JP2009505726A5 - - Google Patents

Info

Publication number

JP2009505726A5

JP2009505726A5 JP2008527962A JP2008527962A JP2009505726A5 JP 2009505726 A5 JP2009505726 A5 JP 2009505726A5 JP 2008527962 A JP2008527962 A JP 2008527962A JP 2008527962 A JP2008527962 A JP 2008527962A JP 2009505726 A5 JP2009505726 A5 JP 2009505726A5

Authority

JP

Japan

Prior art keywords

polymer

group

integer

polymer according

phosphorylcholine

Prior art date

2006-08-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 229920000642 polymer Polymers 0.000 claims 16
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 6
• -1 amino, vinyl Chemical group 0.000 claims 4
• 125000000524 functional group Chemical group 0.000 claims 4
• YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 claims 4
• 229950004354 phosphorylcholine Drugs 0.000 claims 4
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
• 125000004043 oxo group Chemical group O=* 0.000 claims 3
• CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical group N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 claims 3
• 229950009819 zotarolimus Drugs 0.000 claims 3
• MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 2
• 102000000536 PPAR gamma Human genes 0.000 claims 2
• 108010016731 PPAR gamma Proteins 0.000 claims 2
• 239000013543 active substance Substances 0.000 claims 2
• 125000003342 alkenyl group Chemical group 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 230000001028 anti-proliverative effect Effects 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• 229940127089 cytotoxic agent Drugs 0.000 claims 2
• 229910052739 hydrogen Inorganic materials 0.000 claims 2
• 239000001257 hydrogen Substances 0.000 claims 2
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
• 239000003112 inhibitor Substances 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• 229920000728 polyester Polymers 0.000 claims 2
• 230000002792 vascular Effects 0.000 claims 2
• 229940122361 Bisphosphonate Drugs 0.000 claims 1
• 102000009024 Epidermal Growth Factor Human genes 0.000 claims 1
• 101800003838 Epidermal growth factor Proteins 0.000 claims 1
• YACHGFWEQXFSBS-UHFFFAOYSA-N Leptomycin B Natural products OC(=O)C=C(C)CC(C)C(O)C(C)C(=O)C(C)C=C(C)C=CCC(C)C=C(CC)C=CC1OC(=O)C=CC1C YACHGFWEQXFSBS-UHFFFAOYSA-N 0.000 claims 1
• 108010006519 Molecular Chaperones Proteins 0.000 claims 1
• 229940079156 Proteasome inhibitor Drugs 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 230000000692 anti-sense effect Effects 0.000 claims 1
• 229940088710 antibiotic agent Drugs 0.000 claims 1
• 230000000975 bioactive effect Effects 0.000 claims 1
• 229920000249 biocompatible polymer Polymers 0.000 claims 1
• 229920002988 biodegradable polymer Polymers 0.000 claims 1
• 239000004621 biodegradable polymer Substances 0.000 claims 1
• 150000004663 bisphosphonates Chemical class 0.000 claims 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 1
• 239000011248 coating agent Substances 0.000 claims 1
• 238000000576 coating method Methods 0.000 claims 1
• 125000004122 cyclic group Chemical group 0.000 claims 1
• 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 1
• 229940116977 epidermal growth factor Drugs 0.000 claims 1
• 229940011871 estrogen Drugs 0.000 claims 1
• 239000000262 estrogen Substances 0.000 claims 1
• 210000003709 heart valve Anatomy 0.000 claims 1
• 150000002596 lactones Chemical group 0.000 claims 1
• YACHGFWEQXFSBS-XYERBDPFSA-N leptomycin B Chemical compound OC(=O)/C=C(C)/C[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)/C=C(\C)/C=C/C[C@@H](C)/C=C(/CC)\C=C\[C@@H]1OC(=O)C=C[C@@H]1C YACHGFWEQXFSBS-XYERBDPFSA-N 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• 239000000178 monomer Substances 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
• 239000002243 precursor Substances 0.000 claims 1
• 239000003207 proteasome inhibitor Substances 0.000 claims 1
• 208000037803 restenosis Diseases 0.000 claims 1
• 238000007142 ring opening reaction Methods 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 1
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 1