JP2009511525A5 - - Google Patents
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- JP2009511525A5 JP2009511525A5 JP2008534935A JP2008534935A JP2009511525A5 JP 2009511525 A5 JP2009511525 A5 JP 2009511525A5 JP 2008534935 A JP2008534935 A JP 2008534935A JP 2008534935 A JP2008534935 A JP 2008534935A JP 2009511525 A5 JP2009511525 A5 JP 2009511525A5
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- pharmaceutical composition
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- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 208000035475 disorder Diseases 0.000 claims 4
- 208000015114 central nervous system disease Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- 208000012661 Dyskinesia Diseases 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 208000029028 brain injury Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 230000000642 iatrogenic effect Effects 0.000 claims 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 208000014094 Dystonic disease Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000027534 Emotional disease Diseases 0.000 claims 1
- SVFSPEITHFODPU-UHFFFAOYSA-N FC=1C=C(C=C(C1)S(=O)(=O)C)C1CCN(CC1)CCC.C(C)N1CCC(CC1)C1=CC(=CC(=C1)S(=O)(=O)C)F Chemical compound FC=1C=C(C=C(C1)S(=O)(=O)C)C1CCN(CC1)CCC.C(C)N1CCC(CC1)C1=CC(=CC(=C1)S(=O)(=O)C)F SVFSPEITHFODPU-UHFFFAOYSA-N 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- 208000004547 Hallucinations Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020852 Hypertonia Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 1
- 208000019022 Mood disease Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000027089 Parkinsonian disease Diseases 0.000 claims 1
- 206010034010 Parkinsonism Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 206010044565 Tremor Diseases 0.000 claims 1
- 208000029560 autism spectrum disease Diseases 0.000 claims 1
- 206010008129 cerebral palsy Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000003920 cognitive function Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000010118 dystonia Diseases 0.000 claims 1
- 231100000317 environmental toxin Toxicity 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 230000001146 hypoxic effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000007659 motor function Effects 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 230000036407 pain Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 208000012201 sexual and gender identity disease Diseases 0.000 claims 1
- 208000015891 sexual disease Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0502254A SE529246C2 (sv) | 2005-10-13 | 2005-10-13 | Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission |
| SE0502254-6 | 2005-10-13 | ||
| PCT/EP2006/009866 WO2007042295A1 (en) | 2005-10-13 | 2006-10-12 | 3, 5-disubstituted phenyl-piperidines as mdulators of dopamine? neurotransmission |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009511525A JP2009511525A (ja) | 2009-03-19 |
| JP2009511525A5 true JP2009511525A5 (enExample) | 2009-11-26 |
| JP4857346B2 JP4857346B2 (ja) | 2012-01-18 |
Family
ID=37467527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008534935A Expired - Fee Related JP4857346B2 (ja) | 2005-10-13 | 2006-10-12 | ドーパミン神経伝達のモジュレーターとしての３，５−二置換フェニル−ピペリジン |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8501777B2 (enExample) |
| EP (1) | EP1948606B1 (enExample) |
| JP (1) | JP4857346B2 (enExample) |
| KR (1) | KR20080046720A (enExample) |
| CN (1) | CN101273014B (enExample) |
| AT (1) | ATE494277T1 (enExample) |
| AU (1) | AU2006301432B2 (enExample) |
| BR (1) | BRPI0617355A2 (enExample) |
| CA (1) | CA2625663A1 (enExample) |
| DE (1) | DE602006019470D1 (enExample) |
| DK (1) | DK1948606T3 (enExample) |
| ES (1) | ES2358537T3 (enExample) |
| HR (1) | HRP20110196T1 (enExample) |
| IL (1) | IL189298A0 (enExample) |
| MY (1) | MY143241A (enExample) |
| NO (1) | NO20082174L (enExample) |
| NZ (1) | NZ566015A (enExample) |
| PL (1) | PL1948606T3 (enExample) |
| RU (1) | RU2418787C2 (enExample) |
| SE (1) | SE529246C2 (enExample) |
| UA (1) | UA93380C2 (enExample) |
| WO (1) | WO2007042295A1 (enExample) |
| ZA (1) | ZA200802238B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904723D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
| DE602005021641D1 (de) | 2004-06-08 | 2010-07-15 | Nsab, Filial Af Neurosearch Sweden Ab | Neue disubstituierte phenylpiperidine und piperazine als modulatoren der dopamin-neurotransmission |
| US7851629B2 (en) | 2004-06-08 | 2010-12-14 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission |
| SE0401465D0 (sv) | 2004-06-08 | 2004-06-08 | Carlsson A Research Ab | New substituted piperdines as modulators of dopamine neurotransmission |
| ES2659577T3 (es) | 2004-10-13 | 2018-03-16 | Teva Pharmaceuticals International Gmbh | Proceso para la síntesis de 4-(3-metanosulfonilfenil)-1-N-propil-piperidina |
| JP5393654B2 (ja) * | 2007-04-12 | 2014-01-22 | イヴァックス インテルナツィオナール ゲゼルシャフト ミット ベシュレンクテル ハフツンク | 改善された心血管副作用プロフィールを呈する、ドーパミン受容体安定剤／調節剤のｎ−オキシド誘導体及び／又はジ−ｎ−オキシド誘導体 |
| JP5514804B2 (ja) * | 2008-04-29 | 2014-06-04 | エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ | ドーパミン神経伝達のモジュレーター |
| JP2011519839A (ja) * | 2008-04-29 | 2011-07-14 | エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ | ドーパミン神経伝達のモジュレーター |
| US8492372B2 (en) * | 2008-04-29 | 2013-07-23 | Integrated Research Laboratories Sweden Ab | Modulators of dopamine neurotransmission |
| WO2011107583A1 (en) | 2010-03-04 | 2011-09-09 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Substituted 4-phenyl-n-alkyl-piperidines for preventing onset or slowing progression of neurodegenerative disorders |
| EP2611759A1 (en) | 2010-09-03 | 2013-07-10 | Ivax International Gmbh | Deuterated analogs of pridopidine useful as dopaminergic stabilizers |
| CN103958469B (zh) | 2011-09-07 | 2016-04-20 | 梯瓦制药国际有限责任公司 | 一种新的普利多匹定盐酸盐多晶型形态 |
| UY34503A (es) | 2011-12-08 | 2013-07-31 | Ivax Int Gmbh | ?sal de bromhidrato de pridopidina? |
| US20130267552A1 (en) | 2012-04-04 | 2013-10-10 | IVAX International GmbH | Pharmaceutical compositions for combination therapy |
| TW201613859A (en) * | 2014-06-30 | 2016-04-16 | Teva Pharma | Analogs of PRIDOPIDINE, their preparation and use |
| CA3035099C (en) | 2016-08-24 | 2023-01-17 | Prilenia Therapeutics Development Ltd. | Use of pridopidine for treating dystonias |
| EP3678664A1 (en) * | 2017-09-08 | 2020-07-15 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating drug induced dyskinesias |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB850662A (en) | 1956-10-22 | 1960-10-05 | Parke Davis & Co | Substituted piperazines and processes for their production |
| BE662455A (enExample) | 1964-04-14 | |||
| GB1060160A (en) | 1964-08-05 | 1967-03-01 | Allen & Hanburys Ltd | 4-phenylpiperidine derivatives |
| FR1459013A (fr) | 1964-08-05 | 1966-04-29 | Allen & Hanburys Ltd | Procédé de préparation de dérivés de la 4-phényl-pipéridine |
| US3539573A (en) | 1967-03-22 | 1970-11-10 | Jean Schmutz | 11-basic substituted dibenzodiazepines and dibenzothiazepines |
| ZA7546B (en) | 1974-01-21 | 1976-08-25 | Parke Davis & Co | New antibacterial amide compounds and methods for their production |
| GB1560271A (en) | 1977-01-14 | 1980-02-06 | Joullie International Sa | Therapeutically useful m-trifluoromethylphenylpiperazine derivatives |
| US4202898A (en) | 1978-06-05 | 1980-05-13 | Synthelabo | Method of treating anxiety and depression |
| FR2459797A2 (fr) | 1978-08-01 | 1981-01-16 | Synthelabo | Derives de phenyl-1 piperazine et leur application en therapeutique |
| US4333942A (en) | 1979-08-03 | 1982-06-08 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Anti-depressant and analgesic 4-phenoxypiperidines |
| US4518712A (en) | 1980-06-30 | 1985-05-21 | Taiho Pharmaceutical Company Limited | Piperazine derivative and analgesic composition containing the same |
| GB2083476B (en) | 1980-09-12 | 1984-02-08 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| FR2501506A1 (fr) | 1981-03-11 | 1982-09-17 | Sanofi Sa | Compositions pharmaceutiques a action anorexigene contenant des derives de la tetrahydropyridine |
| US4415736A (en) | 1981-12-28 | 1983-11-15 | E. I. Du Pont De Nemours & Co. | Certain tetrahydropyridine intermediates |
| EP0094159B1 (en) | 1982-05-10 | 1990-03-14 | Takeda Chemical Industries, Ltd. | Dihydropyridine derivatives, their production and use |
| US4504660A (en) | 1982-07-06 | 1985-03-12 | American Home Products Corporation | Process for the production of 2,6-diaminobenzonitrile derivatives |
| HU198454B (en) | 1987-12-14 | 1989-10-30 | Richter Gedeon Vegyeszet | Process for production of new derivatives of tetrahydrospiridin and medical compositions containing these compounds |
| FR2639226B1 (fr) | 1988-11-18 | 1993-11-05 | Sanofi | Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs |
| EP0507863A4 (en) | 1989-12-28 | 1993-07-07 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
| CA2105666C (en) | 1991-04-17 | 2006-02-14 | Kjell Anders Ivan Svensson | New centrally acting substituted phenylazacycloalkanes |
| JPH06509069A (ja) | 1991-06-27 | 1994-10-13 | バージニア・コモンウェルス・ユニバーシティ | シグマレセプターリガンドおよびその用途 |
| IE914218A1 (en) | 1991-09-11 | 1993-03-24 | Mcneilab Inc | Novel 4-arylpiperazines and 4-arylpiperidines |
| GB9119920D0 (en) | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
| GB9119932D0 (en) | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
| DE69232003T2 (de) | 1991-09-18 | 2002-04-25 | Glaxo Group Ltd., Greenford | Benzanilidderivate als 5-HT1D-Antagonisten |
| US5502050A (en) | 1993-11-29 | 1996-03-26 | Cornell Research Foundation, Inc. | Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis |
| EP0659743A1 (en) | 1993-12-27 | 1995-06-28 | Hoechst Aktiengesellschaft | Piperidine derivatives as inhibitors of platelet aggregation and their preparation |
| CA2144669A1 (en) | 1994-03-29 | 1995-09-30 | Kozo Akasaka | Biphenyl derivatives |
| IL114027A (en) | 1994-06-08 | 1999-11-30 | Lundbeck & Co As H | 4-Phenyl piperazine (piperidine or tetrahydropyridine) derivatives serotinin 5-HT1A and dopamin D2 receptor ligand pharmaceutical compositions containing them |
| AU6470096A (en) | 1995-07-19 | 1997-02-18 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused triazole compounds |
| TW340842B (en) * | 1995-08-24 | 1998-09-21 | Pfizer | Substituted benzylaminopiperidine compounds |
| US5892041A (en) | 1996-08-12 | 1999-04-06 | Neurogen Corporation | Fused indolecarboxamides: dopamine receptor subtype specific ligands |
| DE19637237A1 (de) | 1996-09-13 | 1998-03-19 | Merck Patent Gmbh | Piperazin-Derivate |
| SK283394B6 (sk) | 1997-06-10 | 2003-07-01 | Synthon B. V. | Zlúčeniny 4-fenylpiperidínu a jej farmaceuticky prijateľné soli, spôsob ich prípravy, liečivo s ich obsahom a ich použitie |
| US6232326B1 (en) | 1998-07-14 | 2001-05-15 | Jodi A. Nelson | Treatment for schizophrenia and other dopamine system dysfunctions |
| JP2000086603A (ja) | 1998-07-15 | 2000-03-28 | Yoshitomi Pharmaceut Ind Ltd | 桂皮酸アミド誘導体および３―フェニルプロピオン酸アミド誘導体 |
| RU2243226C2 (ru) | 1999-06-22 | 2004-12-27 | НьюроСёрч А/С | Новые производные бензимидазола и содержащие эти соединения фармацевтические композиции |
| SE9904723D0 (sv) * | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
| SE9904724D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
| WO2002005819A1 (en) | 2000-07-15 | 2002-01-24 | Smithkline Beecham Corporation | Compounds and methods |
| WO2002059108A1 (en) | 2001-01-23 | 2002-08-01 | Eli Lilly And Company | Melanocortin receptor agonists |
| US20050004164A1 (en) | 2003-04-30 | 2005-01-06 | Caggiano Thomas J. | 2-Cyanopropanoic acid amide and ester derivatives and methods of their use |
| US7160888B2 (en) | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
| DE602005021641D1 (de) | 2004-06-08 | 2010-07-15 | Nsab, Filial Af Neurosearch Sweden Ab | Neue disubstituierte phenylpiperidine und piperazine als modulatoren der dopamin-neurotransmission |
| SE0401465D0 (sv) | 2004-06-08 | 2004-06-08 | Carlsson A Research Ab | New substituted piperdines as modulators of dopamine neurotransmission |
| ES2346452T3 (es) | 2004-06-08 | 2010-10-15 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Nuevas fenilpiperidinas/piperazinas disustituidas utilizadas como moduladores de la neurotransmision de la dopamina. |
| US7884104B2 (en) | 2004-10-01 | 2011-02-08 | Merck Sharp & Dohme Corp. | Aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
| JP2008515952A (ja) | 2004-10-13 | 2008-05-15 | ニューロサーチ スウェーデン アクチボラゲット | ４−（３−スルホニルフェニル）−ピペリジンの合成方法 |
| US20080318999A1 (en) | 2005-08-05 | 2008-12-25 | Methvin Isaac | Tricyclic Benzimidazoles and Their Use as Metabotropic Glutamate Receptor Modulators |
| EP1963268B1 (en) | 2005-12-07 | 2010-12-01 | NSAB, Filial af NeuroSearch Sweden AB, Sverige | Disubstituted phenylpiperidines as modulators of cortical catecholaminergic neurotransmission |
-
2005
- 2005-10-13 SE SE0502254A patent/SE529246C2/sv unknown
-
2006
- 2006-10-12 RU RU2008108618/04A patent/RU2418787C2/ru not_active IP Right Cessation
- 2006-10-12 WO PCT/EP2006/009866 patent/WO2007042295A1/en not_active Ceased
- 2006-10-12 JP JP2008534935A patent/JP4857346B2/ja not_active Expired - Fee Related
- 2006-10-12 ZA ZA200802238A patent/ZA200802238B/xx unknown
- 2006-10-12 NZ NZ566015A patent/NZ566015A/en not_active IP Right Cessation
- 2006-10-12 CN CN2006800352682A patent/CN101273014B/zh not_active Expired - Fee Related
- 2006-10-12 DK DK06806224.9T patent/DK1948606T3/da active
- 2006-10-12 AU AU2006301432A patent/AU2006301432B2/en not_active Ceased
- 2006-10-12 PL PL06806224T patent/PL1948606T3/pl unknown
- 2006-10-12 BR BRPI0617355-1A patent/BRPI0617355A2/pt not_active IP Right Cessation
- 2006-10-12 ES ES06806224T patent/ES2358537T3/es active Active
- 2006-10-12 EP EP06806224A patent/EP1948606B1/en active Active
- 2006-10-12 KR KR1020087008815A patent/KR20080046720A/ko not_active Abandoned
- 2006-10-12 HR HR20110196T patent/HRP20110196T1/hr unknown
- 2006-10-12 AT AT06806224T patent/ATE494277T1/de active
- 2006-10-12 MY MYPI20081021A patent/MY143241A/en unknown
- 2006-10-12 CA CA002625663A patent/CA2625663A1/en not_active Abandoned
- 2006-10-12 US US12/089,412 patent/US8501777B2/en not_active Expired - Fee Related
- 2006-10-12 DE DE602006019470T patent/DE602006019470D1/de active Active
- 2006-12-10 UA UAA200801380A patent/UA93380C2/ru unknown
-
2008
- 2008-02-05 IL IL189298A patent/IL189298A0/en unknown
- 2008-05-09 NO NO20082174A patent/NO20082174L/no not_active Application Discontinuation