JP2009509544A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009509544A5 JP2009509544A5 JP2008533689A JP2008533689A JP2009509544A5 JP 2009509544 A5 JP2009509544 A5 JP 2009509544A5 JP 2008533689 A JP2008533689 A JP 2008533689A JP 2008533689 A JP2008533689 A JP 2008533689A JP 2009509544 A5 JP2009509544 A5 JP 2009509544A5
- Authority
- JP
- Japan
- Prior art keywords
- promoter
- cell
- construct
- vector
- cis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 51
- 230000004927 fusion Effects 0.000 claims 39
- 230000001105 regulatory effect Effects 0.000 claims 38
- 239000003795 chemical substances by application Substances 0.000 claims 30
- 108091030071 RNAI Proteins 0.000 claims 29
- 230000009368 gene silencing by RNA Effects 0.000 claims 29
- 239000013598 vector Substances 0.000 claims 28
- 239000000203 mixture Substances 0.000 claims 26
- 230000014509 gene expression Effects 0.000 claims 25
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 24
- 108090000623 proteins and genes Proteins 0.000 claims 21
- 101710135281 DNA polymerase III PolC-type Proteins 0.000 claims 20
- 230000033228 biological regulation Effects 0.000 claims 17
- 230000000694 effects Effects 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 150000007523 nucleic acids Chemical class 0.000 claims 14
- 102000014450 RNA Polymerase III Human genes 0.000 claims 11
- 108010078067 RNA Polymerase III Proteins 0.000 claims 11
- 241001465754 Metazoa Species 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108091027967 Small hairpin RNA Proteins 0.000 claims 8
- 108020004459 Small interfering RNA Proteins 0.000 claims 8
- 230000005764 inhibitory process Effects 0.000 claims 8
- 239000004055 small Interfering RNA Substances 0.000 claims 8
- 230000001225 therapeutic effect Effects 0.000 claims 6
- 108091026890 Coding region Proteins 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000013612 plasmid Substances 0.000 claims 5
- 239000013603 viral vector Substances 0.000 claims 5
- 230000002068 genetic effect Effects 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 210000004102 animal cell Anatomy 0.000 claims 2
- 230000009286 beneficial effect Effects 0.000 claims 2
- 230000000052 comparative effect Effects 0.000 claims 2
- 229940011871 estrogen Drugs 0.000 claims 2
- 239000000262 estrogen Substances 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 230000009261 transgenic effect Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000022131 cell cycle Effects 0.000 claims 1
- 239000013626 chemical specie Substances 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 239000007972 injectable composition Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000013641 positive control Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 230000006335 response to radiation Effects 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72256805P | 2005-10-01 | 2005-10-01 | |
| US60/722,568 | 2005-10-01 | ||
| PCT/US2006/038154 WO2007041350A2 (en) | 2005-10-01 | 2006-09-29 | Regulatable fusion promoters |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012219504A Division JP2012254098A (ja) | 2005-10-01 | 2012-10-01 | 調節可能な融合プロモーター |
| JP2015175115A Division JP6199934B2 (ja) | 2005-10-01 | 2015-09-04 | 調節可能な融合プロモーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009509544A JP2009509544A (ja) | 2009-03-12 |
| JP2009509544A5 true JP2009509544A5 (https=) | 2010-11-18 |
| JP5976986B2 JP5976986B2 (ja) | 2016-08-24 |
Family
ID=37906746
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008533689A Expired - Fee Related JP5976986B2 (ja) | 2005-10-01 | 2006-09-29 | 調節可能な融合プロモーター |
| JP2012219504A Pending JP2012254098A (ja) | 2005-10-01 | 2012-10-01 | 調節可能な融合プロモーター |
| JP2015175115A Expired - Fee Related JP6199934B2 (ja) | 2005-10-01 | 2015-09-04 | 調節可能な融合プロモーター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012219504A Pending JP2012254098A (ja) | 2005-10-01 | 2012-10-01 | 調節可能な融合プロモーター |
| JP2015175115A Expired - Fee Related JP6199934B2 (ja) | 2005-10-01 | 2015-09-04 | 調節可能な融合プロモーター |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090053295A1 (https=) |
| EP (2) | EP2386564B1 (https=) |
| JP (3) | JP5976986B2 (https=) |
| AU (1) | AU2006297112B2 (https=) |
| CA (1) | CA2665080C (https=) |
| WO (1) | WO2007041350A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070299029A1 (en) * | 2005-06-09 | 2007-12-27 | Agency For Science, Technology And Research | Hepatic stellate cell specific promoter and uses thereof |
| WO2006132606A1 (en) * | 2005-06-09 | 2006-12-14 | Agency For Science, Technology And Research | Hepatic stellate cell specific promoter and uses thereof |
| DK2341943T3 (en) * | 2008-09-22 | 2019-02-25 | Dicerna Pharmaceuticals Inc | COMPOSITIONS AND METHODS OF SPECIFIC INHIBITION OF DSRNA REPRINT WITH MODIFICATIONS |
| US8829173B2 (en) | 2008-09-26 | 2014-09-09 | Tocagen Inc. | Recombinant vectors |
| CN102227503B (zh) * | 2008-09-26 | 2015-10-21 | 托卡根公司 | 重组载体 |
| KR101728655B1 (ko) * | 2008-12-18 | 2017-04-19 | 다이서나 파마수이티컬, 인크. | 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법 |
| ES2786051T3 (es) | 2012-10-25 | 2020-10-08 | Tocagen Inc | Vector retroviral con casete de mini-promotor |
| JP2018526007A (ja) | 2015-09-04 | 2018-09-13 | トカジェン インコーポレーテッド | ２ａペプチドを含む組換えベクター |
| US12269863B2 (en) | 2018-05-23 | 2025-04-08 | Manysmart Therapeutics, Inc. | Bispecific T cell engager and uses thereof |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5573933A (en) | 1987-04-14 | 1996-11-12 | Luminis Pty, Ltd. | Transgenic pigs |
| US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| WO1992011033A1 (en) * | 1990-12-20 | 1992-07-09 | Arch Development Corporation | Control of gene expression by ionizing radiation |
| US5922854A (en) | 1991-06-14 | 1999-07-13 | Kumar; Ramesh | Purifying Human Hemogloblin from transgenic pig red cells and plasmids containing pig globin nucleic acids |
| JPH07507921A (ja) | 1992-06-12 | 1995-09-07 | ディーエヌエックス コーポレーション | トランスジェニックブタにおけるヒトヘモグロビンの生産 |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| FR2738842B1 (fr) * | 1995-09-15 | 1997-10-31 | Rhone Poulenc Rorer Sa | Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique |
| US5874304A (en) * | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| US6818209B1 (en) * | 1998-05-22 | 2004-11-16 | Oxford Biomedica (Uk) Limited | Retroviral delivery system |
| US6924123B2 (en) | 1996-10-29 | 2005-08-02 | Oxford Biomedica (Uk) Limited | Lentiviral LTR-deleted vector |
| DE19751587A1 (de) * | 1997-11-21 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Onkogen- oder virusgesteuerte Expressionssysteme |
| DE19756975A1 (de) * | 1997-12-20 | 1999-06-24 | Hoechst Marion Roussel De Gmbh | Bindungspartner für Inhibitoren von cyclinabhängigen Kinasen und ihre Verwendung zur Suche nach Inhibitoren, zur Diagnose oder zur Therapie einer Erkrankung |
| AU762615B2 (en) * | 1998-06-15 | 2003-07-03 | Arch Development Corporation | Combination of radiotherapy and anti-angiogenic factors |
| DE19831420A1 (de) * | 1998-07-14 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Expressionssysteme enthaltend chimäre Promotoren mit Bindungsstellen für rekombinante Transkriptionsfaktoren |
| WO2000055378A1 (en) * | 1999-03-16 | 2000-09-21 | Dana-Farber Cancer Institute, Inc. | Lentiviral vector system for high quantity screening |
| WO2000072886A1 (en) | 1999-05-26 | 2000-12-07 | Dana-Farber Cancer Institute, Inc. | Episomally replicating lentiviral vectors |
| JP3704037B2 (ja) * | 1999-11-05 | 2005-10-05 | 独立行政法人産業技術総合研究所 | スライディング可能な機能性キメラ分子 |
| US6579522B1 (en) * | 2000-06-27 | 2003-06-17 | Genvec, Inc. | Replication deficient adenoviral TNF vector |
| JP3613576B2 (ja) * | 2000-10-30 | 2005-01-26 | 独立行政法人産業技術総合研究所 | 細胞内で高機能な核酸分子の選択方法 |
| JP2005504520A (ja) * | 2001-06-13 | 2005-02-17 | イースタン ヴァージニア メディカル スクール | 治療用核酸の標的化発現の方法 |
| JP4745563B2 (ja) * | 2001-09-11 | 2011-08-10 | 一般財団法人 化学物質評価研究機構 | レポータープラスミド |
| GB0130955D0 (en) * | 2001-12-24 | 2002-02-13 | Cancer Res Ventures | Expression system |
| US6863884B2 (en) | 2002-05-01 | 2005-03-08 | Cell Genesys, Inc. | Pseudotyped retroviral vectors |
| US20050196862A1 (en) * | 2002-08-30 | 2005-09-08 | Wooddell Christine I. | DNA cassette for cellular expression of small RNA |
| US6799657B2 (en) * | 2002-10-02 | 2004-10-05 | Carrier Corporation | Absorptive/reactive muffler for variable speed compressors |
| AU2003297474A1 (en) * | 2002-12-18 | 2004-07-14 | Salk Institute For Biological Studies | Methods of inhibiting gene expression by rna interference |
| EP2314687B1 (en) * | 2003-01-17 | 2017-12-27 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inducible small interfering rna (sirna) expression constructs for targeted gene silencing |
| US20050013018A1 (en) | 2003-07-16 | 2005-01-20 | Alex Ning | Compact lens assembly |
| WO2005007875A2 (en) * | 2003-07-18 | 2005-01-27 | University Of Massachusetts | Enhanced promoters for synthesis of small hairpin rna |
| WO2005007877A2 (en) * | 2003-07-18 | 2005-01-27 | University Of Massachusetts | Regulatable promoters for synthesis of small hairpin rna |
| WO2005021733A2 (en) * | 2003-09-02 | 2005-03-10 | The Scripps Research Institute | Methods and compositions for sirna expression |
| US20050166272A1 (en) * | 2003-12-09 | 2005-07-28 | National Institute Of Advanced Industrial Science And Technology | Enhancement of RNAi activity through mutation |
| JP4753130B2 (ja) * | 2003-12-12 | 2011-08-24 | 独立行政法人産業技術総合研究所 | インターフェロン応答が軽減された長い干渉用二重鎖ｒｎａ |
| JPWO2005068630A1 (ja) * | 2003-12-16 | 2007-07-26 | 独立行政法人産業技術総合研究所 | 干渉用二重鎖ｒｎａ |
| US20050164210A1 (en) * | 2004-01-23 | 2005-07-28 | Vivek Mittal | Regulated polymerase III expression systems and related methods |
| US20050203047A1 (en) * | 2004-03-10 | 2005-09-15 | Ulrich Thomann | Delivery vectors for short interfering RNA, micro-RNA and antisense RNA |
| WO2005112620A2 (en) * | 2004-05-18 | 2005-12-01 | Massachusetts Institute Of Technology | A cre-lox based method for conditional rna interference |
| US8008468B2 (en) * | 2005-02-16 | 2011-08-30 | Benitec, Inc. | RNAi expression constructs with liver-specific enhancer/promoter |
-
2006
- 2006-09-29 AU AU2006297112A patent/AU2006297112B2/en not_active Ceased
- 2006-09-29 WO PCT/US2006/038154 patent/WO2007041350A2/en not_active Ceased
- 2006-09-29 EP EP11160708.1A patent/EP2386564B1/en not_active Not-in-force
- 2006-09-29 EP EP06815854A patent/EP1943265B1/en not_active Not-in-force
- 2006-09-29 US US12/088,921 patent/US20090053295A1/en not_active Abandoned
- 2006-09-29 JP JP2008533689A patent/JP5976986B2/ja not_active Expired - Fee Related
- 2006-09-29 CA CA2665080A patent/CA2665080C/en not_active Expired - Fee Related
-
2012
- 2012-10-01 JP JP2012219504A patent/JP2012254098A/ja active Pending
-
2015
- 2015-09-04 JP JP2015175115A patent/JP6199934B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Meloni et al. | Local inhibition of microRNA-24 improves reparative angiogenesis and left ventricle remodeling and function in mice with myocardial infarction | |
| Li et al. | MicroRNA-214 suppresses gluconeogenesis by targeting activating transcriptional factor 4 | |
| ES2739804T3 (es) | Compuestos terapéuticos | |
| KR101706259B1 (ko) | 섬유증을 조절하는 마이크로-ｒｎａ 집단 및 이의 용도 | |
| Sakakibara et al. | Six homeoproteins and a linc-RNA at the fast MYH locus lock fast myofiber terminal phenotype | |
| KR20100057022A (ko) | 마이오신 발현 및 근섬유 동일성을 제어하는 마이크로-ｒｎａｓ | |
| KR20100099158A (ko) | 심근세포 생존과 심장 회복을 제어하는 ＭＩＲ-15 집단의 마이크로ＲＮＡｓ | |
| KR20090037968A (ko) | 베타-마이오신 중사슬의 발현을 활성화하는 마이크로-ｒｎａ의 동정 | |
| Ali et al. | miR-1 mediated suppression of Sorcin regulates myocardial contractility through modulation of Ca2+ signaling | |
| JP2012029693A5 (https=) | ||
| Van Gestel et al. | shRNA-induced saturation of the microRNA pathway in the rat brain | |
| Yang et al. | Cardiac hypertrophy and dysfunction induced by overexpression of miR-214 in vivo | |
| Deng et al. | Transgenic overexpression of miR-133a in skeletal muscle | |
| CN111218451B (zh) | 一种提高猪肌肉量的方法 | |
| Yang et al. | miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy | |
| JP2009509544A5 (https=) | ||
| Zhang et al. | Molecular mechanism for hypertensive renal disease: Differential regulation of chromogranin a expression at 3′-untranslated region polymorphism C+ 87T by MicroRNA-107 | |
| Teng et al. | Cardiac fibroblast miR‐27a may function as an endogenous anti‐fibrotic by negatively regulating Early Growth Response Protein 3 (EGR3) | |
| Lin et al. | RNA-based antipsoriatic gene therapy: an updated review focusing on evidence from animal models | |
| Tu et al. | In vitro and in vivo direct monitoring of miRNA-22 expression in isoproterenol-induced cardiac hypertrophy by bioluminescence imaging | |
| Yue et al. | A Binary siRNA‐Loaded Tetrahedral DNA Nanobox for Synergetic Anti‐Aging Therapy | |
| Ni et al. | Aberrant expression of miR-127, miR-21 and miR-16 in placentas of deceased cloned sheep | |
| CN103589730A (zh) | 一种抑制IRS1基因表达的shRNA及应用 | |
| CN112386698A (zh) | Nogo-B抑制剂在制备治疗糖脂代谢紊乱药物中的应用和治疗糖脂代谢紊乱的药物 | |
| JP2011055755A (ja) | Ｍｘｄ３遺伝子の発現阻害による肥満の抑制 |