JP2009505726A - 生分解性ポリマーを含むことにより向上した官能性を有する医療機器及びコーティング - Google Patents
生分解性ポリマーを含むことにより向上した官能性を有する医療機器及びコーティング Download PDFInfo
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- JP2009505726A JP2009505726A JP2008527962A JP2008527962A JP2009505726A JP 2009505726 A JP2009505726 A JP 2009505726A JP 2008527962 A JP2008527962 A JP 2008527962A JP 2008527962 A JP2008527962 A JP 2008527962A JP 2009505726 A JP2009505726 A JP 2009505726A
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| US71199105P | 2005-08-25 | 2005-08-25 | |
| PCT/US2006/031130 WO2007024492A2 (en) | 2005-08-25 | 2006-08-09 | Medical devices and coatings therefore comprising biodegradable polymers with enhanced functionality |
Publications (2)
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| JP2009505726A true JP2009505726A (ja) | 2009-02-12 |
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| JP2015021038A (ja) * | 2013-07-17 | 2015-02-02 | 日油株式会社 | ホスホリルコリン基含有重合体及びその製造方法 |
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| US20060198867A1 (en) * | 1997-09-25 | 2006-09-07 | Abbott Laboratories, Inc. | Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy |
| GB0329654D0 (en) | 2003-12-23 | 2004-01-28 | Smith & Nephew | Tunable segmented polyacetal |
| JP5416090B2 (ja) | 2007-04-18 | 2014-02-12 | スミス アンド ネフュー ピーエルシー | 形状記憶ポリマーの膨張成形 |
| AU2008243035B2 (en) | 2007-04-19 | 2013-09-12 | Smith & Nephew, Inc. | Graft fixation |
| JP5520814B2 (ja) | 2007-04-19 | 2014-06-11 | スミス アンド ネフュー インコーポレーテッド | マルチモーダル形状記憶ポリマー |
| US8852620B2 (en) | 2007-07-20 | 2014-10-07 | Medtronic Vascular, Inc. | Medical devices comprising polymeric drug delivery systems with drug solubility gradients |
| US8182829B2 (en) | 2007-07-27 | 2012-05-22 | Abbott Cardiovascular Systems Inc. | Drug eluting implantable medical device with hemocompatible and/or prohealing topcoat |
| US20090155337A1 (en) * | 2007-11-12 | 2009-06-18 | Endologix, Inc. | Method and agent for in-situ stabilization of vascular tissue |
| US8147744B2 (en) * | 2009-04-10 | 2012-04-03 | Abbott Cardiovascular Systems Inc. | Method of making a stent formed from crosslinked bioabsorbable polymer |
| US8709465B2 (en) * | 2009-04-13 | 2014-04-29 | Medtronic Vascular, Inc. | Diazeniumdiolated phosphorylcholine polymers for nitric oxide release |
| US20110182964A1 (en) * | 2010-01-22 | 2011-07-28 | Medtronic, Inc. | Vascular Stent Which Elutes Amino Acid-Methyl-Ester Derivatives for the Treatment of Vulnerable Plaque and Vascular Disease |
| CN106232106B (zh) | 2014-04-18 | 2020-08-11 | 奥本大学 | 用于诱导先天性和适应性免疫力的颗粒状疫苗制剂 |
| US10293044B2 (en) | 2014-04-18 | 2019-05-21 | Auburn University | Particulate formulations for improving feed conversion rate in a subject |
| US10583199B2 (en) | 2016-04-26 | 2020-03-10 | Northwestern University | Nanocarriers having surface conjugated peptides and uses thereof for sustained local release of drugs |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000234016A (ja) * | 1998-12-15 | 2000-08-29 | Takeda Chem Ind Ltd | ポリマーの製造方法 |
| JP2002356542A (ja) * | 2001-05-31 | 2002-12-13 | Canon Inc | ポリヒドロキシアルカノエートを含むカード |
| WO2004021976A2 (en) * | 2002-09-05 | 2004-03-18 | Hilborn Joens | New polymers and applications |
| JP2004538132A (ja) * | 2001-06-04 | 2004-12-24 | ユニベルシテ・ド・リエージュ | 導電性表面上に強力に接着したポリマーコーティングを堆積させるプロセス |
| WO2005092406A1 (en) * | 2004-03-22 | 2005-10-06 | Advanced Cardiovascular Systems, Inc. | Phosphoryl choline coating compositions |
| JP2006022324A (ja) * | 2004-06-11 | 2006-01-26 | Canon Inc | ビニル基、エステル基、カルボキシル基並びにスルホン酸基を有するポリヒドロキシアルカノエート並びにその製造方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030129215A1 (en) * | 1998-09-24 | 2003-07-10 | T-Ram, Inc. | Medical devices containing rapamycin analogs |
-
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- 2006-08-09 US US12/064,105 patent/US8871238B2/en active Active
- 2006-08-09 WO PCT/US2006/031130 patent/WO2007024492A2/en not_active Ceased
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000234016A (ja) * | 1998-12-15 | 2000-08-29 | Takeda Chem Ind Ltd | ポリマーの製造方法 |
| JP2002356542A (ja) * | 2001-05-31 | 2002-12-13 | Canon Inc | ポリヒドロキシアルカノエートを含むカード |
| JP2004538132A (ja) * | 2001-06-04 | 2004-12-24 | ユニベルシテ・ド・リエージュ | 導電性表面上に強力に接着したポリマーコーティングを堆積させるプロセス |
| WO2004021976A2 (en) * | 2002-09-05 | 2004-03-18 | Hilborn Joens | New polymers and applications |
| WO2005092406A1 (en) * | 2004-03-22 | 2005-10-06 | Advanced Cardiovascular Systems, Inc. | Phosphoryl choline coating compositions |
| JP2006022324A (ja) * | 2004-06-11 | 2006-01-26 | Canon Inc | ビニル基、エステル基、カルボキシル基並びにスルホン酸基を有するポリヒドロキシアルカノエート並びにその製造方法 |
Non-Patent Citations (2)
| Title |
|---|
| JPN6012050613; Ｂｒｙａｎ Ｐａｒｒｉｓｈ，他: 'Ｆｕｎｃｔｉｏｎａｌ ｐｏｌｙｅｓｔｅｒｓ ｐｒｅｐａｒｅｄ ｂｙ ｐｏｌｙｍｅｒｉｚａｔｉｏｎ ｏｆ alpha-ａｌｌｙｌ（ｖａｌｅｒｏｌａｃｔｏｎｅ） ａｎｄ ｉｔｓ ｃｏｐｏｌｙｍｅｒｉｚａｔｉｏｎ' Ｊｏｕｒｎａｌ ｏｆ Ｐｏｌｙｍｅｒ Ｓｃｉｅｎｃｅ， Ｐａｒｔ Ａ： Ｐｏｌｙｍｅｒ Ｃｈｅｍｉｓｔｒｙ 第４０巻，第１２号, 2002, 第１９８３頁-第１９９０頁 * |
| JPN6012050616; 'Ｓｅｌｅｃｔｉｖｅ ｓｙｎｔｈｅｓｉｓ ｏｆ ｓｔｒｕｃｔｕｒａｌｌｙ ｉｓｏｍｅｒｉｃ ｐｏｌｙ-beta-ｅｓｔｅｒ ａｎｄ ｐｏｌｙ-delta-ｅｓｔｅｒ ｆｒｏｍ beta-（２-ａｃｅｔｏｘｙｅｔｈｙｌ' Ｊｏｕｒｎａｌ ｏｆ Ｐｏｌｙｍｅｒ Ｓｃｉｅｎｃｅ， Ｐｏｌｙｍｅｒ Ｃｈｅｍｉｓｔｒｙ Ｅｄｉｔｉｏｎ 第２０巻，第１２号, 1982, 第３３３７頁-第３３５０頁 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015021038A (ja) * | 2013-07-17 | 2015-02-02 | 日油株式会社 | ホスホリルコリン基含有重合体及びその製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20080233168A1 (en) | 2008-09-25 |
| EP1940481B1 (en) | 2015-01-14 |
| EP1940481A2 (en) | 2008-07-09 |
| US8871238B2 (en) | 2014-10-28 |
| WO2007024492A3 (en) | 2008-01-10 |
| WO2007024492A2 (en) | 2007-03-01 |
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