|
US7807706B2
(en)
|
2005-08-12 |
2010-10-05 |
Astrazeneca Ab |
Metabotropic glutamate-receptor-potentiating isoindolones
|
|
AR059898A1
(es)
|
2006-03-15 |
2008-05-07 |
Janssen Pharmaceutica Nv |
Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
|
|
US20080139846A1
(en)
*
|
2006-09-01 |
2008-06-12 |
Astrazeneca Ab |
New Process 298
|
|
TW200845978A
(en)
|
2007-03-07 |
2008-12-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
|
|
TW200900065A
(en)
|
2007-03-07 |
2009-01-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
|
|
WO2008130853A1
(en)
*
|
2007-04-17 |
2008-10-30 |
Astrazeneca Ab |
Hydrazides and their use as metabotropic glutamate receptor potentiators - 681
|
|
JP2010525073A
(ja)
*
|
2007-04-23 |
2010-07-22 |
ハウス イアー インスティトゥート |
代謝型グルタミン酸受容体７の調節による老人性難聴の治療及び／又は予防
|
|
KR20100017372A
(ko)
|
2007-05-25 |
2010-02-16 |
애보트 게엠베하 운트 콤파니 카게 |
향대사성 글루타메이트 수용체 2（ｍｇｌｕ2 수용체）의 포지티브 조절자로서의 헤테로사이클릭 화합물
|
|
TW200911255A
(en)
*
|
2007-06-07 |
2009-03-16 |
Astrazeneca Ab |
Metabotropic glutamate receptor oxadiazole ligands and their use as potentiators-841
|
|
TWI417100B
(zh)
|
2007-06-07 |
2013-12-01 |
Astrazeneca Ab |
二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途
|
|
WO2009004430A1
(en)
*
|
2007-06-29 |
2009-01-08 |
Pfizer Inc. |
N-benzyl oxazolidinones and related heterocycleic compounds as potentiators of glutamate receptors
|
|
BRPI0816970A2
(pt)
|
2007-09-14 |
2015-03-24 |
Ortho Mcneil Janssen Pharm |
1,3-dissubstituídas-4-fenil-1h-piridin-2-onas
|
|
EA017648B1
(ru)
|
2007-09-14 |
2013-02-28 |
Орто-Макнейл-Янссен Фармасьютикалз, Инк. |
1',3'-двузамещенные-4-фенил-3,4,5,6-тетрагидро-2н,1'н-[1,4']бипириди-нил-2'-оны
|
|
SA109300358B1
(ar)
*
|
2008-06-06 |
2012-11-03 |
استرازينيكا ايه بي |
مقويات مستقبل جلوتامات ذي انتحاء أيضي من أيزو إندولون
|
|
GB0811643D0
(en)
|
2008-06-25 |
2008-07-30 |
Cancer Rec Tech Ltd |
New therapeutic agents
|
|
TW201006801A
(en)
|
2008-07-18 |
2010-02-16 |
Lilly Co Eli |
Imidazole carboxamides
|
|
JP5547194B2
(ja)
|
2008-09-02 |
2014-07-09 |
ジャンセン ファーマシューティカルズ， インコーポレイテッド． |
代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体
|
|
WO2010043396A1
(en)
|
2008-10-16 |
2010-04-22 |
Ortho-Mcneil-Janssen Pharmaceuticals, Inc. |
Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
|
|
JP5690277B2
(ja)
|
2008-11-28 |
2015-03-25 |
ジャンセン ファーマシューティカルズ， インコーポレイテッド． |
代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体
|
|
WO2010104195A1
(en)
*
|
2009-03-11 |
2010-09-16 |
Banyu Pharmaceutical Co.,Ltd. |
Novel isoindolin-1-one derivative
|
|
CN102439015B
(zh)
|
2009-05-12 |
2015-05-13 |
杨森制药有限公司 |
1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途
|
|
HRP20131122T1
(hr)
|
2009-05-12 |
2013-12-20 |
Janssen Pharmaceuticals, Inc. |
Derivati 1,2,4-triazolo[4,3-a] piridina i njihova uporaba u lijeäśenju ili prevenciji neuroloških i psihijatrijskih poremeä†aja
|
|
MY153913A
(en)
|
2009-05-12 |
2015-04-15 |
Janssen Pharmaceuticals Inc |
7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
|
|
US8415485B2
(en)
*
|
2009-10-09 |
2013-04-09 |
Celgene Corporation |
Processes for the preparation of 2-(1-phenylethyl)isoindolin-1-one compounds
|
|
US8507521B2
(en)
|
2009-11-02 |
2013-08-13 |
Merck Sharp + Dohme B.V. |
Heterocyclic derivatives
|
|
US20130203995A1
(en)
*
|
2010-01-07 |
2013-08-08 |
Astrazeneca Ab |
Process for Making a Metabotropic Glutamate Receptor Positive Allosteric Modulator - 874
|
|
US8314120B2
(en)
|
2010-03-30 |
2012-11-20 |
Abbott Gmbh & Co. Kg |
Small molecule potentiators of metabotropic glutamate receptors
|
|
US8664214B2
(en)
|
2010-03-30 |
2014-03-04 |
AbbVie Deutschland GmbH & Co. KG |
Small molecule potentiators of metabotropic glutamate receptors I
|
|
EP2661435B1
(en)
|
2010-11-08 |
2015-08-19 |
Janssen Pharmaceuticals, Inc. |
1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
|
|
JP5852664B2
(ja)
|
2010-11-08 |
2016-02-03 |
ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド |
１，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
|
|
ES2536433T3
(es)
|
2010-11-08 |
2015-05-25 |
Janssen Pharmaceuticals, Inc. |
Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
|
|
WO2013056015A1
(en)
|
2011-10-14 |
2013-04-18 |
Incyte Corporation |
Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors
|
|
US9586964B2
(en)
*
|
2011-10-28 |
2017-03-07 |
Vanderbilt University |
Substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1
|
|
JO3368B1
(ar)
|
2013-06-04 |
2019-03-13 |
Janssen Pharmaceutica Nv |
مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
|
|
JO3367B1
(ar)
|
2013-09-06 |
2019-03-13 |
Janssen Pharmaceutica Nv |
مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
|
|
ME03518B
(me)
|
2014-01-21 |
2020-04-20 |
Janssen Pharmaceutica Nv |
Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena
|
|
PL3096790T3
(pl)
|
2014-01-21 |
2020-01-31 |
Janssen Pharmaceutica, N.V. |
Kombinacje zawierające pozytywne modulatory allosteryczne lub agonistów ortosterycznych metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie
|
|
TWI713455B
(zh)
|
2014-06-25 |
2020-12-21 |
美商伊凡克特治療公司 |
ＭｎＫ抑制劑及其相關方法
|
|
GB201517216D0
(en)
|
2015-09-29 |
2015-11-11 |
Cancer Res Technology Ltd And Astex Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB201517217D0
(en)
|
2015-09-29 |
2015-11-11 |
Astex Therapeutics Ltd And Cancer Res Technology Ltd |
Pharmaceutical compounds
|
|
SG11201803242TA
(en)
|
2015-10-29 |
2018-05-30 |
Effector Therapeutics Inc |
Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of mnk1 and mnk2
|
|
CA3002558A1
(en)
|
2015-10-29 |
2017-05-04 |
Effector Therapeutics, Inc. |
Pyrrolo-, pyrazolo-, imidazo-pyrimidine and pyridine compounds that inhibit mnk1 and mnk2
|
|
WO2017087808A1
(en)
|
2015-11-20 |
2017-05-26 |
Effector Therapeutics, Inc. |
Heterocyclic compounds that inhibit the kinase activity of mnk useful for treating various cancers
|
|
CN105837557A
(zh)
*
|
2016-05-05 |
2016-08-10 |
青岛辰达生物科技有限公司 |
一种用于治疗ii型糖尿病的阿格列汀的制备方法
|
|
CN106279182B
(zh)
*
|
2016-07-29 |
2019-06-07 |
中国药科大学 |
一种吡咯并[2，1-a]异吲哚酮类化合物及其合成方法
|
|
DK3582776T3
(da)
|
2017-02-14 |
2024-01-08 |
Effector Therapeutics Inc |
Piperidinsubstituerede mnk-hæmmere og dertil relaterede fremgangsmåder
|
|
GB201704966D0
(en)
|
2017-03-28 |
2017-05-10 |
Astex Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB201704965D0
(en)
|
2017-03-28 |
2017-05-10 |
Astex Therapeutics Ltd |
Pharmaceutical compounds
|
|
EP3459939A1
(en)
*
|
2017-09-26 |
2019-03-27 |
Pragma Therapeutics |
Novel heterocyclic compounds as modulators of mglur7
|
|
EP3870178A4
(en)
|
2018-10-24 |
2022-08-03 |
Effector Therapeutics Inc. |
Crystalline forms of mnk inhibitors
|
|
WO2020102216A1
(en)
|
2018-11-13 |
2020-05-22 |
Incyte Corporation |
Substituted heterocyclic derivatives as pi3k inhibitors
|
|
US11161838B2
(en)
|
2018-11-13 |
2021-11-02 |
Incyte Corporation |
Heterocyclic derivatives as PI3K inhibitors
|
|
WO2020102198A1
(en)
|
2018-11-13 |
2020-05-22 |
Incyte Corporation |
Heterocyclic derivatives as pi3k inhibitors
|
|
US12637418B2
(en)
|
2019-01-24 |
2026-05-26 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compounds as antagonist of NMDA
|
|
CN110498759A
(zh)
*
|
2019-09-12 |
2019-11-26 |
天津瑞岭化工有限公司 |
异吲哚啉酮类化合物的合成方法
|
|
JP2021080177A
(ja)
|
2019-11-14 |
2021-05-27 |
武田薬品工業株式会社 |
複素環化合物及びその用途
|