JP2009510182A - シクリトールリンカーポリマー抱合体 - Google Patents

シクリトールリンカーポリマー抱合体 Download PDF

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Publication number
JP2009510182A
JP2009510182A JP2008524213A JP2008524213A JP2009510182A JP 2009510182 A JP2009510182 A JP 2009510182A JP 2008524213 A JP2008524213 A JP 2008524213A JP 2008524213 A JP2008524213 A JP 2008524213A JP 2009510182 A JP2009510182 A JP 2009510182A
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JP
Japan
Prior art keywords
group
polymer
compound
biologically active
conjugate
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JP2008524213A
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English (en)
Japanese (ja)
Inventor
ターナー，デイビツド・アイ
カリアス，ペリー
クツク，ゲイリー・ピー
シマ，デイビツド・テイー
Original Assignee
（オーエスアイ）アイテツク・インコーポレーテツド
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Application filed by （オーエスアイ）アイテツク・インコーポレーテツド filed Critical （オーエスアイ）アイテツク・インコーポレーテツド
Publication of JP2009510182A publication Critical patent/JP2009510182A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
JP2008524213A 2005-07-28 2006-07-27 シクリトールリンカーポリマー抱合体 Pending JP2009510182A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70313305P 2005-07-28 2005-07-28
PCT/US2006/029503 WO2007016380A2 (fr) 2005-07-28 2006-07-27 Dispositifs et methodes d'execution de procedures sur un sein

Publications (1)

Publication Number Publication Date
JP2009510182A true JP2009510182A (ja) 2009-03-12

Family

ID=37451164

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008524213A Pending JP2009510182A (ja) 2005-07-28 2006-07-27 シクリトールリンカーポリマー抱合体

Country Status (3)

Country Link
EP (1) EP1912676A2 (fr)
JP (1) JP2009510182A (fr)
WO (1) WO2007016380A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011055751A (ja) * 2009-09-09 2011-03-24 Tokyo Univ Of Agriculture & Technology デンドリマー修飾磁気微粒子の製造方法
JP2015509986A (ja) * 2012-03-16 2015-04-02 ザ・ジョンズ・ホプキンス・ユニバーシティー 活性剤の送達のための非線状マルチブロックコポリマー薬物コンジュゲート
WO2016063957A1 (fr) * 2014-10-22 2016-04-28 スガイ化学工業株式会社 Dérivé de décaline et procédé de production associé

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889193B2 (en) 2010-02-25 2014-11-18 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
WO2012039979A2 (fr) 2010-09-10 2012-03-29 The Johns Hopkins University Diffusion rapide de grosses nanoparticules polymères dans le cerveau de mammifères
US9327037B2 (en) 2011-02-08 2016-05-03 The Johns Hopkins University Mucus penetrating gene carriers
CN104936620B (zh) 2012-01-19 2019-08-09 约翰霍普金斯大学 增强粘膜渗透的纳米粒子调配物
CA2867381C (fr) 2012-03-16 2016-09-20 The Johns Hopkins University Formulations a liberation controlee pour l'administration d'inhibiteurs du hif-1
EP2849728A1 (fr) 2012-05-04 2015-03-25 The Johns Hopkins University Véhicules de médicament à base de lipide pour pénétration rapide à travers les revêtements de mucus
US9533068B2 (en) 2012-05-04 2017-01-03 The Johns Hopkins University Drug loaded microfiber sutures for ophthalmic application
SG11201501914XA (en) 2012-10-11 2015-05-28 Ascendis Pharma Ophthalmology Division As Vegf neutralizing prodrugs for the treatment of ocular conditions
CN103830741B (zh) * 2012-11-27 2019-02-19 杨子剑 含有陶扎色替类似物结构的化合物以及制备方法和用途
CN103848901A (zh) * 2012-11-28 2014-06-11 杨子剑 含有万古霉素结构的新化合物以及制备方法和用途
CN103848894A (zh) * 2012-11-30 2014-06-11 杨子剑 含有达托霉素结构的新化合物以及制备方法和用途
CN103897041A (zh) * 2012-12-24 2014-07-02 杨子剑 含有万古霉素结构的新化合物以及制备方法和用途
WO2014124006A1 (fr) 2013-02-05 2014-08-14 The Johns Hopkins University Nanoparticules pour le suivi de l'imagerie par résonance magnétique et procédés de fabrication et d'utilisation associés
WO2015127389A1 (fr) 2014-02-23 2015-08-27 The Johns Hopkins University Formulations de lavement hypotonique et méthodes d'utilisation
KR20170106460A (ko) 2015-01-27 2017-09-20 더 존스 홉킨스 유니버시티 점막표면에서 활성제의 향상된 수송을 위한 저장성 하이드로겔 제제

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089419A1 (fr) * 2003-04-04 2004-10-21 The University Of Tokyo Structure de membrane lipidique comportant un anticorps monoclonal anti-mt-mmp
JP2005508299A (ja) * 2001-06-21 2005-03-31 ジェネンテック・インコーポレーテッド 徐放性組成物
JP2005516033A (ja) * 2002-01-23 2005-06-02 イマークス セラピューティクス、インコーポレイテッド 診断および治療で使用する新規な標的組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996021440A1 (fr) * 1995-01-09 1996-07-18 Alpha-Therapeutics, Inc. Procedes pour accroitre la biodisponibilite d'agents ayant une activite biologique
PT957929E (pt) * 1996-10-25 2006-06-30 Gilead Sciences Inc Complexos de ligandos de acido nucleico do factor de crescimento endotelial vascular
KR20060015505A (ko) * 2003-04-13 2006-02-17 엔존 파마슈티컬즈, 인코포레이티드 올리고뉴클레오타이드 전구약물
EP1737497A2 (fr) * 2004-04-13 2007-01-03 (Osi) Eyetech, Inc. Conjugues biologiquement actifs ameliores

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005508299A (ja) * 2001-06-21 2005-03-31 ジェネンテック・インコーポレーテッド 徐放性組成物
JP2005516033A (ja) * 2002-01-23 2005-06-02 イマークス セラピューティクス、インコーポレイテッド 診断および治療で使用する新規な標的組成物
WO2004089419A1 (fr) * 2003-04-04 2004-10-21 The University Of Tokyo Structure de membrane lipidique comportant un anticorps monoclonal anti-mt-mmp

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011055751A (ja) * 2009-09-09 2011-03-24 Tokyo Univ Of Agriculture & Technology デンドリマー修飾磁気微粒子の製造方法
JP2015509986A (ja) * 2012-03-16 2015-04-02 ザ・ジョンズ・ホプキンス・ユニバーシティー 活性剤の送達のための非線状マルチブロックコポリマー薬物コンジュゲート
JP2017125075A (ja) * 2012-03-16 2017-07-20 ザ・ジョンズ・ホプキンス・ユニバーシティー 活性剤の送達のための非線状マルチブロックコポリマー薬物コンジュゲート
WO2016063957A1 (fr) * 2014-10-22 2016-04-28 スガイ化学工業株式会社 Dérivé de décaline et procédé de production associé
JPWO2016063957A1 (ja) * 2014-10-22 2017-08-03 スガイ化学工業株式会社 デカリン誘導体及びその製造方法

Also Published As

Publication number Publication date
EP1912676A2 (fr) 2008-04-23
WO2007016380A2 (fr) 2007-02-08
WO2007016380A3 (fr) 2007-08-16

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