JP2023113650A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2023113650A5 JP2023113650A5 JP2023077882A JP2023077882A JP2023113650A5 JP 2023113650 A5 JP2023113650 A5 JP 2023113650A5 JP 2023077882 A JP2023077882 A JP 2023077882A JP 2023077882 A JP2023077882 A JP 2023077882A JP 2023113650 A5 JP2023113650 A5 JP 2023113650A5
- Authority
- JP
- Japan
- Prior art keywords
- erdafitinib
- composition
- serum phosphate
- patient
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229950004444 erdafitinib Drugs 0.000 claims 13
- OLAHOMJCDNXHFI-UHFFFAOYSA-N n'-(3,5-dimethoxyphenyl)-n'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-n-propan-2-ylethane-1,2-diamine Chemical compound COC1=CC(OC)=CC(N(CCNC(C)C)C=2C=C3N=C(C=NC3=CC=2)C2=CN(C)N=C2)=C1 OLAHOMJCDNXHFI-UHFFFAOYSA-N 0.000 claims 13
- 229910019142 PO4 Inorganic materials 0.000 claims 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 8
- 239000010452 phosphate Substances 0.000 claims 8
- 210000002966 serum Anatomy 0.000 claims 8
- 108091008794 FGF receptors Proteins 0.000 claims 7
- 102000052178 fibroblast growth factor receptor activity proteins Human genes 0.000 claims 7
- 230000002411 adverse Effects 0.000 claims 3
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 3
- 238000009121 systemic therapy Methods 0.000 claims 3
- 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 claims 2
- 101710182389 Fibroblast growth factor receptor 2 Proteins 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17174295 | 2017-06-02 | ||
| EP17174295.0 | 2017-06-02 | ||
| EP18171315 | 2018-05-08 | ||
| EP18171315.7 | 2018-05-08 | ||
| JP2019566178A JP2020521794A (ja) | 2017-06-02 | 2018-06-01 | 胆管癌の治療のためのｆｇｆｒ２阻害剤 |
| PCT/EP2018/064523 WO2018220206A1 (en) | 2017-06-02 | 2018-06-01 | Fgfr2 inhibitors for the treatment of cholangiocarcinoma |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019566178A Division JP2020521794A (ja) | 2017-06-02 | 2018-06-01 | 胆管癌の治療のためのｆｇｆｒ２阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023113650A JP2023113650A (ja) | 2023-08-16 |
| JP2023113650A5 true JP2023113650A5 (enExample) | 2024-02-16 |
Family
ID=62555054
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019566178A Withdrawn JP2020521794A (ja) | 2017-06-02 | 2018-06-01 | 胆管癌の治療のためのｆｇｆｒ２阻害剤 |
| JP2023077882A Pending JP2023113650A (ja) | 2017-06-02 | 2023-05-10 | 胆管癌の治療のためのｆｇｆｒ２阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019566178A Withdrawn JP2020521794A (ja) | 2017-06-02 | 2018-06-01 | 胆管癌の治療のためのｆｇｆｒ２阻害剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11707463B2 (enExample) |
| EP (1) | EP3634414A1 (enExample) |
| JP (2) | JP2020521794A (enExample) |
| KR (1) | KR20200010505A (enExample) |
| CN (1) | CN111050769A (enExample) |
| AU (1) | AU2018278271B2 (enExample) |
| BR (1) | BR112019025056A2 (enExample) |
| CA (1) | CA3064317A1 (enExample) |
| IL (1) | IL271058A (enExample) |
| JO (1) | JOP20190280A1 (enExample) |
| MA (1) | MA49248A (enExample) |
| MX (1) | MX2019014366A (enExample) |
| MY (1) | MY204203A (enExample) |
| PH (1) | PH12019502710A1 (enExample) |
| UA (1) | UA126478C2 (enExample) |
| WO (1) | WO2018220206A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES3014202T3 (en) | 2014-03-26 | 2025-04-21 | Astex Therapeutics Ltd | Cmet-inhibitors for use in delaying the emergence in resistance to fgfr inhibitors |
| JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
| JOP20190280A1 (ar) * | 2017-06-02 | 2019-12-02 | Janssen Pharmaceutica Nv | مثبطات fgfr2 لعلاج سرطان الأوعية الصفراوية |
| MA54932A (fr) * | 2019-02-12 | 2021-12-22 | Janssen Pharmaceutica Nv | Traitement contre le cancer |
| WO2020205493A1 (en) * | 2019-03-29 | 2020-10-08 | Janssen Pharmaceutica Nv | Fgfr tyrosine kinase inhibitors for the treatment of urothelial carcinoma |
| CA3141869A1 (en) | 2019-05-28 | 2020-12-03 | Qed Therapeutics, Inc. | Methods of treating cholangiocarcinoma |
| WO2021023178A1 (zh) * | 2019-08-05 | 2021-02-11 | 江苏恒瑞医药股份有限公司 | 一种吡咯并六元杂环化合物在制备治疗fgfr2基因变异的肿瘤的药物中的用途 |
| CN114945367A (zh) * | 2020-01-17 | 2022-08-26 | 贝达医药公司 | 作为fgfr激酶抑制剂的哒嗪和1,2,4-三嗪衍生物 |
| CN111596058A (zh) * | 2020-05-18 | 2020-08-28 | 山东第一医科大学(山东省医学科学院) | 一种检测胆管癌患者外周血循环肿瘤细胞fgfr基因突变的试剂盒及检测方法 |
| DE102021126650A1 (de) | 2021-10-14 | 2023-04-20 | Rheinische Friedrich-Wilhelms-Universität Bonn, Körperschaft des öffentlichen Rechts | Verfahren zur bestimmung der ansprechwahrscheinlichkeit einer malignen erkrankung auf eine behandlung mit einem pharmazeutischen hemmwirkstoff |
| KR20250117064A (ko) | 2024-01-26 | 2025-08-04 | 충북대학교 산학협력단 | 아무렌신 g를 유효성분으로 포함하는 담관암 예방 또는 치료용 약학적 조성물 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US6218529B1 (en) | 1995-07-31 | 2001-04-17 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer |
| US5882864A (en) | 1995-07-31 | 1999-03-16 | Urocor Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
| GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
| EP2270000B1 (en) | 2005-05-23 | 2015-07-29 | Novartis AG | Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts |
| US8163923B2 (en) | 2007-03-14 | 2012-04-24 | Advenchen Laboratories, Llc | Spiro substituted compounds as angiogenesis inhibitors |
| CA2680046A1 (en) * | 2007-03-23 | 2008-10-02 | The Translational Genomics Research Institute | Methods of diagnosing, classifying and treating endometrial cancer and precancer |
| GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
| AR088941A1 (es) | 2011-11-23 | 2014-07-16 | Bayer Ip Gmbh | Anticuerpos anti-fgfr2 y sus usos |
| US9254288B2 (en) * | 2012-05-07 | 2016-02-09 | The Translational Genomics Research Institute | Susceptibility of tumors to tyrosine kinase inhibitors and treatment thereof |
| EP3939614A1 (en) | 2013-01-18 | 2022-01-19 | Foundation Medicine, Inc. | Methods of treating cholangiocarcinoma |
| SMT202200177T1 (it) | 2014-09-26 | 2022-05-12 | Janssen Pharmaceutica Nv | Uso di gruppi di geni mutanti del fgfr nell'identificazione di pazienti affetti da cancro che saranno responsivi al trattamento con un inibitore del fgfr |
| CA3002560A1 (en) | 2015-10-23 | 2017-04-27 | Array Biopharma, Inc. | 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2h)-one compounds as inhibitors of fgfr tyrosine kinases |
| JOP20190280A1 (ar) * | 2017-06-02 | 2019-12-02 | Janssen Pharmaceutica Nv | مثبطات fgfr2 لعلاج سرطان الأوعية الصفراوية |
-
2017
- 2017-06-16 JO JOP/2019/0280A patent/JOP20190280A1/ar unknown
-
2018
- 2018-06-01 WO PCT/EP2018/064523 patent/WO2018220206A1/en not_active Ceased
- 2018-06-01 JP JP2019566178A patent/JP2020521794A/ja not_active Withdrawn
- 2018-06-01 CA CA3064317A patent/CA3064317A1/en active Pending
- 2018-06-01 CN CN201880050198.0A patent/CN111050769A/zh active Pending
- 2018-06-01 BR BR112019025056-5A patent/BR112019025056A2/pt not_active Application Discontinuation
- 2018-06-01 UA UAA201912271A patent/UA126478C2/uk unknown
- 2018-06-01 MA MA049248A patent/MA49248A/fr unknown
- 2018-06-01 US US16/616,067 patent/US11707463B2/en active Active
- 2018-06-01 KR KR1020197038249A patent/KR20200010505A/ko not_active Ceased
- 2018-06-01 AU AU2018278271A patent/AU2018278271B2/en not_active Ceased
- 2018-06-01 EP EP18729631.4A patent/EP3634414A1/en active Pending
- 2018-06-01 MY MYPI2019007030A patent/MY204203A/en unknown
- 2018-06-01 MX MX2019014366A patent/MX2019014366A/es unknown
-
2019
- 2019-11-29 PH PH12019502710A patent/PH12019502710A1/en unknown
- 2019-12-01 IL IL271058A patent/IL271058A/en unknown
-
2023
- 2023-05-10 JP JP2023077882A patent/JP2023113650A/ja active Pending
- 2023-06-26 US US18/341,023 patent/US12350266B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2023113650A5 (enExample) | ||
| Rashad et al. | Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer | |
| JP2020505425A5 (enExample) | ||
| Pypendop et al. | Cardiovascular effects of dexmedetomidine, with or without MK-467, following intravenous administration in cats | |
| US10376487B2 (en) | Method of treatment | |
| JP2020521794A5 (enExample) | ||
| HUE035847T2 (en) | Transdermal delivery system | |
| Farrand et al. | Effects of vagus nerve stimulation are mediated in part by TrkB in a parkinson’s disease model | |
| Coakley et al. | Prolonged neurogenic weakness in patients requiring mechanical ventilation for acute airflow limitation | |
| Giacchetti | Chronotherapy of colorectal cancer | |
| Suzuki et al. | Sustained-release lidocaine sheet for pain following tooth extraction: A randomized, single-blind, dose-response, controlled, clinical study of efficacy and safety | |
| McElroy et al. | Randomized, double-blind, placebo-controlled study of divalproex extended release loading monotherapy in ambulatory bipolar spectrum disorder patients with moderate-to-severe hypomania or mild mania | |
| JP2001089382A (ja) | 早期血管再生及び低分子量ヘパリン投与による不安定冠動脈疾患の治療方法 | |
| CN109966329A (zh) | 一种梅花草提取物在治疗急性咽炎中的应用 | |
| Kang et al. | Reversal with sugammadex for rocuronium-induced deep neuromuscular block after pretreatment of magnesium sulfate in rabbits | |
| JP3916563B2 (ja) | Ｐ物質の投与を含む治療方法 | |
| Djabir et al. | The protective effect of Paliasa (Kleinhovia hospita L.) leaf extract against elevated total bilirubin serum induced by toxic dose of antituberculosis in rats | |
| TW436287B (en) | Pharmaceutical composition for intramuscular administration comprising N-substituted benzamides, phenothiazines and their acid addition salts | |
| CA3177260A1 (en) | Endoxifen for the treatment of bipolar i disorder | |
| CN1083357A (zh) | 治疗风湿病的药 | |
| WO1996040038A2 (en) | Treatment of anemia with procaine compositions | |
| RU2201179C2 (ru) | Способ лечения диабетических ретинопатий | |
| Apter et al. | Lithium augmentation of bupropion in refractory depression | |
| Bhandari et al. | Gabapentin pre-treatment for pressor response to direct laryngoscopy and tracheal intubation: a randomized, doubleblind, placebo controlled study | |
| Mathews et al. | Are the effectiveness of gabapentin and pregabalin comparable in symptom relief in adult patients with postherpetic neuralgia? |