JP2009500621A - 回転式の多重蛍光検出装置用の弁制御システム - Google Patents
回転式の多重蛍光検出装置用の弁制御システム Download PDFInfo
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- JP2009500621A JP2009500621A JP2008520233A JP2008520233A JP2009500621A JP 2009500621 A JP2009500621 A JP 2009500621A JP 2008520233 A JP2008520233 A JP 2008520233A JP 2008520233 A JP2008520233 A JP 2008520233A JP 2009500621 A JP2009500621 A JP 2009500621A
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Abstract
Description
Claims (67)
- 弁によってプロセスチャンバから分離された保持チャンバを有するディスクを回転させるためのモータと、
前記ディスクの位置を決定するために第1のレベルで、また前記弁を開放して前記保持チャンバから前記プロセスチャンバに流体を流れさせるために第2のレベルで、電磁エネルギーを出力するエネルギー源と、を備える検出装置。 - 前記電磁エネルギーを検出すると信号を出力するセンサと、
前記センサに結合された制御ユニットであって、前記センサから前記信号を受信すると、前記ディスク上の前記弁の位置を決定する制御ユニットと、をさらに備える、請求項1に記載の検出装置。 - 前記ディスクは、前記エネルギー源から前記センサへ前記電磁エネルギーを通すためのスロットを有する、請求項2に記載の検出装置。
- 前記センサは、前記ディスク内の前記スロットが前記エネルギー源と前記センサとの間に整列したとき、前記エネルギー源からの電磁エネルギーを検出する、請求項3に記載の検出装置。
- 前記ディスクは、前記エネルギー源から前記センサへの前記電磁エネルギーを遮断するためのタブを有する、請求項2に記載の検出装置。
- 前記センサは、前記ディスク上の前記タブが前記エネルギー源と前記センサとの間に整列していないとき、前記エネルギー源からの電磁エネルギーを検出する、請求項5に記載の検出装置。
- 前記ディスク内の前記スロットは、矩形、円形、楕円形または不規則形の形状のものである、請求項3に記載の検出装置。
- 前記スロットは、0.5ミリメートルと2ミリメートルの間の直径を有する、請求項3に記載の検出装置。
- 複数の弁をさらに備え、
前記制御ユニットは、前記センサから前記信号を受信すると、前記弁の配置のマップを作成する、請求項2に記載の検出装置。 - 前記制御ユニットは、ユーザーによって指定された1つ以上の反応に基づいて、開放する1つ以上の前記弁を選択し、前記マップに基づいて前記ディスク上の選択した前記弁に前記電磁エネルギーを向ける、請求項9に記載の検出装置。
- 前記電磁エネルギーのパルスが、1つ以上の弁を加熱して開放し、前記保持チャンバと前記プロセスチャンバとの間の流体連通を可能にする、請求項10に記載の検出装置。
- 前記エネルギー源を前記ディスク上の正確な配置に整列させるためのガントリをさらに備える、請求項1に記載の検出装置。
- 前記ガントリは、複数の光学モジュールを1つ以上のプロセスチャンバに整列させる、請求項12に記載の検出装置。
- 前記エネルギー源はレーザである、請求項1に記載の検出装置。
- 前記レーザは、前記ディスクの位置を決定するための低エネルギーの近赤外光と、前記弁を開放するための高エネルギーの近赤外光と、を生成する、請求項14に記載の検出装置。
- 前記プロセスチャンバは、試料と複数の蛍光染料とを保持する、請求項1に記載の検出装置。
- 複数の取り外し可能な光学モジュールであって、それぞれが、異なる1つの染料に対して選択された光源と、前記ディスクから放出された蛍光を捕捉するためのレンズと、を有する光学チャネルを含む光学モジュールをさらに備える、請求項1に記載の検出装置。
- 前記エネルギー源は、前記複数の取り外し可能な光学モジュールの1つに含められる、請求項17に記載の検出装置。
- 前記エネルギー源は、
前記ディスクの位置を決定するために、前記第1のレベルで電磁エネルギーを出力する第1のエネルギー源と、
前記ディスクの位置を決定し、この後に前記弁を開放して流体を前記保持チャンバから前記プロセスチャンバに流れさせるために、前記第2のレベルで電磁エネルギーを出力する第2のエネルギー源と、を含む請求項1に記載の検出装置。 - 前記第1のエネルギー源からの前記電磁エネルギーを検出するための第1のセンサと、
前記第2のエネルギー源からの前記電磁エネルギーを検出するための第2のセンサと、をさらに備える、請求項19に記載の検出装置。 - 前記ディスクは、前記ディスクが回転しているとき、前記第1のセンサによって検出される、前記第1のエネルギー源からの電磁エネルギーの量、または、前記第2のセンサから検出される、前記第2のエネルギー源からの電磁エネルギーの量のいずれかを変化させる構造体を有する、請求項20に記載の検出装置。
- 前記構造体は、前記ディスクによって形成されたスロット、タブ、または反射材料である、請求項21に記載の検出装置。
- 前記第1の検出器は、前記ディスクが回転しているときに、前記ディスク上の前記構造体を検出して前記ディスクの位置を決定することができる、請求項21に記載の検出装置。
- 前記第2の検出器は、前記ディスクが回転しているとき、および/または、前記第2のエネルギー源が前記ディスクに対して移動しているとき、前記ディスクの前記構造体の1つ以上の形体を検出して前記ディスクの位置を決定することができる、請求項21に記載の検出装置。
- 前記第2のエネルギー源は、前記第2の検出器によって決定された前記ディスクの位置に基づいて前記弁を加熱する、請求項24に記載の検出装置。
- 前記第1の検出器および前記第2の検出器は、協働して前記ディスクの位置をマップする、請求項21に記載の検出装置。
- データ取得装置と、
前記データ取得装置に結合された検出装置であって、
弁によってプロセスチャンバから分離された保持チャンバを有するディスクを回転させるためのモータと、
前記ディスクの位置を決定し、この後に前記弁を開放して流体を前記保持チャンバから前記プロセスチャンバに流れさせるために、電磁エネルギーを出力する第2のエネルギー源と、を含む検出装置と、を備える検出システム。 - 前記電磁エネルギーを検出すると信号を出力するセンサと、
前記センサに結合された制御ユニットであって、前記センサから前記信号を受信すると、前記ディスク上の前記弁の位置を決定する制御ユニットと、をさらに備える、請求項27に記載の検出システム。 - 前記ディスクは、前記エネルギー源から前記センサへ前記電磁エネルギーを通すためのスロットを有する、請求項28に記載の検出システム。
- 前記センサは、前記ディスク内の前記スロットが前記エネルギー源と前記センサとの間に整列したとき、前記エネルギー源からの電磁エネルギーを検出する、請求項29に記載の検出システム。
- 前記ディスク内の前記スロットは、矩形、円形、楕円形または不規則形の形状のものである、請求項29に記載の検出システム。
- 前記スロットは、0.5ミリメートルと2ミリメートルの間の直径を有する、請求項29に記載の検出システム。
- 複数の弁をさらに備え、
前記制御ユニットは、前記センサから前記信号を受信すると、前記弁の配置のマップを作成する、請求項28に記載の検出システム。 - 前記制御ユニットは、ユーザーによって指定された1つ以上の反応に基づいて、開放する1つ以上の前記弁を選択し、前記マップに基づいて前記ディスク上の選択した前記弁に前記電磁エネルギーを向ける、請求項33に記載の検出システム。
- 前記電磁エネルギーのパルスが、1つ以上の弁を加熱して開放し、前記保持チャンバと前記プロセスチャンバとの間の流体連通を可能にする、請求項34に記載の検出システム。
- 前記エネルギー源を前記ディスク上の正確な配置に整列させるためのガントリをさらに備える、請求項27に記載の検出システム。
- 前記ガントリは、前記複数の光学モジュールを1つ以上のプロセスチャンバに整列させる、請求項34に記載の検出システム。
- 前記エネルギー源はレーザである、請求項27に記載の検出システム。
- 前記レーザは、前記ディスクの位置を決定するための低エネルギーの近赤外光と、前記弁を開放するための高エネルギーの近赤外光と、を生成する、請求項38に記載の検出システム。
- 前記プロセスチャンバは、試料と複数の蛍光染料とを保持する、請求項27に記載の検出システム。
- 複数の取り外し可能な光学モジュールであって、それぞれが、異なる1つの染料に対して選択された光源と、前記ディスクから放出された蛍光を捕捉するためのレンズと、を有する光学チャネルを含む光学モジュールをさらに備える、請求項27に記載の検出システム。
- 前記エネルギー源は、前記複数の取り外し可能な光学モジュールの1つに含められる、請求項41に記載の検出システム。
- 弁によってプロセスチャンバから分離された保持チャンバを有するディスクを回転させるステップと、
前記ディスクの位置を決定するために、第1のレベルで電磁エネルギーを放出するステップと、
前記弁を開放して前記保持チャンバから前記プロセスチャンバに流体を流れさせるために、第2のレベルで電磁エネルギーを放出するステップと、を含む方法。 - 前記電磁エネルギーをセンサで検出し、信号を出力するステップと、
前記センサから前記信号を受信すると、前記ディスク上の前記弁の位置を制御ユニットで決定するステップと、を含む、請求項43に記載の方法。 - 前記ディスクは、前記エネルギー源から前記センサへ前記電磁エネルギーを通すためのスロットを有する、請求項44に記載の方法。
- 前記センサは、前記ディスク内の前記スロットが前記エネルギー源と前記センサとの間に整列したとき、前記エネルギー源からの電磁エネルギーを検出する、請求項45に記載の方法。
- 前記ディスク内の前記スロットは、矩形、円形、楕円形または不規則形の形状のものである、請求項45に記載の方法。
- 前記ディスク上の前記弁の正確な配置を決定するために前記スロットの縁部を検出するステップをさらに含む、請求項45に記載の方法。
- 前記ディスクは複数の弁をさらに備え、前記制御ユニットは、前記センサから前記信号を受信すると前記弁の配置のマップを作成する、請求項44に記載の方法。
- ユーザーによって指定された1つ以上の反応に基づいて、開放する1つ以上の前記弁を選択し、前記マップに基づいて前記ディスク上の選択した前記弁に前記電磁エネルギーを向けるステップをさらに含む、請求項49に記載の方法。
- 1つ以上の弁を加熱して開放し、前記保持チャンバと前記プロセスチャンバとの間の流体連通を可能にするために、電磁エネルギーのパルスを生成するステップをさらに含む、請求項50に記載の方法。
- 前記エネルギー源を前記ディスク上の正確な配置にガントリで整列させるステップをさらに含む、請求項43に記載の方法。
- 前記複数の光学モジュールを1つ以上のプロセスチャンバに前記ガントリで整列させる、請求項52に記載の方法。
- 前記電磁エネルギーはレーザによって生成される、請求項43に記載の方法。
- 前記レーザは、前記ディスクの位置を決定するための低エネルギーの近赤外光と、前記弁を開放するための高エネルギーの近赤外光と、を生成する、請求項54に記載の方法。
- 前記プロセスチャンバは、試料と複数の蛍光染料とを保持する、請求項43に記載の方法。
- 複数の放出蛍光光線を生成するために、複数の光線で前記ディスクを励起するステップと、
複数の異なる光学モジュールで前記蛍光光線を捕捉するステップであって、前記光学モジュールは、前記異なる波長に対して光学的に構成されているステップと、をさらに含む、請求項43に記載の方法。 - 前記電磁エネルギーは、前記複数の取り外し可能な光学モジュールの1つに含められたエネルギー源によって放出される、請求項57に記載の方法。
- 前記ディスクの構造体の位置を第1のシステムで検出するステップと、
前記ディスクの前記構造体内の1つ以上の形体の位置を第2のシステムで検出するステップと、をさらに含む、請求項43に記載の方法。 - 前記構造体は、前記ディスクによって形成されたスロット、タブ、または反射材料である、請求項59に記載の方法。
- 第1のレベルの前記電磁エネルギーを前記第1のシステムのセンサで感知するステップをさらに含み、第1のレベルの前記電磁エネルギーは、前記第1のシステムのエネルギー源によって生成される、請求項60に記載の方法。
- 前記電磁エネルギーは赤外光である、請求項61に記載の方法。
- 第2のレベルの前記電磁エネルギーを前記第2のシステムのセンサで感知するステップをさらに含み、第2のレベルの前記電磁エネルギーは、前記第2のシステムのエネルギー源によって生成される、請求項60に記載の方法。
- 前記電磁エネルギーはレーザまたは近赤外光である、請求項63に記載の方法。
- 前記第2のシステムは前記弁を加熱する、請求項59に記載の方法。
- 前記第1のシステムおよび前記第2のシステムは、協働して前記ディスクの位置をマップする、請求項59に記載の方法。
- 前記ディスクの構造体の半径方向位置を決定するために、前記ディスクを回転させると共に電磁エネルギーを放出するステップと、
前記ディスクの前記構造体の角度位置を決定するために、前記ディスクを回転させると共に電磁エネルギーを放出するステップと、
電磁エネルギーを前記弁に向けて前記保持チャンバと前記プロセスチャンバとの間の流体連通を可能にするために、前記半径方向位置および前記角度位置を使用するステップと、をさらに含む、請求項43に記載の方法。
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US11/174,957 US7527763B2 (en) | 2005-07-05 | 2005-07-05 | Valve control system for a rotating multiplex fluorescence detection device |
PCT/US2006/010750 WO2007005076A1 (en) | 2005-07-05 | 2006-03-24 | Valve control system for a rotating multiplex fluorescence detection device |
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JP2011505548A (ja) * | 2007-11-22 | 2011-02-24 | サムスン エレクトロニクス カンパニー リミテッド | 薄膜バルブ装置及びその制御装置 |
JP2014517293A (ja) * | 2011-05-18 | 2014-07-17 | スリーエム イノベイティブ プロパティズ カンパニー | 試料処理装置内で材料の選択された体積の存在を検出するためのシステム及び方法 |
Also Published As
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BRPI0613798B1 (pt) | 2018-01-23 |
KR20080041617A (ko) | 2008-05-13 |
TW200710394A (en) | 2007-03-16 |
BRPI0613798A2 (pt) | 2011-02-15 |
CN101218496B (zh) | 2013-04-03 |
ES2863590T3 (es) | 2021-10-11 |
JP4908507B2 (ja) | 2012-04-04 |
AU2006266464A1 (en) | 2007-01-11 |
US20070009383A1 (en) | 2007-01-11 |
MX2008000252A (es) | 2008-03-18 |
CA2614151A1 (en) | 2007-01-11 |
KR101257130B1 (ko) | 2013-04-22 |
US20090189089A1 (en) | 2009-07-30 |
EP1902306A1 (en) | 2008-03-26 |
US7867767B2 (en) | 2011-01-11 |
WO2007005076A1 (en) | 2007-01-11 |
ZA200801187B (en) | 2009-03-25 |
EP1902306B1 (en) | 2021-01-20 |
CN101218496A (zh) | 2008-07-09 |
US7527763B2 (en) | 2009-05-05 |
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