JP2008546694A5 - - Google Patents
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- Publication number
- JP2008546694A5 JP2008546694A5 JP2008516976A JP2008516976A JP2008546694A5 JP 2008546694 A5 JP2008546694 A5 JP 2008546694A5 JP 2008516976 A JP2008516976 A JP 2008516976A JP 2008516976 A JP2008516976 A JP 2008516976A JP 2008546694 A5 JP2008546694 A5 JP 2008546694A5
- Authority
- JP
- Japan
- Prior art keywords
- dione
- diene
- oxy
- fluoro
- bis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 cyclohexylmethylene Chemical group 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 238000009472 formulation Methods 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000000443 aerosol Substances 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- CHNUOJQWGUIOLD-NFZZJPOKSA-N epalrestat Chemical compound C=1C=CC=CC=1\C=C(/C)\C=C1/SC(=S)N(CC(O)=O)C1=O CHNUOJQWGUIOLD-NFZZJPOKSA-N 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 206010006482 Bronchospasm Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- QIEPWCSVQYUPIY-LEKSSAKUSA-N Delta(1)-progesterone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 QIEPWCSVQYUPIY-LEKSSAKUSA-N 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 230000007885 bronchoconstriction Effects 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 229940112141 dry powder inhaler Drugs 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69054505P | 2005-06-14 | 2005-06-14 | |
| PCT/US2006/022790 WO2006138212A1 (en) | 2005-06-14 | 2006-06-12 | SUBSTITUTED PHENYLPHOSPHATES AS MUTUAL PRODRUGS OF STEROIDS AND β -AGONISTS FOR THE TREATMENT OF PULMONARY INFLAMMATION AND BRONCHOCONSTRICTION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008546694A JP2008546694A (ja) | 2008-12-25 |
| JP2008546694A5 true JP2008546694A5 (enExample) | 2009-07-23 |
Family
ID=37570763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008516976A Pending JP2008546694A (ja) | 2005-06-14 | 2006-06-12 | 肺炎及び気管支の治療のためのステロイド及びβ−アゴニストの相互プロドラッグとしての置換されたフェニルホスファート |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20100209508A1 (enExample) |
| EP (1) | EP1893220A4 (enExample) |
| JP (1) | JP2008546694A (enExample) |
| KR (1) | KR20060130515A (enExample) |
| CN (1) | CN101227912A (enExample) |
| AR (1) | AR054475A1 (enExample) |
| AU (1) | AU2006259604A1 (enExample) |
| BR (1) | BRPI0611567A2 (enExample) |
| CA (1) | CA2612364A1 (enExample) |
| IL (1) | IL187816A0 (enExample) |
| NO (1) | NO20080182L (enExample) |
| RU (1) | RU2008100237A (enExample) |
| TW (1) | TW200718707A (enExample) |
| WO (1) | WO2006138212A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010503722A (ja) * | 2006-09-19 | 2010-02-04 | シプラ・リミテッド | シクレソニドとその結晶変異体の調製方法 |
| CN101657460A (zh) * | 2006-12-13 | 2010-02-24 | 基利得科学公司 | 用于治疗肺炎症和支气管收缩的作为抗炎性信号转导调节剂(AISTM’S)和β-激动剂的相互前药的单磷酸酯 |
| US20100112061A1 (en) * | 2006-12-13 | 2010-05-06 | William Baker | Monophosphates as Mutual Prodrugs of Muscarinic Receptor Antagonists and Beta-Agonists for the Treatment of COPD And Chronic Bronchitis |
| JP2011507878A (ja) * | 2007-12-21 | 2011-03-10 | シェーリング コーポレイション | Ｃ２０−ｃ２１置換グルココルチコイド受容体アゴニスト |
| WO2009085880A2 (en) * | 2007-12-21 | 2009-07-09 | Schering Corporation | C-21 thioethers as glucocorticoid receptor agonists |
| WO2009152171A1 (en) * | 2008-06-10 | 2009-12-17 | Gilead Sciences, Inc. | Corticosteroid linked beta-agonist compounds for use in therapy |
| WO2010126953A1 (en) * | 2009-04-29 | 2010-11-04 | Gilead Sciences, Inc. | Corticosteroid linked beta-agonist compounds for use in therapy |
| WO2010132743A1 (en) * | 2009-05-15 | 2010-11-18 | Gilead Sciences, Inc. | Corticosteroid beta-agonist compounds for use in therapy |
| AR077101A1 (es) * | 2009-06-16 | 2011-08-03 | Schering Corp | Esteroides de heteroarilo (3,2-c), como agonistas de receptor glucocorticoide, composiciones y usos de los mismos |
| JP2013504524A (ja) * | 2009-09-11 | 2013-02-07 | シエシー ファルマセウティチィ ソシエタ ペル アチオニ | イソオキサゾリジン誘導体 |
| WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
| JP6124176B2 (ja) * | 2013-03-26 | 2017-05-10 | 株式会社伏見製薬所 | 樹脂成形体用組成物 |
| CN104510726A (zh) * | 2013-09-27 | 2015-04-15 | 张金华 | 一种用于清洁呼吸道系统的食盐干粉吸入剂 |
| PT107567B (pt) * | 2014-03-31 | 2019-02-13 | Hovione Farm S A | Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização |
| ES2877548T3 (es) | 2016-06-02 | 2021-11-17 | Abbvie Inc | Agonista del receptor de glucocorticoides e inmunoconjugados del mismo |
| AU2017359043B2 (en) | 2016-11-08 | 2022-06-16 | Regeneron Pharmaceuticals, Inc. | Steroids and protein-conjugates thereof |
| KR20200007905A (ko) | 2017-05-18 | 2020-01-22 | 리제너론 파마슈티칼스 인코포레이티드 | 사이클로덱스트린 단백질 약물 접합체 |
| CA3080857A1 (en) | 2017-11-07 | 2019-05-16 | Regeneron Pharmaceuticals, Inc. | Hydrophilic linkers for antibody drug conjugates |
| AU2018374634A1 (en) | 2017-12-01 | 2020-05-28 | Abbvie Inc. | Glucocorticoid receptor agonist and immunoconjugates thereof |
| EA202091672A1 (ru) | 2018-01-08 | 2021-02-01 | Регенерон Фармасьютикалз, Инк. | Стероиды и их антитело-конъюгаты |
| WO2019217591A1 (en) | 2018-05-09 | 2019-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-msr1 antibodies and methods of use thereof |
| IT201900014178A1 (it) * | 2019-08-06 | 2021-02-06 | Genetic S P A | Esteri del montelukast e loro formulazioni farmaceutiche |
| JP7656784B2 (ja) * | 2020-11-26 | 2025-04-04 | 国立医薬品食品衛生研究所長 | 新規化合物及び抗コロナウイルス剤 |
| CN112592280B (zh) * | 2020-12-09 | 2023-05-23 | 青岛职业技术学院 | 一种消旋沙丁胺醇的制备方法 |
| AR125084A1 (es) | 2021-03-23 | 2023-06-07 | Lilly Co Eli | Agonistas del receptor de glucocorticoides novedosos |
| AR125079A1 (es) | 2021-03-23 | 2023-06-07 | Lilly Co Eli | Agonistas de receptores de glucocorticoides sustituidos con carboxi |
| PE20240889A1 (es) | 2021-03-23 | 2024-04-24 | Lilly Co Eli | Agonistas del receptor de glucocorticoides |
| JP2024523545A (ja) * | 2021-06-24 | 2024-06-28 | 江蘇先声薬業有限公司 | ステロイド系化合物、その医薬組成物及びその応用 |
| US20250179114A1 (en) * | 2021-09-14 | 2025-06-05 | Duality Biologics (Suzhou) Co., Ltd. | Anti-Inflammatory Compound and Use Thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB933868A (en) * | 1958-12-08 | 1963-08-14 | American Cyanamid Co | Process for fluorinating steroids |
| US4757079A (en) * | 1986-06-24 | 1988-07-12 | Dynamac Corporaton | Anti-hypertensive piperidine compounds |
| GR1001529B (el) * | 1990-09-07 | 1994-03-31 | Elmuquimica Farm Sl | Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης. |
| DE59407183D1 (de) * | 1993-04-02 | 1998-12-03 | Byk Gulden Lomberg Chem Fab | Neue prednisolonderivate |
| US6300326B1 (en) * | 1994-11-02 | 2001-10-09 | Michael R. Dobbs | Composition and method for control and treatment of cutaneous inflammation |
| IT1303671B1 (it) * | 1998-07-28 | 2001-02-23 | Nicox Sa | Sali dell'acido nitrico con farmaci attivi nel trattamento dipatologie del sistema respiratorio |
| EP1635844A1 (en) * | 2003-05-22 | 2006-03-22 | ALTANA Pharma AG | Salmeterol and ciclesonide combination |
| WO2005028495A1 (en) * | 2003-09-24 | 2005-03-31 | Glaxo Group Limited | Anti-inflammatory glucocorticoids |
| WO2005063777A1 (en) * | 2003-12-23 | 2005-07-14 | Corus Pharma | Benzylphosphate and substituted benzylphosphate prodrugs for the treatment of pulmonary inflammation |
-
2006
- 2006-06-12 BR BRPI0611567A patent/BRPI0611567A2/pt not_active IP Right Cessation
- 2006-06-12 US US11/922,258 patent/US20100209508A1/en not_active Abandoned
- 2006-06-12 AU AU2006259604A patent/AU2006259604A1/en not_active Abandoned
- 2006-06-12 JP JP2008516976A patent/JP2008546694A/ja active Pending
- 2006-06-12 WO PCT/US2006/022790 patent/WO2006138212A1/en not_active Ceased
- 2006-06-12 CA CA002612364A patent/CA2612364A1/en not_active Abandoned
- 2006-06-12 EP EP06784777A patent/EP1893220A4/en not_active Withdrawn
- 2006-06-12 RU RU2008100237/04A patent/RU2008100237A/ru not_active Application Discontinuation
- 2006-06-12 CN CNA2006800213783A patent/CN101227912A/zh active Pending
- 2006-06-14 KR KR1020060053519A patent/KR20060130515A/ko not_active Withdrawn
- 2006-06-14 TW TW095121230A patent/TW200718707A/zh unknown
- 2006-06-14 AR ARP060102527A patent/AR054475A1/es unknown
-
2007
- 2007-12-02 IL IL187816A patent/IL187816A0/en unknown
-
2008
- 2008-01-11 NO NO20080182A patent/NO20080182L/no not_active Application Discontinuation
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