BR0117063A - Uso de ciclopamina no tratamento de carcinoma de células basais e outros tumores - Google Patents

Uso de ciclopamina no tratamento de carcinoma de células basais e outros tumores

Info

Publication number
BR0117063A
BR0117063A BR0117063-5A BR0117063A BR0117063A BR 0117063 A BR0117063 A BR 0117063A BR 0117063 A BR0117063 A BR 0117063A BR 0117063 A BR0117063 A BR 0117063A
Authority
BR
Brazil
Prior art keywords
cyclopamine
tumors
cell carcinoma
basal cell
tumor
Prior art date
Application number
BR0117063-5A
Other languages
English (en)
Inventor
Sinan Tas
Oktay Avci
Original Assignee
Sinan Tas
Oktay Avci
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21619326&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0117063(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sinan Tas, Oktay Avci filed Critical Sinan Tas
Publication of BR0117063A publication Critical patent/BR0117063A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"USO DE CICLOPAMINA NO TRATAMENTO DE CARCINOMA DE CéLULAS BASAIS E OUTROS TUMORES". Esta invenção refere-se ao uso de ciclopamina in vivo em Carcinomas de células basais, para atingir efeito terapêutico por causar a diferenciação das células tumorosas, e ao mesmo tempo, a morte apoptótica e a remoção altamente eficientes destas células tumorosas, e ao mesmo tempo, conservando as células teciduais normais, inclusive as células indiferenciadas da camada basal epidérmica normal e os folículos pilosos. Causar apoptose por ciclopamina é por um mecanismo não-genotóxico. Estes efeitos tornam o uso de ciclopamina altamente desejável no tratamento de Carcinomas de células basais e outros tumores que usam a via de transdução de sinais hedgehog/abrandada para a proliferação e prevenção de apoptose.
BR0117063-5A 2001-07-02 2001-07-02 Uso de ciclopamina no tratamento de carcinoma de células basais e outros tumores BR0117063A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/TR2001/000027 WO2002078703A1 (en) 2001-07-02 2001-07-02 Use of cyclopamine in the treatment of basal cell carcinoma and other tumors

Publications (1)

Publication Number Publication Date
BR0117063A true BR0117063A (pt) 2004-07-27

Family

ID=21619326

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0117063-5A BR0117063A (pt) 2001-07-02 2001-07-02 Uso de ciclopamina no tratamento de carcinoma de células basais e outros tumores

Country Status (14)

Country Link
EP (4) EP2862570A1 (pt)
JP (3) JP2004536045A (pt)
KR (1) KR20090125833A (pt)
CN (2) CN1525859B (pt)
AT (2) ATE305300T1 (pt)
AU (1) AU2001272892B8 (pt)
BR (1) BR0117063A (pt)
CA (1) CA2452151C (pt)
DE (2) DE60113733T2 (pt)
DK (2) DK1401438T3 (pt)
ES (3) ES2250434T3 (pt)
PT (1) PT1411938E (pt)
RU (1) RU2312661C2 (pt)
WO (2) WO2002078703A1 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US20170326118A1 (en) 2001-07-02 2017-11-16 Sinan Tas Drug treatment of tumors wherein hedgehog/smoothened signaling is utilized for inhibition of apoptosis of tumor cells
EP2862570A1 (en) * 2001-07-02 2015-04-22 Sinan Tas Use of cyclopamine in the treatment of basal cell carcinoma and other tumors
EP1411938B1 (en) 2001-07-02 2005-07-06 Tas, Sinan Use of cyclopamine for the manufacture of a medicament for the treatemnt of psoriasis
US8653083B2 (en) 2005-08-22 2014-02-18 The Johns Hopkins University Hedgehog pathway antagonists to treat disease
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
HUE031122T2 (en) 2005-10-31 2017-07-28 Oncomed Pharm Inc Preparations and methods for the treatment of cancer based on human FZD receptors
WO2008121102A2 (en) * 2006-02-21 2008-10-09 The Regents Of The University Of Michigan Hedgehog signaling pathway antagonist cancer treatment
WO2008070357A2 (en) * 2006-10-31 2008-06-12 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Smoothened polypeptides and methods of use
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
US8148147B2 (en) 2007-01-24 2012-04-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
US7648994B2 (en) 2007-03-07 2010-01-19 Infinity Discovery, Inc. Heterocyclic cyclopamine analogs and methods of use thereof
AU2008222655B2 (en) 2007-03-07 2014-03-27 Infinity Pharmaceuticals, Inc. Cyclopamine lactam analogs and methods of use thereof
CA2710858A1 (en) 2007-12-27 2009-07-09 Infinity Pharmaceuticals, Inc. Methods for stereoselective reduction
WO2009099625A2 (en) * 2008-02-08 2009-08-13 The Board Of Regents Of The University Of Texas System Cyclopamine tartrate salt and uses thereof
BRPI0919473A2 (pt) 2008-09-26 2017-08-29 Oncomed Pharm Inc Agentes de ligação frizzled e usos dos mesmos
WO2010080817A2 (en) * 2009-01-06 2010-07-15 Utah State University Carbohydrate-cyclopamine conjugates as anticancer agents
JP2009143963A (ja) * 2009-03-25 2009-07-02 Sinan Tas 腫瘍細胞のアポトーシスを阻害するためにヘッジホッグ／スムーズンド信号を使用する腫瘍を治療するための製薬組成物
EP2462115B1 (en) 2009-08-05 2016-01-06 Infinity Pharmaceuticals, Inc. Enzymatic transamination of cyclopamine analogs
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
MX347515B (es) 2010-04-01 2017-04-28 Oncomed Pharmaceuticals Inc * Agentes que se unen al receptor encrespado y usos de los mismos.
US9376447B2 (en) 2010-09-14 2016-06-28 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
CA2887711A1 (en) 2012-10-23 2014-05-01 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using wnt pathway-binding agents
WO2014121196A1 (en) 2013-02-04 2014-08-07 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a wnt pathway inhibitor
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
WO2015096654A1 (zh) * 2013-12-26 2015-07-02 中国科学院上海生命科学研究院 Shh信号通路特异性抑制剂的应用
US10369147B2 (en) 2015-06-04 2019-08-06 PellePharm, Inc. Topical formulations for delivery of hedgehog inhibitor compounds and use thereof
US20170231968A1 (en) * 2016-02-11 2017-08-17 PellePharm, Inc. Method for relief of and treatment of pruritus
EP4344410A1 (en) 2021-09-13 2024-04-03 Sinan Tas Effective interventions with aging and diseases of aging of human and their consequences
CN114292279B (zh) * 2022-01-07 2023-05-09 吉林省农业科学院 一种藜芦抗癌有效成分环杷明提取与分离方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999052534A1 (en) * 1998-04-09 1999-10-21 Johns Hopkins University School Of Medicine Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways
US6291516B1 (en) * 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
CA2376210A1 (en) * 1999-06-08 2000-12-14 Lorantis Limited Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway
WO2001027135A2 (en) * 1999-10-13 2001-04-19 Johns Hopkins University School Of Medicine Regulators of the hedgehog pathway, compositions and uses related thereto
CA2392958A1 (en) * 1999-11-30 2001-06-07 Curis, Inc. Methods and compositions for regulating lymphocyte activity
CU23175A1 (es) * 2000-07-17 2006-09-22 Ct De Investigacion Y Desarrol Formulacion liposomica de propionato de clobetasol
EP1411938B1 (en) * 2001-07-02 2005-07-06 Tas, Sinan Use of cyclopamine for the manufacture of a medicament for the treatemnt of psoriasis
EP2862570A1 (en) * 2001-07-02 2015-04-22 Sinan Tas Use of cyclopamine in the treatment of basal cell carcinoma and other tumors

Also Published As

Publication number Publication date
RU2312661C2 (ru) 2007-12-20
DE60113733T2 (de) 2006-06-29
JP2010132691A (ja) 2010-06-17
WO2002078703A1 (en) 2002-10-10
DE60204966D1 (de) 2005-08-11
PT1411938E (pt) 2005-11-30
CN1525859B (zh) 2010-05-05
AU2001272892B2 (en) 2006-03-16
EP2216022A1 (en) 2010-08-11
JP5424923B2 (ja) 2014-02-26
EP1561464A3 (en) 2007-04-25
ES2246011T3 (es) 2006-02-01
AU2001272892B8 (en) 2006-05-04
EP1561464A2 (en) 2005-08-10
EP1401438B1 (en) 2005-09-28
EP1401438A1 (en) 2004-03-31
JP2004536045A (ja) 2004-12-02
WO2002078704A1 (en) 2002-10-10
ATE299022T1 (de) 2005-07-15
ATE305300T1 (de) 2005-10-15
CN1522146A (zh) 2004-08-18
DK1401438T3 (da) 2006-02-13
DK1411938T3 (da) 2005-11-07
EP2216022B1 (en) 2015-01-07
CN1230169C (zh) 2005-12-07
EP2862570A1 (en) 2015-04-22
DE60113733D1 (de) 2006-02-09
WO2002078703A8 (en) 2003-06-12
ES2250434T3 (es) 2006-04-16
CN1525859A (zh) 2004-09-01
KR20090125833A (ko) 2009-12-07
CA2452151C (en) 2012-01-03
RU2004103074A (ru) 2005-05-10
JP2014028834A (ja) 2014-02-13
CA2452151A1 (en) 2002-10-10
DE60204966T2 (de) 2006-05-18
ES2534400T3 (es) 2015-04-22

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: SINAN TAS (TR)

Free format text: TRANSFERIDO DE: OKTAY AVCI

B25G Requested change of headquarter approved

Owner name: SINAN TAS (TR)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020060181175/RJ DE 05/12/2006.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]