KR101449507B1 - 아팝토시스의 생체내 검출 - Google Patents

아팝토시스의 생체내 검출 Download PDF

Info

Publication number
KR101449507B1
KR101449507B1 KR1020087012034A KR20087012034A KR101449507B1 KR 101449507 B1 KR101449507 B1 KR 101449507B1 KR 1020087012034 A KR1020087012034 A KR 1020087012034A KR 20087012034 A KR20087012034 A KR 20087012034A KR 101449507 B1 KR101449507 B1 KR 101449507B1
Authority
KR
South Korea
Prior art keywords
animal
caspase
labeling agent
affinity labeling
caspase affinity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020087012034A
Other languages
English (en)
Korean (ko)
Other versions
KR20080072859A (ko
Inventor
게리 존슨
브라이언 더블유. 리
Original Assignee
씨드 리써치 앤드 디벨롭먼트, 엘엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 씨드 리써치 앤드 디벨롭먼트, 엘엘씨 filed Critical 씨드 리써치 앤드 디벨롭먼트, 엘엘씨
Publication of KR20080072859A publication Critical patent/KR20080072859A/ko
Application granted granted Critical
Publication of KR101449507B1 publication Critical patent/KR101449507B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020087012034A 2005-10-21 2006-10-12 아팝토시스의 생체내 검출 Expired - Fee Related KR101449507B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72922705P 2005-10-21 2005-10-21
US60/729,227 2005-10-21
PCT/US2006/040047 WO2007050319A1 (en) 2005-10-21 2006-10-12 In vivo detection of apoptosis

Publications (2)

Publication Number Publication Date
KR20080072859A KR20080072859A (ko) 2008-08-07
KR101449507B1 true KR101449507B1 (ko) 2014-10-13

Family

ID=37968120

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087012034A Expired - Fee Related KR101449507B1 (ko) 2005-10-21 2006-10-12 아팝토시스의 생체내 검출

Country Status (8)

Country Link
US (3) US8187573B2 (cg-RX-API-DMAC7.html)
EP (1) EP1946101A4 (cg-RX-API-DMAC7.html)
JP (3) JP2009512700A (cg-RX-API-DMAC7.html)
KR (1) KR101449507B1 (cg-RX-API-DMAC7.html)
AU (1) AU2006306592A1 (cg-RX-API-DMAC7.html)
CA (1) CA2626392A1 (cg-RX-API-DMAC7.html)
IL (1) IL190949A0 (cg-RX-API-DMAC7.html)
WO (1) WO2007050319A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2626392A1 (en) * 2005-10-21 2007-05-03 Immunochemistry Technologies, Llc In vivo detection of apoptosis
WO2016065174A1 (en) * 2014-10-22 2016-04-28 Seed Research And Development Llc Caspase probes for detection of apoptosis
WO2016090169A1 (en) * 2014-12-03 2016-06-09 Seed Research And Development Llc Intracellular caspase probes for detection of apoptosis and inflammation and kits containing such probes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003531871A (ja) * 2000-04-25 2003-10-28 ワシントン・ユニバーシティ 医用画像解析、診断、および薬物療法のための膜透過性ペプチド複合体

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756207B1 (en) * 1997-02-27 2004-06-29 Cellomics, Inc. System for cell-based screening
PL336571A1 (en) * 1997-04-30 2000-07-03 Univ Leland Stanford Junior Method of in vitro visualising the cellular death
EP1076563B1 (en) * 1998-03-16 2005-05-11 Cytovia, Inc. Dipeptide caspase inhibitors and the use thereof
CA2328457A1 (en) * 1998-06-20 1999-12-29 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
AU5366499A (en) * 1998-08-19 2000-03-14 Ontario Cancer Institute, The The use of high frequency ultrasound imaging to detect and monitor the process of apoptosis in living tissues, (ex-vivo) tissues and cell-culture
WO2000042048A1 (en) * 1999-01-19 2000-07-20 Leif Robert C A reagent system and method for increasing the luminescence of lanthanide(iii) macrocyclic complexes
WO2001089584A2 (en) 2000-05-23 2001-11-29 Amersham Health As Contrast agents
IL145210A (en) * 2000-12-06 2011-12-29 Aposense Ltd Use of pmbc in the preparation of an agent for the selective binding of cells, a method for the detection of apoptosis and a pharmaceutical composition for the treatment of a disease characterized by the presence of apoptosis in cells, tissues or cellular structures
WO2003059877A2 (en) 2001-12-21 2003-07-24 Immunochemistry Technologies, Llc Novel affinity labels
WO2003060466A2 (en) 2001-12-21 2003-07-24 Immunochemistry Technologies, Llc Affinity labeling of serine proteases for simultaneous detection of multiple serine protease activity levels
WO2003058194A2 (en) 2001-12-21 2003-07-17 Immunochemistry Technologies, Llc Affinity labeling of enzymes for detection of enzyme activity level in living cells
AU2003272189A1 (en) 2002-04-05 2004-01-19 Cytovia, Inc. Caspase inhibitors for the treatment of diseases and conditions caused by exposure to radionuclides, biological agents, or chemical agents
IL153183A (en) * 2002-06-04 2010-05-17 Aposense Ltd Agents for imaging and diagnostic methods using them
US7056947B2 (en) * 2002-07-05 2006-06-06 Georgia Tech Research Corp. Aza-peptide epoxides
EP1594819A1 (en) 2003-02-07 2005-11-16 Merck Frosst Canada & Co. Irreversible caspase-3 inhibitors as active site probes
KR20050034922A (ko) 2003-10-10 2005-04-15 주식회사 엘지생명과학 2-알킬-4-옥소부타노일 그룹을 함유하는 케스페이즈저해제 및 그의 약제학적 조성물
GB0327494D0 (en) * 2003-11-26 2003-12-31 Amersham Plc Novel imaging agents
US20070082377A1 (en) * 2005-10-07 2007-04-12 Olin Michael R Cytotoxicity assays
CA2626392A1 (en) * 2005-10-21 2007-05-03 Immunochemistry Technologies, Llc In vivo detection of apoptosis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003531871A (ja) * 2000-04-25 2003-10-28 ワシントン・ユニバーシティ 医用画像解析、診断、および薬物療法のための膜透過性ペプチド複合体

Also Published As

Publication number Publication date
US20120328515A1 (en) 2012-12-27
EP1946101A1 (en) 2008-07-23
CA2626392A1 (en) 2007-05-03
IL190949A0 (en) 2009-09-22
JP2013165729A (ja) 2013-08-29
US8187573B2 (en) 2012-05-29
US20150093329A1 (en) 2015-04-02
KR20080072859A (ko) 2008-08-07
EP1946101A4 (en) 2011-08-10
JP2009512700A (ja) 2009-03-26
US20090142260A1 (en) 2009-06-04
AU2006306592A1 (en) 2007-05-03
WO2007050319A1 (en) 2007-05-03
JP2015204844A (ja) 2015-11-19

Similar Documents

Publication Publication Date Title
US9763577B2 (en) Imaging agent for detection of diseased cells
US20030129579A1 (en) Multi-use multimodal imaging chelates
KR20000010533A (ko) 시각적 조직 특이성 조영제로서의 형광 킬레이트
DE102007028090A1 (de) Aktivierbare diagnostische und therapeutische Verbindung
US20100290997A1 (en) Imaging Agents and Methods
Cohen et al. Delta-opioid receptor (δOR) targeted near-infrared fluorescent agent for imaging of lung cancer: Synthesis and evaluation in vitro and in vivo
JP6754531B2 (ja) インビトロおよびインビボにおいてグラム陰性菌を検出するための分子プローブ
CN108721649A (zh) 一种肿瘤靶向近红外荧光显像剂的设计、合成及应用
US20150093329A1 (en) In vivo detection of apoptosis
Lee et al. A bright blue fluorescent dextran for two-photon in vivo imaging of blood vessels
Griffin et al. Use of a fluorescently labeled poly-caspase inhibitor for in vivo detection of apoptosis related to vascular-targeting agent arsenic trioxide for cancer therapy
US20230149567A1 (en) Mechanical opening of lipid bilayers by molecular nanomachines
CN113358615B (zh) 美兰和荧光素钠双染色法于活细胞成像中的应用
US20160051704A1 (en) Molecular imaging probes for lung cancer intraoperative guidance
AU2015272006A1 (en) In vivo detection of apoptosis
AU2013202374A1 (en) In vivo detection of apoptosis
WO2008012102A2 (de) Röntgendichtes konjugat
Berger et al. In vivo monitoring the fate of Cy5. 5-Tat labeled T lymphocytes by quantitative near-infrared fluorescence imaging during acute brain inflammation in a rat model of experimental autoimmune encephalomyelitis
CN113358614B (zh) 一种用于活细胞成像的染色法
EP3470082A1 (en) Photosensitizer-peptide conjugate comprising degradable linker, and composition for photodynamic diagnosis or treatment comprising same
EP4317946A1 (en) Use of methylene blue and fluorescein sodium double-staining in live cell imaging
CN116510043A (zh) 一种用于胶质瘤边界判定的分子影像纳米探针及其制备方法
Ke Noninvasive Imaging of Heterotopic Ossification and Targeted Intervention

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

N231 Notification of change of applicant
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20170919

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R11-asn-PN2301

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R14-asn-PN2301

FPAY Annual fee payment

Payment date: 20181001

Year of fee payment: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R11-asn-PN2301

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R14-asn-PN2301

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20211003

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20211003