 2003-12-17 | 2005-06-30 | Titan Pharmaceuticals, Inc. | Use of gallium to treat inflammatory arthritis |
| CN1695493A (zh) * | 2004-05-12 | 2005-11-16 | 陕西沃森生物基因技术股份有限公司 | 富有机镓豆芽的生产方法及应用 |
| EP1962774B1 (en) | 2005-11-01 | 2014-01-01 | Mount Sinai School of Medicine | Growth control of oral and superficial microorganisms using gallium compounds |
| US20070231406A1 (en) * | 2006-01-30 | 2007-10-04 | Bucalo Louis R | Use of gallium to treat biofilm-associated infections |
| US20100074932A1 (en) | 2006-09-22 | 2010-03-25 | Silke Talsma | Antimicrobial compositions containing gallium |
| WO2009009171A2 (en) * | 2007-04-02 | 2009-01-15 | Sideromics, Llc | Methods for preventing or treating infectious diseases using gallium compounds |
-
2006
- 2006-10-31 EP EP06836675.6A patent/EP1962774B1/en not_active Ceased
- 2006-10-31 JP JP2008538960A patent/JP5264494B2/ja not_active Expired - Fee Related
- 2006-10-31 US US11/589,915 patent/US20110038809A1/en not_active Abandoned
- 2006-10-31 CN CNA2006800410404A patent/CN101484178A/zh active Pending
- 2006-10-31 EP EP13190163.9A patent/EP2689783B1/en not_active Not-in-force
- 2006-10-31 KR KR1020087013139A patent/KR20080072697A/ko not_active Ceased
- 2006-10-31 CN CN201410641475.9A patent/CN104473962B/zh not_active Expired - Fee Related
- 2006-10-31 CA CA2784168A patent/CA2784168C/en not_active Expired - Fee Related
- 2006-10-31 WO PCT/US2006/042381 patent/WO2007053581A2/en not_active Ceased
- 2006-10-31 KR KR1020117007522A patent/KR101218854B1/ko not_active Expired - Fee Related
- 2006-10-31 CA CA2627430A patent/CA2627430C/en not_active Expired - Fee Related
-
2012
- 2012-09-18 JP JP2012204408A patent/JP5877776B2/ja not_active Expired - Fee Related
-
2014
- 2014-03-13 US US14/208,748 patent/US20140193520A1/en not_active Abandoned
-
2015
- 2015-12-31 US US14/985,474 patent/US10632148B2/en not_active Expired - Fee Related
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