AU2006259604A1 - Substituted phenylphosphates as mutual prodrugs of steroids and beta -agonists for the treatment of pulmonary inflammation and bronchoconstriction - Google Patents
Substituted phenylphosphates as mutual prodrugs of steroids and beta -agonists for the treatment of pulmonary inflammation and bronchoconstriction Download PDFInfo
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- AU2006259604A1 AU2006259604A1 AU2006259604A AU2006259604A AU2006259604A1 AU 2006259604 A1 AU2006259604 A1 AU 2006259604A1 AU 2006259604 A AU2006259604 A AU 2006259604A AU 2006259604 A AU2006259604 A AU 2006259604A AU 2006259604 A1 AU2006259604 A1 AU 2006259604A1
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- Prior art keywords
- diene
- dione
- bis
- fluoro
- oxy
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- CMPQUABWPXYYSH-UHFFFAOYSA-N phenyl phosphate Chemical class OP(O)(=O)OC1=CC=CC=C1 CMPQUABWPXYYSH-UHFFFAOYSA-N 0.000 title claims description 15
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69054505P | 2005-06-14 | 2005-06-14 | |
| US60/690,545 | 2005-06-14 | ||
| PCT/US2006/022790 WO2006138212A1 (en) | 2005-06-14 | 2006-06-12 | SUBSTITUTED PHENYLPHOSPHATES AS MUTUAL PRODRUGS OF STEROIDS AND β -AGONISTS FOR THE TREATMENT OF PULMONARY INFLAMMATION AND BRONCHOCONSTRICTION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2006259604A1 true AU2006259604A1 (en) | 2006-12-28 |
Family
ID=37570763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2006259604A Abandoned AU2006259604A1 (en) | 2005-06-14 | 2006-06-12 | Substituted phenylphosphates as mutual prodrugs of steroids and beta -agonists for the treatment of pulmonary inflammation and bronchoconstriction |
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| Country | Link |
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| US (1) | US20100209508A1 (enExample) |
| EP (1) | EP1893220A4 (enExample) |
| JP (1) | JP2008546694A (enExample) |
| KR (1) | KR20060130515A (enExample) |
| CN (1) | CN101227912A (enExample) |
| AR (1) | AR054475A1 (enExample) |
| AU (1) | AU2006259604A1 (enExample) |
| BR (1) | BRPI0611567A2 (enExample) |
| CA (1) | CA2612364A1 (enExample) |
| IL (1) | IL187816A0 (enExample) |
| NO (1) | NO20080182L (enExample) |
| RU (1) | RU2008100237A (enExample) |
| TW (1) | TW200718707A (enExample) |
| WO (1) | WO2006138212A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2008035066A2 (en) * | 2006-09-19 | 2008-03-27 | Cipla Limited | Processes for the preparation of ciclesonide and its crystal form |
| JP2010513277A (ja) * | 2006-12-13 | 2010-04-30 | ギリード・サイエンシズ・インコーポレーテッド | ＣＯＰＤおよび慢性気管支炎の治療のためのムスカリン受容体アンタゴニストおよびβ−アゴニストの共通プロドラッグとしてのモノホスフェート |
| WO2008076265A1 (en) * | 2006-12-13 | 2008-06-26 | Gilead Sciences, Inc. | MONOPHOSPHATES AS MUTUAL PRODRUGS OF ANTI-INFLAMMATORY SIGNAL TRANSDUCTION MODULATORS (AISTM'S) AND β-AGONISTS FOR THE TREATMENT OF PULMONARY INFLAMMATION AND BRONCHOCONSTRICTION |
| WO2009085879A2 (en) | 2007-12-21 | 2009-07-09 | Schering Corporation | C20-c21 substituted glucocorticoid receptor agonists |
| CL2008003802A1 (es) * | 2007-12-21 | 2010-02-19 | Schering Corp | Compuestos derivados de tioeteres c-21, agonistas del receptor de glucocorticoide; composicion farmaceutica; y uso para el tratamiento o profilaxis de una enfermedad o afeccion inmune, autoinmune o inflamatoria, tales como artritis reumatoide y esclerosis multiple. |
| US20090318396A1 (en) * | 2008-06-10 | 2009-12-24 | Gilead Sciences, Inc. | Corticosteroid linked beta-agonist compounds for use in therapy |
| WO2010126953A1 (en) * | 2009-04-29 | 2010-11-04 | Gilead Sciences, Inc. | Corticosteroid linked beta-agonist compounds for use in therapy |
| WO2010132743A1 (en) * | 2009-05-15 | 2010-11-18 | Gilead Sciences, Inc. | Corticosteroid beta-agonist compounds for use in therapy |
| CA2764830A1 (en) * | 2009-06-16 | 2010-12-23 | Schering Corporation | Novel [3,2-c] heteroaryl steroids as glucocorticoid receptor agonists, compositions and uses thereof |
| BR112012005503B1 (pt) * | 2009-09-11 | 2021-10-13 | Chiesi Farmaceutici S.P.A. | Derivados de isoxazolidina |
| WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
| JP6124176B2 (ja) * | 2013-03-26 | 2017-05-10 | 株式会社伏見製薬所 | 樹脂成形体用組成物 |
| CN104510726A (zh) * | 2013-09-27 | 2015-04-15 | 张金华 | 一种用于清洁呼吸道系统的食盐干粉吸入剂 |
| PT107567B (pt) * | 2014-03-31 | 2019-02-13 | Hovione Farm S A | Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização |
| MY194619A (en) | 2016-06-02 | 2022-12-07 | Abbvie Inc | Glucocorticoid receptor agonist and immunoconjugates thereof |
| MY199937A (en) | 2016-11-08 | 2023-11-29 | Regeneron Pharma | Steroids and protein-conjugates thereof |
| KR20200007905A (ko) | 2017-05-18 | 2020-01-22 | 리제너론 파마슈티칼스 인코포레이티드 | 사이클로덱스트린 단백질 약물 접합체 |
| CN111601619A (zh) | 2017-11-07 | 2020-08-28 | 里珍纳龙药品有限公司 | 用于抗体药物偶联物的亲水性连接体 |
| BR112020010694A2 (pt) | 2017-12-01 | 2020-11-10 | Abbvie Inc. | agonista de receptor de glicocorticoides e imunoconjugados do mesmo |
| US12070506B2 (en) | 2018-01-08 | 2024-08-27 | Regeneron Pharmaceuticals, Inc. | Steroids and antibody-conjugates thereof |
| AU2019265703A1 (en) | 2018-05-09 | 2020-11-19 | Regeneron Pharmaceuticals, Inc. | Anti-MSR1 antibodies and methods of use thereof |
| IT201900014178A1 (it) * | 2019-08-06 | 2021-02-06 | Genetic S P A | Esteri del montelukast e loro formulazioni farmaceutiche |
| JP7656784B2 (ja) * | 2020-11-26 | 2025-04-04 | 国立医薬品食品衛生研究所長 | 新規化合物及び抗コロナウイルス剤 |
| CN112592280B (zh) * | 2020-12-09 | 2023-05-23 | 青岛职业技术学院 | 一种消旋沙丁胺醇的制备方法 |
| AR125079A1 (es) | 2021-03-23 | 2023-06-07 | Lilly Co Eli | Agonistas de receptores de glucocorticoides sustituidos con carboxi |
| BR112023016448A2 (pt) | 2021-03-23 | 2023-10-24 | Lilly Co Eli | Agonistas de receptor de glucocorticoide |
| TW202304464A (zh) | 2021-03-23 | 2023-02-01 | 美商美國禮來大藥廠 | 新穎糖皮質素受體激動劑 |
| CN117580849A (zh) * | 2021-06-24 | 2024-02-20 | 江苏先声药业有限公司 | 甾体类化合物、其药物组合物及其应用 |
| CN118201943A (zh) * | 2021-09-14 | 2024-06-14 | 映恩生物制药（苏州）有限公司 | 一种抗炎症的化合物及其用途 |
Family Cites Families (9)
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|---|---|---|---|---|
| GB933868A (en) * | 1958-12-08 | 1963-08-14 | American Cyanamid Co | Process for fluorinating steroids |
| US4757079A (en) * | 1986-06-24 | 1988-07-12 | Dynamac Corporaton | Anti-hypertensive piperidine compounds |
| GR1001529B (el) * | 1990-09-07 | 1994-03-31 | Elmuquimica Farm Sl | Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης. |
| HU220868B1 (en) * | 1993-04-02 | 2002-06-29 | Byk Gulden Lomberg Chem Fab | New prednisolone derivative, process for its production, use of the same and pharmaceutical composition containing the same |
| US6300326B1 (en) * | 1994-11-02 | 2001-10-09 | Michael R. Dobbs | Composition and method for control and treatment of cutaneous inflammation |
| IT1303671B1 (it) * | 1998-07-28 | 2001-02-23 | Nicox Sa | Sali dell'acido nitrico con farmaci attivi nel trattamento dipatologie del sistema respiratorio |
| EP1635844A1 (en) * | 2003-05-22 | 2006-03-22 | ALTANA Pharma AG | Salmeterol and ciclesonide combination |
| WO2005028495A1 (en) * | 2003-09-24 | 2005-03-31 | Glaxo Group Limited | Anti-inflammatory glucocorticoids |
| WO2005063777A1 (en) * | 2003-12-23 | 2005-07-14 | Corus Pharma | Benzylphosphate and substituted benzylphosphate prodrugs for the treatment of pulmonary inflammation |
-
2006
- 2006-06-12 US US11/922,258 patent/US20100209508A1/en not_active Abandoned
- 2006-06-12 EP EP06784777A patent/EP1893220A4/en not_active Withdrawn
- 2006-06-12 BR BRPI0611567A patent/BRPI0611567A2/pt not_active IP Right Cessation
- 2006-06-12 CN CNA2006800213783A patent/CN101227912A/zh active Pending
- 2006-06-12 JP JP2008516976A patent/JP2008546694A/ja active Pending
- 2006-06-12 RU RU2008100237/04A patent/RU2008100237A/ru not_active Application Discontinuation
- 2006-06-12 AU AU2006259604A patent/AU2006259604A1/en not_active Abandoned
- 2006-06-12 WO PCT/US2006/022790 patent/WO2006138212A1/en not_active Ceased
- 2006-06-12 CA CA002612364A patent/CA2612364A1/en not_active Abandoned
- 2006-06-14 TW TW095121230A patent/TW200718707A/zh unknown
- 2006-06-14 AR ARP060102527A patent/AR054475A1/es unknown
- 2006-06-14 KR KR1020060053519A patent/KR20060130515A/ko not_active Withdrawn
-
2007
- 2007-12-02 IL IL187816A patent/IL187816A0/en unknown
-
2008
- 2008-01-11 NO NO20080182A patent/NO20080182L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101227912A (zh) | 2008-07-23 |
| JP2008546694A (ja) | 2008-12-25 |
| IL187816A0 (en) | 2008-08-07 |
| US20100209508A1 (en) | 2010-08-19 |
| EP1893220A1 (en) | 2008-03-05 |
| BRPI0611567A2 (pt) | 2016-11-16 |
| CA2612364A1 (en) | 2006-12-28 |
| WO2006138212A1 (en) | 2006-12-28 |
| EP1893220A4 (en) | 2011-06-15 |
| AR054475A1 (es) | 2007-06-27 |
| RU2008100237A (ru) | 2009-07-20 |
| KR20060130515A (ko) | 2006-12-19 |
| TW200718707A (en) | 2007-05-16 |
| NO20080182L (no) | 2008-02-21 |
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Owner name: GILEAD SCIENCES, INC. Free format text: FORMER APPLICANT(S): CORUS PHARMA, INC. |
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| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |