CA2613141A1 - Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders - Google Patents

Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders Download PDF

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Publication number
CA2613141A1
CA2613141A1 CA002613141A CA2613141A CA2613141A1 CA 2613141 A1 CA2613141 A1 CA 2613141A1 CA 002613141 A CA002613141 A CA 002613141A CA 2613141 A CA2613141 A CA 2613141A CA 2613141 A1 CA2613141 A1 CA 2613141A1
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Canada
Prior art keywords
compound
sirtuin
formula
activating compound
further embodiment
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Abandoned
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CA002613141A
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English (en)
French (fr)
Inventor
Michael Milburn
Jill Milne
Johan Auwerx
Carmen Argmann
Marie Lagouge
Michelle Dipp
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Sirtris Pharmaceuticals Inc
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Individual
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Publication of CA2613141A1 publication Critical patent/CA2613141A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
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    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
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    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/12Antihypertensives
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
CA002613141A 2005-07-07 2006-07-07 Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders Abandoned CA2613141A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US69744305P 2005-07-07 2005-07-07
US60/697,443 2005-07-07
US73652805P 2005-11-14 2005-11-14
US60/736,528 2005-11-14
US75360605P 2005-12-23 2005-12-23
US60/753,606 2005-12-23
US78380206P 2006-03-16 2006-03-16
US60/783,802 2006-03-16
PCT/US2006/026272 WO2007008548A2 (en) 2005-07-07 2006-07-07 Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders

Publications (1)

Publication Number Publication Date
CA2613141A1 true CA2613141A1 (en) 2007-01-18

Family

ID=37492426

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002613141A Abandoned CA2613141A1 (en) 2005-07-07 2006-07-07 Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders

Country Status (6)

Country Link
EP (1) EP1898897A2 (https=)
JP (1) JP2009500357A (https=)
CN (1) CN103055313A (https=)
AU (1) AU2006269459B2 (https=)
CA (1) CA2613141A1 (https=)
WO (1) WO2007008548A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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WO2019143560A1 (en) * 2018-01-16 2019-07-25 The Regents Of The University Of California Methods for promoting mitochondrial biogenesis in neural cells

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