JP2009509921A5 - - Google Patents

Download PDF

Info

Publication number
JP2009509921A5
JP2009509921A5 JP2008525977A JP2008525977A JP2009509921A5 JP 2009509921 A5 JP2009509921 A5 JP 2009509921A5 JP 2008525977 A JP2008525977 A JP 2008525977A JP 2008525977 A JP2008525977 A JP 2008525977A JP 2009509921 A5 JP2009509921 A5 JP 2009509921A5
Authority
JP
Japan
Prior art keywords
disorder
pain
disorders
disease
neurological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008525977A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009509921A (ja
Filing date
Publication date
Priority claimed from PCT/US2005/028760 external-priority patent/WO2006020879A1/en
Application filed filed Critical
Priority claimed from PCT/US2006/005247 external-priority patent/WO2007021309A1/en
Publication of JP2009509921A publication Critical patent/JP2009509921A/ja
Publication of JP2009509921A5 publication Critical patent/JP2009509921A5/ja
Pending legal-status Critical Current

Links

JP2008525977A 2005-08-12 2006-02-15 置換イソインドロン類及び代謝調節型グルタミン酸受容体増強剤としてのその使用 Pending JP2009509921A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2005/028760 WO2006020879A1 (en) 2004-08-13 2005-08-12 Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
PCT/US2006/005247 WO2007021309A1 (en) 2005-08-12 2006-02-15 Substituted isoindolones and their use as metabotropic glutamate receptor potentiators

Publications (2)

Publication Number Publication Date
JP2009509921A JP2009509921A (ja) 2009-03-12
JP2009509921A5 true JP2009509921A5 (enExample) 2009-04-23

Family

ID=36464390

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008525977A Pending JP2009509921A (ja) 2005-08-12 2006-02-15 置換イソインドロン類及び代謝調節型グルタミン酸受容体増強剤としてのその使用
JP2008525976A Expired - Fee Related JP5031745B2 (ja) 2005-08-12 2006-02-15 代謝型グルタミン酸受容体増強性イソインドロン

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008525976A Expired - Fee Related JP5031745B2 (ja) 2005-08-12 2006-02-15 代謝型グルタミン酸受容体増強性イソインドロン

Country Status (4)

Country Link
EP (2) EP1912939A1 (enExample)
JP (2) JP2009509921A (enExample)
CN (2) CN101309905A (enExample)
WO (2) WO2007021308A1 (enExample)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7807706B2 (en) 2005-08-12 2010-10-05 Astrazeneca Ab Metabotropic glutamate-receptor-potentiating isoindolones
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
US20080139846A1 (en) * 2006-09-01 2008-06-12 Astrazeneca Ab New Process 298
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
WO2008130853A1 (en) * 2007-04-17 2008-10-30 Astrazeneca Ab Hydrazides and their use as metabotropic glutamate receptor potentiators - 681
US20100197800A1 (en) * 2007-04-23 2010-08-05 Richard Friedman Treatment and/or Prevention of Presbycusis by Modulation of Metabotropic Glutamate Receptor 7
BRPI0812163A2 (pt) 2007-05-25 2014-12-16 Abbott Gmbh & Co Kg Compostos heterocíclicos como moduladores positivos do receptor metabotrópico de glutamato 2 (receptor mglu2)
TWI417100B (zh) * 2007-06-07 2013-12-01 Astrazeneca Ab 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途
TW200911255A (en) * 2007-06-07 2009-03-16 Astrazeneca Ab Metabotropic glutamate receptor oxadiazole ligands and their use as potentiators-841
WO2009004430A1 (en) * 2007-06-29 2009-01-08 Pfizer Inc. N-benzyl oxazolidinones and related heterocycleic compounds as potentiators of glutamate receptors
JP5433579B2 (ja) 2007-09-14 2014-03-05 ジャンセン ファーマシューティカルズ， インコーポレイテッド． １，３−二置換−４−フェニル−１ｈ−ピリジン−２−オン
TWI475995B (zh) 2007-09-14 2015-03-11 Janssen Pharmaceuticals Inc １’，３’－二取代－４－苯基－３，４，５，６－四氫－２ｈ，１’ｈ－〔１，４’〕聯吡啶基－２’－酮化物
SA109300358B1 (ar) * 2008-06-06 2012-11-03 استرازينيكا ايه بي مقويات مستقبل جلوتامات ذي انتحاء أيضي من أيزو إندولون
GB0811643D0 (en) 2008-06-25 2008-07-30 Cancer Rec Tech Ltd New therapeutic agents
TW201006801A (en) 2008-07-18 2010-02-16 Lilly Co Eli Imidazole carboxamides
EP2344470B1 (en) 2008-09-02 2013-11-06 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
RU2517181C2 (ru) 2008-10-16 2014-05-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов
US8691813B2 (en) 2008-11-28 2014-04-08 Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
CA2754688A1 (en) * 2009-03-11 2010-09-16 Msd K.K. Novel isoindolin-1-one derivative
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN102439015B (zh) 2009-05-12 2015-05-13 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途
ES2440001T3 (es) 2009-05-12 2014-01-27 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-A]piridina y su uso para el tratamiento o prevención de trastornos neurológicos y psiquiátricos
MX2012004024A (es) * 2009-10-09 2012-05-08 Celgene Corp Proceso para la preparacion de 2 - (1 - feniletil) - isoindolin - 1 - ona.
EP2496569A2 (en) 2009-11-02 2012-09-12 MSD Oss B.V. Heterocyclic derivatives
RU2012134329A (ru) * 2010-01-07 2014-02-20 Астразенека Аб Способ получения позитивного аллостерического модулятора метаботропных глутаматных рецепторов-874
US8314120B2 (en) 2010-03-30 2012-11-20 Abbott Gmbh & Co. Kg Small molecule potentiators of metabotropic glutamate receptors
US8664214B2 (en) 2010-03-30 2014-03-04 AbbVie Deutschland GmbH & Co. KG Small molecule potentiators of metabotropic glutamate receptors I
US8993591B2 (en) 2010-11-08 2015-03-31 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
WO2012062751A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
CN103298810B (zh) 2010-11-08 2016-03-16 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
US8895571B2 (en) 2011-10-14 2014-11-25 Incyte Corporation Isoindolinone and pyrrolopyridinone derivatives as Akt inhibitors
US9586964B2 (en) * 2011-10-28 2017-03-07 Vanderbilt University Substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
PH12019500127B1 (en) 2014-01-21 2022-05-04 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
EP3424535A1 (en) 2014-01-21 2019-01-09 Janssen Pharmaceutica NV Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
TWI713455B (zh) 2014-06-25 2020-12-21 美商伊凡克特治療公司 ＭｎＫ抑制劑及其相關方法
GB201517217D0 (en) 2015-09-29 2015-11-11 Astex Therapeutics Ltd And Cancer Res Technology Ltd Pharmaceutical compounds
GB201517216D0 (en) 2015-09-29 2015-11-11 Cancer Res Technology Ltd And Astex Therapeutics Ltd Pharmaceutical compounds
CN108602814A (zh) 2015-10-29 2018-09-28 效应治疗股份有限公司 抑制mnk1和mnk2的吡咯并-、吡唑并-、咪唑并-嘧啶和吡啶化合物
BR112018008714A2 (pt) 2015-10-29 2018-10-30 Effector Therapeutics Inc inibidores de isoindolina, azaisoindolina, dihidroindenona e dihidroazaindenona da mnk1 e mnk2
WO2017087808A1 (en) 2015-11-20 2017-05-26 Effector Therapeutics, Inc. Heterocyclic compounds that inhibit the kinase activity of mnk useful for treating various cancers
CN105837557A (zh) * 2016-05-05 2016-08-10 青岛辰达生物科技有限公司 一种用于治疗ii型糖尿病的阿格列汀的制备方法
CN106279182B (zh) * 2016-07-29 2019-06-07 中国药科大学 一种吡咯并[2，1-a]异吲哚酮类化合物及其合成方法
MX394700B (es) 2017-02-14 2025-03-24 Effector Therapeutics Inc Inhibidores de mnk sustituidos con piperidina y métodos relacionados con los mismos.
GB201704966D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
GB201704965D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
EP3459939A1 (en) * 2017-09-26 2019-03-27 Pragma Therapeutics Novel heterocyclic compounds as modulators of mglur7
KR20210102211A (ko) 2018-10-24 2021-08-19 이펙터 테라퓨틱스, 인크. Mnk 억제제의 결정질 형태
WO2020102198A1 (en) 2018-11-13 2020-05-22 Incyte Corporation Heterocyclic derivatives as pi3k inhibitors
US11161838B2 (en) 2018-11-13 2021-11-02 Incyte Corporation Heterocyclic derivatives as PI3K inhibitors
WO2020102216A1 (en) 2018-11-13 2020-05-22 Incyte Corporation Substituted heterocyclic derivatives as pi3k inhibitors
CN110498759A (zh) * 2019-09-12 2019-11-26 天津瑞岭化工有限公司 异吲哚啉酮类化合物的合成方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE620654C (de) * 1933-04-29 1935-10-24 Smith & Sons Ltd S Geschwindigkeitsanzeiger
US3579524A (en) * 1968-06-05 1971-05-18 Miles Lab 2-aminoalkyl derivatives of phthalimidines
US3993617A (en) * 1975-10-30 1976-11-23 Morton-Norwich Products, Inc. Antifungal 2-substituted phthalimidines
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JPH02184667A (ja) * 1989-01-11 1990-07-19 Meiji Seika Kaisha Ltd Ｎ，ｎ’―ジ置換ピペラジル誘導体及びそれを有効成分とする排尿障害改善剤
TW219935B (enExample) * 1991-12-25 1994-02-01 Mitsubishi Chemicals Co Ltd
RU2124511C1 (ru) * 1993-05-14 1999-01-10 Фармасьютикал Ко., Лтд Производные пиперазина
US5681954A (en) * 1993-05-14 1997-10-28 Daiichi Pharmaceutical Co., Ltd. Piperazine derivatives
CN1158264C (zh) * 1997-11-21 2004-07-21 Nps药物有限公司 用于治疗中枢神经系统疾病的代谢性谷氨酸受体拮抗剂
EP1260512B1 (en) * 2000-02-29 2007-07-04 Mitsubishi Pharma Corporation Novel cyclic amide derivatives
DE10031391A1 (de) * 2000-07-03 2002-02-07 Knoll Ag Bicyclische Verbindungen und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie
EP1304324B1 (en) * 2000-07-18 2007-10-03 Dainippon Sumitomo Pharma Co., Ltd. Serotonin reuptake inhibitors
DE10238865A1 (de) * 2002-08-24 2004-03-11 Boehringer Ingelheim International Gmbh Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
GB0223232D0 (en) * 2002-10-07 2002-11-13 Pfizer Ltd Chemical compounds
US20070135485A1 (en) * 2003-10-22 2007-06-14 Gillig James R Novel mch receptor antagonists
EP1713775A4 (en) * 2004-01-30 2009-08-12 Smithkline Beecham Corp CHEMICAL COMPOUNDS
BRPI0508140B1 (pt) * 2004-03-05 2015-03-17 Nissan Chemical Ind Ltd Composto benzamida substituída por isoxazolina da fórmula (1); da fórmula (2) substituído por 3,5-bis (aril substituído); da fórmula (4) substituída por alquinibenzeno ou um sal do mesmo; "pesticida, agroquímico, inseticida, parasiticida contendo como ingrediente ativo um ou mais composto benzamida substituída por isoxazolina e sal do mesmo"
WO2005085214A1 (ja) * 2004-03-05 2005-09-15 Banyu Pharmaceutical Co., Ltd ジアリール置換複素５員環誘導体
TW200613272A (en) * 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators

Similar Documents

Publication Publication Date Title
JP2009509921A5 (enExample)
JP2009509920A5 (enExample)
RU2009147708A (ru) Производные оксадиазола и их применение в качестве потенцирующих средств метаботропных глутаматных рецепторов-842
WO2009117515A3 (en) Novel compounds advantageous in the treatment of central nervous system diseases and disorders
JP2013544277A5 (enExample)
MX2010001824A (es) Heterociclos como moduladores de canal de potasio.
PH12012501514A1 (en) (2s, 3r)-n-(2-((3-pyridinyl)methyl)-1-azabycyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms, and methods of use thereof
MX2016008842A (es) Derivados de n-fenil-lactama capaces de estimular la neurogenesis y su uso en el tratamiento de trastornos neurologicos.
WO2004058704A8 (en) Quinazolinones as potassium channel modulators
WO2010039186A3 (en) Benzoxazoles useful as faah modulators and uses thereof
EP2604602A4 (en) HETEROARYL PYRAZOLE DERIVATIVE
JP2013512926A5 (enExample)
FI3494119T3 (fi) Yhdisteitä ja koostumuksia ja niiden käyttötapoja
JP2012530129A5 (enExample)
NI200900131A (es) Compuesto de [1,2,3]-benzotriazinona-3-. sustituid
JP2013519728A5 (enExample)
GB2462235A (en) NMDA and MC receptor antagonists exhibiting neuroprotective and memory enhancing activities
TW200745135A (en) Therapeutic agents
JP2014500885A5 (enExample)
WO2006019886A3 (en) Pyrrolo(oxo)isoquinolines as 5ht ligands
RU2016132574A (ru) Органические соединения
JP2010523540A5 (enExample)
WO2009001356A3 (en) Acyl-urea derivatives and uses thereof
JP2008519056A5 (enExample)
CA2616177A1 (en) Imidazolylalkyl-pyridines for the treatment of a sleep disorder