JP2016521254A5 - - Google Patents

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JP2016521254A5
JP2016521254A5 JP2016503068A JP2016503068A JP2016521254A5 JP 2016521254 A5 JP2016521254 A5 JP 2016521254A5 JP 2016503068 A JP2016503068 A JP 2016503068A JP 2016503068 A JP2016503068 A JP 2016503068A JP 2016521254 A5 JP2016521254 A5 JP 2016521254A5
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alkylene
alkyl
optionally substituted
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optionally
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JP2016521254A (ja
JP6606487B2 (ja
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Priority claimed from PCT/US2014/029350 external-priority patent/WO2014144793A1/en
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JP2016503068A 2013-03-15 2014-03-14 invitroおよびinvivoイメージングおよび検出のための置換シラキサンテニウム赤色〜近赤外蛍光色素 Active JP6606487B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361794188P 2013-03-15 2013-03-15
US61/794,188 2013-03-15
PCT/US2014/029350 WO2014144793A1 (en) 2013-03-15 2014-03-14 Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection

Publications (3)

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JP2016521254A JP2016521254A (ja) 2016-07-21
JP2016521254A5 true JP2016521254A5 (OSRAM) 2017-04-20
JP6606487B2 JP6606487B2 (ja) 2019-11-13

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JP2016503068A Active JP6606487B2 (ja) 2013-03-15 2014-03-14 invitroおよびinvivoイメージングおよび検出のための置換シラキサンテニウム赤色〜近赤外蛍光色素

Country Status (7)

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US (1) US9649389B2 (OSRAM)
EP (1) EP2970342B1 (OSRAM)
JP (1) JP6606487B2 (OSRAM)
CN (1) CN105073761B (OSRAM)
AU (1) AU2014228504C1 (OSRAM)
CA (1) CA2901379C (OSRAM)
WO (1) WO2014144793A1 (OSRAM)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101296927A (zh) 2005-09-02 2008-10-29 Visen医药公司 生物相容的含n,n-二取代磺酰胺的荧光染料标记
EP1973575B1 (en) 2005-12-22 2019-07-24 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
EP2732826B1 (en) 2008-01-18 2017-11-08 Visen Medical, Inc. Fluorescent imaging agents
CA2835286C (en) 2011-05-09 2021-03-23 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
AU2014228504C1 (en) 2013-03-15 2019-10-03 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection
CA2901000C (en) 2013-03-15 2023-03-14 Visen Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
JP6190534B2 (ja) 2013-08-22 2017-08-30 ソニー株式会社 水溶性蛍光染料又は有色染料及びその使用方法
WO2015083799A1 (ja) * 2013-12-04 2015-06-11 国立大学法人 東京大学 近赤外線消光団
WO2015153813A1 (en) * 2014-04-01 2015-10-08 Howard Hughes Medical Institute Azetidine-substituted fluorescent compounds
KR102676814B1 (ko) 2015-02-26 2024-06-21 소니그룹주식회사 접합 그룹을 포함하는 수용성 형광 또는 착색 염료
JP6898301B2 (ja) * 2015-07-28 2021-07-07 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California 長波長電圧感受性色素
JP2017149806A (ja) * 2016-02-22 2017-08-31 富士フイルム株式会社 着色組成物、インクジェット用インク、及び捺染方法
US20170240951A1 (en) * 2016-02-24 2017-08-24 Saudi Arabian Oil Company Detecting Xanthan Gum
CN107580618A (zh) 2016-04-01 2018-01-12 索尼公司 超亮二聚或多聚染料
CN109415574B (zh) 2016-04-01 2021-05-28 索尼公司 具有刚性间隔基团的超亮二聚体或聚合物染料
JP7069033B2 (ja) 2016-04-06 2022-05-17 ソニーグループ株式会社 スペーシングリンカー基を有する超明色ダイマーまたはポリマー染料
EP3450963A4 (en) * 2016-04-28 2020-01-29 National University Corporation Nagoya University FLUORESCENT PROBE, METHOD FOR DETECTING FLUORESCENCE AND METHOD OF USING FLUORESCENT PROBE
WO2017197014A2 (en) 2016-05-10 2017-11-16 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
JP7527537B2 (ja) * 2016-05-10 2024-08-05 ソニーグループ株式会社 ペプチド骨格を有する超明色ポリマー染料
AU2017264861B2 (en) 2016-05-11 2021-09-23 Sony Group Corporation Ultra bright dimeric or polymeric dyes
WO2017214165A1 (en) 2016-06-06 2017-12-14 Sony Corporation Ionic polymers comprising fluorescent or colored reporter groups
TW201800416A (zh) * 2016-06-22 2018-01-01 和光純藥工業股份有限公司 含矽雜環消光劑、化合物以及聚合物
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
EP3551034A1 (en) * 2016-12-07 2019-10-16 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
JP7008339B2 (ja) * 2017-02-17 2022-01-25 国立大学法人 東京大学 ペプチダーゼ活性検出用赤色蛍光プローブ
EP3691689A1 (en) 2017-10-05 2020-08-12 Sony Corporation Programmable dendritic drugs
JP7551056B2 (ja) 2017-10-05 2024-09-17 ソニーグループ株式会社 プログラマブルなポリマー薬物
JP2021503450A (ja) 2017-11-16 2021-02-12 ソニー株式会社 プログラム可能なポリマー薬
JP7813098B2 (ja) 2018-01-12 2026-02-12 ソニーグループ株式会社 生物学的に活性な化合物を含む剛性間隔基を有するポリマー
CN111565757A (zh) 2018-01-12 2020-08-21 索尼公司 包含生物活性化合物的磷酸烷基聚合物
JP2021510698A (ja) 2018-01-12 2021-04-30 ソニー株式会社 生物学的に活性な化合物を含むホスホアルキルリボースポリマー
KR102742386B1 (ko) 2018-03-19 2024-12-16 소니그룹주식회사 형광 신호 향상을 위한 2가 금속의 사용
WO2019182766A1 (en) 2018-03-21 2019-09-26 Sony Corporation Polymeric tandem dyes with linker groups
EP3793618A4 (en) 2018-05-18 2022-03-02 Singular Genomics Systems, Inc. DETECTABLE COMPOUNDS CONTAINING SILICON
KR102228538B1 (ko) 2018-06-01 2021-03-15 주식회사 엘지화학 염료 화합물 및 포토폴리머 조성물
KR102854332B1 (ko) 2018-06-27 2025-09-03 소니그룹주식회사 디옥시리보오스를 포함하는 링커 군을 갖는 중합체성 염료
EP3820944A1 (en) 2018-07-13 2021-05-19 Sony Corporation Polymeric dyes having a backbone comprising organophosphate units
BR112021002507A2 (pt) * 2018-08-10 2021-07-27 Life Technologies Corporation corantes de rodamina substituída por silício e conjugados de corante
EP3849496B1 (en) 2018-09-11 2023-10-25 Oregon Health & Science University Near-infrared nerve-sparing benzo[c]phenoxazine fluorophores
KR102283067B1 (ko) * 2019-07-18 2021-07-28 아주대학교산학협력단 미토콘드리아를 표적으로 하는 신규한 근적외선 형광 프로브 및 이를 포함하는 종양 진단 및 치료 겸용 조성물
WO2021062176A2 (en) 2019-09-26 2021-04-01 Sony Corporation Polymeric tandem dyes with linker groups
JP7816141B2 (ja) 2019-09-30 2026-02-18 ソニーグループ株式会社 ヌクレオチドプローブ
EP4055023A4 (en) 2019-11-07 2024-01-03 Singular Genomics Systems, Inc. SILICON-CONTAINING DETECTED COMPOUNDS AND USES THEREOF
CN114787286A (zh) * 2019-12-09 2022-07-22 豪夫迈·罗氏有限公司 双阳离子荧光染料
JP7481122B2 (ja) 2020-02-03 2024-05-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 蛍光色素及びその利用
EP4256078A1 (en) 2020-12-07 2023-10-11 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes
CN113045599B (zh) * 2021-03-17 2022-04-19 山西大学 一种高对比度区分癌细胞/组织的方法及荧光探针的制备
EP4313398A1 (en) * 2021-04-01 2024-02-07 Agfa-Gevaert Nv Nir absorbing capsules
WO2022241418A1 (en) * 2021-05-10 2022-11-17 University Of Virginia Patent Foundation Phosphinate ester-containing dyes having tunable properties and methods of making the same
CN113563298B (zh) * 2021-07-20 2023-07-28 北京大学 一类含水溶性取代基罗丹明荧光染料其制备方法和应用
JP7787670B2 (ja) * 2021-08-31 2025-12-17 富士フイルム株式会社 化合物及びこれを用いた標識生体物質
CN113801145B (zh) * 2021-10-12 2022-06-07 南京大学 一种激活型近红外小分子荧光探针及其制备方法与应用
CN114869227B (zh) * 2022-04-02 2025-09-05 北京信息科技大学 一种可穿戴式微型活体流式图像细胞仪
CN115322205B (zh) * 2022-04-06 2025-09-26 大连理工大学 一类近红外二区荧光染料及制备方法与抗肿瘤应用
US20250362644A1 (en) * 2022-11-04 2025-11-27 Lg Chem, Ltd. Hologram recording medium, preparation method thereof and optical element comprising the same
CN119095890A (zh) 2022-11-04 2024-12-06 株式会社Lg化学 全息图记录介质和包括其的光学元件
WO2024096360A1 (ko) * 2022-11-04 2024-05-10 주식회사 엘지화학 포토폴리머 조성물, 홀로그램 기록 매체, 이의 제조 방법 및 이를 포함하는 광학 소자
US12359068B2 (en) 2023-02-10 2025-07-15 Singular Genomics Systems, Inc. Rhodamine fluorescent compounds and production methods thereof
EP4674845A1 (en) * 2023-04-28 2026-01-07 SFC Co., Ltd. Novel compound and use thereof
GB202415958D0 (en) * 2024-10-30 2024-12-11 Tocris Cookson Ltd Compounds

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4219335A (en) 1978-09-18 1980-08-26 E. I. Du Pont De Nemours And Company Immunochemical testing using tagged reagents
US6086737A (en) 1984-03-29 2000-07-11 Li-Cor, Inc. Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor
US6048982A (en) 1986-04-18 2000-04-11 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5164297A (en) 1990-05-03 1992-11-17 Advanced Magnetics Inc. Solvent mediated relaxation assay system
US5445970A (en) 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
WO1994005203A1 (en) 1992-09-04 1994-03-17 The General Hospital Corporation Biocompatible polymers containing diagnostic or therapeutic moieties
DE4445065A1 (de) 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
IT1276833B1 (it) 1995-10-09 1997-11-03 Sorin Biomedica Cardio Spa Coloranti fluorescenti della famiglia della solfo benz e indocianina
DE19717904A1 (de) 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US6046585A (en) 1997-11-21 2000-04-04 Quantum Design, Inc. Method and apparatus for making quantitative measurements of localized accumulations of target particles having magnetic particles bound thereto
US6083486A (en) 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US6592847B1 (en) 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
EP1090073B1 (en) 1999-04-23 2003-03-05 Molecular Probes Inc. Xanthene dyes and their application as luminescence quenching compounds
ATE435262T1 (de) 1999-07-02 2009-07-15 Visen Medical Inc Fluoreszierende cyaninlabels mit einem sulphamidobrückenglied
ATE352586T2 (de) 2000-09-29 2007-02-15 Molecular Probes Inc Modifizierte carbocyaninfarbstoffe und deren konjugate
WO2002038190A2 (en) 2000-10-27 2002-05-16 Beth Israel Deaconess Medical Center Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates
US6615063B1 (en) 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
EP1209205A1 (en) 2000-11-28 2002-05-29 Innosense S.r.l. Improved process and method for the preparation of asymetric monofunctionalised indocyanine labelling reagents and obtained compounds
EP1221465A1 (en) 2001-01-03 2002-07-10 Innosense S.r.l. Symmetric, monofunctionalised polymethine dyes labelling reagents
US20030044353A1 (en) 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
AU2003207438A1 (en) 2002-01-02 2003-07-24 Visen Medical, Inc. Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor
WO2003061711A2 (en) 2002-01-16 2003-07-31 Visen Medical, Inc. Chromophore probes for optical imaging
AU2003225763A1 (en) 2002-03-11 2003-09-29 Visen Medical, Inc. Optical imaging probes
EP2410315B1 (en) 2002-06-04 2020-04-01 Visen Medical, Inc. Imaging volumes with arbitrary geometries in contact and non-contact tomography
JP4713343B2 (ja) * 2003-09-05 2011-06-29 哲雄 長野 蛍光プローブ
US20060239916A1 (en) 2005-01-07 2006-10-26 Kai Licha Use of cyanine dyes for the diagnosis of proliferative diseases
DK1937676T3 (en) 2005-09-02 2017-03-06 Visen Medical Inc Biocompatible fluorescent imaging compounds
WO2007028118A2 (en) 2005-09-02 2007-03-08 Visen Medical, Inc. Nicotinic acid and picolinic acid derived near-infrared fluorophores
CN101296927A (zh) 2005-09-02 2008-10-29 Visen医药公司 生物相容的含n,n-二取代磺酰胺的荧光染料标记
EP1973575B1 (en) 2005-12-22 2019-07-24 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
CN100361999C (zh) * 2006-03-03 2008-01-16 大连理工大学 含硅元素的阳离子发色团及其衍生物
US20100189657A1 (en) 2006-03-20 2010-07-29 The General Hospital Corporation Intramolecularly quenched fluorochrome conjugates and methods of use
DK2118206T3 (en) 2007-02-09 2018-06-18 Visen Medical Inc POLYCYCLOF COLORS AND APPLICATION THEREOF
WO2008109832A2 (en) 2007-03-08 2008-09-12 Visen Medical, Inc. Viable near-infrared fluorochrome labeled cells and methods of making and using same
EP2732826B1 (en) 2008-01-18 2017-11-08 Visen Medical, Inc. Fluorescent imaging agents
WO2009114776A2 (en) 2008-03-14 2009-09-17 Visen Medical, Inc. Integrin targeting agents and methods of using same
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
JP5526124B2 (ja) * 2009-04-30 2014-06-18 国立大学法人 東京大学 近赤外蛍光化合物
WO2012083064A1 (en) * 2010-12-16 2012-06-21 Southern Illinois University Carbondale Silaanthracene as a red and near infrared sensor and a method to manufacture such a sensor
US9329184B2 (en) * 2011-02-18 2016-05-03 The University Of Tokyo Fluorescent probe
WO2012118715A2 (en) 2011-02-28 2012-09-07 The Board Of Trustees Of Leland Stanford Junior University Non-peptidic quenched fluorescent imaging probes
CA2835286C (en) 2011-05-09 2021-03-23 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
WO2013029650A1 (en) * 2011-08-26 2013-03-07 Ecole Polytechnique Federale De Lausanne (Epfl) Cell permeable, fluorescent dye
WO2014028057A1 (en) 2012-08-15 2014-02-20 Visen Medical, Inc. Prostate specific antigen agents and methods of using same for prostate cancer imaging
JP6367307B2 (ja) * 2013-03-15 2018-08-01 プロメガ コーポレイションPromega Corporation 遺伝的同一性における使用のための新規ケイ素およびゲルマニウム色素
CA2901000C (en) 2013-03-15 2023-03-14 Visen Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
AU2014228504C1 (en) 2013-03-15 2019-10-03 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection

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