JP2008542367A5 - - Google Patents
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- Publication number
- JP2008542367A5 JP2008542367A5 JP2008514588A JP2008514588A JP2008542367A5 JP 2008542367 A5 JP2008542367 A5 JP 2008542367A5 JP 2008514588 A JP2008514588 A JP 2008514588A JP 2008514588 A JP2008514588 A JP 2008514588A JP 2008542367 A5 JP2008542367 A5 JP 2008542367A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cyanomethyl
- phenyl
- carboxamide
- quinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC1C=CC(C(*)N(C(c2c(CC#N)c(C3=CC=C*(*)C=C3)nc3c2cccc3)=O)I)=CC=C1 Chemical compound CC1C=CC(C(*)N(C(c2c(CC#N)c(C3=CC=C*(*)C=C3)nc3c2cccc3)=O)I)=CC=C1 0.000 description 1
- AQFLVLHRZFLDDV-VIFPVBQESA-N CC[C@@H](c1ccccc1)N Chemical compound CC[C@@H](c1ccccc1)N AQFLVLHRZFLDDV-VIFPVBQESA-N 0.000 description 1
- ZLQPXWZKRCEEHM-HSZRJFAPSA-N CC[C@H](c1ccccc1)NC(c1c(CC#N)c(-c2cccc(F)c2)nc2c1cccc2)=O Chemical compound CC[C@H](c1ccccc1)NC(c1c(CC#N)c(-c2cccc(F)c2)nc2c1cccc2)=O ZLQPXWZKRCEEHM-HSZRJFAPSA-N 0.000 description 1
- OBXIJGKFCRSVFY-UHFFFAOYSA-N N#CCc1c(C(NC(C2CC2)c2cc(F)ccc2)=O)c(cccc2)c2nc1-c1ccccc1 Chemical compound N#CCc1c(C(NC(C2CC2)c2cc(F)ccc2)=O)c(cccc2)c2nc1-c1ccccc1 OBXIJGKFCRSVFY-UHFFFAOYSA-N 0.000 description 1
- WJCDZNCXXWHQFR-UHFFFAOYSA-N N#CCc1c(C(O)=O)c(cccc2)c2nc1-c1cccc(F)c1 Chemical compound N#CCc1c(C(O)=O)c(cccc2)c2nc1-c1cccc(F)c1 WJCDZNCXXWHQFR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68741805P | 2005-06-03 | 2005-06-03 | |
| PCT/SE2006/000630 WO2006130080A2 (en) | 2005-06-03 | 2006-05-30 | Quinoline derivatives as nk3 anatgonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008542367A JP2008542367A (ja) | 2008-11-27 |
| JP2008542367A5 true JP2008542367A5 (https=) | 2009-07-16 |
Family
ID=37482086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008514588A Pending JP2008542367A (ja) | 2005-06-03 | 2006-05-30 | Ｎｋ−３アンタゴニストとしてのキノリン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20080200500A1 (https=) |
| EP (1) | EP1891012A2 (https=) |
| JP (1) | JP2008542367A (https=) |
| KR (1) | KR20080016591A (https=) |
| CN (1) | CN101189211A (https=) |
| AU (1) | AU2006253054A1 (https=) |
| CA (1) | CA2611060A1 (https=) |
| IL (1) | IL187410A0 (https=) |
| MX (1) | MX2007014831A (https=) |
| NO (1) | NO20080033L (https=) |
| WO (1) | WO2006130080A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008131779A1 (en) | 2007-04-26 | 2008-11-06 | H. Lundbeck A/S | Isoquinolinone derivatives as nk3 antagonists |
| US8173639B2 (en) | 2007-04-26 | 2012-05-08 | H. Lundbeck A/S | Isoquinolinone derivatives as NK3 antagonists |
| EA201170074A1 (ru) | 2008-06-23 | 2011-10-31 | Х. Лундбекк А/С | Изохинолиноновые производные в качестве антагонистов nk3 |
| US8242134B2 (en) | 2008-09-15 | 2012-08-14 | H. Lundbeck A/S | Isoquinolinone derivatives as NK3 antagonists |
| TW201016688A (en) | 2008-10-20 | 2010-05-01 | Lundbeck & Co As H | Isoquinolinone derivatives as NK3 antagonists |
| TW201143768A (en) | 2009-12-15 | 2011-12-16 | Lundbeck & Co As H | Pyridone derivatives as NK3 antagonists |
| TW201144311A (en) | 2010-03-12 | 2011-12-16 | Lundbeck & Co As H | Azaisoquionolinone derivatives as NK3 antagonists |
| EP3915560A1 (en) | 2014-06-25 | 2021-12-01 | Emory University | Methods of managing conditioned fear with neurokinin receptor antagonists |
| KR20160069683A (ko) | 2014-12-09 | 2016-06-17 | 백찬욱 | 콤비보트 및 그 제작 방법 |
| EP3704271B1 (en) | 2017-11-02 | 2026-01-28 | California Institute of Technology | Neurokinin antagonists and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK282721B6 (sk) * | 1994-05-27 | 2002-11-06 | Smithkline Beecham S.P.A. | Nepeptidové NK3 antagonistické látky, spôsob ich výroby, farmaceutické prostriedky s ich obsahom a ich použitie |
| IT1270615B (it) * | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
| AR004735A1 (es) * | 1995-11-24 | 1999-03-10 | Smithkline Beecham Spa | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. |
| GB9524137D0 (en) * | 1995-11-24 | 1996-01-24 | Smithkline Beecham Spa | Novel compounds |
| EP0983262B1 (en) * | 1997-05-23 | 2003-07-09 | GlaxoSmithKline S.p.A. | Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists |
| AP1201A (en) * | 1997-09-17 | 2003-09-01 | Smithkline Beecham Corp | Method for the synthesis of quinoline derivatives. |
| JP2002530377A (ja) * | 1998-11-20 | 2002-09-17 | スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ | Ｎｋ−３およびｎｋ−２受容体アンタゴニストとしてのキノリン−４−カルボキシアミド誘導体 |
| DE60209362T2 (de) * | 2001-04-11 | 2006-10-26 | Glaxosmithkline S.P.A. | 3-substituierte chinolin-4-carbonsäureamidderivate als nk-3- und nk-2-rezeptorantagonisten |
| CN101282964A (zh) * | 2005-08-11 | 2008-10-08 | 阿斯利康(瑞典)有限公司 | 作为nk3受体调节剂的氧-吡啶基喹啉酰胺 |
| AR058051A1 (es) * | 2005-09-21 | 2008-01-23 | Astrazeneca Ab | Quinolinas de alquilnitrilo.proceso de obtencion y composiciones farmaceuticas. |
| EP1981882A4 (en) * | 2006-01-27 | 2009-11-18 | Astrazeneca Ab | QUINOLINES SUBSTITUTED BY AN AMIDE |
-
2006
- 2006-05-30 MX MX2007014831A patent/MX2007014831A/es not_active Application Discontinuation
- 2006-05-30 EP EP06747824A patent/EP1891012A2/en not_active Withdrawn
- 2006-05-30 JP JP2008514588A patent/JP2008542367A/ja active Pending
- 2006-05-30 AU AU2006253054A patent/AU2006253054A1/en not_active Abandoned
- 2006-05-30 KR KR1020077027965A patent/KR20080016591A/ko not_active Withdrawn
- 2006-05-30 US US11/914,583 patent/US20080200500A1/en not_active Abandoned
- 2006-05-30 WO PCT/SE2006/000630 patent/WO2006130080A2/en not_active Ceased
- 2006-05-30 CA CA002611060A patent/CA2611060A1/en not_active Abandoned
- 2006-05-30 CN CNA2006800196735A patent/CN101189211A/zh active Pending
-
2007
- 2007-11-15 IL IL187410A patent/IL187410A0/en unknown
-
2008
- 2008-01-03 NO NO20080033A patent/NO20080033L/no unknown
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