CA2626392A1 - In vivo detection of apoptosis - Google Patents

In vivo detection of apoptosis Download PDF

Info

Publication number
CA2626392A1
CA2626392A1 CA002626392A CA2626392A CA2626392A1 CA 2626392 A1 CA2626392 A1 CA 2626392A1 CA 002626392 A CA002626392 A CA 002626392A CA 2626392 A CA2626392 A CA 2626392A CA 2626392 A1 CA2626392 A1 CA 2626392A1
Authority
CA
Canada
Prior art keywords
animal
affinity labeling
labeling agent
caspase
caspase affinity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002626392A
Other languages
English (en)
French (fr)
Inventor
Gary Johnson
Brian W. Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SEED RESEARCH AND DEVELOPMENT LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2626392A1 publication Critical patent/CA2626392A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002626392A 2005-10-21 2006-10-12 In vivo detection of apoptosis Abandoned CA2626392A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72922705P 2005-10-21 2005-10-21
US60/729,227 2005-10-21
PCT/US2006/040047 WO2007050319A1 (en) 2005-10-21 2006-10-12 In vivo detection of apoptosis

Publications (1)

Publication Number Publication Date
CA2626392A1 true CA2626392A1 (en) 2007-05-03

Family

ID=37968120

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002626392A Abandoned CA2626392A1 (en) 2005-10-21 2006-10-12 In vivo detection of apoptosis

Country Status (8)

Country Link
US (3) US8187573B2 (cg-RX-API-DMAC7.html)
EP (1) EP1946101A4 (cg-RX-API-DMAC7.html)
JP (3) JP2009512700A (cg-RX-API-DMAC7.html)
KR (1) KR101449507B1 (cg-RX-API-DMAC7.html)
AU (1) AU2006306592A1 (cg-RX-API-DMAC7.html)
CA (1) CA2626392A1 (cg-RX-API-DMAC7.html)
IL (1) IL190949A0 (cg-RX-API-DMAC7.html)
WO (1) WO2007050319A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2626392A1 (en) * 2005-10-21 2007-05-03 Immunochemistry Technologies, Llc In vivo detection of apoptosis
WO2016065174A1 (en) * 2014-10-22 2016-04-28 Seed Research And Development Llc Caspase probes for detection of apoptosis
WO2016090169A1 (en) * 2014-12-03 2016-06-09 Seed Research And Development Llc Intracellular caspase probes for detection of apoptosis and inflammation and kits containing such probes

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756207B1 (en) * 1997-02-27 2004-06-29 Cellomics, Inc. System for cell-based screening
PL336571A1 (en) * 1997-04-30 2000-07-03 Univ Leland Stanford Junior Method of in vitro visualising the cellular death
EP1076563B1 (en) * 1998-03-16 2005-05-11 Cytovia, Inc. Dipeptide caspase inhibitors and the use thereof
CA2328457A1 (en) * 1998-06-20 1999-12-29 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
US6589503B1 (en) * 1998-06-20 2003-07-08 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
AU5366499A (en) * 1998-08-19 2000-03-14 Ontario Cancer Institute, The The use of high frequency ultrasound imaging to detect and monitor the process of apoptosis in living tissues, (ex-vivo) tissues and cell-culture
WO2000042048A1 (en) * 1999-01-19 2000-07-20 Leif Robert C A reagent system and method for increasing the luminescence of lanthanide(iii) macrocyclic complexes
WO2001089584A2 (en) 2000-05-23 2001-11-29 Amersham Health As Contrast agents
IL145210A (en) * 2000-12-06 2011-12-29 Aposense Ltd Use of pmbc in the preparation of an agent for the selective binding of cells, a method for the detection of apoptosis and a pharmaceutical composition for the treatment of a disease characterized by the presence of apoptosis in cells, tissues or cellular structures
WO2003059877A2 (en) 2001-12-21 2003-07-24 Immunochemistry Technologies, Llc Novel affinity labels
WO2003060466A2 (en) 2001-12-21 2003-07-24 Immunochemistry Technologies, Llc Affinity labeling of serine proteases for simultaneous detection of multiple serine protease activity levels
WO2003058194A2 (en) 2001-12-21 2003-07-17 Immunochemistry Technologies, Llc Affinity labeling of enzymes for detection of enzyme activity level in living cells
AU2003272189A1 (en) 2002-04-05 2004-01-19 Cytovia, Inc. Caspase inhibitors for the treatment of diseases and conditions caused by exposure to radionuclides, biological agents, or chemical agents
IL153183A (en) * 2002-06-04 2010-05-17 Aposense Ltd Agents for imaging and diagnostic methods using them
US7056947B2 (en) * 2002-07-05 2006-06-06 Georgia Tech Research Corp. Aza-peptide epoxides
EP1594819A1 (en) 2003-02-07 2005-11-16 Merck Frosst Canada & Co. Irreversible caspase-3 inhibitors as active site probes
KR20050034922A (ko) 2003-10-10 2005-04-15 주식회사 엘지생명과학 2-알킬-4-옥소부타노일 그룹을 함유하는 케스페이즈저해제 및 그의 약제학적 조성물
GB0327494D0 (en) * 2003-11-26 2003-12-31 Amersham Plc Novel imaging agents
US20070082377A1 (en) * 2005-10-07 2007-04-12 Olin Michael R Cytotoxicity assays
CA2626392A1 (en) * 2005-10-21 2007-05-03 Immunochemistry Technologies, Llc In vivo detection of apoptosis

Also Published As

Publication number Publication date
KR101449507B1 (ko) 2014-10-13
US20120328515A1 (en) 2012-12-27
EP1946101A1 (en) 2008-07-23
IL190949A0 (en) 2009-09-22
JP2013165729A (ja) 2013-08-29
US8187573B2 (en) 2012-05-29
US20150093329A1 (en) 2015-04-02
KR20080072859A (ko) 2008-08-07
EP1946101A4 (en) 2011-08-10
JP2009512700A (ja) 2009-03-26
US20090142260A1 (en) 2009-06-04
AU2006306592A1 (en) 2007-05-03
WO2007050319A1 (en) 2007-05-03
JP2015204844A (ja) 2015-11-19

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20170502