JP2009507036A5 - - Google Patents

Info

Publication number

JP2009507036A5

JP2009507036A5 JP2008529359A JP2008529359A JP2009507036A5 JP 2009507036 A5 JP2009507036 A5 JP 2009507036A5 JP 2008529359 A JP2008529359 A JP 2008529359A JP 2008529359 A JP2008529359 A JP 2008529359A JP 2009507036 A5 JP2009507036 A5 JP 2009507036A5

Authority

JP

Japan

Prior art keywords

group

alkyl

alkylenyl

compound

heteroaryl

Prior art date

2006-09-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 125000000217 alkyl group Chemical group 0.000 claims 48
• 125000005466 alkylenyl group Chemical group 0.000 claims 35
• 150000003839 salts Chemical class 0.000 claims 30
• 150000001875 compounds Chemical class 0.000 claims 27
• -1 arylalkylenyl Chemical group 0.000 claims 26
• 229910052739 hydrogen Inorganic materials 0.000 claims 24
• 239000001257 hydrogen Substances 0.000 claims 24
• 125000000623 heterocyclic group Chemical group 0.000 claims 22
• 125000003118 aryl group Chemical group 0.000 claims 19
• 125000001072 heteroaryl group Chemical group 0.000 claims 19
• 125000002947 alkylene group Chemical group 0.000 claims 15
• 150000002431 hydrogen Chemical group 0.000 claims 14
• 229910052736 halogen Inorganic materials 0.000 claims 13
• 150000002367 halogens Chemical group 0.000 claims 13
• 125000003342 alkenyl group Chemical group 0.000 claims 12
• 125000003545 alkoxy group Chemical group 0.000 claims 12
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 11
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
• 125000004663 dialkyl amino group Chemical group 0.000 claims 10
• 125000005553 heteroaryloxy group Chemical group 0.000 claims 10
• 125000001424 substituent group Chemical group 0.000 claims 10
• 125000000304 alkynyl group Chemical group 0.000 claims 9
• 125000004438 haloalkoxy group Chemical group 0.000 claims 8
• 125000001188 haloalkyl group Chemical group 0.000 claims 8
• 125000003282 alkyl amino group Chemical group 0.000 claims 7
• 125000005532 aryl alkyleneoxy group Chemical group 0.000 claims 7
• 125000004104 aryloxy group Chemical group 0.000 claims 7
• 125000004093 cyano group Chemical group *C#N 0.000 claims 7
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 7
• 239000008194 pharmaceutical composition Substances 0.000 claims 7
• 125000004450 alkenylene group Chemical group 0.000 claims 6
• 125000004419 alkynylene group Chemical group 0.000 claims 6
• 125000000266 alpha-aminoacyl group Chemical group 0.000 claims 6
• 125000000732 arylene group Chemical group 0.000 claims 6
• 125000005549 heteroarylene group Chemical group 0.000 claims 6
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 5
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
• 125000005529 alkyleneoxy group Chemical group 0.000 claims 4
• 230000015572 biosynthetic process Effects 0.000 claims 4
• 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 3
• 230000001939 inductive effect Effects 0.000 claims 3
• 230000001404 mediated effect Effects 0.000 claims 3
• PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 3
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
• 150000008574 D-amino acids Chemical class 0.000 claims 2
• 150000008575 L-amino acids Chemical class 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 125000001589 carboacyl group Chemical group 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 230000003612 virological effect Effects 0.000 claims 2
• 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
• 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
• 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 claims 1
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 125000002252 acyl group Chemical group 0.000 claims 1
• 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000006698 induction Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
• 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• 0 C[C@@]1C(C)=CC*C1 Chemical compound C[C@@]1C(C)=CC*C1 0.000 description 5