IL187816A0 - Substituted phenylphosphates as mutual prodrugs of steroids and ??-agonists for the treatment of pulmonary inflammation and bronchoconstriction - Google Patents

Substituted phenylphosphates as mutual prodrugs of steroids and ??-agonists for the treatment of pulmonary inflammation and bronchoconstriction

Info

Publication number
IL187816A0
IL187816A0 IL187816A IL18781607A IL187816A0 IL 187816 A0 IL187816 A0 IL 187816A0 IL 187816 A IL187816 A IL 187816A IL 18781607 A IL18781607 A IL 18781607A IL 187816 A0 IL187816 A0 IL 187816A0
Authority
IL
Israel
Prior art keywords
bronchoconstriction
steroids
agonists
treatment
pulmonary inflammation
Prior art date
Application number
IL187816A
Other languages
English (en)
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of IL187816A0 publication Critical patent/IL187816A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
IL187816A 2005-06-14 2007-12-02 Substituted phenylphosphates as mutual prodrugs of steroids and ??-agonists for the treatment of pulmonary inflammation and bronchoconstriction IL187816A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69054505P 2005-06-14 2005-06-14
PCT/US2006/022790 WO2006138212A1 (en) 2005-06-14 2006-06-12 SUBSTITUTED PHENYLPHOSPHATES AS MUTUAL PRODRUGS OF STEROIDS AND β -AGONISTS FOR THE TREATMENT OF PULMONARY INFLAMMATION AND BRONCHOCONSTRICTION

Publications (1)

Publication Number Publication Date
IL187816A0 true IL187816A0 (en) 2008-08-07

Family

ID=37570763

Family Applications (1)

Application Number Title Priority Date Filing Date
IL187816A IL187816A0 (en) 2005-06-14 2007-12-02 Substituted phenylphosphates as mutual prodrugs of steroids and ??-agonists for the treatment of pulmonary inflammation and bronchoconstriction

Country Status (14)

Country Link
US (1) US20100209508A1 (enExample)
EP (1) EP1893220A4 (enExample)
JP (1) JP2008546694A (enExample)
KR (1) KR20060130515A (enExample)
CN (1) CN101227912A (enExample)
AR (1) AR054475A1 (enExample)
AU (1) AU2006259604A1 (enExample)
BR (1) BRPI0611567A2 (enExample)
CA (1) CA2612364A1 (enExample)
IL (1) IL187816A0 (enExample)
NO (1) NO20080182L (enExample)
RU (1) RU2008100237A (enExample)
TW (1) TW200718707A (enExample)
WO (1) WO2006138212A1 (enExample)

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EP2064227A2 (en) * 2006-09-19 2009-06-03 Cipla Ltd. Processes for the preparation of ciclesonide and its crystal form
AR064307A1 (es) * 2006-12-13 2009-03-25 Gilead Sciences Inc Monofosfatos utiles para el tratamiento de la inflamacion pulmonar y broncoconstriccion, formulaciones aerosolicas que los contienen, y metodo de preparacion.
US20100112061A1 (en) * 2006-12-13 2010-05-06 William Baker Monophosphates as Mutual Prodrugs of Muscarinic Receptor Antagonists and Beta-Agonists for the Treatment of COPD And Chronic Bronchitis
CN101970452A (zh) * 2007-12-21 2011-02-09 先灵公司 C20-c21取代的糖皮质激素受体激动剂
US20110262368A1 (en) * 2007-12-21 2011-10-27 Schering Corporation C21 thioethers as glucocorticoid receptor agonists
EP2294077A1 (en) * 2008-06-10 2011-03-16 Gilead Sciences, Inc. Corticosteroid linked beta-agonist compounds for use in therapy
WO2010126953A1 (en) * 2009-04-29 2010-11-04 Gilead Sciences, Inc. Corticosteroid linked beta-agonist compounds for use in therapy
WO2010132743A1 (en) * 2009-05-15 2010-11-18 Gilead Sciences, Inc. Corticosteroid beta-agonist compounds for use in therapy
TW201111392A (en) * 2009-06-16 2011-04-01 Schering Corp Novel [3,2-c] heteroaryl steroids as glucocorticoid receptor agonists, compositions and uses thereof
NZ598662A (en) * 2009-09-11 2014-03-28 Chiesi Farma Spa Pregnane derivatives condensed in the 16, 17 position with an n-substituted isoxazolidine ring as anti-inflammatory agents
WO2011081937A1 (en) 2009-12-15 2011-07-07 Gilead Sciences, Inc. Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy
JP6124176B2 (ja) * 2013-03-26 2017-05-10 株式会社伏見製薬所 樹脂成形体用組成物
CN104510726A (zh) * 2013-09-27 2015-04-15 张金华 一种用于清洁呼吸道系统的食盐干粉吸入剂
PT107567B (pt) * 2014-03-31 2019-02-13 Hovione Farm S A Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização
RS62040B1 (sr) 2016-06-02 2021-07-30 Abbvie Inc Agonist receptora glukokortikoida i njegovi imunokonjugati
CA3042428A1 (en) * 2016-11-08 2018-05-17 Regeneron Pharmaceuticals, Inc. Steroids and protein-conjugates thereof
KR20250008984A (ko) 2017-05-18 2025-01-16 리제너론 파마슈티칼스 인코포레이티드 사이클로덱스트린 단백질 약물 접합체
CA3247730A1 (en) 2017-11-07 2025-10-30 Regeneron Pharmaceuticals, Inc. Hydrophilic linkers for antibody drug conjugates
EP3658192B1 (en) 2017-12-01 2021-04-28 AbbVie Inc. Glucocorticoid receptor agonist and immunoconjugates thereof
MA50259A1 (fr) 2018-01-08 2021-07-29 Regeneron Pharma Stéroïdes et leurs conjugués-anticorps
WO2019217591A1 (en) 2018-05-09 2019-11-14 Regeneron Pharmaceuticals, Inc. Anti-msr1 antibodies and methods of use thereof
IT201900014178A1 (it) * 2019-08-06 2021-02-06 Genetic S P A Esteri del montelukast e loro formulazioni farmaceutiche
JP7656784B2 (ja) * 2020-11-26 2025-04-04 国立医薬品食品衛生研究所長 新規化合物及び抗コロナウイルス剤
CN112592280B (zh) * 2020-12-09 2023-05-23 青岛职业技术学院 一种消旋沙丁胺醇的制备方法
AR125079A1 (es) 2021-03-23 2023-06-07 Lilly Co Eli Agonistas de receptores de glucocorticoides sustituidos con carboxi
AR125084A1 (es) 2021-03-23 2023-06-07 Lilly Co Eli Agonistas del receptor de glucocorticoides novedosos
TWI899455B (zh) 2021-03-23 2025-10-01 美商美國禮來大藥廠 糖皮質素受體激動劑
EP4365183A4 (en) * 2021-06-24 2025-12-03 Jiangsu Simcere Pharm Co Ltd STEROID COMPOUND, PHARMACEUTICAL COMPOSITION AND ASSOCIATED USES
US20250179114A1 (en) * 2021-09-14 2025-06-05 Duality Biologics (Suzhou) Co., Ltd. Anti-Inflammatory Compound and Use Thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB933867A (en) * 1958-12-08 1963-08-14 American Cyanamid Co Fluorinated steroids
US4757079A (en) * 1986-06-24 1988-07-12 Dynamac Corporaton Anti-hypertensive piperidine compounds
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
CZ287877B6 (cs) * 1993-04-02 2001-03-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Prednisolonové deriváty a farmaceutické prostředky s jejich obsahem
US6300326B1 (en) * 1994-11-02 2001-10-09 Michael R. Dobbs Composition and method for control and treatment of cutaneous inflammation
IT1303671B1 (it) * 1998-07-28 2001-02-23 Nicox Sa Sali dell'acido nitrico con farmaci attivi nel trattamento dipatologie del sistema respiratorio
AU2004241746A1 (en) * 2003-05-22 2004-12-02 Nycomed Gmbh Salmeterol and ciclesonide combination
WO2005028495A1 (en) * 2003-09-24 2005-03-31 Glaxo Group Limited Anti-inflammatory glucocorticoids
WO2005063777A1 (en) * 2003-12-23 2005-07-14 Corus Pharma Benzylphosphate and substituted benzylphosphate prodrugs for the treatment of pulmonary inflammation

Also Published As

Publication number Publication date
TW200718707A (en) 2007-05-16
NO20080182L (no) 2008-02-21
US20100209508A1 (en) 2010-08-19
EP1893220A1 (en) 2008-03-05
CA2612364A1 (en) 2006-12-28
JP2008546694A (ja) 2008-12-25
EP1893220A4 (en) 2011-06-15
AU2006259604A1 (en) 2006-12-28
AR054475A1 (es) 2007-06-27
CN101227912A (zh) 2008-07-23
BRPI0611567A2 (pt) 2016-11-16
RU2008100237A (ru) 2009-07-20
KR20060130515A (ko) 2006-12-19
WO2006138212A1 (en) 2006-12-28

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