JP2009284902A5 - - Google Patents
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- Publication number
- JP2009284902A5 JP2009284902A5 JP2009124803A JP2009124803A JP2009284902A5 JP 2009284902 A5 JP2009284902 A5 JP 2009284902A5 JP 2009124803 A JP2009124803 A JP 2009124803A JP 2009124803 A JP2009124803 A JP 2009124803A JP 2009284902 A5 JP2009284902 A5 JP 2009284902A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- recombinantly produced
- target polypeptide
- analyte
- detecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020001507 fusion proteins Proteins 0.000 claims 15
- 102000037865 fusion proteins Human genes 0.000 claims 15
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 239000012491 analyte Substances 0.000 claims 4
- 102000053602 DNA Human genes 0.000 claims 3
- 108020004511 Recombinant DNA Proteins 0.000 claims 3
- 238000003018 immunoassay Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 102000014914 Carrier Proteins Human genes 0.000 claims 2
- 108010006519 Molecular Chaperones Proteins 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 108091008324 binding proteins Proteins 0.000 claims 2
- 210000001124 body fluid Anatomy 0.000 claims 2
- 239000010839 body fluid Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 238000004220 aggregation Methods 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 230000009260 cross reactivity Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08009537.5 | 2008-05-26 | ||
| EP08009537A EP2127678A1 (en) | 2008-05-26 | 2008-05-26 | SlpA as a tool for recombinant protein and enzyme technology |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009284902A JP2009284902A (ja) | 2009-12-10 |
| JP2009284902A5 true JP2009284902A5 (https=) | 2011-11-17 |
| JP5611540B2 JP5611540B2 (ja) | 2014-10-22 |
Family
ID=39590486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009124803A Active JP5611540B2 (ja) | 2008-05-26 | 2009-05-25 | 組換えタンパク質および酵素技術のためのツールとしてのＳｌｐＡ |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8263086B2 (https=) |
| EP (2) | EP2127678A1 (https=) |
| JP (1) | JP5611540B2 (https=) |
| CN (1) | CN101591665B (https=) |
| CA (1) | CA2667177C (https=) |
| ES (1) | ES2590340T3 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2617731A1 (en) * | 2012-01-19 | 2013-07-24 | Roche Diagnostics GmbH | Soluble immunoreactive Treponema pallidum TpN47 antigens |
| EP2706115A1 (en) * | 2012-09-06 | 2014-03-12 | Roche Diagnostics GmbH | Chaperone-chaperone fusion polypeptides for reduction of interference and stabilization of immunoassays |
| EP2827146A1 (en) | 2013-07-18 | 2015-01-21 | Roche Diagnostics GmbH | Vibrio cholerae lipoprotein 15 (Lp15) variants as anti-interference additive in TpN17-based immunoassays for detection of anti-Treponema antibodies |
| BR112016014010B1 (pt) * | 2013-12-19 | 2022-08-30 | Intervet International B.V. | Método para detectar anticorpos contra vírus da febre suína clássica tipo selvagem (csfv) em uma amostra de teste e kit de teste de diagnóstico |
| EP2913338A1 (en) * | 2014-02-28 | 2015-09-02 | Roche Diagniostics GmbH | Soluable and immunoreactive variants of HTLV capsid antigen p24 |
| US10562943B2 (en) | 2014-10-24 | 2020-02-18 | University Of Florida Research Foundation, Incorporated | Lactobacillus acidophilus surface layer protein A (SlpA) as a therapeutic agent for the treatment of inflammatory diseases |
| JP6817939B2 (ja) | 2014-12-01 | 2021-01-20 | フェネックス インク． | ペプチド産生のための融合パートナー |
| EP3465217B1 (en) | 2016-05-31 | 2025-09-03 | Roche Diagnostics GmbH | Method for serological detection of viral antigens |
| JP7044721B2 (ja) | 2016-05-31 | 2022-03-30 | エフ．ホフマン－ラ ロシュ アーゲー | Ｈｃｖコア抗原の迅速な検出のための前処理法 |
| WO2018141768A1 (en) | 2017-02-02 | 2018-08-09 | Roche Diagnostics Gmbh | Immunoassay using at least two pegylated analyte-specific binding agents |
| ES2961462T3 (es) | 2017-07-27 | 2024-03-12 | Roche Diagnostics Gmbh | Proteína de fusión multiepítopo de un antígeno del VHC y usos de la misma |
| EP3957995A1 (en) * | 2018-11-19 | 2022-02-23 | Bioaster | Methods and reagents for multiplex binding experiments |
| WO2023060116A2 (en) * | 2021-10-05 | 2023-04-13 | Viro Research, Llc | Herpes simplex virus types 1 and 2 lateral flow assay |
| WO2025098623A1 (en) | 2023-11-09 | 2025-05-15 | Roche Diagnostics Gmbh | Transglutaminase substrates for labeling |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7157089B1 (en) * | 1996-11-26 | 2007-01-02 | Stressgen Biotechnologies Corporation | Immune responses using compositions containing stress proteins |
| US5989868A (en) | 1997-09-12 | 1999-11-23 | The Board Of Regents Of The University Of Oklahoma | Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli |
| DK1402015T3 (da) | 2001-06-22 | 2011-12-05 | Hoffmann La Roche | Opløseligt kompleks omfattende et retroviralt overfladeglycoprotein og FkpA eller SlyD |
| CA2636075C (en) | 2006-01-03 | 2011-11-08 | F. Hoffmann-La Roche Ag | Chimaeric fusion protein with superior chaperone and folding activities |
-
2008
- 2008-05-26 EP EP08009537A patent/EP2127678A1/en not_active Withdrawn
-
2009
- 2009-05-06 US US12/436,396 patent/US8263086B2/en active Active
- 2009-05-25 JP JP2009124803A patent/JP5611540B2/ja active Active
- 2009-05-25 ES ES09006933.7T patent/ES2590340T3/es active Active
- 2009-05-25 EP EP09006933.7A patent/EP2127679B1/en active Active
- 2009-05-25 CA CA2667177A patent/CA2667177C/en active Active
- 2009-05-25 CN CN200910142690.3A patent/CN101591665B/zh active Active
-
2012
- 2012-08-08 US US13/569,353 patent/US8790659B2/en active Active
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