JP2010518236A5 - - Google Patents
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- JP2010518236A5 JP2010518236A5 JP2009549253A JP2009549253A JP2010518236A5 JP 2010518236 A5 JP2010518236 A5 JP 2010518236A5 JP 2009549253 A JP2009549253 A JP 2009549253A JP 2009549253 A JP2009549253 A JP 2009549253A JP 2010518236 A5 JP2010518236 A5 JP 2010518236A5
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- Prior art keywords
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- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims description 63
- 239000007850 fluorescent dye Substances 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 125000000217 alkyl group Chemical group 0.000 claims description 19
- 201000010099 disease Diseases 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- -1 N- hydroxy sulfosuccinimide ester Chemical class 0.000 claims description 15
- 125000003118 aryl group Chemical group 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 239000000523 sample Substances 0.000 claims description 8
- 229910052717 sulfur Inorganic materials 0.000 claims description 8
- 238000012634 optical imaging Methods 0.000 claims description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 125000005647 linker group Chemical group 0.000 claims description 4
- 230000003287 optical effect Effects 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 230000003213 activating effect Effects 0.000 claims description 3
- 239000012472 biological sample Substances 0.000 claims description 3
- 238000000338 in vitro Methods 0.000 claims description 3
- HFHFGHLXUCOHLN-UHFFFAOYSA-N 2-fluorophenol Chemical class OC1=CC=CC=C1F HFHFGHLXUCOHLN-UHFFFAOYSA-N 0.000 claims description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 2
- 208000020084 Bone disease Diseases 0.000 claims description 2
- 208000035473 Communicable disease Diseases 0.000 claims description 2
- 208000026350 Inborn Genetic disease Diseases 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 claims description 2
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical class ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims description 2
- 150000001540 azides Chemical class 0.000 claims description 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 2
- 150000007942 carboxylates Chemical class 0.000 claims description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 2
- 150000001733 carboxylic acid esters Chemical class 0.000 claims description 2
- 238000002659 cell therapy Methods 0.000 claims description 2
- 238000002591 computed tomography Methods 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 208000016097 disease of metabolism Diseases 0.000 claims description 2
- 208000030533 eye disease Diseases 0.000 claims description 2
- 208000016361 genetic disease Diseases 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 238000003384 imaging method Methods 0.000 claims description 2
- 208000026278 immune system disease Diseases 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 230000004054 inflammatory process Effects 0.000 claims description 2
- 208000030159 metabolic disease Diseases 0.000 claims description 2
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 230000004770 neurodegeneration Effects 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000008300 phosphoramidites Chemical class 0.000 claims description 2
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims description 2
- NAYYNDKKHOIIOD-UHFFFAOYSA-N phthalamide Chemical compound NC(=O)C1=CC=CC=C1C(N)=O NAYYNDKKHOIIOD-UHFFFAOYSA-N 0.000 claims description 2
- 125000003367 polycyclic group Chemical group 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 208000023504 respiratory system disease Diseases 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 229910052711 selenium Inorganic materials 0.000 claims description 2
- 208000017520 skin disease Diseases 0.000 claims description 2
- 229940124530 sulfonamide Drugs 0.000 claims description 2
- 150000003456 sulfonamides Chemical class 0.000 claims description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 2
- 238000003325 tomography Methods 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims 2
- 230000007762 localization of cell Effects 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88906607P | 2007-02-09 | 2007-02-09 | |
| US60/889,066 | 2007-02-09 | ||
| PCT/US2008/053399 WO2008100817A2 (en) | 2007-02-09 | 2008-02-08 | Polycyclo dyes and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014071365A Division JP2014167119A (ja) | 2007-02-09 | 2014-03-31 | ポリシクロ染料およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010518236A JP2010518236A (ja) | 2010-05-27 |
| JP2010518236A5 true JP2010518236A5 (OSRAM) | 2012-03-22 |
| JP5643514B2 JP5643514B2 (ja) | 2014-12-17 |
Family
ID=39690741
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549253A Active JP5643514B2 (ja) | 2007-02-09 | 2008-02-08 | ポリシクロ染料およびその使用 |
| JP2014071365A Withdrawn JP2014167119A (ja) | 2007-02-09 | 2014-03-31 | ポリシクロ染料およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014071365A Withdrawn JP2014167119A (ja) | 2007-02-09 | 2014-03-31 | ポリシクロ染料およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8221721B2 (OSRAM) |
| EP (1) | EP2118206B9 (OSRAM) |
| JP (2) | JP5643514B2 (OSRAM) |
| DK (1) | DK2118206T3 (OSRAM) |
| ES (1) | ES2670852T3 (OSRAM) |
| WO (1) | WO2008100817A2 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002038190A2 (en) * | 2000-10-27 | 2002-05-16 | Beth Israel Deaconess Medical Center | Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates |
| CN101296927A (zh) | 2005-09-02 | 2008-10-29 | Visen医药公司 | 生物相容的含n,n-二取代磺酰胺的荧光染料标记 |
| WO2007028118A2 (en) | 2005-09-02 | 2007-03-08 | Visen Medical, Inc. | Nicotinic acid and picolinic acid derived near-infrared fluorophores |
| DK1937676T3 (en) * | 2005-09-02 | 2017-03-06 | Visen Medical Inc | Biocompatible fluorescent imaging compounds |
| EP1973575B1 (en) | 2005-12-22 | 2019-07-24 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| DK2118206T3 (en) | 2007-02-09 | 2018-06-18 | Visen Medical Inc | POLYCYCLOF COLORS AND APPLICATION THEREOF |
| WO2008109832A2 (en) * | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| EP2732826B1 (en) | 2008-01-18 | 2017-11-08 | Visen Medical, Inc. | Fluorescent imaging agents |
| US9023611B2 (en) * | 2009-02-06 | 2015-05-05 | Beth Israel Deaconess Medical Center | Charged-balanced imaging agents |
| CA2835286C (en) | 2011-05-09 | 2021-03-23 | Visen Medical, Inc. | Carbonic anhydrase targeting agents and methods of using same |
| CN104245954A (zh) | 2012-03-30 | 2014-12-24 | 文森医学公司 | 细菌成像剂及其使用方法 |
| US20140051973A1 (en) * | 2012-08-15 | 2014-02-20 | Aspect Imaging Ltd | Mri imaging system for generating a rendered image |
| US20140051975A1 (en) * | 2012-08-15 | 2014-02-20 | Aspect Imaging Ltd. | Multiple heterogeneous imaging systems for clinical and preclinical diagnosis |
| WO2014028057A1 (en) | 2012-08-15 | 2014-02-20 | Visen Medical, Inc. | Prostate specific antigen agents and methods of using same for prostate cancer imaging |
| IL221489A0 (en) * | 2012-08-15 | 2012-12-31 | Aspect Imaging Ltd | Imaging system for generating a rendered image |
| CA2901000C (en) | 2013-03-15 | 2023-03-14 | Visen Medical, Inc. | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
| AU2014228504C1 (en) | 2013-03-15 | 2019-10-03 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
| EP3165153A1 (en) * | 2015-11-05 | 2017-05-10 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | System for fluorescence aided surgery |
| US11549017B2 (en) | 2017-09-29 | 2023-01-10 | Perkinelmer Health Sciences, Inc. | NIR to SWIR fluorescent compounds for imaging and detection |
| US10633542B2 (en) | 2018-03-21 | 2020-04-28 | Ecole polytechnique fédérale de Lausanne (EPFL) | Azacyanine dyes and use thereof |
| EA202092228A1 (ru) * | 2018-03-21 | 2021-07-19 | Эколь Политекник Федераль Де Лозанн (Эпфл) | Азацианиновые красители и их применение |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4219335A (en) | 1978-09-18 | 1980-08-26 | E. I. Du Pont De Nemours And Company | Immunochemical testing using tagged reagents |
| US6086737A (en) | 1984-03-29 | 2000-07-11 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor |
| US6048982A (en) | 1986-04-18 | 2000-04-11 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
| US5164297A (en) | 1990-05-03 | 1992-11-17 | Advanced Magnetics Inc. | Solvent mediated relaxation assay system |
| US5445970A (en) | 1992-03-20 | 1995-08-29 | Abbott Laboratories | Magnetically assisted binding assays using magnetically labeled binding members |
| WO1994005203A1 (en) | 1992-09-04 | 1994-03-17 | The General Hospital Corporation | Biocompatible polymers containing diagnostic or therapeutic moieties |
| DE69434016T2 (de) * | 1993-03-04 | 2005-02-10 | Fuji Photo Film Co., Ltd., Minami-Ashigara | Photographisches Silberhalogenidmaterial |
| JPH0862763A (ja) * | 1994-08-17 | 1996-03-08 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| DE4445065A1 (de) | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| IT1276833B1 (it) | 1995-10-09 | 1997-11-03 | Sorin Biomedica Cardio Spa | Coloranti fluorescenti della famiglia della solfo benz e indocianina |
| US5876915A (en) | 1996-07-24 | 1999-03-02 | Agfa-Gevaert | Photothermographic recording material comprising sensitizing dyes and a recording process therefor |
| JP3794793B2 (ja) * | 1996-07-24 | 2006-07-12 | アグフア−ゲヴエルト，ナームローゼ・フエンノートシヤツプ | 増感色素を含むフオトサーモグラフイ記録材料及びそのための記録法 |
| DE19717904A1 (de) | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
| US6046585A (en) | 1997-11-21 | 2000-04-04 | Quantum Design, Inc. | Method and apparatus for making quantitative measurements of localized accumulations of target particles having magnetic particles bound thereto |
| US6214533B1 (en) * | 1998-04-10 | 2001-04-10 | Konica Corporation | Thermally developable photosensitive material |
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| DK1937676T3 (en) | 2005-09-02 | 2017-03-06 | Visen Medical Inc | Biocompatible fluorescent imaging compounds |
| WO2007028118A2 (en) | 2005-09-02 | 2007-03-08 | Visen Medical, Inc. | Nicotinic acid and picolinic acid derived near-infrared fluorophores |
| EP1973575B1 (en) | 2005-12-22 | 2019-07-24 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| US20100189657A1 (en) | 2006-03-20 | 2010-07-29 | The General Hospital Corporation | Intramolecularly quenched fluorochrome conjugates and methods of use |
| DK2118206T3 (en) | 2007-02-09 | 2018-06-18 | Visen Medical Inc | POLYCYCLOF COLORS AND APPLICATION THEREOF |
| WO2008109832A2 (en) | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| US20090037114A1 (en) | 2007-07-30 | 2009-02-05 | Chengbin Peng | 4d+ prestack seismic data structure, and methods and apparatus for processing 4d+ prestack seismic data |
| EP2732826B1 (en) | 2008-01-18 | 2017-11-08 | Visen Medical, Inc. | Fluorescent imaging agents |
| WO2009114776A2 (en) | 2008-03-14 | 2009-09-17 | Visen Medical, Inc. | Integrin targeting agents and methods of using same |
| US8864821B2 (en) | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
-
2008
- 2008-02-08 DK DK08729371.8T patent/DK2118206T3/en active
- 2008-02-08 EP EP08729371.8A patent/EP2118206B9/en active Active
- 2008-02-08 WO PCT/US2008/053399 patent/WO2008100817A2/en not_active Ceased
- 2008-02-08 ES ES08729371.8T patent/ES2670852T3/es active Active
- 2008-02-08 US US12/028,209 patent/US8221721B2/en not_active Expired - Fee Related
- 2008-02-08 JP JP2009549253A patent/JP5643514B2/ja active Active
-
2012
- 2012-07-13 US US13/548,451 patent/US9365721B2/en active Active
-
2014
- 2014-03-31 JP JP2014071365A patent/JP2014167119A/ja not_active Withdrawn
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