JP2009510041A5 - - Google Patents

Download PDF

Info

Publication number
JP2009510041A5
JP2009510041A5 JP2008532868A JP2008532868A JP2009510041A5 JP 2009510041 A5 JP2009510041 A5 JP 2009510041A5 JP 2008532868 A JP2008532868 A JP 2008532868A JP 2008532868 A JP2008532868 A JP 2008532868A JP 2009510041 A5 JP2009510041 A5 JP 2009510041A5
Authority
JP
Japan
Prior art keywords
group
pyran
dihydro
piperidinyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008532868A
Other languages
English (en)
Japanese (ja)
Other versions
JP5209481B2 (ja
JP2009510041A (ja
Filing date
Publication date
Priority claimed from GBGB0519949.2A external-priority patent/GB0519949D0/en
Priority claimed from GB0602856A external-priority patent/GB0602856D0/en
Application filed filed Critical
Priority claimed from PCT/GB2006/003595 external-priority patent/WO2007036718A2/en
Publication of JP2009510041A publication Critical patent/JP2009510041A/ja
Publication of JP2009510041A5 publication Critical patent/JP2009510041A5/ja
Application granted granted Critical
Publication of JP5209481B2 publication Critical patent/JP5209481B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2008532868A 2005-09-30 2006-09-27 Ｍ１受容体にて活性を有する化合物および医薬におけるそれらの使用 Expired - Fee Related JP5209481B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0519949.2 2005-09-30
GBGB0519949.2A GB0519949D0 (en) 2005-09-30 2005-09-30 Compounds
GB0602856.7 2006-02-13
GB0602856A GB0602856D0 (en) 2006-02-13 2006-02-13 Compounds
PCT/GB2006/003595 WO2007036718A2 (en) 2005-09-30 2006-09-27 Compounds which have activity at m1 receptor and their uses in medicine

Publications (3)

Publication Number Publication Date
JP2009510041A JP2009510041A (ja) 2009-03-12
JP2009510041A5 true JP2009510041A5 (https=) 2009-11-12
JP5209481B2 JP5209481B2 (ja) 2013-06-12

Family

ID=37635729

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008532868A Expired - Fee Related JP5209481B2 (ja) 2005-09-30 2006-09-27 Ｍ１受容体にて活性を有する化合物および医薬におけるそれらの使用

Country Status (8)

Country Link
US (1) US8288412B2 (https=)
EP (1) EP1960389B1 (https=)
JP (1) JP5209481B2 (https=)
AR (1) AR055667A1 (https=)
ES (1) ES2391107T3 (https=)
PE (1) PE20070586A1 (https=)
TW (1) TW200804355A (https=)
WO (1) WO2007036718A2 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0616609A2 (pt) * 2005-09-30 2011-06-28 Glaxo Group Ltd compostos que têm atividade no receptor m1, composição farmacêutica contendo tais compostos, processo para preparação dos mesmos, bem como seus usos em medicina
WO2007036711A1 (en) * 2005-09-30 2007-04-05 Glaxo Group Limited BENZIMIDAZOLONES WHICH HAVE ACTIVITY AT Ml RECEPTOR
EP1960389B1 (en) 2005-09-30 2012-08-15 Glaxo Group Limited Compounds which have activity at m1 receptor and their uses in medicine
GB0605784D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
GB0706165D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706170D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706164D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706174D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0718415D0 (en) * 2007-09-20 2007-10-31 Glaxo Group Ltd Compounds
UY31672A1 (es) * 2008-02-28 2009-09-30 "agonistas de receptores muscarínicos composiciones farmacéuticas métodos de tratamiento de los mismos, y procedimientos para su preparación"
US20090221642A1 (en) * 2008-03-03 2009-09-03 Astrazeneca Ab Muscarinic receptor agonists, compositions, methods of treatment thereof, and processes for preparation thereof-176
GB0817982D0 (en) 2008-10-01 2008-11-05 Glaxo Group Ltd Compounds
WO2010103306A1 (en) 2009-03-10 2010-09-16 Astrazeneca Uk Limited Benzimidazole derivatives and their use as antivaral agents
US20180250270A1 (en) 2015-09-11 2018-09-06 Chase Pharmaceuticals Corporation Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
CN106316864A (zh) * 2016-08-22 2017-01-11 苏州天马精细化学品股份有限公司 4‑甲基‑3‑三氟甲基苯胺的制备方法
CN111848406B (zh) * 2019-04-26 2022-03-29 沈阳中化农药化工研发有限公司 一种2-氯-4-氟-5-硝基苯甲醛的制备方法
CN113637001A (zh) * 2021-08-09 2021-11-12 安康市农业科学研究院 一种氟哌利多中间体的合成方法
WO2023114224A1 (en) 2021-12-13 2023-06-22 Sage Therapeutics, Inc. Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3161645A (en) 1962-12-18 1964-12-15 Res Lab Dr C Janssen N V 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds
US3989707A (en) * 1974-06-21 1976-11-02 Janssen Pharmaceutica N.V. Benzimidazolinone derivatives
US4292321A (en) 1979-05-24 1981-09-29 Warner-Lambert Company 1,3,8-Triazaspirodecane-4-ones, pharmaceutical compositions thereof and method of use thereof
US4411904A (en) * 1981-05-29 1983-10-25 Warner-Lambert Company Diphenylpropanamines, compositions thereof and use thereof
DE3124366A1 (de) 1981-06-20 1982-12-30 Hoechst Ag, 6000 Frankfurt N-oxacyclyl-alkylpiperidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und deren verwendung
DE4040300A1 (de) 1990-12-17 1992-07-02 Leifeld Gmbh & Co Drueckmaschine mit wenigstens einem rollenhalter
JP3916093B2 (ja) * 1993-09-17 2007-05-16 杏林製薬株式会社 光学活性イミダゾリジノン誘導体とその製造方法
JP2002515008A (ja) * 1994-10-27 2002-05-21 メルク エンド カンパニー インコーポレーテッド ムスカリン・アンタゴニスト
US5691323A (en) * 1995-05-12 1997-11-25 Merck & Co., Inc. Muscarine antagonists
US5574044A (en) 1994-10-27 1996-11-12 Merck & Co., Inc. Muscarine antagonists
WO1997016186A1 (en) 1995-10-31 1997-05-09 Merck & Co., Inc. Muscarine agonists
US5718912A (en) 1996-10-28 1998-02-17 Merck & Co., Inc. Muscarine agonists
US5977134A (en) 1996-12-05 1999-11-02 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
US6162804A (en) 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
AU2307999A (en) 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
ATE275141T1 (de) * 1999-10-13 2004-09-15 Banyu Pharma Co Ltd Substituierte imidazolin-derivate
SE9904652D0 (sv) 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
US20020019395A1 (en) 2000-02-01 2002-02-14 Bing-Yan Zhu Indalone and benzimidazolone inhibitors of factor Xa
US6872733B2 (en) 2001-04-18 2005-03-29 Euro-Celtique S.A. Benzimidazolone compounds
JPWO2002085890A1 (ja) 2001-04-20 2004-08-12 萬有製薬株式会社 ベンズイミダゾロン誘導体
US6951849B2 (en) 2001-10-02 2005-10-04 Acadia Pharmaceuticals Inc. Benzimidazolidinone derivatives as muscarinic agents
ATE516030T1 (de) 2001-10-02 2011-07-15 Acadia Pharm Inc Benzimidazolidinon-derivate als muscarinische mittel
WO2004089942A2 (en) 2001-10-02 2004-10-21 Acadia Pharmaceuticals Inc. Benzimidazolidinone derivatives as muscarinic agents
WO2003037890A2 (en) 2001-11-01 2003-05-08 Icagen, Inc. Piperidines
JP4056977B2 (ja) 2002-03-29 2008-03-05 田辺三菱製薬株式会社 睡眠障害治療薬
JP2005532361A (ja) 2002-06-17 2005-10-27 メルク　エンド　カムパニー　インコーポレーテッド 高眼圧症の治療用の眼科用組成物
BR0317230A (pt) 2002-12-13 2005-10-25 Smithkline Beecham Corp Composto, composição, métodos de antagonizar uma atividade do receptor de quimiocina ccr-5, e de tratar uma infecção viral em um paciente, e, uso de um composto
WO2005009996A1 (en) 2003-07-23 2005-02-03 Wyeth Sulfonyldihydro- benzimidazolone compounds as 5-hydroxytryptamine-6 ligands
KR100738784B1 (ko) 2003-09-03 2007-07-12 화이자 인코포레이티드 5-ｈｔ4 수용체 효능 활성을 갖는 벤즈이미다졸론
MX2007005290A (es) 2004-11-02 2007-07-09 Pfizer Derivados de sulfonilbencimidazol.
US7300947B2 (en) 2005-07-13 2007-11-27 Banyu Pharmaceutical Co., Ltd. N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
EP1960389B1 (en) 2005-09-30 2012-08-15 Glaxo Group Limited Compounds which have activity at m1 receptor and their uses in medicine
BRPI0616609A2 (pt) 2005-09-30 2011-06-28 Glaxo Group Ltd compostos que têm atividade no receptor m1, composição farmacêutica contendo tais compostos, processo para preparação dos mesmos, bem como seus usos em medicina
WO2007036711A1 (en) 2005-09-30 2007-04-05 Glaxo Group Limited BENZIMIDAZOLONES WHICH HAVE ACTIVITY AT Ml RECEPTOR
WO2008029377A2 (en) 2006-09-08 2008-03-13 The Gillette Company Toothbrush with multiple bristle states
GB0706170D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706173D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706190D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706187D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706167D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706189D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706164D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706165D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706188D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706174D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706168D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds

Similar Documents

Publication Publication Date Title
JP2009510041A5 (https=)
JP2009512635A5 (https=)
JP2009510037A5 (https=)
AU2023201399B2 (en) Modulators of the integrated stress pathway
JP5795402B2 (ja) 新規抗血小板薬
AU2018282336B2 (en) Trk-inhibiting compound
JP5313865B2 (ja) ベンゾイミダゾール化合物およびその医薬用途
CN100352816C (zh) 伤害感受肽类似物
JP2008513496A5 (https=)
AU2015335703B2 (en) Carbazole derivatives
JP2005516969A (ja) メタボトロピックグルタミン酸受容体−５のヘテロアリール置換ピロールモジュレーター
JP2009530348A5 (https=)
JP2011500758A5 (https=)
CA2624504A1 (en) Benzimidazolone compounds which have activity at m1 receptor and their uses in medicine
CN1358182A (zh) 呼吸道合胞病毒复制抑制剂
US20130157995A1 (en) Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use
CA2934251A1 (en) A combination of heterocyclic modulators of lipid synthesis and chemotherapeutic drugs in treatment of cancer
TW200904817A (en) Compounds and uses thereof
JP2012513398A5 (https=)
JP2005289816A (ja) ベンズイミダゾール誘導体
TW201018682A (en) Heterocyclic biaryl derivative, and pde inhibitor comprising same as active ingredient
WO2014151630A2 (en) Compounds and compositions for the treatment of parasitic diseases
WO2004089308A2 (en) Di-aryl substituted pyrrole modulators of metabotropic glutamate receptor-5
CN100441182C (zh) 伤害感受肽化合物
WO2013053725A1 (en) 2-oxo-piperidinyl derivatives