JP2009507108A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009507108A5 JP2009507108A5 JP2008529317A JP2008529317A JP2009507108A5 JP 2009507108 A5 JP2009507108 A5 JP 2009507108A5 JP 2008529317 A JP2008529317 A JP 2008529317A JP 2008529317 A JP2008529317 A JP 2008529317A JP 2009507108 A5 JP2009507108 A5 JP 2009507108A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- unsubstituted
- substituted
- membered
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052760 oxygen Inorganic materials 0.000 claims 20
- 229910052717 sulfur Inorganic materials 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 18
- 229910052736 halogen Inorganic materials 0.000 claims 15
- 150000002367 halogens Chemical class 0.000 claims 15
- 125000000524 functional group Chemical group 0.000 claims 13
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 230000000269 nucleophilic effect Effects 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000002877 alkyl aryl group Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000002837 carbocyclic group Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 125000001931 aliphatic group Chemical group 0.000 claims 6
- 150000001408 amides Chemical class 0.000 claims 5
- 150000001412 amines Chemical class 0.000 claims 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 5
- 150000007942 carboxylates Chemical class 0.000 claims 5
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 5
- 150000001735 carboxylic acids Chemical class 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 229940124530 sulfonamide Drugs 0.000 claims 5
- 150000003456 sulfonamides Chemical class 0.000 claims 5
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 5
- 125000000542 sulfonic acid group Chemical group 0.000 claims 5
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 4
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 4
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000012038 nucleophile Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229910052711 selenium Inorganic materials 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 230000003287 optical effect Effects 0.000 claims 3
- 150000003460 sulfonic acids Chemical class 0.000 claims 3
- -1 Q is absent Chemical group 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 2
- 238000012634 optical imaging Methods 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- HFHFGHLXUCOHLN-UHFFFAOYSA-N 2-fluorophenol Chemical class OC1=CC=CC=C1F HFHFGHLXUCOHLN-UHFFFAOYSA-N 0.000 claims 1
- 125000001963 4 membered heterocyclic group Chemical group 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 229940126062 Compound A Drugs 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 208000026350 Inborn Genetic disease Diseases 0.000 claims 1
- 208000029534 Infectious Bone disease Diseases 0.000 claims 1
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical class ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000002659 cell therapy Methods 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 239000003610 charcoal Substances 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 208000016361 genetic disease Diseases 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 230000004807 localization Effects 0.000 claims 1
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 150000008300 phosphoramidites Chemical class 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical group [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 230000032258 transport Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71363205P | 2005-09-02 | 2005-09-02 | |
| US60/713,632 | 2005-09-02 | ||
| PCT/US2006/034260 WO2007028037A1 (en) | 2005-09-02 | 2006-09-01 | Biocompatible n, n-disubstituted sulfonamide-containing fluorescent dye labels |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012183467A Division JP2012224646A (ja) | 2005-09-02 | 2012-08-22 | 生体適合性ｎ，ｎ−二置換スルホンアミド含有蛍光色素標識 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009507108A JP2009507108A (ja) | 2009-02-19 |
| JP2009507108A5 true JP2009507108A5 (OSRAM) | 2009-10-22 |
| JP5106397B2 JP5106397B2 (ja) | 2012-12-26 |
Family
ID=37649605
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008529317A Active JP5106397B2 (ja) | 2005-09-02 | 2006-09-01 | 生体適合性ｎ，ｎ−二置換スルホンアミド含有蛍光色素標識 |
| JP2012183467A Withdrawn JP2012224646A (ja) | 2005-09-02 | 2012-08-22 | 生体適合性ｎ，ｎ−二置換スルホンアミド含有蛍光色素標識 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012183467A Withdrawn JP2012224646A (ja) | 2005-09-02 | 2012-08-22 | 生体適合性ｎ，ｎ−二置換スルホンアミド含有蛍光色素標識 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9574085B2 (OSRAM) |
| EP (1) | EP1934211B1 (OSRAM) |
| JP (2) | JP5106397B2 (OSRAM) |
| CN (2) | CN101296927A (OSRAM) |
| AU (1) | AU2006284565B2 (OSRAM) |
| CA (1) | CA2621137C (OSRAM) |
| DK (1) | DK1934211T3 (OSRAM) |
| ES (1) | ES2618361T3 (OSRAM) |
| WO (1) | WO2007028037A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003207438A1 (en) | 2002-01-02 | 2003-07-24 | Visen Medical, Inc. | Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor |
| CN101296927A (zh) | 2005-09-02 | 2008-10-29 | Visen医药公司 | 生物相容的含n,n-二取代磺酰胺的荧光染料标记 |
| WO2007028118A2 (en) | 2005-09-02 | 2007-03-08 | Visen Medical, Inc. | Nicotinic acid and picolinic acid derived near-infrared fluorophores |
| EP1973575B1 (en) | 2005-12-22 | 2019-07-24 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| DK2118206T3 (en) * | 2007-02-09 | 2018-06-18 | Visen Medical Inc | POLYCYCLOF COLORS AND APPLICATION THEREOF |
| WO2008109832A2 (en) * | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| EP2732826B1 (en) | 2008-01-18 | 2017-11-08 | Visen Medical, Inc. | Fluorescent imaging agents |
| US8864821B2 (en) | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
| TW201036941A (en) * | 2009-03-30 | 2010-10-16 | Sumitomo Chemical Co | Method for producing sulfonamide compound |
| CA2835286C (en) | 2011-05-09 | 2021-03-23 | Visen Medical, Inc. | Carbonic anhydrase targeting agents and methods of using same |
| CN104245954A (zh) | 2012-03-30 | 2014-12-24 | 文森医学公司 | 细菌成像剂及其使用方法 |
| WO2014028057A1 (en) * | 2012-08-15 | 2014-02-20 | Visen Medical, Inc. | Prostate specific antigen agents and methods of using same for prostate cancer imaging |
| US9636425B2 (en) * | 2012-09-18 | 2017-05-02 | Focal Point Technologies, Llc | Method of dry dye delivery for staining the eye |
| EP3488871B1 (en) | 2013-03-14 | 2020-09-02 | Profusa, Inc. | Oxygen sensors |
| CA2901000C (en) | 2013-03-15 | 2023-03-14 | Visen Medical, Inc. | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
| AU2014228504C1 (en) | 2013-03-15 | 2019-10-03 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
| CN106662581B (zh) | 2014-07-15 | 2019-04-09 | 瓦里泰细胞有限公司 | 一种测定样品中抗体浓度的方法 |
| CN110352036B (zh) * | 2016-12-21 | 2022-11-15 | 普罗菲尤萨股份有限公司 | 可聚合的近红外染料 |
| EP3348560A1 (en) * | 2017-01-16 | 2018-07-18 | Spago Nanomedical AB | Chemical compounds for coating of nanostructures |
| WO2020006248A1 (en) | 2018-06-27 | 2020-01-02 | Soya Gamsey | Near-ir glucose sensors |
| CN116947823B (zh) * | 2023-07-25 | 2025-02-07 | 李哲 | 一种具有长余辉发光性质的有机小分子及其生物应用 |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2121014A1 (de) * | 1971-04-29 | 1972-11-02 | Agfa-Gevaert Ag, 5090 Leverkusen | Sensibilisierte elektrophotographische Schichten |
| JPS6025781B2 (ja) * | 1977-03-11 | 1985-06-20 | 富士ゼロックス株式会社 | 電子写真用感光材料 |
| US4370401A (en) * | 1979-12-07 | 1983-01-25 | Minnesota Mining And Manufacturing Company | Light sensitive, thermally developable imaging system |
| US5627027A (en) * | 1986-04-18 | 1997-05-06 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
| US5569587A (en) * | 1986-04-18 | 1996-10-29 | Carnegie Mellon University | Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes |
| US5268486A (en) * | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| US5073171A (en) * | 1989-01-12 | 1991-12-17 | Eaton John W | Biocompatible materials comprising albumin-binding dyes |
| US4981977A (en) * | 1989-06-09 | 1991-01-01 | Carnegie-Mellon University | Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups |
| JP2824917B2 (ja) * | 1989-08-30 | 1998-11-18 | 株式会社林原生物化学研究所 | 抗腫瘍剤 |
| EP0428000A1 (en) * | 1989-11-03 | 1991-05-22 | Abbott Laboratories | Fluorogenic substrates for the detection of proteolytic enzyme activity |
| WO1994005203A1 (en) * | 1992-09-04 | 1994-03-17 | The General Hospital Corporation | Biocompatible polymers containing diagnostic or therapeutic moieties |
| US5808044A (en) * | 1993-01-22 | 1998-09-15 | Pharmacia Biotech Inc. | Indocarbocyanine and benzindocarbocyanine phosphoramidites |
| US5605809A (en) * | 1994-10-28 | 1997-02-25 | Oncoimmunin, Inc. | Compositions for the detection of proteases in biological samples and methods of use thereof |
| DE4445065A1 (de) | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| US6127134A (en) * | 1995-04-20 | 2000-10-03 | Carnegie Mellon University | Difference gel electrophoresis using matched multiple dyes |
| US6008373A (en) * | 1995-06-07 | 1999-12-28 | Carnegie Mellon University | Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
| IT1276833B1 (it) * | 1995-10-09 | 1997-11-03 | Sorin Biomedica Cardio Spa | Coloranti fluorescenti della famiglia della solfo benz e indocianina |
| US6004536A (en) * | 1995-11-14 | 1999-12-21 | Molecular Probes, Inc. | Lipophilic cyanine dyes with enchanced aqueous solubilty |
| EP0898596B1 (en) | 1996-04-19 | 2001-08-29 | Amersham Pharmacia Biotech UK Limited | Squarate dyes and their use in fluorescent sequencing method |
| JPH1071766A (ja) | 1996-06-25 | 1998-03-17 | Fuji Photo Film Co Ltd | 情報記録媒体及び色素化合物 |
| JP3840301B2 (ja) | 1996-07-18 | 2006-11-01 | 富士写真フイルム株式会社 | 情報記録媒体 |
| US6027709A (en) * | 1997-01-10 | 2000-02-22 | Li-Cor Inc. | Fluorescent cyanine dyes |
| DE19717904A1 (de) * | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
| US5877310A (en) * | 1997-04-25 | 1999-03-02 | Carnegie Mellon University | Glycoconjugated fluorescent labeling reagents |
| US6133445A (en) * | 1997-12-17 | 2000-10-17 | Carnegie Mellon University | Rigidized trimethine cyanine dyes |
| JP4927253B2 (ja) | 1997-12-17 | 2012-05-09 | カーネギー メロン ユニヴァーシティ | 硬化トリメチンシアニン色素 |
| WO1999051702A1 (en) | 1998-04-08 | 1999-10-14 | Terpetschnig Ewald A | Luminescent compounds |
| US6002003A (en) * | 1998-04-14 | 1999-12-14 | Beckman Instruments, Inc. | Cyanine dye activating group with improved coupling selectivity |
| US6083486A (en) * | 1998-05-14 | 2000-07-04 | The General Hospital Corporation | Intramolecularly-quenched near infrared fluorescent probes |
| US6592847B1 (en) * | 1998-05-14 | 2003-07-15 | The General Hospital Corporation | Intramolecularly-quenched near infrared flourescent probes |
| DE69920473T2 (de) * | 1998-07-21 | 2006-02-23 | Cytovia, Inc., San Diego | Neue fluoreszenzfarbstoffe und ihre anwendung in fluoreszenznachweisverfahren ganzer zellen für kaspasen, peptidasen, proteasen und andere enzyme sowie deren verwendung |
| JP2000095758A (ja) * | 1998-09-18 | 2000-04-04 | Schering Ag | 近赤外蛍光造影剤および蛍光造影方法 |
| EP1090073B1 (en) * | 1999-04-23 | 2003-03-05 | Molecular Probes Inc. | Xanthene dyes and their application as luminescence quenching compounds |
| ATE435262T1 (de) * | 1999-07-02 | 2009-07-15 | Visen Medical Inc | Fluoreszierende cyaninlabels mit einem sulphamidobrückenglied |
| DE19937024A1 (de) | 1999-08-05 | 2001-02-08 | Bayer Ag | Verwendung von Acylsulfonamido substituierten Polymethin-Farbstoffen als Fluoreszenz-Farbstoffe und/oder Marker |
| WO2001021624A1 (en) | 1999-09-20 | 2001-03-29 | Fuji Photo Film Co., Ltd. | Compounds for fluorescence labeling |
| JP2001323179A (ja) * | 1999-10-06 | 2001-11-20 | Hayashibara Biochem Lab Inc | シアニン色素 |
| US6620858B2 (en) | 2000-08-07 | 2003-09-16 | Eastman Chemical Company | Colorants containing copolymerizable vinyl groups and sulfonamide linkages |
| WO2002038190A2 (en) * | 2000-10-27 | 2002-05-16 | Beth Israel Deaconess Medical Center | Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates |
| EP1209205A1 (en) * | 2000-11-28 | 2002-05-29 | Innosense S.r.l. | Improved process and method for the preparation of asymetric monofunctionalised indocyanine labelling reagents and obtained compounds |
| EP1221465A1 (en) * | 2001-01-03 | 2002-07-10 | Innosense S.r.l. | Symmetric, monofunctionalised polymethine dyes labelling reagents |
| US20030044353A1 (en) * | 2001-01-05 | 2003-03-06 | Ralph Weissleder | Activatable imaging probes |
| AU2003207438A1 (en) * | 2002-01-02 | 2003-07-24 | Visen Medical, Inc. | Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor |
| WO2003061711A2 (en) * | 2002-01-16 | 2003-07-31 | Visen Medical, Inc. | Chromophore probes for optical imaging |
| AU2003225763A1 (en) * | 2002-03-11 | 2003-09-29 | Visen Medical, Inc. | Optical imaging probes |
| US7647091B2 (en) * | 2003-02-05 | 2010-01-12 | The General Hospital Corporation | Method and system for free space optical tomography of diffuse media |
| US20080102036A1 (en) * | 2003-06-04 | 2008-05-01 | Poss Kirtland G | Biocompatible Fluorescent Silicon Nanoparticles |
| US20060099712A1 (en) * | 2004-11-08 | 2006-05-11 | Eastman Kodak Company | Correlation of anti-cancer activity of dyes with redox potentials |
| US20080312540A1 (en) * | 2004-12-08 | 2008-12-18 | Vasilis Ntziachristos | System and Method for Normalized Flourescence or Bioluminescence Imaging |
| US20060239916A1 (en) * | 2005-01-07 | 2006-10-26 | Kai Licha | Use of cyanine dyes for the diagnosis of proliferative diseases |
| WO2007028118A2 (en) | 2005-09-02 | 2007-03-08 | Visen Medical, Inc. | Nicotinic acid and picolinic acid derived near-infrared fluorophores |
| DK1937676T3 (en) | 2005-09-02 | 2017-03-06 | Visen Medical Inc | Biocompatible fluorescent imaging compounds |
| CN101296927A (zh) | 2005-09-02 | 2008-10-29 | Visen医药公司 | 生物相容的含n,n-二取代磺酰胺的荧光染料标记 |
| EP1973575B1 (en) * | 2005-12-22 | 2019-07-24 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| US20100189657A1 (en) * | 2006-03-20 | 2010-07-29 | The General Hospital Corporation | Intramolecularly quenched fluorochrome conjugates and methods of use |
| DK2118206T3 (en) * | 2007-02-09 | 2018-06-18 | Visen Medical Inc | POLYCYCLOF COLORS AND APPLICATION THEREOF |
| WO2008109832A2 (en) * | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| WO2009009178A2 (en) * | 2007-04-06 | 2009-01-15 | The General Hospital Corporation | Systems and methods for optical imaging using early arriving photons |
| EP2732826B1 (en) * | 2008-01-18 | 2017-11-08 | Visen Medical, Inc. | Fluorescent imaging agents |
| WO2009114776A2 (en) | 2008-03-14 | 2009-09-17 | Visen Medical, Inc. | Integrin targeting agents and methods of using same |
| JP2010071766A (ja) | 2008-09-17 | 2010-04-02 | Olympus Corp | 分注装置、自動分析装置および分注不良確認方法 |
| US8864821B2 (en) | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
| CA2835286C (en) | 2011-05-09 | 2021-03-23 | Visen Medical, Inc. | Carbonic anhydrase targeting agents and methods of using same |
| WO2014028057A1 (en) | 2012-08-15 | 2014-02-20 | Visen Medical, Inc. | Prostate specific antigen agents and methods of using same for prostate cancer imaging |
| CA2901000C (en) | 2013-03-15 | 2023-03-14 | Visen Medical, Inc. | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
| AU2014228504C1 (en) | 2013-03-15 | 2019-10-03 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
-
2006
- 2006-09-01 CN CNA2006800403608A patent/CN101296927A/zh active Pending
- 2006-09-01 AU AU2006284565A patent/AU2006284565B2/en active Active
- 2006-09-01 WO PCT/US2006/034260 patent/WO2007028037A1/en not_active Ceased
- 2006-09-01 CA CA2621137A patent/CA2621137C/en active Active
- 2006-09-01 US US12/065,387 patent/US9574085B2/en active Active
- 2006-09-01 JP JP2008529317A patent/JP5106397B2/ja active Active
- 2006-09-01 DK DK06802829.9T patent/DK1934211T3/en active
- 2006-09-01 EP EP06802829.9A patent/EP1934211B1/en active Active
- 2006-09-01 CN CN201510093931.5A patent/CN104788433A/zh active Pending
- 2006-09-01 ES ES06802829.9T patent/ES2618361T3/es active Active
-
2012
- 2012-08-22 JP JP2012183467A patent/JP2012224646A/ja not_active Withdrawn
-
2017
- 2017-02-15 US US15/433,688 patent/US10442930B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Sun et al. | Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery | |
| JP2009507035A5 (OSRAM) | ||
| JP3565758B2 (ja) | 腫瘍治療用増感剤 | |
| JP2010518236A5 (OSRAM) | ||
| Li et al. | Self-assembled NIR-II fluorophores with ultralong blood circulation for cancer imaging and image-guided surgery | |
| US8372868B2 (en) | Targeted, NIR imaging agents for therapy efficacy monitoring, deep tissue disease demarcation and deep tissue imaging | |
| EP2958596B1 (en) | Psma ligands and uses thereof | |
| JP5733716B2 (ja) | 中枢神経系組織標識用組成物、中枢神経系組織の標識方法、及び中枢神経系組織標識用組成物を用いたスクリーニング方法 | |
| JP2012520856A5 (OSRAM) | ||
| US8293782B2 (en) | Compound, probe containing the novel compound, and fluorescence-imaging contrast agent containing the novel compound or the probe | |
| WO2009012109A2 (en) | Cyanine-containing compounds for cancer imaging and treatment | |
| CN1328471A (zh) | 近红外荧光造影剂和荧光成像 | |
| JP2016519080A5 (OSRAM) | ||
| JP2015532641A5 (OSRAM) | ||
| JP5795963B2 (ja) | がん診断薬 | |
| JP5106397B2 (ja) | 生体適合性ｎ，ｎ−二置換スルホンアミド含有蛍光色素標識 | |
| EP2849752B1 (en) | Cancer cell inhibitory drug and cancer stem-cell detection probe | |
| ES3016407T3 (en) | Tricyclic compounds as histone methyl-transferase inhibitors | |
| CN111362971A (zh) | 靶向psma的双苯并噻二唑类化合物及其制备方法与应用 | |
| JP2023539353A (ja) | 腫瘍造影化合物、その調製方法および腫瘍診断イメージングへの応用 | |
| US12306194B2 (en) | Reagent for fluorescence imaging of lipid droplets in cell and tissue | |
| CN106929004B (zh) | 一种信号增强型近红外荧光探针及其制备方法和应用 | |
| JP2018090536A (ja) | 近赤外蛍光レシオ型プローブ | |
| CN116284028B (zh) | 一种特异性靶向脂筏荧光探针及其制备方法和应用 | |
| JP2007238650A (ja) | 希土類金属錯体及びそれを用いた蛍光発光材料 |