ATE299022T1 - Verwendung von cyclopamine zur herstellung eines arzneimittels zur behandlung von psoriasis - Google Patents
Verwendung von cyclopamine zur herstellung eines arzneimittels zur behandlung von psoriasisInfo
- Publication number
- ATE299022T1 ATE299022T1 AT02736467T AT02736467T ATE299022T1 AT E299022 T1 ATE299022 T1 AT E299022T1 AT 02736467 T AT02736467 T AT 02736467T AT 02736467 T AT02736467 T AT 02736467T AT E299022 T1 ATE299022 T1 AT E299022T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclopamine
- treatment
- psoriasis
- production
- medicinal product
- Prior art date
Links
- QASFUMOKHFSJGL-LAFRSMQTSA-N Cyclopamine Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H](CC2=C3C)[C@@H]1[C@@H]2CC[C@@]13O[C@@H]2C[C@H](C)CN[C@H]2[C@H]1C QASFUMOKHFSJGL-LAFRSMQTSA-N 0.000 title abstract 3
- QASFUMOKHFSJGL-UHFFFAOYSA-N cyclopamine Natural products C1C=C2CC(O)CCC2(C)C(CC2=C3C)C1C2CCC13OC2CC(C)CNC2C1C QASFUMOKHFSJGL-UHFFFAOYSA-N 0.000 title abstract 3
- 201000004681 Psoriasis Diseases 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 241000027355 Ferocactus setispinus Species 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 230000006907 apoptotic process Effects 0.000 abstract 2
- 230000011664 signaling Effects 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 230000008034 disappearance Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/TR2001/000027 WO2002078703A1 (en) | 2001-07-02 | 2001-07-02 | Use of cyclopamine in the treatment of basal cell carcinoma and other tumors |
| PCT/TR2002/000017 WO2002078704A1 (en) | 2001-07-02 | 2002-04-19 | Use of cyclopamine in the treatment of psoriasis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE299022T1 true ATE299022T1 (de) | 2005-07-15 |
Family
ID=21619326
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01952097T ATE305300T1 (de) | 2001-07-02 | 2001-07-02 | Verwendung von cyclopamine, zur behandlung des basalzellkarzinoms und anderer tumoren |
| AT02736467T ATE299022T1 (de) | 2001-07-02 | 2002-04-19 | Verwendung von cyclopamine zur herstellung eines arzneimittels zur behandlung von psoriasis |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01952097T ATE305300T1 (de) | 2001-07-02 | 2001-07-02 | Verwendung von cyclopamine, zur behandlung des basalzellkarzinoms und anderer tumoren |
Country Status (14)
| Country | Link |
|---|---|
| EP (4) | EP2862570A1 (de) |
| JP (3) | JP2004536045A (de) |
| KR (1) | KR20090125833A (de) |
| CN (2) | CN1525859B (de) |
| AT (2) | ATE305300T1 (de) |
| AU (1) | AU2001272892B8 (de) |
| BR (1) | BR0117063A (de) |
| CA (1) | CA2452151C (de) |
| DE (2) | DE60113733T2 (de) |
| DK (2) | DK1401438T3 (de) |
| ES (3) | ES2534400T3 (de) |
| PT (1) | PT1411938E (de) |
| RU (1) | RU2312661C2 (de) |
| WO (2) | WO2002078703A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
| EP1411938B1 (de) | 2001-07-02 | 2005-07-06 | Tas, Sinan | Verwendung von cyclopamine zur Herstellung eines Arzneimittels zur Behandlung von Psoriasis |
| JP2004536045A (ja) * | 2001-07-02 | 2004-12-02 | タシ、シナン | 基底細胞癌及び他の腫瘍の治療におけるシクロパミンの使用方法 |
| US20170326118A1 (en) | 2001-07-02 | 2017-11-16 | Sinan Tas | Drug treatment of tumors wherein hedgehog/smoothened signaling is utilized for inhibition of apoptosis of tumor cells |
| EP1919480B1 (de) * | 2005-08-22 | 2013-01-16 | The Johns Hopkins University | Hedgehog-weg-antagonisten zur behandlung von krankheiten |
| PT2500360E (pt) | 2005-10-31 | 2015-10-15 | Oncomed Pharm Inc | Composições e métodos para diagnóstico e tratamento do cancro |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| WO2008070357A2 (en) * | 2006-10-31 | 2008-06-12 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Smoothened polypeptides and methods of use |
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| WO2008092002A2 (en) | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| BRPI0808444A2 (pt) | 2007-03-07 | 2017-06-06 | Infinity Discovery Inc | análogos de ciclopamina lactam e métodos de uso dos mesmos |
| EP2129677B1 (de) * | 2007-03-07 | 2014-12-17 | Infinity Discovery, Inc. | Heterocyclische cyclopamin-analoga und verfahren zu ihrer verwendung |
| CN101917853B (zh) | 2007-12-27 | 2014-03-19 | 无限药品股份有限公司 | 立体选择性还原的方法 |
| WO2009099625A2 (en) * | 2008-02-08 | 2009-08-13 | The Board Of Regents Of The University Of Texas System | Cyclopamine tartrate salt and uses thereof |
| ES2663536T3 (es) | 2008-09-26 | 2018-04-13 | Oncomed Pharmaceuticals, Inc. | Agentes que se unen a receptores frizzled y usos de los mismos |
| WO2010080817A2 (en) * | 2009-01-06 | 2010-07-15 | Utah State University | Carbohydrate-cyclopamine conjugates as anticancer agents |
| JP2009143963A (ja) * | 2009-03-25 | 2009-07-02 | Sinan Tas | 腫瘍細胞のアポトーシスを阻害するためにヘッジホッグ／スムーズンド信号を使用する腫瘍を治療するための製薬組成物 |
| AU2010279325B2 (en) | 2009-08-05 | 2016-10-20 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| CN102971337B (zh) | 2010-04-01 | 2016-09-21 | 昂考梅德药品有限公司 | 卷曲蛋白结合药剂及其应用 |
| US9394313B2 (en) | 2010-09-14 | 2016-07-19 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| HK1212216A1 (en) | 2012-10-23 | 2016-06-10 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
| JP2016510411A (ja) | 2013-02-04 | 2016-04-07 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| CN104740633A (zh) * | 2013-12-26 | 2015-07-01 | 中国科学院上海生命科学研究院 | Shh信号通路特异性抑制剂的应用 |
| US10369147B2 (en) | 2015-06-04 | 2019-08-06 | PellePharm, Inc. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
| WO2017139497A1 (en) * | 2016-02-11 | 2017-08-17 | PellePharm, Inc. | Hedgehog inhibitor for use in relief of and treatment of pruritus or itching |
| CN117940170A (zh) | 2021-09-13 | 2024-04-26 | 辛南·塔斯 | 有效干预人类衰老和衰老疾病及其效果 |
| CN114292279B (zh) * | 2022-01-07 | 2023-05-09 | 吉林省农业科学院 | 一种藜芦抗癌有效成分环杷明提取与分离方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5851993A (en) * | 1994-06-13 | 1998-12-22 | Biotie Therapies Ltd. | Suppression of tumor cell growth by syndecan-1 ectodomain |
| EP1067939B1 (de) * | 1998-04-09 | 2015-09-16 | The Johns Hopkins University | Verwendung von steroidalkaloidderivaten als inhibitoren der hedgehog-protein signalwege |
| EP1115398B1 (de) * | 1998-09-23 | 2010-05-05 | Research Development Foundation | Tocopherole, tocotrienole, sonstige chroman- und seitenkettenderivate, sowie deren verwendungen |
| US6291516B1 (en) * | 1999-01-13 | 2001-09-18 | Curis, Inc. | Regulators of the hedgehog pathway, compositions and uses related thereto |
| GB0013674D0 (en) * | 1999-06-08 | 2000-07-26 | Lorantis Ltd | Therapeutic use |
| JP5420128B2 (ja) * | 1999-10-13 | 2014-02-19 | ジョンズ ホプキンス ユニバーシティ スクール オブ メディシン | ヘッジホッグ経路の調節物質、並びにそれに関する組成物及び利用法 |
| EP1646395B8 (de) * | 1999-11-30 | 2014-12-17 | Curis, Inc. | Verfahren und zusammensetzungen zur regulierung der lymphozytenaktivität |
| CU23175A1 (es) * | 2000-07-17 | 2006-09-22 | Ct De Investigacion Y Desarrol | Formulacion liposomica de propionato de clobetasol |
| JP2004536045A (ja) * | 2001-07-02 | 2004-12-02 | タシ、シナン | 基底細胞癌及び他の腫瘍の治療におけるシクロパミンの使用方法 |
| EP1411938B1 (de) * | 2001-07-02 | 2005-07-06 | Tas, Sinan | Verwendung von cyclopamine zur Herstellung eines Arzneimittels zur Behandlung von Psoriasis |
-
2001
- 2001-07-02 JP JP2002576969A patent/JP2004536045A/ja active Pending
- 2001-07-02 AU AU2001272892A patent/AU2001272892B8/en not_active Ceased
- 2001-07-02 EP EP20140196071 patent/EP2862570A1/de not_active Withdrawn
- 2001-07-02 BR BR0117063-5A patent/BR0117063A/pt active Search and Examination
- 2001-07-02 CA CA2452151A patent/CA2452151C/en not_active Expired - Fee Related
- 2001-07-02 CN CN018234429A patent/CN1525859B/zh not_active Expired - Fee Related
- 2001-07-02 EP EP01952097A patent/EP1401438B1/de not_active Revoked
- 2001-07-02 AT AT01952097T patent/ATE305300T1/de not_active IP Right Cessation
- 2001-07-02 DE DE60113733T patent/DE60113733T2/de not_active Expired - Lifetime
- 2001-07-02 EP EP10163813.8A patent/EP2216022B1/de not_active Expired - Lifetime
- 2001-07-02 DK DK01952097T patent/DK1401438T3/da active
- 2001-07-02 ES ES10163813.8T patent/ES2534400T3/es not_active Expired - Lifetime
- 2001-07-02 EP EP05008758A patent/EP1561464A3/de not_active Withdrawn
- 2001-07-02 WO PCT/TR2001/000027 patent/WO2002078703A1/en not_active Ceased
- 2001-07-02 ES ES01952097T patent/ES2250434T3/es not_active Expired - Lifetime
-
2002
- 2002-04-19 ES ES02736467T patent/ES2246011T3/es not_active Expired - Lifetime
- 2002-04-19 PT PT02736467T patent/PT1411938E/pt unknown
- 2002-04-19 WO PCT/TR2002/000017 patent/WO2002078704A1/en not_active Ceased
- 2002-04-19 RU RU2004103074/15A patent/RU2312661C2/ru not_active IP Right Cessation
- 2002-04-19 DE DE60204966T patent/DE60204966T2/de not_active Expired - Lifetime
- 2002-04-19 AT AT02736467T patent/ATE299022T1/de not_active IP Right Cessation
- 2002-04-19 CN CNB02813429XA patent/CN1230169C/zh not_active Expired - Fee Related
- 2002-04-19 DK DK02736467T patent/DK1411938T3/da active
-
2003
- 2003-03-17 KR KR1020097022024A patent/KR20090125833A/ko not_active Ceased
-
2010
- 2010-02-10 JP JP2010028010A patent/JP5424923B2/ja not_active Expired - Fee Related
-
2013
- 2013-09-18 JP JP2013193304A patent/JP2014028834A/ja not_active Ceased
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| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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| REN | Ceased due to non-payment of the annual fee |