JP2009505727A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009505727A5 JP2009505727A5 JP2008527964A JP2008527964A JP2009505727A5 JP 2009505727 A5 JP2009505727 A5 JP 2009505727A5 JP 2008527964 A JP2008527964 A JP 2008527964A JP 2008527964 A JP2008527964 A JP 2008527964A JP 2009505727 A5 JP2009505727 A5 JP 2009505727A5
- Authority
- JP
- Japan
- Prior art keywords
- medical device
- biodegradable polymer
- ratio
- formula
- zotarolimus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920002988 biodegradable polymer Polymers 0.000 claims 15
- 239000004621 biodegradable polymer Substances 0.000 claims 15
- CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical compound N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 claims 7
- 229950009819 zotarolimus Drugs 0.000 claims 7
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 230000002792 vascular Effects 0.000 claims 6
- 108010016731 PPAR gamma Proteins 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 229940122361 Bisphosphonate Drugs 0.000 claims 2
- 102400001368 Epidermal growth factor Human genes 0.000 claims 2
- 101800003838 Epidermal growth factor Proteins 0.000 claims 2
- YACHGFWEQXFSBS-UHFFFAOYSA-N Leptomycin B Natural products OC(=O)C=C(C)CC(C)C(O)C(C)C(=O)C(C)C=C(C)C=CCC(C)C=C(CC)C=CC1OC(=O)C=CC1C YACHGFWEQXFSBS-UHFFFAOYSA-N 0.000 claims 2
- 108010006519 Molecular Chaperones Proteins 0.000 claims 2
- 102000000536 PPAR gamma Human genes 0.000 claims 2
- 102000012132 Peroxisome proliferator-activated receptor gamma Human genes 0.000 claims 2
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 2
- 229940079156 Proteasome inhibitor Drugs 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 2
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 229940088710 antibiotic agent Drugs 0.000 claims 2
- -1 antibodies Substances 0.000 claims 2
- 210000000013 bile duct Anatomy 0.000 claims 2
- 150000004663 bisphosphonates Chemical class 0.000 claims 2
- 229940116977 epidermal growth factor Drugs 0.000 claims 2
- 229940011871 estrogen Drugs 0.000 claims 2
- 239000000262 estrogen Substances 0.000 claims 2
- 210000003709 heart valve Anatomy 0.000 claims 2
- YACHGFWEQXFSBS-XYERBDPFSA-N leptomycin B Chemical compound OC(=O)/C=C(C)/C[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)/C=C(\C)/C=C/C[C@@H](C)/C=C(/CC)\C=C\[C@@H]1OC(=O)C=C[C@@H]1C YACHGFWEQXFSBS-XYERBDPFSA-N 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 2
- 239000003207 proteasome inhibitor Substances 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 2
- VPVXHAANQNHFSF-UHFFFAOYSA-N 1,4-dioxan-2-one Chemical compound O=C1COCCO1 VPVXHAANQNHFSF-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims 1
- 229910000531 Co alloy Inorganic materials 0.000 claims 1
- RZTOWFMDBDPERY-UHFFFAOYSA-N Delta-Hexanolactone Chemical compound CC1CCCC(=O)O1 RZTOWFMDBDPERY-UHFFFAOYSA-N 0.000 claims 1
- 229910001069 Ti alloy Inorganic materials 0.000 claims 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000000975 bioactive effect Effects 0.000 claims 1
- 239000000560 biocompatible material Substances 0.000 claims 1
- 229920000249 biocompatible polymer Polymers 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 229910052804 chromium Inorganic materials 0.000 claims 1
- 239000011651 chromium Substances 0.000 claims 1
- 229910017052 cobalt Inorganic materials 0.000 claims 1
- 239000010941 cobalt Substances 0.000 claims 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 claims 1
- 229910001000 nickel titanium Inorganic materials 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 239000010935 stainless steel Substances 0.000 claims 1
- 229910001220 stainless steel Inorganic materials 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229920001059 synthetic polymer Polymers 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 239000010936 titanium Substances 0.000 claims 1
- 229910052719 titanium Inorganic materials 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71190005P | 2005-08-25 | 2005-08-25 | |
| PCT/US2006/031290 WO2007024501A2 (en) | 2005-08-25 | 2006-08-09 | Nitric oxide-releasing biodegradable polymers useful as medical devices and coatings therefore |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009505727A JP2009505727A (ja) | 2009-02-12 |
| JP2009505727A5 true JP2009505727A5 (enExample) | 2009-09-24 |
Family
ID=37635806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008527964A Pending JP2009505727A (ja) | 2005-08-25 | 2006-08-09 | 医療機器及びそのコーティングとして有益な一酸化窒素放出生分解性ポリマー |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8021679B2 (enExample) |
| EP (1) | EP1933845A2 (enExample) |
| JP (1) | JP2009505727A (enExample) |
| WO (1) | WO2007024501A2 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2552735C (en) * | 2004-01-07 | 2012-09-11 | Noxilizer, Inc. | Sterilization system and device |
| US8017074B2 (en) | 2004-01-07 | 2011-09-13 | Noxilizer, Inc. | Sterilization system and device |
| JP5274248B2 (ja) | 2005-05-27 | 2013-08-28 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 酸化窒素治療及び医生物的応用のための酸化窒素放出粒子 |
| US8021679B2 (en) | 2005-08-25 | 2011-09-20 | Medtronic Vascular, Inc | Nitric oxide-releasing biodegradable polymers useful as medical devices and coatings therefore |
| ATE472340T1 (de) * | 2005-08-25 | 2010-07-15 | Medtronic Vascular Inc | Polymere zusammensetzungen auf 4- azacaprolactonbasis, die sich für die herstellung von biologisch abbaubaren medizinischen geräten und als beschichtungen für medizinische geräte eignen |
| US20070053952A1 (en) * | 2005-09-07 | 2007-03-08 | Medtronic Vascular, Inc. | Nitric oxide-releasing polymers derived from modified polymers |
| US8241619B2 (en) | 2006-05-15 | 2012-08-14 | Medtronic Vascular, Inc. | Hindered amine nitric oxide donating polymers for coating medical devices |
| US20090112197A1 (en) | 2007-10-30 | 2009-04-30 | Searete Llc | Devices configured to facilitate release of nitric oxide |
| US7862598B2 (en) * | 2007-10-30 | 2011-01-04 | The Invention Science Fund I, Llc | Devices and systems that deliver nitric oxide |
| US8642093B2 (en) | 2007-10-30 | 2014-02-04 | The Invention Science Fund I, Llc | Methods and systems for use of photolyzable nitric oxide donors |
| US8221690B2 (en) | 2007-10-30 | 2012-07-17 | The Invention Science Fund I, Llc | Systems and devices that utilize photolyzable nitric oxide donors |
| US7811600B2 (en) * | 2007-03-08 | 2010-10-12 | Medtronic Vascular, Inc. | Nitric oxide donating medical devices and methods of making same |
| US8273828B2 (en) | 2007-07-24 | 2012-09-25 | Medtronic Vascular, Inc. | Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation |
| US8877508B2 (en) | 2007-10-30 | 2014-11-04 | The Invention Science Fund I, Llc | Devices and systems that deliver nitric oxide |
| US10080823B2 (en) | 2007-10-30 | 2018-09-25 | Gearbox Llc | Substrates for nitric oxide releasing devices |
| US8980332B2 (en) | 2007-10-30 | 2015-03-17 | The Invention Science Fund I, Llc | Methods and systems for use of photolyzable nitric oxide donors |
| US7897399B2 (en) | 2007-10-30 | 2011-03-01 | The Invention Science Fund I, Llc | Nitric oxide sensors and systems |
| US8349262B2 (en) | 2007-10-30 | 2013-01-08 | The Invention Science Fund I, Llc | Nitric oxide permeable housings |
| US20090222088A1 (en) * | 2008-02-29 | 2009-09-03 | Medtronic Vascular, Inc. | Secondary Amine Containing Nitric Oxide Releasing Polymer Composition |
| US20090232863A1 (en) * | 2008-03-17 | 2009-09-17 | Medtronic Vascular, Inc. | Biodegradable Carbon Diazeniumdiolate Based Nitric Oxide Donating Polymers |
| US20090232868A1 (en) * | 2008-03-17 | 2009-09-17 | Medtronic Vascular, Inc. | Nitric Oxide Releasing Polymer Composition |
| US20090299466A1 (en) * | 2008-06-02 | 2009-12-03 | Medtronic Vascular, Inc. | Local Delivery of Matrix Metalloproteinase Inhibitors |
| AU2009293653B2 (en) * | 2008-09-19 | 2014-12-11 | Northwestern University | Biodegradable nitric oxide generating polymers and related biomedical devices |
| US8158187B2 (en) * | 2008-12-19 | 2012-04-17 | Medtronic Vascular, Inc. | Dry diazeniumdiolation methods for producing nitric oxide releasing medical devices |
| US8425837B2 (en) | 2009-02-23 | 2013-04-23 | Noxilizer, Inc. | Device and method for gas sterilization |
| US8709465B2 (en) | 2009-04-13 | 2014-04-29 | Medtronic Vascular, Inc. | Diazeniumdiolated phosphorylcholine polymers for nitric oxide release |
| DK2467173T3 (da) | 2009-08-21 | 2019-07-29 | Novan Inc | Sårbandager, fremgangsmåder til anvendelse heraf og fremgangsmåder til dannelse deraf |
| ES2958410T3 (es) | 2009-08-21 | 2024-02-08 | Novan Inc | Geles tópicos |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| EP2678041A4 (en) | 2011-02-24 | 2015-12-23 | Univ Colorado State Res Found | MATERIALS FOR MODULATING BIOLOGICAL REACTIONS AND MANUFACTURING METHOD THEREFOR |
| WO2012118819A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same |
| US10293044B2 (en) | 2014-04-18 | 2019-05-21 | Auburn University | Particulate formulations for improving feed conversion rate in a subject |
| CN106232106B (zh) | 2014-04-18 | 2020-08-11 | 奥本大学 | 用于诱导先天性和适应性免疫力的颗粒状疫苗制剂 |
| US10583199B2 (en) | 2016-04-26 | 2020-03-10 | Northwestern University | Nanocarriers having surface conjugated peptides and uses thereof for sustained local release of drugs |
| AU2017371223B2 (en) | 2016-12-09 | 2023-04-27 | Zenflow, Inc. | Systems, devices, and methods for the accurate deployment of an implant in the prostatic urethra |
| WO2018191415A1 (en) | 2017-04-11 | 2018-10-18 | Colorado State University Research Foundation | Functionalization of metal-organic frameworks |
| WO2019014348A1 (en) | 2017-07-11 | 2019-01-17 | Colorado State University Research Foundation | CHITOSAN COMPOSITE MATERIAL AND METALLO-ORGANIC STRUCTURE |
| US20210052855A1 (en) * | 2018-05-03 | 2021-02-25 | Bionaut Labs Ltd. | Hybrid electromagnetic device for remote control of micro-nano scale robots, medical tools and implantable devices |
| WO2021101951A1 (en) | 2019-11-19 | 2021-05-27 | Zenflow, Inc. | Systems, devices, and methods for the accurate deployment and imaging of an implant in the prostatic urethra |
| US20230044613A1 (en) * | 2019-12-17 | 2023-02-09 | Nanyang Technological University | Block copolymers with nitric oxide donor |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4954526A (en) | 1989-02-28 | 1990-09-04 | The United States Of America As Represented By The Department Of Health And Human Services | Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents |
| US5039705A (en) | 1989-09-15 | 1991-08-13 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof |
| US5212204A (en) | 1989-10-18 | 1993-05-18 | The United States Of America As Represented By The Department Of Health And Human Services | Antihypertensive compositions and use thereof |
| US5155137A (en) | 1990-09-20 | 1992-10-13 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Complexes of nitric oxide with polyamines |
| US5268465A (en) | 1991-01-18 | 1993-12-07 | The Johns Hopkins University | Purification and molecular cloning of nitric oxide synthase |
| US5380758A (en) | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
| ES2112332T3 (es) | 1991-09-24 | 1998-04-01 | Us Health | Derivados de substitucion de oxigeno de productos de adicion de nucleofilo-oxido nitrico utilizados como promedicamentos donadores de oxido nitrico. |
| US5525357A (en) | 1992-08-24 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US5650447A (en) * | 1992-08-24 | 1997-07-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitric oxide-releasing polymers to treat restenosis and related disorders |
| US5632981A (en) | 1992-08-24 | 1997-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US5405919A (en) | 1992-08-24 | 1995-04-11 | The United States Of America As Represented By The Secretary Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders |
| US5910316A (en) | 1992-08-24 | 1999-06-08 | The United States Of America, As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents to treat impotency |
| US5658565A (en) | 1994-06-24 | 1997-08-19 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Inducible nitric oxide synthase gene for treatment of disease |
| WO1994012645A2 (en) | 1992-11-25 | 1994-06-09 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | cDNA CLONE FOR HUMAN INDUCIBLE NITRIC OXYDE SYNTHASE AND PROCESS FOR PREPARING SAME |
| EP0689465A1 (en) | 1993-03-18 | 1996-01-03 | Cedars-Sinai Medical Center | Drug incorporating and releasing polymeric coating for bioprosthesis |
| US5891459A (en) | 1993-06-11 | 1999-04-06 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of vascular function by modulation of endogenous nitric oxide production or activity |
| US5428070A (en) | 1993-06-11 | 1995-06-27 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production of activity |
| US5945452A (en) | 1993-06-11 | 1999-08-31 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production or activity |
| US6087479A (en) | 1993-09-17 | 2000-07-11 | Nitromed, Inc. | Localized use of nitric oxide-adducts to prevent internal tissue damage |
| US5788687A (en) * | 1994-02-01 | 1998-08-04 | Caphco, Inc | Compositions and devices for controlled release of active ingredients |
| US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| US5583101A (en) | 1994-07-15 | 1996-12-10 | Harvard College | Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction |
| US5665077A (en) | 1995-04-24 | 1997-09-09 | Nitrosci Pharmaceuticals Llc | Nitric oxide-releasing nitroso compositions and methods and intravascular devices for using them to prevent restenosis |
| EP0910351A1 (en) * | 1996-06-27 | 1999-04-28 | G.D. Searle & Co. | Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications |
| US6232434B1 (en) | 1996-08-02 | 2001-05-15 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
| WO1998007696A1 (en) | 1996-08-21 | 1998-02-26 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Stable non-hygroscopic crystalline form of n-[n-n-(4-(piperidin-4-yl)butanoyl)-n-ethylglycyl] compounds |
| CA2705474C (en) | 1996-09-27 | 2013-07-16 | The Government Of The United States Of America, Represented By The Secre Tary, Department Of Health And Human Services | O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates |
| DE69842142D1 (de) | 1997-07-03 | 2011-04-07 | Us Gov Health & Human Serv | Stickoxid freistetzende amidin- und enaminverwandte diazeniumdiolate, zubereitungen und verwendungen davon und verfahren zu ihrer herstellung |
| US20030129215A1 (en) * | 1998-09-24 | 2003-07-10 | T-Ram, Inc. | Medical devices containing rapamycin analogs |
| US6015815A (en) | 1997-09-26 | 2000-01-18 | Abbott Laboratories | Tetrazole-containing rapamycin analogs with shortened half-lives |
| US7378105B2 (en) | 1997-09-26 | 2008-05-27 | Abbott Laboratories | Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens |
| GB9801398D0 (en) | 1998-01-22 | 1998-03-18 | Anggard Erik E | Chemical compounds |
| US6224626B1 (en) * | 1998-02-17 | 2001-05-01 | Md3, Inc. | Ultra-thin expandable stent |
| DE69820023T2 (de) | 1998-03-26 | 2004-09-02 | Biomat B.V. | Endovaskuläre Gefässprothesen mit polymerer Beschichtung |
| US6379691B1 (en) * | 1998-09-29 | 2002-04-30 | Medtronic/Ave, Inc. | Uses for medical devices having a lubricious, nitric oxide-releasing coating |
| US6299980B1 (en) | 1998-09-29 | 2001-10-09 | Medtronic Ave, Inc. | One step lubricious coating |
| WO2001010344A1 (en) * | 1999-08-04 | 2001-02-15 | C.R. Bard, Inc. | Nitric oxide releasing medical devices |
| US6737447B1 (en) | 1999-10-08 | 2004-05-18 | The University Of Akron | Nitric oxide-modified linear poly(ethylenimine) fibers and uses thereof |
| US6270779B1 (en) * | 2000-05-10 | 2001-08-07 | United States Of America | Nitric oxide-releasing metallic medical devices |
| US7416559B2 (en) | 2000-10-27 | 2008-08-26 | Poly-Med, Inc. | Micromantled drug-eluting stent |
| US6706274B2 (en) | 2001-01-18 | 2004-03-16 | Scimed Life Systems, Inc. | Differential delivery of nitric oxide |
| US6841166B1 (en) | 2001-08-21 | 2005-01-11 | The Regents Of The University Of Michigan | Nitric oxide-releasing polymers incorporating diazeniumdiolated silane derivatives |
| US6673338B1 (en) | 2001-09-10 | 2004-01-06 | The United States Of America As Represented By The Department Of Health And Human Services | Nitric oxide-releasing imidate and thioimidate diazeniumdiolates, compositions, uses thereof and method of making same |
| US20030083739A1 (en) * | 2001-09-24 | 2003-05-01 | Robert Cafferata | Rational drug therapy device and methods |
| US6703046B2 (en) | 2001-10-04 | 2004-03-09 | Medtronic Ave Inc. | Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use |
| US7919075B1 (en) | 2002-03-20 | 2011-04-05 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices |
| US20030181973A1 (en) * | 2002-03-20 | 2003-09-25 | Harvinder Sahota | Reduced restenosis drug containing stents |
| US7070798B1 (en) | 2002-06-21 | 2006-07-04 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine |
| US6949530B2 (en) | 2002-07-18 | 2005-09-27 | The United States Of America As Represented By The Department Of Health And Human Services | Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same |
| AU2003281815A1 (en) | 2002-08-02 | 2004-02-23 | The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Hu | Cross-linked nitric oxide-releasing polyamine coated substrates, compositions comprising same and method of making same |
| US6951902B2 (en) | 2002-08-16 | 2005-10-04 | Michigan Biotechnology Institute | Two dimensional polymer that generates nitric oxide |
| EP1572029B1 (en) * | 2002-11-07 | 2010-03-24 | Abbott Laboratories | Method of loading beneficial agent to a prosthesis by fluid-jet application |
| US20040236415A1 (en) * | 2003-01-02 | 2004-11-25 | Richard Thomas | Medical devices having drug releasing polymer reservoirs |
| US20040180131A1 (en) | 2003-03-14 | 2004-09-16 | Medtronic Ave. | Stent coating method |
| FR2859729B1 (fr) * | 2003-09-12 | 2006-02-24 | Roquette Freres | Dispersions aqueuses d'au moins un polymere biodegradable |
| JP2007508121A (ja) | 2003-10-14 | 2007-04-05 | キューブ メディカル エーエス | 血管形成術用バルーン |
| US20050171596A1 (en) | 2004-02-03 | 2005-08-04 | Furst Joseph G. | Stents with amphiphilic copolymer coatings |
| EP1718603A4 (en) | 2004-02-09 | 2009-09-23 | Noxilizer Inc | MOLECULES RELEASING NITROGEN MONOXIDE |
| US7569559B2 (en) | 2004-02-09 | 2009-08-04 | Noxilizer, Inc. | Nitric oxide-releasing molecules |
| WO2005112954A1 (en) | 2004-05-14 | 2005-12-01 | William Marsh Rice University | Nitric oxide releasing compositions and associated methods |
| US20050281866A1 (en) | 2004-05-24 | 2005-12-22 | Genzyme Corporation | Adherent polymeric compositions |
| US20060008529A1 (en) | 2004-07-12 | 2006-01-12 | Meyerhoff Mark E | Use of additive sites to control nitric oxide release from nitric oxide donors contained within polymers |
| WO2006037105A2 (en) | 2004-09-27 | 2006-04-06 | Government Of The United States Of America, Represented By The Secretary Department Of Health And Human Services | Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof |
| US20060099235A1 (en) | 2004-11-11 | 2006-05-11 | Medtronic Vascular, Inc. | Medical devices and compositions useful for treating or inhibiting restenosis |
| US20060251824A1 (en) | 2005-05-05 | 2006-11-09 | Boulais Dennis R | Coating of medical devices with solids |
| US8021679B2 (en) | 2005-08-25 | 2011-09-20 | Medtronic Vascular, Inc | Nitric oxide-releasing biodegradable polymers useful as medical devices and coatings therefore |
| US20070053952A1 (en) | 2005-09-07 | 2007-03-08 | Medtronic Vascular, Inc. | Nitric oxide-releasing polymers derived from modified polymers |
| US7928079B2 (en) | 2005-10-31 | 2011-04-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates |
| WO2007053578A2 (en) | 2005-10-31 | 2007-05-10 | Amulet Pharmaceuticals, Inc. | Multi-phasic nitric oxide and drug co-eluting stent coatings |
| WO2007092417A1 (en) | 2006-02-07 | 2007-08-16 | Tepha, Inc. | Toughened polylactic acid polymers and copolymers |
| US8241619B2 (en) | 2006-05-15 | 2012-08-14 | Medtronic Vascular, Inc. | Hindered amine nitric oxide donating polymers for coating medical devices |
| US7811600B2 (en) | 2007-03-08 | 2010-10-12 | Medtronic Vascular, Inc. | Nitric oxide donating medical devices and methods of making same |
| US8273828B2 (en) | 2007-07-24 | 2012-09-25 | Medtronic Vascular, Inc. | Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation |
| US20090222088A1 (en) | 2008-02-29 | 2009-09-03 | Medtronic Vascular, Inc. | Secondary Amine Containing Nitric Oxide Releasing Polymer Composition |
| US20090232863A1 (en) | 2008-03-17 | 2009-09-17 | Medtronic Vascular, Inc. | Biodegradable Carbon Diazeniumdiolate Based Nitric Oxide Donating Polymers |
| US20090232868A1 (en) | 2008-03-17 | 2009-09-17 | Medtronic Vascular, Inc. | Nitric Oxide Releasing Polymer Composition |
-
2006
- 2006-08-09 US US12/064,112 patent/US8021679B2/en not_active Expired - Fee Related
- 2006-08-09 JP JP2008527964A patent/JP2009505727A/ja active Pending
- 2006-08-09 WO PCT/US2006/031290 patent/WO2007024501A2/en not_active Ceased
- 2006-08-09 EP EP06801203A patent/EP1933845A2/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009505727A5 (enExample) | ||
| JP2009506869A5 (enExample) | ||
| RU2400256C2 (ru) | Захват эндотелиальных клеток-предшественников элюирующим лекарственные средства имплантируемым медицинским устройством | |
| US7541048B2 (en) | Coating compositions for bioactive agents | |
| US8221783B2 (en) | Medical devices with triggerable bioadhesive material | |
| US8142836B2 (en) | Multi-layered coatings and methods for controlling elution of active agents | |
| JP3954616B2 (ja) | 生物活性物質放出コーティングを提供するための方法およびシステム | |
| JP3771573B2 (ja) | 芳香族ポリメタクリレートを有する生体活性物質放出コーティング | |
| JP5743287B2 (ja) | ビス−（アルファ−アミノ−ジオール−ジエステル）を含有するポリエステルアミドを含むコーティング | |
| US20120100187A1 (en) | Coatings and methods for controlled elution of hydrophilic active agents | |
| JP2005523045A (ja) | 持効性の薬剤送出系を被覆したステント及びその使用方法 | |
| JP2004536799A (ja) | コドラッグを含有する持続的放出用ドラッグデリバリーシステム | |
| EP2205292B1 (en) | Therapeutic agent-eluting medical devices having textured polymeric surfaces | |
| JP2009523489A (ja) | 被覆医療用具及びその製造方法 | |
| EP2197502A2 (en) | A biocompatible polymer system for extended drug release | |
| WO2007058190A1 (ja) | 薬剤放出制御組成物および薬剤放出性医療器具 | |
| JP2009543659A (ja) | 滅菌中に薬物を保護するためのフリーラジカルスカベンジャーを用いた薬剤溶出性埋め込み型医療機器及び関連する方法 | |
| JP2009505726A5 (enExample) | ||
| CN1964750A (zh) | 用于医疗用具的生物活性的涂料组合物 | |
| Liang et al. | Evaluation of the Degradation Rates and Biocompatibility of Magnesium Pins with Different Compositions, and Processing Techniques for Oral Staplers In Vivo and In Vitro | |
| US20120121658A1 (en) | Functionalized rgd peptidomimetics and their manufacture, and implant having a coating containing such functionalized rgd peptidomimetics |