JP2009511420A5 - - Google Patents
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- Publication number
- JP2009511420A5 JP2009511420A5 JP2008536142A JP2008536142A JP2009511420A5 JP 2009511420 A5 JP2009511420 A5 JP 2009511420A5 JP 2008536142 A JP2008536142 A JP 2008536142A JP 2008536142 A JP2008536142 A JP 2008536142A JP 2009511420 A5 JP2009511420 A5 JP 2009511420A5
- Authority
- JP
- Japan
- Prior art keywords
- molar ratio
- ions
- hydroxyapatite
- ion
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims 20
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims 20
- 150000002500 ions Chemical group 0.000 claims 18
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims 7
- 235000012239 silicon dioxide Nutrition 0.000 claims 7
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 6
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 5
- -1 silicate ion Chemical class 0.000 claims 5
- 229910004283 SiO 4 Inorganic materials 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 102000008186 Collagen Human genes 0.000 claims 3
- 108010035532 Collagen Proteins 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 229920002148 Gellan gum Polymers 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- 229940072056 alginate Drugs 0.000 claims 2
- 235000010443 alginic acid Nutrition 0.000 claims 2
- 229920000615 alginic acid Polymers 0.000 claims 2
- 239000000316 bone substitute Substances 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 235000010492 gellan gum Nutrition 0.000 claims 2
- 239000000216 gellan gum Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920005615 natural polymer Polymers 0.000 claims 2
- 229940085991 phosphate ion Drugs 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 229920001059 synthetic polymer Polymers 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 229910052586 apatite Inorganic materials 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2005A001966 | 2005-10-18 | ||
| IT001966A ITMI20051966A1 (it) | 2005-10-18 | 2005-10-18 | Una idrossiapatite plurisostituita ed il relativo composito con un polimero naturale e-o sintetico loro preparazione e usi |
| PCT/IB2006/002844 WO2007045954A1 (en) | 2005-10-18 | 2006-10-12 | A plurisubstituted hydroxyapatite and the composite thereof with a natural and/or synthetic polymer, their preparation and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009511420A JP2009511420A (ja) | 2009-03-19 |
| JP2009511420A5 true JP2009511420A5 (enExample) | 2009-12-03 |
| JP5524485B2 JP5524485B2 (ja) | 2014-06-18 |
Family
ID=37745866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008536142A Active JP5524485B2 (ja) | 2005-10-18 | 2006-10-12 | 多置換されたヒドロキシアパタイトと、天然および／または合成ポリマーとの複合体と、それらの生成および使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9327976B2 (enExample) |
| EP (1) | EP1948561B1 (enExample) |
| JP (1) | JP5524485B2 (enExample) |
| AU (1) | AU2006305677B2 (enExample) |
| BR (1) | BRPI0617493B8 (enExample) |
| CA (1) | CA2625173C (enExample) |
| DK (1) | DK1948561T3 (enExample) |
| ES (1) | ES2606466T3 (enExample) |
| IT (1) | ITMI20051966A1 (enExample) |
| PL (1) | PL1948561T3 (enExample) |
| SI (1) | SI1948561T1 (enExample) |
| WO (1) | WO2007045954A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20051967A1 (it) * | 2005-10-18 | 2007-04-19 | C N R Consiglio Naz Delle Ri C | Un composito a base di apatite e di un polisaccaride metodo per la sua preparazione e suoi usi |
| GB2448489A (en) | 2007-04-11 | 2008-10-22 | Univ Aberdeen | Substituted calcium phosphate materials |
| SE535536C2 (sv) * | 2009-04-27 | 2012-09-11 | Biomatcell Ab | Jonsubstituerade hydroxiapatitytbeläggningar |
| US9205035B2 (en) * | 2009-08-04 | 2015-12-08 | Psilox Ab | Ion substituted calcium phosphate particles |
| IT1396934B1 (it) * | 2009-11-25 | 2012-12-20 | Fin Ceramica Faenza Spa | Materiali bio-mimetici compositi, relativo processo di preparazione e loro uso per la realizzazione di strutture mono-, bi- o multi-strato per la rigenerazione di tessuto osseo, cartilagineo o osteocartilagineo |
| GB201010761D0 (en) * | 2010-06-25 | 2010-08-11 | Univ Aberdeen | Bone graft system |
| ITMI20102070A1 (it) * | 2010-11-08 | 2012-05-09 | Consiglio Nazionale Ricerche | Impianti per sostituzioni ossee "load bearing" ad architettura gerarchicamente organizzata derivante dalla trasformazione di strutture vegetali |
| ES2802374T3 (es) | 2014-06-19 | 2021-01-19 | Consiglio Naz Delle Ricerche C N R | Cemento de apatita inyectable de sustitución iónica múltiple para vertebroplastia regenerativa y cifoplastia |
| CN104725673A (zh) * | 2015-03-20 | 2015-06-24 | 东华大学 | 一种原位生成改性纳米羟基磷灰石/壳聚糖复合膜的方法 |
| ITUB20156918A1 (it) * | 2015-12-10 | 2017-06-10 | Curasept A D S S R L | Apatiti multi sostituite e loro uso nella rimineralizzazione e riduzione della sensibilita? dentale |
| JP6864360B2 (ja) * | 2016-10-29 | 2021-04-28 | 公立大学法人奈良県立医科大学 | ケイ酸ストロンチウムアパタイトおよびこれを含む細胞培養基材と生体活性インプラント |
| CN107865980A (zh) * | 2017-10-10 | 2018-04-03 | 唐林元 | 一种仿生人工骨的制备方法 |
| EP3786109A4 (en) * | 2018-04-27 | 2022-01-19 | Bioapatite, Inc. | HYDROXYLAPATITE |
| CN108529580B (zh) * | 2018-05-18 | 2021-06-11 | 南京农业大学 | 一种富集碳酸根的羟基磷灰石、制备其的设备、制备方法和应用 |
| JP7281796B2 (ja) * | 2019-01-09 | 2023-05-26 | 国立研究開発法人日本原子力研究開発機構 | 炭酸基高含有炭酸アパタイト |
| KR102100961B1 (ko) * | 2019-08-30 | 2020-04-14 | 김범수 | 유공충 유래의 골 이식재 |
| CN112870450A (zh) * | 2021-01-28 | 2021-06-01 | 中南大学湘雅医院 | 载二甲双胍人工骨材料以及制备人工骨的方法 |
| US20250114281A1 (en) * | 2022-01-18 | 2025-04-10 | Korea Institute Of Science And Technology | Apatite for filler and filler composition comprising same |
| CN116120541B (zh) * | 2022-11-30 | 2025-07-11 | 北京大学 | 一种用于骨牙质文物的原位开环聚合加固方法 |
| CN120531949B (zh) * | 2025-05-08 | 2025-12-26 | 湖北大学 | 骨固定器械用聚乳酸/硅掺杂羟基磷灰石复合材料及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR970004592B1 (ko) * | 1994-04-04 | 1997-03-29 | 이연제약 주식회사 | 자연골치환형 인공골과 그 제조방법 |
| GB2316940A (en) | 1996-08-30 | 1998-03-11 | Queen Mary & Westfield College | Silicon-substituted hydroxyapatite |
| FR2772746B1 (fr) * | 1997-12-23 | 2000-01-28 | Commissariat Energie Atomique | Procede de fabrication d'une ceramique apatitique, en particulier pour usage biologique |
| JP4638979B2 (ja) * | 2000-10-26 | 2011-02-23 | 宇部マテリアルズ株式会社 | ケイ酸含有アパタイト |
| JP4790917B2 (ja) | 2001-02-23 | 2011-10-12 | 独立行政法人科学技術振興機構 | 人工椎体 |
| FR2823992B1 (fr) * | 2001-04-27 | 2003-06-20 | Rhodia Chimie Sa | Dispersions d'hydroxyapatite comprenant un acide amine en tant qu'agent stabilisant, et leur procede de preparation |
| KR100475828B1 (ko) * | 2002-08-30 | 2005-03-10 | 요업기술원 | 산호 유래 인산칼슘계 다공체 및 그 제조방법 |
| GB2395713A (en) * | 2002-11-13 | 2004-06-02 | Univ Cambridge Tech | A synthetic bone material |
| US6905723B2 (en) * | 2003-05-30 | 2005-06-14 | Depuy Products, Inc. | Strontium-substituted apatite coating |
| DE10339953B3 (de) * | 2003-08-27 | 2005-04-21 | Coripharm Medizinprodukte Gmbh & Co. Kg. | Implantatmaterial für den Knochen-Knorpel-Ersatz und seine Verwendung |
| EP3498312A1 (en) * | 2003-09-05 | 2019-06-19 | Synthes GmbH | Bone cement compositions having fiber-reinforcement and/or increased flowability |
| ITFI20040048A1 (it) | 2004-02-27 | 2004-05-27 | Menarini Farma Ind | Composti biomimetici contenenti idrossiapatiti sostituite con magnesio e carbonato e processi per ottenerli |
-
2005
- 2005-10-18 IT IT001966A patent/ITMI20051966A1/it unknown
-
2006
- 2006-10-12 CA CA2625173A patent/CA2625173C/en active Active
- 2006-10-12 US US12/089,887 patent/US9327976B2/en active Active
- 2006-10-12 ES ES06809000.0T patent/ES2606466T3/es active Active
- 2006-10-12 JP JP2008536142A patent/JP5524485B2/ja active Active
- 2006-10-12 PL PL06809000T patent/PL1948561T3/pl unknown
- 2006-10-12 DK DK06809000.0T patent/DK1948561T3/da active
- 2006-10-12 WO PCT/IB2006/002844 patent/WO2007045954A1/en not_active Ceased
- 2006-10-12 AU AU2006305677A patent/AU2006305677B2/en active Active
- 2006-10-12 BR BRPI0617493A patent/BRPI0617493B8/pt active IP Right Grant
- 2006-10-12 SI SI200632115A patent/SI1948561T1/sl unknown
- 2006-10-12 EP EP06809000.0A patent/EP1948561B1/en active Active
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