JP2009500357A5 - - Google Patents
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- Publication number
- JP2009500357A5 JP2009500357A5 JP2008519734A JP2008519734A JP2009500357A5 JP 2009500357 A5 JP2009500357 A5 JP 2009500357A5 JP 2008519734 A JP2008519734 A JP 2008519734A JP 2008519734 A JP2008519734 A JP 2008519734A JP 2009500357 A5 JP2009500357 A5 JP 2009500357A5
- Authority
- JP
- Japan
- Prior art keywords
- sirtuin
- resveratrol
- sirtuin activating
- composition
- food
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000011990 Sirtuin Human genes 0.000 claims 25
- 108050002485 Sirtuin Proteins 0.000 claims 25
- 230000003213 activating effect Effects 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 20
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 13
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 13
- 235000021283 resveratrol Nutrition 0.000 claims 13
- 229940016667 resveratrol Drugs 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 12
- 235000013361 beverage Nutrition 0.000 claims 10
- 235000013305 food Nutrition 0.000 claims 10
- 239000002552 dosage form Substances 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 4
- 235000020956 nicotinamide riboside Nutrition 0.000 claims 4
- 239000011618 nicotinamide riboside Substances 0.000 claims 4
- 239000000883 anti-obesity agent Substances 0.000 claims 2
- 239000003472 antidiabetic agent Substances 0.000 claims 2
- 229940125708 antidiabetic agent Drugs 0.000 claims 2
- 239000003524 antilipemic agent Substances 0.000 claims 2
- 229940125710 antiobesity agent Drugs 0.000 claims 2
- 235000019577 caloric intake Nutrition 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 239000013589 supplement Substances 0.000 claims 2
- 235000017060 Arachis glabrata Nutrition 0.000 claims 1
- 244000105624 Arachis hypogaea Species 0.000 claims 1
- 235000010777 Arachis hypogaea Nutrition 0.000 claims 1
- 235000018262 Arachis monticola Nutrition 0.000 claims 1
- RNTJDJDUXWVMJY-UHFFFAOYSA-N CC(C)(OC(=O)C(=O)c1ccc(O)cc1)C1Cc2cc3ccc(=O)oc3cc2O1 Chemical compound CC(C)(OC(=O)C(=O)c1ccc(O)cc1)C1Cc2cc3ccc(=O)oc3cc2O1 RNTJDJDUXWVMJY-UHFFFAOYSA-N 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 240000000249 Morus alba Species 0.000 claims 1
- 235000008708 Morus alba Nutrition 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 240000007651 Rubus glaucus Species 0.000 claims 1
- 235000011034 Rubus glaucus Nutrition 0.000 claims 1
- 235000009122 Rubus idaeus Nutrition 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 240000000851 Vaccinium corymbosum Species 0.000 claims 1
- 235000003095 Vaccinium corymbosum Nutrition 0.000 claims 1
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims 1
- 235000009754 Vitis X bourquina Nutrition 0.000 claims 1
- 235000012333 Vitis X labruscana Nutrition 0.000 claims 1
- 240000006365 Vitis vinifera Species 0.000 claims 1
- 235000014787 Vitis vinifera Nutrition 0.000 claims 1
- 235000021014 blueberries Nutrition 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940126534 drug product Drugs 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 235000020232 peanut Nutrition 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 230000002459 sustained effect Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69744305P | 2005-07-07 | 2005-07-07 | |
| US73652805P | 2005-11-14 | 2005-11-14 | |
| US75360605P | 2005-12-23 | 2005-12-23 | |
| US78380206P | 2006-03-16 | 2006-03-16 | |
| PCT/US2006/026272 WO2007008548A2 (en) | 2005-07-07 | 2006-07-07 | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009500357A JP2009500357A (ja) | 2009-01-08 |
| JP2009500357A5 true JP2009500357A5 (https=) | 2009-08-20 |
Family
ID=37492426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008519734A Pending JP2009500357A (ja) | 2005-07-07 | 2006-07-07 | 肥満、インスリン抵抗性障害およびミトコンドリア関連障害を処置または予防するための方法および関連する組成物 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1898897A2 (https=) |
| JP (1) | JP2009500357A (https=) |
| CN (1) | CN103055313A (https=) |
| AU (1) | AU2006269459B2 (https=) |
| CA (1) | CA2613141A1 (https=) |
| WO (1) | WO2007008548A2 (https=) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8017634B2 (en) * | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| WO2006094235A1 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Fused heterocyclic compounds and their use as sirtuin modulators |
| ES2600460T3 (es) | 2005-05-10 | 2017-02-09 | Intermune, Inc. | Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés |
| US20090162457A1 (en) * | 2005-10-26 | 2009-06-25 | Kao Corporation | Resveratrol and/or grape leaf extract as i. a. endurance improver, anti-aging agent, muscle strength improver |
| US7718830B2 (en) | 2006-04-24 | 2010-05-18 | Allergan, Inc. | Abnormal cannabidiols as agents for lowering intraocular pressure |
| US7612101B2 (en) | 2006-04-24 | 2009-11-03 | Allergan, Inc. | Abnormal cannabidiols as agents for lowering intraocular pressure |
| US7618966B2 (en) | 2006-04-24 | 2009-11-17 | Allergan, Inc. | Abnormal Cannabidiols as agents for lowering intraocular pressure |
| AU2007244978B2 (en) * | 2006-04-24 | 2013-05-30 | Allergan, Inc. | Abnormal Cannabidiols as agents for lowering intraocular pressure |
| US8778986B1 (en) * | 2007-01-25 | 2014-07-15 | University Of South Florida | Treatment of glycogen synthase kinase-based disease |
| US8802638B1 (en) * | 2007-01-25 | 2014-08-12 | University Of South Florida | Flavonoid treatment of glycogen synthase kinase-based disease |
| US20100047177A1 (en) * | 2007-01-26 | 2010-02-25 | Washington University | Methods and compositions for treating neuropathies |
| US20100130597A1 (en) | 2007-07-06 | 2010-05-27 | The United State Of America, As Represented By The Secretary Of The Dept Of Health And Human Service | Dna-pkcs modulates energy regulation and brain function |
| WO2009054994A2 (en) * | 2007-10-23 | 2009-04-30 | President And Fellows Of Harvard College | Sirt-3 related methods and compositions for mimicking exercise |
| ES2586459T3 (es) | 2008-05-01 | 2016-10-14 | Glaxosmithkline Llc | Quinolinas y análogos relacionados como moduladores de sirtuina |
| CN102099036B (zh) | 2008-06-03 | 2015-05-27 | 英特芒尼公司 | 用于治疗炎性疾患和纤维化疾患的化合物和方法 |
| CA2729128C (en) | 2008-07-03 | 2016-05-31 | Sirtris Pharmaceuticals, Inc. | Benzimidazoles and related analogs as sirtuin modulators |
| WO2010020959A1 (en) * | 2008-08-21 | 2010-02-25 | University Of Cape Town | Resveratrol-containing composition for treating heart failure |
| MX2011003373A (es) | 2008-09-29 | 2011-06-09 | Sirtris Pharmaceuticals Inc | Quinazolinona, quinolona y analogos relacionados como moduladores de sirtuina. |
| JP5655243B2 (ja) * | 2009-10-19 | 2015-01-21 | 国立大学法人 熊本大学 | インドキシル硫酸の産生の阻害剤のスクリーニング方法、インドキシル硫酸代謝産生阻害剤、及び腎障害軽減剤 |
| MX2012004995A (es) | 2009-10-29 | 2012-10-03 | Sirtris Pharmaceuticals Inc | Piridinas biciclicas y analogos como moduladores de sirtuina. |
| DK2496594T3 (en) * | 2009-11-06 | 2018-03-05 | The J David Gladstone Inst | METHODS AND COMPOSITIONS FOR MODULATING TAU LEVELS |
| JP5581071B2 (ja) * | 2010-02-03 | 2014-08-27 | 花王株式会社 | ミトコンドリア機能向上剤 |
| WO2012008549A1 (ja) * | 2010-07-15 | 2012-01-19 | 武田薬品工業株式会社 | 複素環化合物 |
| US9499790B2 (en) | 2010-08-26 | 2016-11-22 | Kyoto University | Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells |
| EP2610249B1 (en) * | 2010-08-26 | 2017-10-11 | Kyoto University | Pluripotent stem cell cardiomyocyte differentiation-promoting agent |
| JP5850503B2 (ja) * | 2010-09-14 | 2016-02-03 | 北海道公立大学法人 札幌医科大学 | 筋ジストロフィーを処置するための組成物 |
| AU2015201809B2 (en) * | 2010-12-20 | 2016-09-29 | Hill's Pet Nutrition, Inc. | Pet food compositions for inducing a satiety response |
| RU2543539C2 (ru) * | 2010-12-20 | 2015-03-10 | Хилл'С Пет Ньютришн, Инк. | Кормовые композиции для домашних животных, вызывающие чувство сытости |
| MX336980B (es) * | 2010-12-21 | 2016-02-09 | Senosiain S A De C V Lab | Combinacion y composicion para el tratamiento de obesidad. |
| WO2012114204A2 (en) * | 2011-02-15 | 2012-08-30 | Ecole Polytechnique Federale De Lausanne (Epfl) Epfl-Tto | Methods of treating mitochondrial dysfunction |
| KR101451357B1 (ko) * | 2011-02-18 | 2014-10-15 | 주식회사 스템디알 | Ｓｉｒｔ１ 발현 유도 물질을 포함하는 패혈증 또는 패혈증 쇼크의 예방 또는 치료용 조성물 |
| WO2012145749A1 (en) * | 2011-04-22 | 2012-10-26 | Napo Pharmaceuticals, Inc. | Pharmacologically optimized multimodal drug delivery system for nordihydroguiaretic acid (ndga) |
| CA2840516A1 (en) * | 2011-06-29 | 2013-01-03 | President And Fellows Of Harvard College | Small molecule cd38 inhibitors and methods of using same |
| RU2631597C2 (ru) | 2011-07-15 | 2017-09-25 | Нусерт Сайенсиз, Инк. | Композиции и способы модулирования метаболических путей |
| JP6155191B2 (ja) * | 2011-10-02 | 2017-06-28 | キユーピー株式会社 | ＲＮＡ干渉によるｍＲＮＡ発現の抑制を促進する促進剤およびその用途 |
| US8916528B2 (en) | 2011-11-16 | 2014-12-23 | Resveratrol Partners, Llc | Compositions containing resveratrol and nucleotides |
| KR101996343B1 (ko) | 2012-01-27 | 2019-07-05 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 전능성 줄기세포의 심근분화 유도방법 |
| EP2872128B1 (en) | 2012-07-16 | 2020-02-19 | Cornell University | Nicotinamide riboside to treat hearing loss |
| WO2014014816A2 (en) * | 2012-07-17 | 2014-01-23 | Ngm Biopharmaceuticals, Inc. | Methods of treating glucose metabolism disorders |
| WO2014014819A2 (en) * | 2012-07-17 | 2014-01-23 | Ngm Biopharmaceuticals, Inc. | Methods of treating glucose metabolism disorders |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| SG10201709195TA (en) | 2012-11-13 | 2017-12-28 | Nusirt Sciences Inc | Compositions and methods for increasing energy metabolism |
| JP6351567B2 (ja) | 2013-03-08 | 2018-07-04 | 国立大学法人京都大学 | Ｅｇｆ受容体阻害剤を含む多能性幹細胞の心筋分化促進剤 |
| CN105228627B (zh) * | 2013-03-15 | 2018-07-13 | 纽斯尔特科学公司 | 亮氨酸和烟酸降低脂质水平 |
| US20160113893A1 (en) * | 2013-06-12 | 2016-04-28 | Proximagen Limited | New therapeutic uses of enzyme inhibitors |
| US20160101072A1 (en) * | 2013-06-12 | 2016-04-14 | Proximagen Limited | Therapeutic uses of enzyme inhibitors |
| CA2928656C (en) * | 2013-10-30 | 2020-07-28 | ChromaDex Inc. | Nicotinamide riboside compositions for topical use in treating skin conditions |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| JP6651218B2 (ja) | 2014-05-30 | 2020-02-19 | 国立大学法人京都大学 | 低分子化合物を用いた多能性幹細胞の心筋分化誘導法 |
| US9370503B1 (en) * | 2015-02-26 | 2016-06-21 | Chi Chou Liao | Compounds for treating ocular diseases |
| JP6545256B2 (ja) * | 2015-03-31 | 2019-07-17 | 新興和製薬株式会社 | レスベラトロールとニコチンアミドモノヌクレオチドを含む食品組成物 |
| EP3347024A2 (en) * | 2015-09-08 | 2018-07-18 | Ecole Polytechnique Federale de Lausanne (EPFL) | Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders |
| EP3393467B1 (en) | 2015-12-24 | 2020-07-01 | Amazentis SA | Compositions comprising nicotinamide riboside and a urolithin |
| WO2018002215A1 (en) * | 2016-06-30 | 2018-01-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cardiomyopathies |
| JPWO2018079719A1 (ja) * | 2016-10-27 | 2019-09-19 | サントリーホールディングス株式会社 | ＰＧＣ−１α活性化用組成物 |
| CN108066348A (zh) * | 2016-11-16 | 2018-05-25 | 成都普睿法药物研发有限公司 | 土大黄苷在制备抗肺纤维化药物中的应用 |
| CN106580951B (zh) * | 2016-11-17 | 2019-07-30 | 珠海雅光生物工程有限公司 | 一种黄烷酮化合物的新用途 |
| WO2018118197A1 (en) * | 2016-12-21 | 2018-06-28 | Richard Postrel | Healthier aging in domesticated animals |
| JP2018172346A (ja) * | 2017-03-31 | 2018-11-08 | 株式会社東洋新薬 | 妊娠サポート用組成物 |
| EP3388072A1 (en) * | 2017-04-10 | 2018-10-17 | Universität Leipzig | Ubiquinone-independent cytoplasmic dihydroorotate dehydrogenase for use as medicament |
| ES3004332T3 (en) | 2017-05-17 | 2025-03-12 | Univ De Valencia Estudi General | Treating and preventing amyotrophic lateral sclerosis with nicotinamide riboside and pterostilbene |
| WO2019043846A1 (ja) | 2017-08-30 | 2019-03-07 | 大塚製薬株式会社 | ケンペロール類縁体含有組成物 |
| CN109896997A (zh) * | 2017-12-08 | 2019-06-18 | 中国药科大学 | N－酰基苯胺类c－Met激酶抑制剂的制备方法及其用途 |
| WO2019143560A1 (en) * | 2018-01-16 | 2019-07-25 | The Regents Of The University Of California | Methods for promoting mitochondrial biogenesis in neural cells |
| CA3122246C (en) * | 2018-12-05 | 2025-06-10 | Celagenex Research (India) Pvt. Ltd. | Synergistic compositions of bioactive agents to optimize cell health |
| KR102712818B1 (ko) * | 2018-12-06 | 2024-09-30 | 한국화학연구원 | Pde9a 저해 활성을 가지는 화합물 및 이들의 의약 용도 |
| WO2021071965A1 (en) * | 2019-10-08 | 2021-04-15 | Applied Therapeutics Inc. | Aldose reductase inhibitors for treatment of phosphomannomutase 2 deficiency |
| CN112516138B (zh) * | 2020-12-15 | 2022-03-29 | 中国人民解放军陆军军医大学 | 化合物yx-2102在制备治疗肺纤维化药物中的应用 |
| ES2974212T3 (es) * | 2020-12-18 | 2024-06-26 | Nuvamid Sa | Derivados de mononucleótidos de nicotinamida en el tratamiento y la prevención de la enfermedad de células falciformes |
| CN117580573A (zh) * | 2021-06-22 | 2024-02-20 | 南京纽邦生物科技有限公司 | L-麦角硫因用于缓解和预防年龄相关的视力退化 |
| WO2022268047A1 (en) | 2021-06-22 | 2022-12-29 | Nanjing Nutrabuilding Bio-Tech Co., Ltd | Use of L-ergothioneine to ameliorate and prevent age-related vitreous degeneration |
| CN113663083A (zh) * | 2021-08-16 | 2021-11-19 | 重庆第二师范学院 | 一种漆黄素磷脂复合物和减肥药物/保健食品及其应用 |
| CN114668845B (zh) * | 2022-04-06 | 2023-04-11 | 北京清华长庚医院 | 肝脏Sirt5蛋白在制备抑制糖异生和提高糖耐量的产品中的应用 |
| CN114920805B (zh) * | 2022-05-06 | 2022-12-06 | 浙江湃肽生物股份有限公司 | 一种具有改善皱纹活性的新型红蝎毒素及包含其的组合物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001072583A (ja) * | 1999-09-07 | 2001-03-21 | Sunstar Inc | 高脂血症の予防又は治療用組成物 |
| US6878751B1 (en) * | 2000-10-19 | 2005-04-12 | Imperial College Of Science Technology And Medicine | Administration of resveratrol to treat inflammatory respiratory disorders |
| WO2002081651A2 (en) * | 2001-02-20 | 2002-10-17 | Uab Research Foundation | Polyphenolics for enhancing endothelial cell-mediated fibrinolysis |
| WO2003099040A1 (en) * | 2002-05-27 | 2003-12-04 | Advance Holdings Limited | Dietary supplements from wine vinasses and relevant production process |
| WO2004105517A1 (en) * | 2003-05-27 | 2004-12-09 | Dsm Ip Assets B.V. | Novel nutraceutical compositions and use thereof |
| JP2007530417A (ja) * | 2003-07-01 | 2007-11-01 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 細胞及び生物の寿命及びストレス応答を操作するための組成物 |
| US20050171027A1 (en) * | 2003-12-29 | 2005-08-04 | President And Fellows Of Harvard College | Compositions for treating or preventing obesity and insulin resistance disorders |
| WO2005069998A2 (en) * | 2004-01-20 | 2005-08-04 | Brigham Young University Technology Transfer Office | Novel sirtuin activating compounds and methods for making the same |
| JP4963670B2 (ja) * | 2004-04-07 | 2012-06-27 | レスベラトロル パートナーズ， エルエルシー | 栄養補助サプリメントおよびそれを処理する方法 |
| EP1850840A2 (en) * | 2005-01-13 | 2007-11-07 | Sirtris Pharmaceuticals, Inc. | Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders |
-
2006
- 2006-07-07 EP EP06786429A patent/EP1898897A2/en not_active Ceased
- 2006-07-07 CN CN2013100114296A patent/CN103055313A/zh active Pending
- 2006-07-07 AU AU2006269459A patent/AU2006269459B2/en not_active Expired - Fee Related
- 2006-07-07 WO PCT/US2006/026272 patent/WO2007008548A2/en not_active Ceased
- 2006-07-07 CA CA002613141A patent/CA2613141A1/en not_active Abandoned
- 2006-07-07 JP JP2008519734A patent/JP2009500357A/ja active Pending
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