JP2009512700A - アポトーシスのインビボ検出 - Google Patents

アポトーシスのインビボ検出 Download PDF

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Publication number
JP2009512700A
JP2009512700A JP2008536695A JP2008536695A JP2009512700A JP 2009512700 A JP2009512700 A JP 2009512700A JP 2008536695 A JP2008536695 A JP 2008536695A JP 2008536695 A JP2008536695 A JP 2008536695A JP 2009512700 A JP2009512700 A JP 2009512700A
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Japan
Prior art keywords
animal
labeling agent
affinity labeling
caspase
caspase affinity
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JP2008536695A
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English (en)
Japanese (ja)
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JP2009512700A5 (cg-RX-API-DMAC7.html
Inventor
ガリー ジョンソン，
ブライアン ダブリュー． リー，
Original Assignee
イミュノケミストリー テクノロジーズ， エルエルシー
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Application filed by イミュノケミストリー テクノロジーズ， エルエルシー filed Critical イミュノケミストリー テクノロジーズ， エルエルシー
Publication of JP2009512700A publication Critical patent/JP2009512700A/ja
Publication of JP2009512700A5 publication Critical patent/JP2009512700A5/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2008536695A 2005-10-21 2006-10-12 アポトーシスのインビボ検出 Withdrawn JP2009512700A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72922705P 2005-10-21 2005-10-21
PCT/US2006/040047 WO2007050319A1 (en) 2005-10-21 2006-10-12 In vivo detection of apoptosis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013094397A Division JP2013165729A (ja) 2005-10-21 2013-04-26 アポトーシスのインビボ検出

Publications (2)

Publication Number Publication Date
JP2009512700A true JP2009512700A (ja) 2009-03-26
JP2009512700A5 JP2009512700A5 (cg-RX-API-DMAC7.html) 2009-10-08

Family

ID=37968120

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2008536695A Withdrawn JP2009512700A (ja) 2005-10-21 2006-10-12 アポトーシスのインビボ検出
JP2013094397A Withdrawn JP2013165729A (ja) 2005-10-21 2013-04-26 アポトーシスのインビボ検出
JP2015160275A Pending JP2015204844A (ja) 2005-10-21 2015-08-17 アポトーシスのインビボ検出

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013094397A Withdrawn JP2013165729A (ja) 2005-10-21 2013-04-26 アポトーシスのインビボ検出
JP2015160275A Pending JP2015204844A (ja) 2005-10-21 2015-08-17 アポトーシスのインビボ検出

Country Status (8)

Country Link
US (3) US8187573B2 (cg-RX-API-DMAC7.html)
EP (1) EP1946101A4 (cg-RX-API-DMAC7.html)
JP (3) JP2009512700A (cg-RX-API-DMAC7.html)
KR (1) KR101449507B1 (cg-RX-API-DMAC7.html)
AU (1) AU2006306592A1 (cg-RX-API-DMAC7.html)
CA (1) CA2626392A1 (cg-RX-API-DMAC7.html)
IL (1) IL190949A0 (cg-RX-API-DMAC7.html)
WO (1) WO2007050319A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2626392A1 (en) * 2005-10-21 2007-05-03 Immunochemistry Technologies, Llc In vivo detection of apoptosis
WO2016065174A1 (en) * 2014-10-22 2016-04-28 Seed Research And Development Llc Caspase probes for detection of apoptosis
WO2016090169A1 (en) * 2014-12-03 2016-06-09 Seed Research And Development Llc Intracellular caspase probes for detection of apoptosis and inflammation and kits containing such probes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002506829A (ja) * 1998-03-16 2002-03-05 サイトビア インコーポレイテッド ジペプチドのアポトーシスインヒビターおよびそれらの使用
WO2003058194A2 (en) 2001-12-21 2003-07-17 Immunochemistry Technologies, Llc Affinity labeling of enzymes for detection of enzyme activity level in living cells
JP2003531871A (ja) * 2000-04-25 2003-10-28 ワシントン・ユニバーシティ 医用画像解析、診断、および薬物療法のための膜透過性ペプチド複合体

Family Cites Families (17)

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US6756207B1 (en) * 1997-02-27 2004-06-29 Cellomics, Inc. System for cell-based screening
PL336571A1 (en) * 1997-04-30 2000-07-03 Univ Leland Stanford Junior Method of in vitro visualising the cellular death
CA2328457A1 (en) * 1998-06-20 1999-12-29 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
AU5366499A (en) * 1998-08-19 2000-03-14 Ontario Cancer Institute, The The use of high frequency ultrasound imaging to detect and monitor the process of apoptosis in living tissues, (ex-vivo) tissues and cell-culture
WO2000042048A1 (en) * 1999-01-19 2000-07-20 Leif Robert C A reagent system and method for increasing the luminescence of lanthanide(iii) macrocyclic complexes
WO2001089584A2 (en) 2000-05-23 2001-11-29 Amersham Health As Contrast agents
IL145210A (en) * 2000-12-06 2011-12-29 Aposense Ltd Use of pmbc in the preparation of an agent for the selective binding of cells, a method for the detection of apoptosis and a pharmaceutical composition for the treatment of a disease characterized by the presence of apoptosis in cells, tissues or cellular structures
WO2003059877A2 (en) 2001-12-21 2003-07-24 Immunochemistry Technologies, Llc Novel affinity labels
WO2003060466A2 (en) 2001-12-21 2003-07-24 Immunochemistry Technologies, Llc Affinity labeling of serine proteases for simultaneous detection of multiple serine protease activity levels
AU2003272189A1 (en) 2002-04-05 2004-01-19 Cytovia, Inc. Caspase inhibitors for the treatment of diseases and conditions caused by exposure to radionuclides, biological agents, or chemical agents
IL153183A (en) * 2002-06-04 2010-05-17 Aposense Ltd Agents for imaging and diagnostic methods using them
US7056947B2 (en) * 2002-07-05 2006-06-06 Georgia Tech Research Corp. Aza-peptide epoxides
EP1594819A1 (en) 2003-02-07 2005-11-16 Merck Frosst Canada & Co. Irreversible caspase-3 inhibitors as active site probes
KR20050034922A (ko) 2003-10-10 2005-04-15 주식회사 엘지생명과학 2-알킬-4-옥소부타노일 그룹을 함유하는 케스페이즈저해제 및 그의 약제학적 조성물
GB0327494D0 (en) * 2003-11-26 2003-12-31 Amersham Plc Novel imaging agents
US20070082377A1 (en) * 2005-10-07 2007-04-12 Olin Michael R Cytotoxicity assays
CA2626392A1 (en) * 2005-10-21 2007-05-03 Immunochemistry Technologies, Llc In vivo detection of apoptosis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002506829A (ja) * 1998-03-16 2002-03-05 サイトビア インコーポレイテッド ジペプチドのアポトーシスインヒビターおよびそれらの使用
JP2003531871A (ja) * 2000-04-25 2003-10-28 ワシントン・ユニバーシティ 医用画像解析、診断、および薬物療法のための膜透過性ペプチド複合体
WO2003058194A2 (en) 2001-12-21 2003-07-17 Immunochemistry Technologies, Llc Affinity labeling of enzymes for detection of enzyme activity level in living cells

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6011068899; Ｌａｘｍａｎ，Ｂ．　ｅｔ　ａｌ．: 'Ｎｏｎｉｎｖａｓｉｖｅ　ｒｅａｌ-ｔｉｍｅ　ｉｍａｇｉｎｇ　ｏｆ　ａｐｏｐｔｏｓｉｓ' Ｐｒｏｃ．　Ｎａｔｌ．　Ａｃａｄ．　Ｓｃｉ．　ＵＳＡ Ｖｏｌ．９９，Ｎｏ．２６, 20021224, Ｐ．１６５５１-１６５５５ *
JPN6014051795; ＢｉｏＴｅｃｈｎｉｑｕｅｓ，２００１，３１（３），ｐ６０８-６１０，６１２，６１４，６１６ , 2001
JPN6014051796; 日本医学放射線学会雑誌，２００２，６２（１０），ｐ５３５-５３９ , 2002
JPN6014051797; Ｓｃｉｅｎｃｅ，　（１９９５）　，Ｖｏｌ．　２６７，　Ｎｏ．　５２０３，　ｐ１４５６-１４６２ , 1995

Also Published As

Publication number Publication date
KR101449507B1 (ko) 2014-10-13
US20120328515A1 (en) 2012-12-27
EP1946101A1 (en) 2008-07-23
CA2626392A1 (en) 2007-05-03
IL190949A0 (en) 2009-09-22
JP2013165729A (ja) 2013-08-29
US8187573B2 (en) 2012-05-29
US20150093329A1 (en) 2015-04-02
KR20080072859A (ko) 2008-08-07
EP1946101A4 (en) 2011-08-10
US20090142260A1 (en) 2009-06-04
AU2006306592A1 (en) 2007-05-03
WO2007050319A1 (en) 2007-05-03
JP2015204844A (ja) 2015-11-19

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