JP2009509544A5 - - Google Patents
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- Publication number
- JP2009509544A5 JP2009509544A5 JP2008533689A JP2008533689A JP2009509544A5 JP 2009509544 A5 JP2009509544 A5 JP 2009509544A5 JP 2008533689 A JP2008533689 A JP 2008533689A JP 2008533689 A JP2008533689 A JP 2008533689A JP 2009509544 A5 JP2009509544 A5 JP 2009509544A5
- Authority
- JP
- Japan
- Prior art keywords
- promoter
- cell
- construct
- vector
- cis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 51
- 230000004927 fusion Effects 0.000 claims 39
- 230000001105 regulatory effect Effects 0.000 claims 38
- 239000003795 chemical substances by application Substances 0.000 claims 30
- 108091030071 RNAI Proteins 0.000 claims 29
- 230000009368 gene silencing by RNA Effects 0.000 claims 29
- 239000013598 vector Substances 0.000 claims 28
- 239000000203 mixture Substances 0.000 claims 26
- 230000014509 gene expression Effects 0.000 claims 25
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 24
- 108090000623 proteins and genes Proteins 0.000 claims 21
- 101710135281 DNA polymerase III PolC-type Proteins 0.000 claims 20
- 230000033228 biological regulation Effects 0.000 claims 17
- 230000000694 effects Effects 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 150000007523 nucleic acids Chemical class 0.000 claims 14
- 102000014450 RNA Polymerase III Human genes 0.000 claims 11
- 108010078067 RNA Polymerase III Proteins 0.000 claims 11
- 241001465754 Metazoa Species 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108091027967 Small hairpin RNA Proteins 0.000 claims 8
- 108020004459 Small interfering RNA Proteins 0.000 claims 8
- 230000005764 inhibitory process Effects 0.000 claims 8
- 239000004055 small Interfering RNA Substances 0.000 claims 8
- 230000001225 therapeutic effect Effects 0.000 claims 6
- 108091026890 Coding region Proteins 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000013612 plasmid Substances 0.000 claims 5
- 239000013603 viral vector Substances 0.000 claims 5
- 230000002068 genetic effect Effects 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 210000004102 animal cell Anatomy 0.000 claims 2
- 230000009286 beneficial effect Effects 0.000 claims 2
- 230000000052 comparative effect Effects 0.000 claims 2
- 229940011871 estrogen Drugs 0.000 claims 2
- 239000000262 estrogen Substances 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 230000009261 transgenic effect Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000022131 cell cycle Effects 0.000 claims 1
- 239000013626 chemical specie Substances 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 239000007972 injectable composition Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000013641 positive control Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 230000006335 response to radiation Effects 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72256805P | 2005-10-01 | 2005-10-01 | |
| US60/722,568 | 2005-10-01 | ||
| PCT/US2006/038154 WO2007041350A2 (en) | 2005-10-01 | 2006-09-29 | Regulatable fusion promoters |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012219504A Division JP2012254098A (ja) | 2005-10-01 | 2012-10-01 | 調節可能な融合プロモーター |
| JP2015175115A Division JP6199934B2 (ja) | 2005-10-01 | 2015-09-04 | 調節可能な融合プロモーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009509544A JP2009509544A (ja) | 2009-03-12 |
| JP2009509544A5 true JP2009509544A5 (enExample) | 2010-11-18 |
| JP5976986B2 JP5976986B2 (ja) | 2016-08-24 |
Family
ID=37906746
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008533689A Expired - Fee Related JP5976986B2 (ja) | 2005-10-01 | 2006-09-29 | 調節可能な融合プロモーター |
| JP2012219504A Pending JP2012254098A (ja) | 2005-10-01 | 2012-10-01 | 調節可能な融合プロモーター |
| JP2015175115A Expired - Fee Related JP6199934B2 (ja) | 2005-10-01 | 2015-09-04 | 調節可能な融合プロモーター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012219504A Pending JP2012254098A (ja) | 2005-10-01 | 2012-10-01 | 調節可能な融合プロモーター |
| JP2015175115A Expired - Fee Related JP6199934B2 (ja) | 2005-10-01 | 2015-09-04 | 調節可能な融合プロモーター |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090053295A1 (enExample) |
| EP (2) | EP2386564B1 (enExample) |
| JP (3) | JP5976986B2 (enExample) |
| AU (1) | AU2006297112B2 (enExample) |
| CA (1) | CA2665080C (enExample) |
| WO (1) | WO2007041350A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070299029A1 (en) * | 2005-06-09 | 2007-12-27 | Agency For Science, Technology And Research | Hepatic stellate cell specific promoter and uses thereof |
| US7863251B2 (en) * | 2005-06-09 | 2011-01-04 | Agency For Science, Technology And Research | Hepatic stellate cell specific promoter and uses thereof |
| WO2010033225A2 (en) * | 2008-09-22 | 2010-03-25 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for the specific inhibition of gene expression by dsrna possessing modifications |
| DK2346995T3 (en) * | 2008-09-26 | 2019-02-11 | Tocagen Inc | GENETERIVE VECTORS AND CYTOSINDEAMINASES |
| US8829173B2 (en) | 2008-09-26 | 2014-09-09 | Tocagen Inc. | Recombinant vectors |
| KR20110110776A (ko) * | 2008-12-18 | 2011-10-07 | 다이서나 파마수이티컬, 인크. | 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법 |
| EP2909324B1 (en) | 2012-10-25 | 2020-02-26 | Tocagen Inc. | Retroviral vector with mini-promoter cassette |
| AU2016317936A1 (en) | 2015-09-04 | 2018-03-08 | Tocagen Inc. | Recombinant vectors comprising 2A peptide |
| CN112512573B (zh) * | 2018-05-23 | 2026-02-27 | 百提威生技股份有限公司 | 双特异性t细胞衔接蛋白及其用途 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5573933A (en) * | 1987-04-14 | 1996-11-12 | Luminis Pty, Ltd. | Transgenic pigs |
| US5166320A (en) * | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| ATE190354T1 (de) * | 1990-12-20 | 2000-03-15 | Arch Dev Corp The University O | Kontrolle der genexpression durch ionisierende strahlung |
| US5922854A (en) | 1991-06-14 | 1999-07-13 | Kumar; Ramesh | Purifying Human Hemogloblin from transgenic pig red cells and plasmids containing pig globin nucleic acids |
| FI945829A7 (fi) | 1992-06-12 | 1995-02-10 | Dnx Corp | Ihmisen hemoglobiinin valmistaminen transgeenisissa sioissa |
| US5523226A (en) * | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| FR2738842B1 (fr) * | 1995-09-15 | 1997-10-31 | Rhone Poulenc Rorer Sa | Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique |
| US5874304A (en) * | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| US6818209B1 (en) * | 1998-05-22 | 2004-11-16 | Oxford Biomedica (Uk) Limited | Retroviral delivery system |
| US6924123B2 (en) * | 1996-10-29 | 2005-08-02 | Oxford Biomedica (Uk) Limited | Lentiviral LTR-deleted vector |
| DE19751587A1 (de) * | 1997-11-21 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Onkogen- oder virusgesteuerte Expressionssysteme |
| DE19756975A1 (de) * | 1997-12-20 | 1999-06-24 | Hoechst Marion Roussel De Gmbh | Bindungspartner für Inhibitoren von cyclinabhängigen Kinasen und ihre Verwendung zur Suche nach Inhibitoren, zur Diagnose oder zur Therapie einer Erkrankung |
| JP2002518341A (ja) * | 1998-06-15 | 2002-06-25 | アーチ・デヴェロップメント・コーポレイション | 放射線療法と抗血管形成因子の組み合わせ |
| DE19831420A1 (de) * | 1998-07-14 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Expressionssysteme enthaltend chimäre Promotoren mit Bindungsstellen für rekombinante Transkriptionsfaktoren |
| AU3893000A (en) * | 1999-03-16 | 2000-10-04 | Dana-Farber Cancer Institute, Inc. | Lentiviral vector system for high quantity screening |
| WO2000072886A1 (en) * | 1999-05-26 | 2000-12-07 | Dana-Farber Cancer Institute, Inc. | Episomally replicating lentiviral vectors |
| JP3704037B2 (ja) * | 1999-11-05 | 2005-10-05 | 独立行政法人産業技術総合研究所 | スライディング可能な機能性キメラ分子 |
| US6579522B1 (en) * | 2000-06-27 | 2003-06-17 | Genvec, Inc. | Replication deficient adenoviral TNF vector |
| JP3613576B2 (ja) * | 2000-10-30 | 2005-01-26 | 独立行政法人産業技術総合研究所 | 細胞内で高機能な核酸分子の選択方法 |
| CA2460095A1 (en) * | 2001-06-13 | 2003-12-19 | Eastern Virginia Medical School | Methods for targeted expression of therapeutic nucleic acid |
| JP4745563B2 (ja) * | 2001-09-11 | 2011-08-10 | 一般財団法人 化学物質評価研究機構 | レポータープラスミド |
| GB0130955D0 (en) * | 2001-12-24 | 2002-02-13 | Cancer Res Ventures | Expression system |
| US6863884B2 (en) | 2002-05-01 | 2005-03-08 | Cell Genesys, Inc. | Pseudotyped retroviral vectors |
| US20050196862A1 (en) * | 2002-08-30 | 2005-09-08 | Wooddell Christine I. | DNA cassette for cellular expression of small RNA |
| US6799657B2 (en) | 2002-10-02 | 2004-10-05 | Carrier Corporation | Absorptive/reactive muffler for variable speed compressors |
| WO2004056966A2 (en) * | 2002-12-18 | 2004-07-08 | Salk Institute For Biological Studies | Methods of inhibiting gene expression by rna interference |
| EP1583832B1 (en) * | 2003-01-17 | 2010-12-01 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inducible small interfering rna (sirna) expression constructs for targeted gene silencing |
| US20050013018A1 (en) | 2003-07-16 | 2005-01-20 | Alex Ning | Compact lens assembly |
| US20050130919A1 (en) * | 2003-07-18 | 2005-06-16 | University Of Massachusetts | Regulatable promoters for synthesis of small hairpin RNA |
| WO2005007875A2 (en) * | 2003-07-18 | 2005-01-27 | University Of Massachusetts | Enhanced promoters for synthesis of small hairpin rna |
| WO2005021733A2 (en) * | 2003-09-02 | 2005-03-10 | The Scripps Research Institute | Methods and compositions for sirna expression |
| US20050166272A1 (en) * | 2003-12-09 | 2005-07-28 | National Institute Of Advanced Industrial Science And Technology | Enhancement of RNAi activity through mutation |
| JP4753130B2 (ja) * | 2003-12-12 | 2011-08-24 | 独立行政法人産業技術総合研究所 | インターフェロン応答が軽減された長い干渉用二重鎖ｒｎａ |
| JPWO2005068630A1 (ja) * | 2003-12-16 | 2007-07-26 | 独立行政法人産業技術総合研究所 | 干渉用二重鎖ｒｎａ |
| US20050164210A1 (en) * | 2004-01-23 | 2005-07-28 | Vivek Mittal | Regulated polymerase III expression systems and related methods |
| US20050203047A1 (en) * | 2004-03-10 | 2005-09-15 | Ulrich Thomann | Delivery vectors for short interfering RNA, micro-RNA and antisense RNA |
| WO2005112620A2 (en) * | 2004-05-18 | 2005-12-01 | Massachusetts Institute Of Technology | A cre-lox based method for conditional rna interference |
| US8008468B2 (en) * | 2005-02-16 | 2011-08-30 | Benitec, Inc. | RNAi expression constructs with liver-specific enhancer/promoter |
-
2006
- 2006-09-29 WO PCT/US2006/038154 patent/WO2007041350A2/en not_active Ceased
- 2006-09-29 JP JP2008533689A patent/JP5976986B2/ja not_active Expired - Fee Related
- 2006-09-29 EP EP11160708.1A patent/EP2386564B1/en not_active Not-in-force
- 2006-09-29 EP EP06815854A patent/EP1943265B1/en not_active Not-in-force
- 2006-09-29 US US12/088,921 patent/US20090053295A1/en not_active Abandoned
- 2006-09-29 CA CA2665080A patent/CA2665080C/en not_active Expired - Fee Related
- 2006-09-29 AU AU2006297112A patent/AU2006297112B2/en not_active Ceased
-
2012
- 2012-10-01 JP JP2012219504A patent/JP2012254098A/ja active Pending
-
2015
- 2015-09-04 JP JP2015175115A patent/JP6199934B2/ja not_active Expired - Fee Related
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