JP2009508902A5 - - Google Patents
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- Publication number
- JP2009508902A5 JP2009508902A5 JP2008531609A JP2008531609A JP2009508902A5 JP 2009508902 A5 JP2009508902 A5 JP 2009508902A5 JP 2008531609 A JP2008531609 A JP 2008531609A JP 2008531609 A JP2008531609 A JP 2008531609A JP 2009508902 A5 JP2009508902 A5 JP 2009508902A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- compound
- iif
- iie
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 238000004519 manufacturing process Methods 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010069351 acute lung injury Diseases 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 239000002537 cosmetic Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000034486 Multi-organ failure Diseases 0.000 claims 1
- 208000010718 Multiple Organ Failure Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010044541 Traumatic shock Diseases 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 230000002612 cardiopulmonary effect Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003596 drug target Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05020508A EP1764095A1 (en) | 2005-09-20 | 2005-09-20 | Novel nitrocatechol derivatives having selectin ligand activity |
| PCT/EP2006/009155 WO2007039114A1 (en) | 2005-09-20 | 2006-09-20 | Novel nitrocatechol derivatives having selectin ligand activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009508902A JP2009508902A (ja) | 2009-03-05 |
| JP2009508902A5 true JP2009508902A5 (https=) | 2009-11-12 |
Family
ID=35892515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008531609A Pending JP2009508902A (ja) | 2005-09-20 | 2006-09-20 | セレクチンリガンド活性を有する新規なニトロカテコール誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7851501B2 (https=) |
| EP (2) | EP1764095A1 (https=) |
| JP (1) | JP2009508902A (https=) |
| CN (2) | CN103230389A (https=) |
| AU (1) | AU2006299184B8 (https=) |
| BR (1) | BRPI0616391A2 (https=) |
| CA (1) | CA2622935A1 (https=) |
| IL (1) | IL190157A0 (https=) |
| RU (1) | RU2428979C2 (https=) |
| WO (1) | WO2007039114A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6838452B2 (en) * | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
| EP1577289A1 (en) * | 2004-03-18 | 2005-09-21 | Revotar Biopharmaceuticals AG | Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders |
| EP1764096A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel phloroglucinol derivatives having selectin ligand activity |
| EP1764094A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel multi-cyclic compounds and their use |
| EP1764093A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel aromatic compounds and their use in medical applications |
| EP1764095A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
| KR20090077813A (ko) * | 2006-09-29 | 2009-07-15 | 아이데닉스 파마슈티칼스, 인코포레이티드 | Ｈｉｖ 억제제로서의 거울상이성질체적으로 순수한 포스포인돌 |
| DE102007018151A1 (de) * | 2007-04-16 | 2008-10-23 | Günenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
| GEP20125379B (en) | 2007-05-03 | 2012-01-10 | Pfizer Ltd | 2 -pyridine carboxamide derivatives as sodium channel modulators |
| JP5241834B2 (ja) * | 2007-07-19 | 2013-07-17 | メルク・シャープ・アンド・ドーム・コーポレーション | プロテインキナーゼ阻害剤としての複素環アミド化合物 |
| TWI529165B (zh) * | 2008-08-29 | 2016-04-11 | Suntory Holdings Ltd | Novel epigallocatechin gallate 3-mer, and the use of alpha-glucosidase inhibitors containing epigallocatechin gallate polymers |
| MY155497A (en) * | 2008-11-19 | 2015-10-30 | Merial Inc | Compositions comprising an aryl pyrazole and/or a formamidine, methods and use thereof |
| TWI432188B (zh) * | 2008-12-19 | 2014-04-01 | Merz Pharma Gmbh & Co Kgaa | 供治療發炎性皮膚疾病之１－胺基－烷基環己烷衍生物類 |
| MX2011006353A (es) | 2008-12-19 | 2011-07-13 | Merz Pharma Gmbh & Co Kgaa | Derivados de 1-amino-alquilciclohexano para el tratamiento de enfermedades mediadas por mastocitos. |
| EP2371826A4 (en) * | 2008-12-29 | 2012-06-27 | Takeda Pharmaceutical | NEW CONNECTION WITH CONDENSED RINGS AND ITS USE |
| US8366791B1 (en) | 2011-09-02 | 2013-02-05 | Warner Babcock Institute | Formulation and method for hair dyeing |
| US8569372B2 (en) * | 2011-09-27 | 2013-10-29 | Hsiao-Ming Chao | Method for preventing or treating a disease, disorder or condition induced by retina ischemia |
| US8828100B1 (en) | 2013-10-14 | 2014-09-09 | John C. Warner | Formulation and processes for hair coloring |
| AU2016209255B2 (en) * | 2015-01-22 | 2021-07-01 | Mitochon Pharmaceuticals, Inc. | Induced expression of brain derived neurotrophic factor (BDNF) for treatment of neuromuscular, neurodegenerative, autoimmune, developmental and/or metabolic diseases |
| CA3109798A1 (en) | 2018-08-17 | 2020-02-20 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of acute lung injury |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4363813A (en) | 1979-07-09 | 1982-12-14 | Kureha Kagaku Kogyo Kabushiki Kaisha | 2-(3,4,5-Trimethoxyphenyl)-4,5-disubstituted thiazoles |
| JPS58156932A (ja) * | 1982-03-11 | 1983-09-19 | Fuji Photo Film Co Ltd | ハロゲン化銀カラ−写真感光材料 |
| US4757084A (en) | 1984-02-29 | 1988-07-12 | Merck & Co., Inc. | 2,5-diaryl tetrahydrothiophenes and analogs thereof as PAF-antagonists |
| GB2238047B (en) | 1989-11-03 | 1993-02-10 | Orion Yhtymae Oy | Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation |
| EP0465122A1 (en) | 1990-06-29 | 1992-01-08 | Merck & Co. Inc. | Process of making 2,5-diaryl tetrahydrofurans and analogs thereof useful as paf antagonists |
| US5374772A (en) | 1992-12-08 | 1994-12-20 | Hoffmann-Laroche Inc. | Substituted benzoic acids, inhibitors of phospholipases A2 |
| US5444050A (en) | 1994-04-29 | 1995-08-22 | Texas Biotechnology Corporation | Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa |
| AU704596B2 (en) * | 1995-06-29 | 1999-04-29 | Texas Biotechnology Corporation | Di- and trivalent small molecule selectin inhibitors |
| EP0836610A1 (en) | 1995-06-29 | 1998-04-22 | Novartis AG | Diglycosylated 1,2-diols as mimetics of sialyl-lewis x and sialyl-lewis a |
| DE19532902A1 (de) * | 1995-09-06 | 1997-03-13 | Hoechst Ag | Neuartige Glycomimetika als Selektin-Antagonisten und daraus hergestellte entzündungshemmend wirkende Arzneimittel |
| EP0883574B1 (en) * | 1996-03-01 | 2004-01-02 | Dionex Corporation | Anion-exchange resins with at least two different nitrogen containing ion-exchange groups |
| FR2761066B1 (fr) * | 1997-03-24 | 2000-11-24 | Sod Conseils Rech Applic | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
| WO1999029706A2 (en) | 1997-12-08 | 1999-06-17 | Glycomed Incorporated | DISALICYLATE ANALOG BASED SIALYL LEWISx MIMETICS |
| AU1804299A (en) | 1997-12-08 | 1999-06-28 | Glycomed Incorporated | Sialyl lewis x and sialyl lewis a glycomimetics |
| AU2164300A (en) | 1998-12-04 | 2000-06-26 | N.V. Organon | Substituted thiazoles for treatment of human diseases involving modulators of p-, l- and e- selectin |
| GB2344819A (en) * | 1998-12-18 | 2000-06-21 | Portela & Ca Sa | 2-Phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones |
| US6248790B1 (en) | 2000-06-29 | 2001-06-19 | Parker Hughes Institute | Treatment of inflammation with 2,4,6-trihydroxy-alpha-rho-methoxyphenylacetophenone, or its pharmaceutically acceptable derivatives |
| US6432957B1 (en) | 2001-06-29 | 2002-08-13 | Kowa Co., Ltd. | Piperazine derivative |
| US20030073712A1 (en) | 2001-07-23 | 2003-04-17 | Bing Wang | Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods |
| JP2003055369A (ja) | 2001-08-06 | 2003-02-26 | Univ Nihon | 新規なフロログルシノール誘導体、及びこれを用いた組成物、抗アレルギー剤 |
| AU2002246135A1 (en) | 2002-03-14 | 2003-09-22 | Bobel 246, S.L. | Use of derivatives of 2,4-disubstituted phenols as inhibitors of the expression of l-selectins and of the isoform that is inducible from nitric oxide synthase |
| WO2003080551A1 (en) | 2002-03-27 | 2003-10-02 | Council Of Scientific And Industrial Research | Formation of neolignan by ddq mediated dimerisation of dihydroasarone |
| JP5183010B2 (ja) | 2002-05-16 | 2013-04-17 | グリコミメティクス， インコーポレイテッド | セレクチンによって媒介される機能を阻害するための化合物および方法 |
| ES2299749T3 (es) | 2002-08-09 | 2008-06-01 | Astellas Pharma Europe B.V. | Compuestos que se unen a p-selectina. |
| WO2004056774A2 (en) * | 2002-12-19 | 2004-07-08 | Neurogen Corporation | Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators |
| JPWO2004112837A1 (ja) * | 2003-05-23 | 2006-07-20 | 久光製薬株式会社 | 非ステロイド系消炎鎮痛剤含有外用経皮製剤およびインターロイキン−１α生成抑制剤 |
| EP1481669A1 (en) * | 2003-05-30 | 2004-12-01 | Yamanouchi Pharmaceutical Co. Ltd. | Use of polyhydroxy phenols and polyphenols for modulating p-selectin activity |
| WO2005051920A2 (en) * | 2003-11-19 | 2005-06-09 | Glycomimetics, Inc. | Specific antagonist for both e- and p-selectins |
| EP1577289A1 (en) * | 2004-03-18 | 2005-09-21 | Revotar Biopharmaceuticals AG | Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders |
| EP1764093A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel aromatic compounds and their use in medical applications |
| EP1764094A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel multi-cyclic compounds and their use |
| EP1764095A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
| EP1764096A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel phloroglucinol derivatives having selectin ligand activity |
-
2005
- 2005-09-20 EP EP05020508A patent/EP1764095A1/en not_active Withdrawn
-
2006
- 2006-09-20 BR BRPI0616391-2A patent/BRPI0616391A2/pt not_active IP Right Cessation
- 2006-09-20 CN CN2013100951106A patent/CN103230389A/zh active Pending
- 2006-09-20 US US12/067,341 patent/US7851501B2/en not_active Expired - Fee Related
- 2006-09-20 EP EP06805784A patent/EP1937238A1/en not_active Withdrawn
- 2006-09-20 AU AU2006299184A patent/AU2006299184B8/en not_active Ceased
- 2006-09-20 WO PCT/EP2006/009155 patent/WO2007039114A1/en not_active Ceased
- 2006-09-20 CN CN2006800387821A patent/CN101374508B/zh not_active Expired - Fee Related
- 2006-09-20 CA CA002622935A patent/CA2622935A1/en not_active Abandoned
- 2006-09-20 RU RU2008115464/15A patent/RU2428979C2/ru not_active IP Right Cessation
- 2006-09-20 JP JP2008531609A patent/JP2009508902A/ja active Pending
-
2008
- 2008-03-13 IL IL190157A patent/IL190157A0/en unknown
-
2010
- 2010-11-08 US US12/941,369 patent/US20110053939A1/en not_active Abandoned
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