JP2008542220A5 - - Google Patents

Info

Publication number

JP2008542220A5

JP2008542220A5 JP2008512759A JP2008512759A JP2008542220A5 JP 2008542220 A5 JP2008542220 A5 JP 2008542220A5 JP 2008512759 A JP2008512759 A JP 2008512759A JP 2008512759 A JP2008512759 A JP 2008512759A JP 2008542220 A5 JP2008542220 A5 JP 2008542220A5

Authority

JP

Japan

Prior art keywords

polymer

active substance

core

biologically active

hours

Prior art date

2006-05-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 229920000642 polymer Polymers 0.000 claims 10
• 238000000034 method Methods 0.000 claims 9
• 229940088623 biologically active substance Drugs 0.000 claims 6
• 239000003094 microcapsule Substances 0.000 claims 5
• 238000013270 controlled release Methods 0.000 claims 3
• 239000003960 organic solvent Substances 0.000 claims 3
• 238000005345 coagulation Methods 0.000 claims 2
• 230000015271 coagulation Effects 0.000 claims 2
• 229920001577 copolymer Polymers 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000000463 material Substances 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 239000000243 solution Substances 0.000 claims 2
• 239000000725 suspension Substances 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
• 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
• 239000004971 Cross linker Substances 0.000 claims 1
• 229920000045 Dermatan sulfate Polymers 0.000 claims 1
• 229920002307 Dextran Polymers 0.000 claims 1
• 229920002527 Glycogen Polymers 0.000 claims 1
• 229920002774 Maltodextrin Polymers 0.000 claims 1
• 239000005913 Maltodextrin Substances 0.000 claims 1
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
• 239000002202 Polyethylene glycol Substances 0.000 claims 1
• 102000007327 Protamines Human genes 0.000 claims 1
• 108010007568 Protamines Proteins 0.000 claims 1
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
• 239000013543 active substance Substances 0.000 claims 1
• 239000007864 aqueous solution Substances 0.000 claims 1
• 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
• 229940059329 chondroitin sulfate Drugs 0.000 claims 1
• 238000005354 coacervation Methods 0.000 claims 1
• 239000011248 coating agent Substances 0.000 claims 1
• 238000000576 coating method Methods 0.000 claims 1
• 230000009918 complex formation Effects 0.000 claims 1
• AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 1
• 229940051593 dermatan sulfate Drugs 0.000 claims 1
• 229960002086 dextran Drugs 0.000 claims 1
• 238000001035 drying Methods 0.000 claims 1
• 230000008014 freezing Effects 0.000 claims 1
• 238000007710 freezing Methods 0.000 claims 1
• 229940096919 glycogen Drugs 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• 229940035034 maltodextrin Drugs 0.000 claims 1
• 239000003921 oil Substances 0.000 claims 1
• 238000010422 painting Methods 0.000 claims 1
• 238000007911 parenteral administration Methods 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 229920000724 poly(L-arginine) polymer Polymers 0.000 claims 1
• 108010011110 polyarginine Proteins 0.000 claims 1
• 229920001223 polyethylene glycol Polymers 0.000 claims 1
• 229920002714 polyornithine Polymers 0.000 claims 1
• 108010055896 polyornithine Proteins 0.000 claims 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
• 229940048914 protamine Drugs 0.000 claims 1
• 238000010526 radical polymerization reaction Methods 0.000 claims 1
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 238000013268 sustained release Methods 0.000 claims 1
• 239000012730 sustained-release form Substances 0.000 claims 1