CN103055313A - 用于治疗或预防肥胖、胰岛素抵抗障碍和线粒体相关障碍的方法和相关组合物 - Google Patents

用于治疗或预防肥胖、胰岛素抵抗障碍和线粒体相关障碍的方法和相关组合物 Download PDF

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CN103055313A
CN103055313A CN2013100114296A CN201310011429A CN103055313A CN 103055313 A CN103055313 A CN 103055313A CN 2013100114296 A CN2013100114296 A CN 2013100114296A CN 201310011429 A CN201310011429 A CN 201310011429A CN 103055313 A CN103055313 A CN 103055313A
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general formula
activating compounds
specifically
sirtuin activating
compound shown
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Chinese (zh)
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M·米尔本
J·米尔恩
J·奥威尔斯
C·阿吉曼
M·拉戈奇
M·迪波
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Sirtris Pharmaceuticals Inc
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Sirtris Pharmaceuticals Inc
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CN2013100114296A 2005-07-07 2006-07-07 用于治疗或预防肥胖、胰岛素抵抗障碍和线粒体相关障碍的方法和相关组合物 Pending CN103055313A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US69744305P 2005-07-07 2005-07-07
US60/697,443 2005-07-07
US73652805P 2005-11-14 2005-11-14
US60/736,528 2005-11-14
US75360605P 2005-12-23 2005-12-23
US60/753,606 2005-12-23
US78380206P 2006-03-16 2006-03-16
US60/783,802 2006-03-16

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EP (1) EP1898897A2 (https=)
JP (1) JP2009500357A (https=)
CN (1) CN103055313A (https=)
AU (1) AU2006269459B2 (https=)
CA (1) CA2613141A1 (https=)
WO (1) WO2007008548A2 (https=)

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CN105873937A (zh) * 2013-10-30 2016-08-17 可劳迈戴斯有限公司 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物
CN106580951A (zh) * 2016-11-17 2017-04-26 珠海雅光生物工程有限公司 一种黄烷酮化合物的新用途
CN108066348A (zh) * 2016-11-16 2018-05-25 成都普睿法药物研发有限公司 土大黄苷在制备抗肺纤维化药物中的应用
CN109896997A (zh) * 2017-12-08 2019-06-18 中国药科大学 N－酰基苯胺类c－Met激酶抑制剂的制备方法及其用途
CN111032027A (zh) * 2017-05-17 2020-04-17 巴伦西亚大学 使用烟酰胺核糖核苷治疗和预防运动神经元疾病
CN112516138A (zh) * 2020-12-15 2021-03-19 中国人民解放军陆军军医大学 化合物yx-2102在制备治疗肺纤维化药物中的应用
CN113663083A (zh) * 2021-08-16 2021-11-19 重庆第二师范学院 一种漆黄素磷脂复合物和减肥药物/保健食品及其应用
CN114667139A (zh) * 2019-10-08 2022-06-24 应用治疗公司 用于治疗磷酸甘露变位酶2缺乏的醛糖还原酶抑制剂
CN114668845A (zh) * 2022-04-06 2022-06-28 北京清华长庚医院 肝脏Sirt5蛋白在制备抑制糖异生和提高糖耐量的产品中的应用
CN114920805A (zh) * 2022-05-06 2022-08-19 浙江湃肽生物股份有限公司 一种具有改善皱纹活性的新型红蝎毒素及包含其的组合物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8017634B2 (en) * 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
WO2006094235A1 (en) 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. Fused heterocyclic compounds and their use as sirtuin modulators
ES2600460T3 (es) 2005-05-10 2017-02-09 Intermune, Inc. Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés
US20090162457A1 (en) * 2005-10-26 2009-06-25 Kao Corporation Resveratrol and/or grape leaf extract as i. a. endurance improver, anti-aging agent, muscle strength improver
US7718830B2 (en) 2006-04-24 2010-05-18 Allergan, Inc. Abnormal cannabidiols as agents for lowering intraocular pressure
US7612101B2 (en) 2006-04-24 2009-11-03 Allergan, Inc. Abnormal cannabidiols as agents for lowering intraocular pressure
US7618966B2 (en) 2006-04-24 2009-11-17 Allergan, Inc. Abnormal Cannabidiols as agents for lowering intraocular pressure
AU2007244978B2 (en) * 2006-04-24 2013-05-30 Allergan, Inc. Abnormal Cannabidiols as agents for lowering intraocular pressure
US8778986B1 (en) * 2007-01-25 2014-07-15 University Of South Florida Treatment of glycogen synthase kinase-based disease
US8802638B1 (en) * 2007-01-25 2014-08-12 University Of South Florida Flavonoid treatment of glycogen synthase kinase-based disease
US20100047177A1 (en) * 2007-01-26 2010-02-25 Washington University Methods and compositions for treating neuropathies
US20100130597A1 (en) 2007-07-06 2010-05-27 The United State Of America, As Represented By The Secretary Of The Dept Of Health And Human Service Dna-pkcs modulates energy regulation and brain function
WO2009054994A2 (en) * 2007-10-23 2009-04-30 President And Fellows Of Harvard College Sirt-3 related methods and compositions for mimicking exercise
ES2586459T3 (es) 2008-05-01 2016-10-14 Glaxosmithkline Llc Quinolinas y análogos relacionados como moduladores de sirtuina
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
CA2729128C (en) 2008-07-03 2016-05-31 Sirtris Pharmaceuticals, Inc. Benzimidazoles and related analogs as sirtuin modulators
WO2010020959A1 (en) * 2008-08-21 2010-02-25 University Of Cape Town Resveratrol-containing composition for treating heart failure
MX2011003373A (es) 2008-09-29 2011-06-09 Sirtris Pharmaceuticals Inc Quinazolinona, quinolona y analogos relacionados como moduladores de sirtuina.
JP5655243B2 (ja) * 2009-10-19 2015-01-21 国立大学法人 熊本大学 インドキシル硫酸の産生の阻害剤のスクリーニング方法、インドキシル硫酸代謝産生阻害剤、及び腎障害軽減剤
MX2012004995A (es) 2009-10-29 2012-10-03 Sirtris Pharmaceuticals Inc Piridinas biciclicas y analogos como moduladores de sirtuina.
DK2496594T3 (en) * 2009-11-06 2018-03-05 The J David Gladstone Inst METHODS AND COMPOSITIONS FOR MODULATING TAU LEVELS
JP5581071B2 (ja) * 2010-02-03 2014-08-27 花王株式会社 ミトコンドリア機能向上剤
WO2012008549A1 (ja) * 2010-07-15 2012-01-19 武田薬品工業株式会社 複素環化合物
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
EP2610249B1 (en) * 2010-08-26 2017-10-11 Kyoto University Pluripotent stem cell cardiomyocyte differentiation-promoting agent
JP5850503B2 (ja) * 2010-09-14 2016-02-03 北海道公立大学法人 札幌医科大学 筋ジストロフィーを処置するための組成物
AU2015201809B2 (en) * 2010-12-20 2016-09-29 Hill's Pet Nutrition, Inc. Pet food compositions for inducing a satiety response
RU2543539C2 (ru) * 2010-12-20 2015-03-10 Хилл'С Пет Ньютришн, Инк. Кормовые композиции для домашних животных, вызывающие чувство сытости
MX336980B (es) * 2010-12-21 2016-02-09 Senosiain S A De C V Lab Combinacion y composicion para el tratamiento de obesidad.
WO2012114204A2 (en) * 2011-02-15 2012-08-30 Ecole Polytechnique Federale De Lausanne (Epfl) Epfl-Tto Methods of treating mitochondrial dysfunction
KR101451357B1 (ko) * 2011-02-18 2014-10-15 주식회사 스템디알 Ｓｉｒｔ１ 발현 유도 물질을 포함하는 패혈증 또는 패혈증 쇼크의 예방 또는 치료용 조성물
WO2012145749A1 (en) * 2011-04-22 2012-10-26 Napo Pharmaceuticals, Inc. Pharmacologically optimized multimodal drug delivery system for nordihydroguiaretic acid (ndga)
CA2840516A1 (en) * 2011-06-29 2013-01-03 President And Fellows Of Harvard College Small molecule cd38 inhibitors and methods of using same
RU2631597C2 (ru) 2011-07-15 2017-09-25 Нусерт Сайенсиз, Инк. Композиции и способы модулирования метаболических путей
JP6155191B2 (ja) * 2011-10-02 2017-06-28 キユーピー株式会社 ＲＮＡ干渉によるｍＲＮＡ発現の抑制を促進する促進剤およびその用途
US8916528B2 (en) 2011-11-16 2014-12-23 Resveratrol Partners, Llc Compositions containing resveratrol and nucleotides
KR101996343B1 (ko) 2012-01-27 2019-07-05 고쿠리츠 다이가쿠 호진 교토 다이가쿠 전능성 줄기세포의 심근분화 유도방법
EP2872128B1 (en) 2012-07-16 2020-02-19 Cornell University Nicotinamide riboside to treat hearing loss
WO2014014816A2 (en) * 2012-07-17 2014-01-23 Ngm Biopharmaceuticals, Inc. Methods of treating glucose metabolism disorders
WO2014014819A2 (en) * 2012-07-17 2014-01-23 Ngm Biopharmaceuticals, Inc. Methods of treating glucose metabolism disorders
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
SG10201709195TA (en) 2012-11-13 2017-12-28 Nusirt Sciences Inc Compositions and methods for increasing energy metabolism
JP6351567B2 (ja) 2013-03-08 2018-07-04 国立大学法人京都大学 Ｅｇｆ受容体阻害剤を含む多能性幹細胞の心筋分化促進剤
CN105228627B (zh) * 2013-03-15 2018-07-13 纽斯尔特科学公司 亮氨酸和烟酸降低脂质水平
US20160113893A1 (en) * 2013-06-12 2016-04-28 Proximagen Limited New therapeutic uses of enzyme inhibitors
US20160101072A1 (en) * 2013-06-12 2016-04-14 Proximagen Limited Therapeutic uses of enzyme inhibitors
MX382781B (es) 2014-04-02 2025-03-13 Intermune Inc Piridinonas anti-fibroticas.
JP6651218B2 (ja) 2014-05-30 2020-02-19 国立大学法人京都大学 低分子化合物を用いた多能性幹細胞の心筋分化誘導法
US9370503B1 (en) * 2015-02-26 2016-06-21 Chi Chou Liao Compounds for treating ocular diseases
JP6545256B2 (ja) * 2015-03-31 2019-07-17 新興和製薬株式会社 レスベラトロールとニコチンアミドモノヌクレオチドを含む食品組成物
EP3347024A2 (en) * 2015-09-08 2018-07-18 Ecole Polytechnique Federale de Lausanne (EPFL) Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders
EP3393467B1 (en) 2015-12-24 2020-07-01 Amazentis SA Compositions comprising nicotinamide riboside and a urolithin
WO2018002215A1 (en) * 2016-06-30 2018-01-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of cardiomyopathies
JPWO2018079719A1 (ja) * 2016-10-27 2019-09-19 サントリーホールディングス株式会社 ＰＧＣ−１α活性化用組成物
WO2018118197A1 (en) * 2016-12-21 2018-06-28 Richard Postrel Healthier aging in domesticated animals
JP2018172346A (ja) * 2017-03-31 2018-11-08 株式会社東洋新薬 妊娠サポート用組成物
EP3388072A1 (en) * 2017-04-10 2018-10-17 Universität Leipzig Ubiquinone-independent cytoplasmic dihydroorotate dehydrogenase for use as medicament
WO2019043846A1 (ja) 2017-08-30 2019-03-07 大塚製薬株式会社 ケンペロール類縁体含有組成物
WO2019143560A1 (en) * 2018-01-16 2019-07-25 The Regents Of The University Of California Methods for promoting mitochondrial biogenesis in neural cells
CA3122246C (en) * 2018-12-05 2025-06-10 Celagenex Research (India) Pvt. Ltd. Synergistic compositions of bioactive agents to optimize cell health
KR102712818B1 (ko) * 2018-12-06 2024-09-30 한국화학연구원 Pde9a 저해 활성을 가지는 화합물 및 이들의 의약 용도
ES2974212T3 (es) * 2020-12-18 2024-06-26 Nuvamid Sa Derivados de mononucleótidos de nicotinamida en el tratamiento y la prevención de la enfermedad de células falciformes
CN117580573A (zh) * 2021-06-22 2024-02-20 南京纽邦生物科技有限公司 L-麦角硫因用于缓解和预防年龄相关的视力退化
WO2022268047A1 (en) 2021-06-22 2022-12-29 Nanjing Nutrabuilding Bio-Tech Co., Ltd Use of L-ergothioneine to ameliorate and prevent age-related vitreous degeneration

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001072583A (ja) * 1999-09-07 2001-03-21 Sunstar Inc 高脂血症の予防又は治療用組成物
US6878751B1 (en) * 2000-10-19 2005-04-12 Imperial College Of Science Technology And Medicine Administration of resveratrol to treat inflammatory respiratory disorders
WO2002081651A2 (en) * 2001-02-20 2002-10-17 Uab Research Foundation Polyphenolics for enhancing endothelial cell-mediated fibrinolysis
WO2003099040A1 (en) * 2002-05-27 2003-12-04 Advance Holdings Limited Dietary supplements from wine vinasses and relevant production process
WO2004105517A1 (en) * 2003-05-27 2004-12-09 Dsm Ip Assets B.V. Novel nutraceutical compositions and use thereof
JP2007530417A (ja) * 2003-07-01 2007-11-01 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 細胞及び生物の寿命及びストレス応答を操作するための組成物
US20050171027A1 (en) * 2003-12-29 2005-08-04 President And Fellows Of Harvard College Compositions for treating or preventing obesity and insulin resistance disorders
WO2005069998A2 (en) * 2004-01-20 2005-08-04 Brigham Young University Technology Transfer Office Novel sirtuin activating compounds and methods for making the same
JP4963670B2 (ja) * 2004-04-07 2012-06-27 レスベラトロル パートナーズ， エルエルシー 栄養補助サプリメントおよびそれを処理する方法
EP1850840A2 (en) * 2005-01-13 2007-11-07 Sirtris Pharmaceuticals, Inc. Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FRÉDÉRIC PICARD,ET AL: "Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ", 《NATURE》 *
KONRAD T. HOWITZ,ET AL: "Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan", 《NATURE》 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105873937A (zh) * 2013-10-30 2016-08-17 可劳迈戴斯有限公司 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物
CN108066348A (zh) * 2016-11-16 2018-05-25 成都普睿法药物研发有限公司 土大黄苷在制备抗肺纤维化药物中的应用
CN106580951A (zh) * 2016-11-17 2017-04-26 珠海雅光生物工程有限公司 一种黄烷酮化合物的新用途
CN111032027A (zh) * 2017-05-17 2020-04-17 巴伦西亚大学 使用烟酰胺核糖核苷治疗和预防运动神经元疾病
CN109896997A (zh) * 2017-12-08 2019-06-18 中国药科大学 N－酰基苯胺类c－Met激酶抑制剂的制备方法及其用途
CN114667139A (zh) * 2019-10-08 2022-06-24 应用治疗公司 用于治疗磷酸甘露变位酶2缺乏的醛糖还原酶抑制剂
CN112516138A (zh) * 2020-12-15 2021-03-19 中国人民解放军陆军军医大学 化合物yx-2102在制备治疗肺纤维化药物中的应用
CN112516138B (zh) * 2020-12-15 2022-03-29 中国人民解放军陆军军医大学 化合物yx-2102在制备治疗肺纤维化药物中的应用
CN113663083A (zh) * 2021-08-16 2021-11-19 重庆第二师范学院 一种漆黄素磷脂复合物和减肥药物/保健食品及其应用
CN114668845A (zh) * 2022-04-06 2022-06-28 北京清华长庚医院 肝脏Sirt5蛋白在制备抑制糖异生和提高糖耐量的产品中的应用
CN114920805A (zh) * 2022-05-06 2022-08-19 浙江湃肽生物股份有限公司 一种具有改善皱纹活性的新型红蝎毒素及包含其的组合物

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