JP2008545678A5 - - Google Patents
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- Publication number
- JP2008545678A5 JP2008545678A5 JP2008512837A JP2008512837A JP2008545678A5 JP 2008545678 A5 JP2008545678 A5 JP 2008545678A5 JP 2008512837 A JP2008512837 A JP 2008512837A JP 2008512837 A JP2008512837 A JP 2008512837A JP 2008545678 A5 JP2008545678 A5 JP 2008545678A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydroxy
- estradi
- group
- trien
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(*)(C1C****)C(*)(*)[C@@](C)(CC2)[C@@]1[C@@](CCc1c3)[C@]2c1cc(*)c3O* Chemical compound CC(*)(C1C****)C(*)(*)[C@@](C)(CC2)[C@@]1[C@@](CCc1c3)[C@]2c1cc(*)c3O* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05104534 | 2005-05-26 | ||
| EP05104534.2 | 2005-05-26 | ||
| PCT/EP2006/062587 WO2006125800A1 (en) | 2005-05-26 | 2006-05-24 | 17β-HSD1 AND STS INHIBITORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008545678A JP2008545678A (ja) | 2008-12-18 |
| JP2008545678A5 true JP2008545678A5 (cg-RX-API-DMAC7.html) | 2009-07-02 |
| JP5268635B2 JP5268635B2 (ja) | 2013-08-21 |
Family
ID=35276406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512837A Expired - Fee Related JP5268635B2 (ja) | 2005-05-26 | 2006-05-24 | １７β−ＨＳＤ１及びＳＴＳインヒビター |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1888615B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5268635B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101364412B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN101189251B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2006251154B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0611623A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2609726C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2388297T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL187620A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2007014736A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20076616L (cg-RX-API-DMAC7.html) |
| RU (1) | RU2412196C2 (cg-RX-API-DMAC7.html) |
| UA (1) | UA92348C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006125800A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200709854B (cg-RX-API-DMAC7.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8080540B2 (en) | 2006-09-19 | 2011-12-20 | Abbott Products Gmbh | Therapeutically active triazoles and their use |
| AU2007327653B2 (en) * | 2006-11-30 | 2013-04-18 | Solvay Pharmaceuticals Gmbh | Substituted estratrien derivatives as 17beta HSD inhibitors |
| US8288367B2 (en) | 2006-11-30 | 2012-10-16 | Solvay Pharmaceuticals Gmbh | Substituted estratriene derivatives as 17BETA HSD inhibitors |
| US11072632B2 (en) | 2011-03-25 | 2021-07-27 | UNIVERSITé LAVAL | Inhibitors of 17β-HSD1, 17β-HSD3 and 17β-HSD10 |
| SG195118A1 (en) | 2011-06-01 | 2013-12-30 | Estetra S A | Process for the production of estetrol intermediates |
| PT2714712T (pt) | 2011-06-01 | 2016-11-08 | Estetra Sprl | Processo para a produção de intermediários de estetrol |
| EP2383279A1 (en) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
| WO2013078413A1 (en) * | 2011-11-22 | 2013-05-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modulators of lipid storage |
| TW201512215A (zh) | 2013-06-25 | 2015-04-01 | Forendo Pharma Ltd | 治療活性雌三烯噻唑衍生物 |
| JP6456373B2 (ja) * | 2013-06-25 | 2019-01-23 | フォレンド ファーマ リミテッド | １７β−ヒドロキシステロイドデヒドロゲナーゼ タイプ１の阻害剤として治療活性のあるエストラトリエンチアゾール誘導体 |
| JP6556125B2 (ja) * | 2013-06-25 | 2019-08-07 | フォレンド ファーマ リミテッド | １７β−ヒドロキシステロイドデヒドロゲナーゼの阻害剤としての治療的に活性な１７−窒素置換エストラトリエンチアゾール誘導体 |
| JP6545266B2 (ja) | 2014-12-23 | 2019-07-17 | フォレンド ファーマ リミテッド | １７β‐ＨＳＤ１抑制剤のプロドラッグ |
| CN107207561B (zh) * | 2014-12-23 | 2020-03-31 | 佛恩多制药有限公司 | 17β-HSD1–抑制剂的前药 |
| LT3310346T (lt) | 2015-06-18 | 2021-06-10 | Estetra Sprl | Burnoje disperguojama tabletė, turinti estetrolio |
| LT3310345T (lt) | 2015-06-18 | 2021-06-25 | Estetra Sprl | Burnoje disperguojama tabletė, turinti estetrolio |
| DK3701944T3 (da) | 2015-06-18 | 2022-03-14 | Estetra Srl | Oro-dispergerbar doseringsenhed indeholdende en estetrolkomponent |
| CR20180042A (es) | 2015-06-18 | 2018-05-03 | Mithra Pharmaceuticals S A | Unidad de dosificación orodispersable que contiene un componente estetrol. |
| CN105963301B (zh) * | 2016-04-26 | 2018-12-28 | 兰州大学 | 以人fkbp51蛋白为靶点的先导化合物及筛选方法与应用 |
| CZ307437B6 (cs) | 2016-06-07 | 2018-08-22 | Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. | 15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz |
| KR102712911B1 (ko) | 2016-08-05 | 2024-10-04 | 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 | 월경통 및 생리통의 관리방법 |
| HRP20240679T1 (hr) * | 2017-06-08 | 2024-08-16 | Organon R&D Finland Ltd | 17-oksimi 15.beta.-[3-propanamido]-supstituiranih etera-1,3,5(10)-trien-17-ona za uporabu u inhibiciji 17.beta.-hidroksisteroid dehidrogenaza |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| CN111989105B (zh) | 2018-04-19 | 2024-07-19 | 埃斯特拉私人有限责任公司 | 化合物以及它们在缓解绝经相关症状中的用途 |
| JP7417608B2 (ja) | 2018-12-05 | 2024-01-18 | フォレンド ファーマ リミテッド | １７－ｈｓｄ１阻害剤としての１６（１７）位でピラゾール環と縮合しているエストラ－１，３，５（１０）－トリエン化合物 |
| TWI893101B (zh) | 2020-04-16 | 2025-08-11 | 比利時商埃斯特拉有限責任公司 | 具有降低之副作用之避孕組成物 |
| US20240082208A1 (en) * | 2021-01-08 | 2024-03-14 | Industry-Academic Cooperation Foundation, Yonsei University | Antiviral pharmaceutical composition comprising steroid sulfatase inhibitor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU208150B (en) * | 1988-10-31 | 1993-08-30 | Endorecherche Inc | Process for producing new estrogen derivatives having steroid hormone inhibitor activity and pharmaceutical compositions comprising such derivatives |
| US7015211B2 (en) * | 2003-03-21 | 2006-03-21 | Yale University | 15α-substituted estradiol carboxylic acid esters as locally active estrogens |
| GB0306718D0 (en) * | 2003-03-24 | 2003-04-30 | Sterix Ltd | Compound |
| TWI331154B (en) * | 2003-11-12 | 2010-10-01 | Solvay Pharm Gmbh | Novel 17-hydroxysteroid dehydrogenase type i inhibitors |
-
2006
- 2006-05-24 CN CN2006800183025A patent/CN101189251B/zh not_active Expired - Fee Related
- 2006-05-24 CN CN2012103102224A patent/CN102796160A/zh active Pending
- 2006-05-24 BR BRPI0611623-0A patent/BRPI0611623A2/pt not_active IP Right Cessation
- 2006-05-24 ZA ZA200709854A patent/ZA200709854B/xx unknown
- 2006-05-24 UA UAA200714185A patent/UA92348C2/ru unknown
- 2006-05-24 RU RU2007147416/04A patent/RU2412196C2/ru not_active IP Right Cessation
- 2006-05-24 CA CA2609726A patent/CA2609726C/en not_active Expired - Fee Related
- 2006-05-24 KR KR1020077028969A patent/KR101364412B1/ko not_active Expired - Fee Related
- 2006-05-24 AU AU2006251154A patent/AU2006251154B2/en not_active Ceased
- 2006-05-24 EP EP06763273A patent/EP1888615B1/en active Active
- 2006-05-24 MX MX2007014736A patent/MX2007014736A/es active IP Right Grant
- 2006-05-24 ES ES06763273T patent/ES2388297T3/es active Active
- 2006-05-24 WO PCT/EP2006/062587 patent/WO2006125800A1/en not_active Ceased
- 2006-05-24 JP JP2008512837A patent/JP5268635B2/ja not_active Expired - Fee Related
-
2007
- 2007-11-25 IL IL187620A patent/IL187620A/en not_active IP Right Cessation
- 2007-12-21 NO NO20076616A patent/NO20076616L/no not_active Application Discontinuation
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