JP2009506054A5 - - Google Patents

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Publication number
JP2009506054A5
JP2009506054A5 JP2008528124A JP2008528124A JP2009506054A5 JP 2009506054 A5 JP2009506054 A5 JP 2009506054A5 JP 2008528124 A JP2008528124 A JP 2008528124A JP 2008528124 A JP2008528124 A JP 2008528124A JP 2009506054 A5 JP2009506054 A5 JP 2009506054A5
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JP
Japan
Prior art keywords
composition
hedgehog
cancer
pathway activity
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008528124A
Other languages
English (en)
Japanese (ja)
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JP2009506054A (ja
JP5435946B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/032952 external-priority patent/WO2007024971A2/en
Publication of JP2009506054A publication Critical patent/JP2009506054A/ja
Publication of JP2009506054A5 publication Critical patent/JP2009506054A5/ja
Application granted granted Critical
Publication of JP5435946B2 publication Critical patent/JP5435946B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2008528124A 2005-08-22 2006-08-22 疾患を処置するためのヘッジホッグ経路アンタゴニスト Expired - Lifetime JP5435946B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71011705P 2005-08-22 2005-08-22
US60/710,117 2005-08-22
PCT/US2006/032952 WO2007024971A2 (en) 2005-08-22 2006-08-22 Hedgehog pathway antagonists to treat disease

Publications (3)

Publication Number Publication Date
JP2009506054A JP2009506054A (ja) 2009-02-12
JP2009506054A5 true JP2009506054A5 (enExample) 2010-08-26
JP5435946B2 JP5435946B2 (ja) 2014-03-05

Family

ID=37772335

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008528124A Expired - Lifetime JP5435946B2 (ja) 2005-08-22 2006-08-22 疾患を処置するためのヘッジホッグ経路アンタゴニスト

Country Status (7)

Country Link
US (1) US8653083B2 (enExample)
EP (2) EP1919480B1 (enExample)
JP (1) JP5435946B2 (enExample)
AU (1) AU2006283040B2 (enExample)
CA (1) CA2619889C (enExample)
ES (1) ES2403006T3 (enExample)
WO (1) WO2007024971A2 (enExample)

Families Citing this family (23)

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CA2452152A1 (en) * 2001-07-02 2002-10-10 Sinan Tas Use of cyclopamine in the treatment of psoriasis
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
JP2011522515A (ja) * 2008-04-10 2011-08-04 マサチューセッツ インスティテュート オブ テクノロジー 癌幹細胞を標的とする薬剤を同定する方法およびその使用
US20240360111A1 (en) * 2011-09-07 2024-10-31 The Johns Hopkins University Itraconazole analogs and use thereof
US9072660B2 (en) 2011-09-09 2015-07-07 The Board Of Trustees Of The Leland Stanford Junior University Topical itraconazole formulations and uses thereof
WO2013130625A1 (en) * 2012-02-27 2013-09-06 Basil Rigas Phospho-ester derivatives and uses thereof
US10106778B2 (en) 2012-11-08 2018-10-23 Whitehead Institute For Biomedical Research Selective targeting of cancer stem cells
US9192609B2 (en) 2013-04-17 2015-11-24 Hedgepath Pharmaceuticals, Inc. Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors
ITRM20130366A1 (it) 2013-06-25 2014-12-26 Univ Roma La Sapienza Multitarget hedgehog pathway inhibitors and uses thereof
WO2015116947A1 (en) 2014-02-01 2015-08-06 University Of Connecticut Itraconazole analogues and methods of use thereof
US10398672B2 (en) 2014-04-29 2019-09-03 Whitehead Institute For Biomedical Research Methods and compositions for targeting cancer stem cells
WO2016196614A1 (en) * 2015-06-01 2016-12-08 University Of Kentucky Research Foundation Chloroquine induction of par-4 and treatment of cancer
BR112017026103B1 (pt) 2015-06-04 2023-10-03 Sol-Gel Technologies Ltd Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos
US20180193335A1 (en) * 2015-10-12 2018-07-12 Vikash J. BHAGWANDIN Compositions, formulations, packaged pharmaceuticals, and methods of using hedgehog pathway modulators for the sensitization of resistant tumors
AU2018253189A1 (en) * 2017-04-12 2019-12-05 Vikash J. BHAGWANDIN Compositions, packaged pharmaceuticals, and methods of using posaconazole for the sensitization of resistant tumors
WO2018211007A1 (en) * 2017-05-18 2018-11-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of mast cell diseases
CA3073228A1 (en) 2017-08-20 2019-02-28 University Of Connecticut Azole analogues and methods of use thereof
CN110279696A (zh) * 2019-07-31 2019-09-27 中国医学科学院皮肤病医院 伊曲康唑在制备抑制肿瘤转移药物中的应用
WO2021030174A1 (en) 2019-08-09 2021-02-18 University Of Connecticut Truncated itraconazole analogues and methods of use thereof
CN113521071A (zh) * 2021-07-22 2021-10-22 广州医科大学 氯喹那多的新应用
CN114081883B (zh) * 2021-11-04 2023-02-28 武汉科技大学 氯喹那多在制备抗肿瘤药物中的应用
WO2024040175A1 (en) 2022-08-18 2024-02-22 Pulmatrix Operating Company, Inc. Methods for treating cancer using inhaled angiogenesis inhibitor
WO2024249959A1 (en) * 2023-06-02 2024-12-05 University Of Massachusetts Medical School Compositions reducing the expression or activity of c1 galt1 for treating ewing sarcoma

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