AU2006306592A1 - In vivo detection of apoptosis - Google Patents
In vivo detection of apoptosis Download PDFInfo
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- AU2006306592A1 AU2006306592A1 AU2006306592A AU2006306592A AU2006306592A1 AU 2006306592 A1 AU2006306592 A1 AU 2006306592A1 AU 2006306592 A AU2006306592 A AU 2006306592A AU 2006306592 A AU2006306592 A AU 2006306592A AU 2006306592 A1 AU2006306592 A1 AU 2006306592A1
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- affinity labeling
- labeling agent
- caspase
- caspase affinity
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- 239000003960 organic solvent Substances 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
- A61K49/0043—Fluorescein, used in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2013202374A AU2013202374A1 (en) | 2005-10-21 | 2013-04-03 | In vivo detection of apoptosis |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72922705P | 2005-10-21 | 2005-10-21 | |
| US60/729,227 | 2005-10-21 | ||
| PCT/US2006/040047 WO2007050319A1 (en) | 2005-10-21 | 2006-10-12 | In vivo detection of apoptosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| AU2013202374A Division AU2013202374A1 (en) | 2005-10-21 | 2013-04-03 | In vivo detection of apoptosis |
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| EP (1) | EP1946101A4 (cg-RX-API-DMAC7.html) |
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| CA (1) | CA2626392A1 (cg-RX-API-DMAC7.html) |
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| CA2626392A1 (en) * | 2005-10-21 | 2007-05-03 | Immunochemistry Technologies, Llc | In vivo detection of apoptosis |
| WO2016065174A1 (en) * | 2014-10-22 | 2016-04-28 | Seed Research And Development Llc | Caspase probes for detection of apoptosis |
| WO2016090169A1 (en) * | 2014-12-03 | 2016-06-09 | Seed Research And Development Llc | Intracellular caspase probes for detection of apoptosis and inflammation and kits containing such probes |
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| US6756207B1 (en) * | 1997-02-27 | 2004-06-29 | Cellomics, Inc. | System for cell-based screening |
| PL336571A1 (en) * | 1997-04-30 | 2000-07-03 | Univ Leland Stanford Junior | Method of in vitro visualising the cellular death |
| EP1076563B1 (en) * | 1998-03-16 | 2005-05-11 | Cytovia, Inc. | Dipeptide caspase inhibitors and the use thereof |
| CA2328457A1 (en) * | 1998-06-20 | 1999-12-29 | Washington University | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
| US6589503B1 (en) * | 1998-06-20 | 2003-07-08 | Washington University | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
| AU5366499A (en) * | 1998-08-19 | 2000-03-14 | Ontario Cancer Institute, The | The use of high frequency ultrasound imaging to detect and monitor the process of apoptosis in living tissues, (ex-vivo) tissues and cell-culture |
| WO2000042048A1 (en) * | 1999-01-19 | 2000-07-20 | Leif Robert C | A reagent system and method for increasing the luminescence of lanthanide(iii) macrocyclic complexes |
| WO2001089584A2 (en) | 2000-05-23 | 2001-11-29 | Amersham Health As | Contrast agents |
| IL145210A (en) * | 2000-12-06 | 2011-12-29 | Aposense Ltd | Use of pmbc in the preparation of an agent for the selective binding of cells, a method for the detection of apoptosis and a pharmaceutical composition for the treatment of a disease characterized by the presence of apoptosis in cells, tissues or cellular structures |
| WO2003059877A2 (en) | 2001-12-21 | 2003-07-24 | Immunochemistry Technologies, Llc | Novel affinity labels |
| WO2003060466A2 (en) | 2001-12-21 | 2003-07-24 | Immunochemistry Technologies, Llc | Affinity labeling of serine proteases for simultaneous detection of multiple serine protease activity levels |
| WO2003058194A2 (en) | 2001-12-21 | 2003-07-17 | Immunochemistry Technologies, Llc | Affinity labeling of enzymes for detection of enzyme activity level in living cells |
| AU2003272189A1 (en) | 2002-04-05 | 2004-01-19 | Cytovia, Inc. | Caspase inhibitors for the treatment of diseases and conditions caused by exposure to radionuclides, biological agents, or chemical agents |
| IL153183A (en) * | 2002-06-04 | 2010-05-17 | Aposense Ltd | Agents for imaging and diagnostic methods using them |
| US7056947B2 (en) * | 2002-07-05 | 2006-06-06 | Georgia Tech Research Corp. | Aza-peptide epoxides |
| EP1594819A1 (en) | 2003-02-07 | 2005-11-16 | Merck Frosst Canada & Co. | Irreversible caspase-3 inhibitors as active site probes |
| KR20050034922A (ko) | 2003-10-10 | 2005-04-15 | 주식회사 엘지생명과학 | 2-알킬-4-옥소부타노일 그룹을 함유하는 케스페이즈저해제 및 그의 약제학적 조성물 |
| GB0327494D0 (en) * | 2003-11-26 | 2003-12-31 | Amersham Plc | Novel imaging agents |
| US20070082377A1 (en) * | 2005-10-07 | 2007-04-12 | Olin Michael R | Cytotoxicity assays |
| CA2626392A1 (en) * | 2005-10-21 | 2007-05-03 | Immunochemistry Technologies, Llc | In vivo detection of apoptosis |
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2006
- 2006-10-12 CA CA002626392A patent/CA2626392A1/en not_active Abandoned
- 2006-10-12 KR KR1020087012034A patent/KR101449507B1/ko not_active Expired - Fee Related
- 2006-10-12 JP JP2008536695A patent/JP2009512700A/ja not_active Withdrawn
- 2006-10-12 US US12/091,031 patent/US8187573B2/en not_active Expired - Fee Related
- 2006-10-12 EP EP06825893A patent/EP1946101A4/en not_active Withdrawn
- 2006-10-12 WO PCT/US2006/040047 patent/WO2007050319A1/en not_active Ceased
- 2006-10-12 AU AU2006306592A patent/AU2006306592A1/en not_active Abandoned
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2008
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2012
- 2012-05-24 US US13/480,072 patent/US20120328515A1/en not_active Abandoned
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2013
- 2013-04-26 JP JP2013094397A patent/JP2013165729A/ja not_active Withdrawn
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2014
- 2014-09-12 US US14/485,199 patent/US20150093329A1/en not_active Abandoned
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2015
- 2015-08-17 JP JP2015160275A patent/JP2015204844A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR101449507B1 (ko) | 2014-10-13 |
| US20120328515A1 (en) | 2012-12-27 |
| EP1946101A1 (en) | 2008-07-23 |
| CA2626392A1 (en) | 2007-05-03 |
| IL190949A0 (en) | 2009-09-22 |
| JP2013165729A (ja) | 2013-08-29 |
| US8187573B2 (en) | 2012-05-29 |
| US20150093329A1 (en) | 2015-04-02 |
| KR20080072859A (ko) | 2008-08-07 |
| EP1946101A4 (en) | 2011-08-10 |
| JP2009512700A (ja) | 2009-03-26 |
| US20090142260A1 (en) | 2009-06-04 |
| WO2007050319A1 (en) | 2007-05-03 |
| JP2015204844A (ja) | 2015-11-19 |
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