JP2009508531A5 - - Google Patents

Info

Publication number

JP2009508531A5

JP2009508531A5 JP2008532349A JP2008532349A JP2009508531A5 JP 2009508531 A5 JP2009508531 A5 JP 2009508531A5 JP 2008532349 A JP2008532349 A JP 2008532349A JP 2008532349 A JP2008532349 A JP 2008532349A JP 2009508531 A5 JP2009508531 A5 JP 2009508531A5

Authority

JP

Japan

Prior art keywords

hybridization

probe

nucleic acid

probe set

sensitive

Prior art date

2006-09-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000523 sample Substances 0.000 claims 28
• 239000003153 chemical reaction reagent Substances 0.000 claims 9
• 238000009396 hybridization Methods 0.000 claims 8
• 241000233866 Fungi Species 0.000 claims 7
• 150000007523 nucleic acids Chemical group 0.000 claims 7
• 230000000295 complement effect Effects 0.000 claims 6
• 229940079593 drug Drugs 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 6
• 230000008685 targeting Effects 0.000 claims 6
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
• 230000000843 anti-fungal effect Effects 0.000 claims 5
• 229940121375 antifungal agent Drugs 0.000 claims 5
• 238000001514 detection method Methods 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 150000001875 compounds Chemical class 0.000 claims 2
• 229960004884 fluconazole Drugs 0.000 claims 2
• RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims 1
• 241000222122 Candida albicans Species 0.000 claims 1
• 108010020326 Caspofungin Proteins 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 241001496375 Iris albicans Species 0.000 claims 1
• APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims 1
• 229960003942 amphotericin b Drugs 0.000 claims 1
• JYIKNQVWKBUSNH-WVDDFWQHSA-N caspofungin Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3CC[C@H](O)[C@H]3C(=O)N[C@H](NCCN)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@H](O)CCN)=CC=C(O)C=C1 JYIKNQVWKBUSNH-WVDDFWQHSA-N 0.000 claims 1
• 229960003034 caspofungin Drugs 0.000 claims 1
• 230000002538 fungal effect Effects 0.000 claims 1
• 238000007901 in situ hybridization Methods 0.000 claims 1
• RXNXLAHQOVLMIE-UHFFFAOYSA-N phenyl 10-methylacridin-10-ium-9-carboxylate Chemical compound C12=CC=CC=C2[N+](C)=C2C=CC=CC2=C1C(=O)OC1=CC=CC=C1 RXNXLAHQOVLMIE-UHFFFAOYSA-N 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 claims 1
• 229960004740 voriconazole Drugs 0.000 claims 1