JP2009513663A5 - - Google Patents

Info

Publication number

JP2009513663A5

JP2009513663A5 JP2008537953A JP2008537953A JP2009513663A5 JP 2009513663 A5 JP2009513663 A5 JP 2009513663A5 JP 2008537953 A JP2008537953 A JP 2008537953A JP 2008537953 A JP2008537953 A JP 2008537953A JP 2009513663 A5 JP2009513663 A5 JP 2009513663A5

Authority

JP

Japan

Prior art keywords

mice

treated

fbn1c1039g

losartan

placebo

Prior art date

2006-10-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 241000699670 Mus sp. Species 0.000 description 6
• 239000002083 C09CA01 - Losartan Substances 0.000 description 3
• KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 description 3
• 229960004773 losartan Drugs 0.000 description 3
• 229940068196 placebo Drugs 0.000 description 3
• 239000000902 placebo Substances 0.000 description 3
• 102000004887 Transforming Growth Factor beta Human genes 0.000 description 2
• 108090001012 Transforming Growth Factor beta Proteins 0.000 description 2
• 230000002093 peripheral effect Effects 0.000 description 2
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 2
• 108700028369 Alleles Proteins 0.000 description 1
• 208000001826 Marfan syndrome Diseases 0.000 description 1
• 101100119832 Mus musculus Fbn1 gene Proteins 0.000 description 1
• 230000005856 abnormality Effects 0.000 description 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• 230000003247 decreasing effect Effects 0.000 description 1
• 230000001771 impaired effect Effects 0.000 description 1
• 210000004072 lung Anatomy 0.000 description 1
• 230000011664 signaling Effects 0.000 description 1